How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

29,584 results for

Antidepressant

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

1. Mental health: Study supports augmentation with a non-antidepressant agent over combining or switching antidepressants in unipolar depression

Mental health: Study supports augmentation with a non-antidepressant agent over combining or switching antidepressants in unipolar depression Study supports augmentation with a non-antidepressant agent over combining or switching antidepressants in unipolar depression | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please (...) see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Study supports augmentation with a non-antidepressant agent over combining or switching antidepressants in unipolar

2018 Evidence-Based Medicine (Requires free registration)

2. Cost-effectiveness, cost-utility and the budget impact of antidepressants versus preventive cognitive therapy with or without tapering of antidepressants. (PubMed)

Cost-effectiveness, cost-utility and the budget impact of antidepressants versus preventive cognitive therapy with or without tapering of antidepressants. As depression has a recurrent course, relapse and recurrence prevention is essential.AimsIn our randomised controlled trial (registered with the Nederlands trial register, identifier: NTR1907), we found that adding preventive cognitive therapy (PCT) to maintenance antidepressants (PCT+AD) yielded substantial protective effects versus (...) antidepressants only in individuals with recurrent depression. Antidepressants were not superior to PCT while tapering antidepressants (PCT/-AD). To inform decision-makers on treatment allocation, we present the corresponding cost-effectiveness, cost-utility and budget impact.Data were analysed (n = 289) using a societal perspective with 24-months of follow-up, with depression-free days and quality-adjusted life years (QALYs) as health outcomes. Incremental cost-effectiveness ratios were calculated and cost

2019 BJPsych open Controlled trial quality: uncertain

3. Adjuvant therapy with antidepressants for the management of inflammatory bowel disease. (PubMed)

Adjuvant therapy with antidepressants for the management of inflammatory bowel disease. Symptoms of anxiety and depression are common in inflammatory bowel disease (IBD). Antidepressants are taken by approximately 30% of people with IBD. However, there are no current guidelines on treating co-morbid anxiety and depression in people with IBD with antidepressants, nor are there clear data on the role of antidepressants in managing physical symptoms of IBD.The objectives were to assess (...) the efficacy and safety of antidepressants for treating anxiety and depression in IBD, and to assess the effects of antidepressants on quality of life (QoL) and managing disease activity in IBD.We searched MEDLINE; Embase, CINAHL, PsycINFO, CENTRAL, and the Cochrane IBD Group Specialized Register from inception to 23 August 2018. Reference lists, trials registers, conference proceedings and grey literature were also searched.Randomised controlled trials (RCTs) and observational studies comparing any type

2019 Cochrane

4. Second-generation antidepressants for preventing seasonal affective disorder in adults. (PubMed)

Second-generation antidepressants for preventing seasonal affective disorder in adults. Seasonal affective disorder (SAD) is a seasonal pattern of recurrent major depressive episodes that most commonly occurs during autumn or winter and remits in spring. The prevalence of SAD ranges from 1.5% to 9%, depending on latitude. The predictable seasonal aspect of SAD provides a promising opportunity for prevention. This review - one of four reviews on efficacy and safety of interventions to prevent (...) SAD - focuses on second-generation antidepressants (SGAs).To assess the efficacy and safety of SGAs (in comparison with other SGAs, placebo, light therapy, melatonin or agomelatine, psychological therapies or lifestyle interventions) in preventing SAD and improving patient-centred outcomes among adults with a history of SAD.We searched Ovid MEDLINE (1950- ), Embase (1974- ), PsycINFO (1967- ) and the Cochrane Central Register of Controlled Trials (CENTRAL) to 19 June 2018. An earlier search

2019 Cochrane

5. Antidepressants plus benzodiazepines for adults with major depression. (PubMed)

Antidepressants plus benzodiazepines for adults with major depression. Anxiety frequently coexists with depression and adding benzodiazepines to antidepressant treatment is common practice to treat people with major depression. However, more evidence is needed to determine whether this combined treatment is more effective and not any more harmful than antidepressants alone. It has been suggested that benzodiazepines may lose their efficacy with long-term administration and their chronic use (...) carries risks of dependence.This is the 2019 updated version of a Cochrane Review first published in 2001, and previously updated in 2005. This update follows a new protocol to conform with the most recent Cochrane methodology guidelines, with the inclusion of 'Summary of findings' tables and GRADE evaluations for quality of evidence.To assess the effects of combining antidepressants with benzodiazepines compared with antidepressants alone for major depression in adults.We searched the Cochrane Common

2019 Cochrane

6. Antidepressants for depression in adults with HIV infection. (PubMed)

Antidepressants for depression in adults with HIV infection. Rates of major depression among people living with HIV (PLWH) are substantially higher than those seen in the general population and this may adversely affect antiretroviral treatment outcomes. Several unique clinical and psychosocial factors may contribute to the development and persistence of depression in PLWH. Given these influences, it is unclear if antