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Antimicrobial Dressing

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1. Chronic wounds: advanced wound dressings and antimicrobial dressings

Chronic wounds: advanced wound dressings and antimicrobial dressings Chronic wounds: advanced wound dressings and Chronic wounds: advanced wound dressings and antimicrobial dressings antimicrobial dressings Evidence summary Published: 30 March 2016 nice.org.uk/guidance/esmpb2 pathways K Ke ey points from the e y points from the evidence vidence The content of this evidence summary was up-to-date in March 2016. See summaries of product characteristics (SPCs), British national formulary (BNF (...) ) or the MHRA or NICE websites for up-to-date information. Overall summary This evidence summary discusses the best available evidence for advanced wound dressings and antimicrobial dressings for managing common chronic wounds (diabetic foot ulcers, pressure ulcers, venous leg ulcers and infected wounds). It includes evidence and recommendations from national guidance (if available) and the most up-to-date systematic reviews and meta-analyses (search date July 2015). Dressings should provide the optimal

2016 National Institute for Health and Clinical Excellence - Advice

2. Antimicrobial dressings for the prevention of catheter-related infections in newborn infants with central venous catheters. Full Text available with Trip Pro

of antimicrobial (antiseptic or antibiotic) dressings in reducing CVC-related infections in newborn infants. Had there been relevant data, we would have evaluated the effects of antimicrobial dressings in different subgroups, including infants who received different types of CVCs, infants who required CVC for different durations, infants with CVCs with and without other antimicrobial modifications, and infants who received an antimicrobial dressing with and without a clearly defined co-intervention.We used (...) Antimicrobial dressings for the prevention of catheter-related infections in newborn infants with central venous catheters. Central venous catheters (CVCs) provide secured venous access in neonates. Antimicrobial dressings applied over the CVC sites have been proposed to reduce catheter-related blood stream infection (CRBSI) by decreasing colonisation. However, there may be concerns on the local and systemic adverse effects of these dressings in neonates.We assessed the effectiveness and safety

2016 Cochrane

3. In Situ Electrospinning Iodine-Based Fibrous Meshes for Antibacterial Wound Dressing Full Text available with Trip Pro

In Situ Electrospinning Iodine-Based Fibrous Meshes for Antibacterial Wound Dressing For effective application of electrospinning and electrospun fibrous meshes in wound dressing, we have in situ electrospun poly(vinyl pyrrolidone)/iodine (PVP/I), PVP/poly(vinyl pyrrolidone)-iodine (PVPI) complex, and poly(vinyl butyral) (PVB)/PVPI solutions into fibrous membranes by a handheld electrospinning apparatus. The morphologies of the electrospun fibers were examined by SEM, and the hydrophobicity (...) , gas permeability, and antibacterial properties of the as-spun meshes were also investigated. The flexibility and feasibility of in situ electrospinning PVP/I, PVP/PVPI, and PVB/PVPI membranes, as well as the excellent gas permeabilities and antibacterial properties of the as-spun meshes, promised their potential applications in wound healing.

2018 Nanoscale research letters

4. Minimum Intracanal Dressing Time of Triple Antibiotic Paste to Eliminate Enterococcus Faecalis (ATCC 29212) and Determination of Minimum Inhibitory Concentration and Minimum Bactericidal Concentration: An Ex Vivo Study Full Text available with Trip Pro

Minimum Intracanal Dressing Time of Triple Antibiotic Paste to Eliminate Enterococcus Faecalis (ATCC 29212) and Determination of Minimum Inhibitory Concentration and Minimum Bactericidal Concentration: An Ex Vivo Study Enterococcus faecalis (E. faecalis) is the most commonly isolated microorganism from teeth with postoperative infection. Triple antibiotic paste (TAP) has the ability to eradicate microorganisms from the root canal system when used as an intracanal medicament. The aim

2018 Journal of dentistry (Tehran, Iran)

5. Antibiotic ointment versus a silver-based dressing for children with extremity burns: A randomized controlled study. (Abstract)

Antibiotic ointment versus a silver-based dressing for children with extremity burns: A randomized controlled study. Antibiotic or silver-based dressings are widely used in burn wound care. Our standard method of dressing pediatric extremity burn wounds consists of an antibiotic ointment or nystatin ointment-impregnated nonadherent gauze (primary layer), followed by rolled gauze, soft cast pad, plaster and soft casting tape (3M™ Scotchcast™, St. Paul, MN). The aim of this study was to compare (...) our standard ointment-based primary layer versus Mepitel Ag® (Mölnlycke Health Care, Gothenburg, Sweden) in the management of pediatric upper and lower extremity burn wounds.Children with a new burn injury to the upper or lower extremities, who presented to the burn clinic were eligible. Eligible children were enrolled and randomized, stratified by burn thickness, to be dressed in an ointment-based dressing or Mepitel Ag®. Study personnel and participants were not blinded to the dressing

2018 Journal of Pediatric Surgery Controlled trial quality: predicted high

6. The influence of human acute wound fluid on the antibacterial efficacy of different antiseptic polyurethane foam dressings: an in-vitro analysis. (Abstract)

The influence of human acute wound fluid on the antibacterial efficacy of different antiseptic polyurethane foam dressings: an in-vitro analysis. Treating infected acute and/or chronic wounds still represents a major challenge in medical care. Various interactions of antiseptic dressings with wound environments regarding antimicrobial efficacy remain unclear. Therefore, this work aimed to investigate the influence of human acute wound fluid (AWF) on the antimicrobial performance of different (...) antiseptic foam dressings in vitro against typical bacterial wound pathogens. Eight antiseptic polyurethane foam dressings containing either a silver formulation or a polyhexamethylene-biguanide (PHMB) were assessed regarding their antimicrobial potency against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa using a modified time-kill assay based on ISO EN 20743. The antiseptic efficacy was evaluated standardly as well as under the influence of human AWF after 2, 4, 6, and 24 hours

2018 Wound Repair and Regeneration

7. Nano-silver-incorporated biomimetic polydopamine coating on a thermoplastic polyurethane porous nanocomposite as an efficient antibacterial wound dressing Full Text available with Trip Pro

candidates as a scaffold; however, their lack of a suitable porous structure and antibacterial activity has limited their application. Antibiotics are generally used for preventing bacterial infections, but the global emergence of drug-resistant bacteria continues to cause social concerns.Consequently, we prepared a flexible dressing based on a TPU membrane with a specific porous structure and then modified it with a biomimetic polydopamine coating to prepare in situ a nano-silver (NS)-based composite (...) Nano-silver-incorporated biomimetic polydopamine coating on a thermoplastic polyurethane porous nanocomposite as an efficient antibacterial wound dressing Developing an ideal wound dressing that meets the multiple demands of good biocompatibility, an appropriate porous structure, superior mechanical property and excellent antibacterial activity against drug-resistant bacteria is highly desirable for clinical wound care. Biocompatible thermoplastic polyurethane (TPU) membranes are promising

2018 Journal of nanobiotechnology

8. Comparative efficacy of 13 antimicrobial dressings and different securement devices in reducing catheter-related bloodstream infections: A Bayesian network meta-analysis. Full Text available with Trip Pro

Comparative efficacy of 13 antimicrobial dressings and different securement devices in reducing catheter-related bloodstream infections: A Bayesian network meta-analysis. The purpose of our study is to carry out a Bayesian network meta-analysis comparing the efficacy of different antimicrobial dressings for prevention of catheter-related blood infections (CRBSI) and rank these antimicrobial dressings for practical consideration.We searched the PubMed, Cochrane library, Embase, earlier relevant (...) meta-analysis and reference lists of included studies for randomized controlled trials (RCTs) that compared dressings for prevention of CRBSI. Two authors independently extracted data from each included RCT according to a predesigned Excel spreadsheet and assessed the methodological quality of included RCTs using the Cochrane risk of bias tool. Data was analyzed using the WinBUGS (V.1.4.3) and the Stata (V.15.0).Finally, 35 RCTs involving 8494 patients and evaluating 13 dressings were included

2019 Medicine

9. Use of antimicrobial dressings in England and the association with published clinical guidance: interrupted time series analysis. Full Text available with Trip Pro

Use of antimicrobial dressings in England and the association with published clinical guidance: interrupted time series analysis. In healthcare systems, practices and products of unproven value and cost-effectiveness can decrease value and increase waste. Using the management of complex wounds, this study investigates temporal trends in the use of antimicrobials dressings, places this in the context of available evidence and discusses the potential impacts on the UK National Health Service (NHS (...) ).Secondary descriptive and interrupted time series (ITS) analysis of NHS prescription data.Prescribing Cost Analysis (PCA) details all NHS prescriptions dispensed in the community in England.An ITS design was used to compare annual changes in the expenditure and use of antimicrobial and non-antimicrobial dressings before and after the publication of the 'intervention' of key evidence-based Scottish Intercollegiate Guidelines Network (SIGN) guidance in 2010.Trends in use and expenditure of antimicrobial

2019 BMJ open

10. Antimicrobial dressing with Activated Carbon Fibre (ACF)

Antimicrobial dressing with Activated Carbon Fibre (ACF) Antimicrobial dressing with Activated Carbon Fibre (ACF) Antimicrobial dressing with Activated Carbon Fibre (ACF) Malaysian Health Technology Assessment (MaHTAS) Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Malaysian Health Technology Assessment (MaHTAS). Antimicrobial dressing (...) with Activated Carbon Fibre (ACF) Putrajaya: Malaysian Health Technology Assessment (MaHTAS). 2014 Authors' objectives To review evidence on the safety, efficacy/effectiveness and cost-effectiveness of BCT™ Antimicrobial Dressing with ACF for wound care. Authors' conclusions There was very limited and fair quality of retrievable evidence from the scientific databases to suggest that the use of BCT™ Antimicrobial Dressing with ACF is effective in wound care. There was no report of adverse events on the use

2014 Health Technology Assessment (HTA) Database.

11. Measuring the microbiome of chronic wounds with use of a topical antimicrobial dressing - A feasibility study. Full Text available with Trip Pro

when a topical antimicrobial dressing is used to reduce bioburden.Patients with chronic wounds defined as >6 weeks in duration and not taking systemic antibiotics were recruited to participate. A wound contact layer containing silver oxynitrate was applied immediately after routine sharp debridement material was collected and swabs of the wound bed taken. Next-generation sequencing of the bacterial 16S rRNA gene in each specimen was used to measure the microbiome.Distinct bacterial communities were (...) Measuring the microbiome of chronic wounds with use of a topical antimicrobial dressing - A feasibility study. Polymicrobial communities colonize all wounds, and biofilms are hypothesized to be a key link to the chronic state and stalled healing. Molecular methods offer greater insight when studying microbial ecology in chronic wounds, as only a small fraction of wound bacteria are cultured by currently available methods and studies have shown little agreement between culture and molecular

2017 PLoS ONE

12. A surfactant polymer dressing potentiates antimicrobial efficacy in biofilm disruption Full Text available with Trip Pro

A surfactant polymer dressing potentiates antimicrobial efficacy in biofilm disruption A 100% water-soluble surfactant polymer dressing (SPD) that is bio-compatible and non-ionic has been reported to improve wound closure in preliminary clinical studies. The mechanism of action of SPD in wound healing remains unclear. Biofilm infection is a significant problem that hinders proper wound closure. The objective of this study was to characterize the mechanism of action of SPD inhibition (...) (SEM) structural imaging, in vitro imaging system (IVIS) proliferation imaging, colony forming units (CFU), viability assay, quantitative PCR (qPCR) for virulence gene expression. Because SPD is a surfactant based dressing, it potentially has a direct effect on Gram negative bacteria such as Pseudomonas primarily due to the lipid-based outer membrane of the bacteria. SPD is a surfactant based dressing that has potent anti-biofilm properties directly or in synergy with antibiotics.

2018 Scientific reports

13. Budget impact of antimicrobial wound dressings in the treatment of venous leg ulcers in the German outpatient care sector: a budget impact analysis Full Text available with Trip Pro

Budget impact of antimicrobial wound dressings in the treatment of venous leg ulcers in the German outpatient care sector: a budget impact analysis Background: Hard-to-heal wounds are associated with high treatment costs and, in Germany, are mostly treated in the outpatient care sector. Wound dressings are the main cost-drivers in venous leg ulcer (VLU) care which prescription is budget-restricted. Objective: To determine to what extent the choice of antimicrobial dressing affects the spending (...) in outpatient care by investigating the budget impact of the bioburden-reducing dressing Cutimed Sorbact. Methods: The budget impact analysis was performed comparing three different scenarios of the intervention mix of antimicrobial dressings. A Markov model was used to estimate the VLU progression during one year. The budget impact was determined by comparing the dressing and medicine resource use and costs of the three scenarios. Results: This analysis confirms the high treatment costs of VLU care

2018 Journal of Market Access & Health Policy

14. Antibacterial Properties of Nonwoven Wound Dressings Coated with Manuka Honey or Methylglyoxal Full Text available with Trip Pro

Antibacterial Properties of Nonwoven Wound Dressings Coated with Manuka Honey or Methylglyoxal Manuka honey (MH) is used as an antibacterial agent in bioactive wound dressings via direct impregnation onto a suitable substrate. MH provides unique antibacterial activity when compared with conventional honeys, owing partly to one of its constituents, methylglyoxal (MGO). Aiming to investigate an antibiotic-free antimicrobial strategy, we studied the antibacterial activity of both MH and MGO (...) -containing fabrics, solutions with much higher MGO concentrations (128 mg L-1-1024 mg L-1) were required to provide either a bacteriostatic or bactericidal effect. The results presented in this study therefore demonstrate the relevance of an MGO-based coating as an environmentally friendly strategy for the design of functional dressings with antibiotic-free antimicrobial chemistries.

2017 Materials

15. Electrospun Gelatin/poly(Glycerol Sebacate) Membrane with Controlled Release of Antibiotics for Wound Dressing Full Text available with Trip Pro

Electrospun Gelatin/poly(Glycerol Sebacate) Membrane with Controlled Release of Antibiotics for Wound Dressing The most important risk that threatens the skin wounds is infections. Therefore, fabrication of a membrane as a wound dressing with the ability of antibiotic delivery in a proper delivery rate is especially important.Poly(glycerol sebacate) (PGS) was prepared from sebacic acid and glycerol with 1:1 ratio; then, it was added to gelatin in the 1:3 ratio and was dissolved in 80% (v/v (...) was higher than 80% before and after crosslinking process. UV-visible spectrophotometry showed the proper rate of ciprofloxacin release occurred from cross-linked membrane that remaining in EDC/NHS ethanol solution for 120 min.The obtained results suggest that this recently developed gelatin/PGS membrane with controlled release of ciprofloxacin could be a promising biodegradable membrane for wound dressing.

2017 Advanced biomedical research

16. Nanosilver–Silica Composite: Prolonged Antibacterial Effects and Bacterial Interaction Mechanisms for Wound Dressings Full Text available with Trip Pro

Nanosilver–Silica Composite: Prolonged Antibacterial Effects and Bacterial Interaction Mechanisms for Wound Dressings Infected superficial wounds were traditionally controlled by topical antibiotics until the emergence of antibiotic-resistant bacteria. Silver (Ag) is a kernel for alternative antibacterial agents to fight this resistance quandary. The present study demonstrates a method for immobilizing small-sized (~5 nm) silver nanoparticles on silica matrix to form a nanosilver-silica (Ag (...) , impregnated with the Ag-SiO₂ composite, showed higher antibacterial effects against MRSA and E . coli than a commercial Ag-containing dressing, indicating a potential for the management and infection control of superficial wounds. Transmission and scanning transmission electron microscope analyses of the composite-treated MRSA revealed an interaction of the released silver ions with the bacterial cytoplasmic constituents, causing ultimately the loss of bacterial membranes. The present results

2017 Nanomaterials

17. Antibacterial Effect of Calcium Hydroxide With or Without Chlorhexidine as Intracanal Dressing in Primary Teeth With Apical Periodontitis. (Abstract)

Antibacterial Effect of Calcium Hydroxide With or Without Chlorhexidine as Intracanal Dressing in Primary Teeth With Apical Periodontitis. The purpose of this study was to evaluate in vivo the antibacterial effect of calcium hydroxide (CH) dressings, with or without chlorhexidine (CHX), on human primary teeth with apical periodontitis.Forty root canals in 40 children were selected. A first microbiological sample was obtained after coronal opening, and the teeth were randomly assigned to Group 1 (...) with a significance level of five percent.Both CH dressings provided a significant reduction in the number of microorganisms (anaerobic, aerobic, black-pigmented bacilli, streptococci and Streptococcus mutans) in a similar way (P>0.05). However, in terms of complete elimination of microbiota, CH paste alone exhibited greater efficacy (P<0.05).The addition of chlorhexidine did not provide additional antimicrobial benefits compared with pure calcium hydroxide paste as an intracanal dressing in primary teeth

2017 Pediatric dentistry Controlled trial quality: uncertain

18. Polyurethane Foam Dressings for the Prevention of Pressure Ulcers: Clinical and Cost-Effectiveness and Guidelines

Polyurethane Foam Dressings for the Prevention of Pressure Ulcers: Clinical and Cost-Effectiveness and Guidelines Absorbable Delivery Products for Treatment of Patients with Periprosthetic Infections: Clinical and Cost-Effectiveness | CADTH.ca Find the information you need Absorbable Delivery Products for Treatment of Patients with Periprosthetic Infections: Clinical and Cost-Effectiveness Absorbable Delivery Products for Treatment of Patients with Periprosthetic Infections: Clinical and Cost (...) -Effectiveness Published on: April 10, 2017 Project Number: RB1080-000 Product Line: Research Type: Devices and Systems Report Type: Summary of Abstracts Result type: Report Question What is the clinical effectiveness of the surgical implantation of absorbable delivery products for local antibiotic treatment of osteomyelitis in the treatment of patients with periprosthetic infections? What is the cost-effectiveness of the surgical implantation of absorbable delivery products for local antibiotic treatment

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

19. Randomized Controlled Trial on Autologous Platelet-Rich Plasma Versus Saline Dressing in Treatment of Non-healing Diabetic Foot Ulcers

Randomized Controlled Trial on Autologous Platelet-Rich Plasma Versus Saline Dressing in Treatment of Non-healing Diabetic Foot Ulcers Randomized Controlled Trial on Autologous Platelet-Rich Plasma Versus Saline Dressing in Treatment of Non-healing Diabetic Foot Ulcers - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy PubMed go to . Clipboard, Search History, and several other advanced (...) characters Choose a collection: Unable to load your collection due to an error Add Cancel Add to My Bibliography My Bibliography Unable to load your delegates due to an error Add Cancel Actions Cite Share Permalink Copy Page navigation World J Surg Actions 2019 Dec 6 [Online ahead of print] Randomized Controlled Trial on Autologous Platelet-Rich Plasma Versus Saline Dressing in Treatment of Non-healing Diabetic Foot Ulcers , , , , , Affiliations Expand Affiliations 1 General Surgery Department, Mansoura

2020 EvidenceUpdates

20. ZnO-NPs embedded biodegradable thiolated bandage for postoperative surgical site infection: In vitro and in vivo evaluation. Full Text available with Trip Pro

ZnO-NPs embedded biodegradable thiolated bandage for postoperative surgical site infection: In vitro and in vivo evaluation. Post-operative surgical site infections (SSI) present a serious threat and may lead to complications. Currently available dressings for SSI lack mucoadhesion, safety, efficacy and most importantly patient compliance. We aimed to address these concerns by developing a bioactive thiolated chitosan-alginate bandage embedded with zinc oxide nanoparticles (ZnO-NPs (...) ) for localized topical treatment of SSI. The FTIR, XRD, DSC and TGA of bandage confirmed the compatibility of ingredients and modifications made. The porosity, swelling index and lysozyme degradation showed good properties for wound healing and biodegradation. Moreover, in-vitro antibacterial activity showed higher bactericidal effect as compared to ZnO-NPs free bandage. In-vivo wound healing in murine model showed significant improved tissue generation and speedy wound healing as compared to positive

2019 PLoS ONE

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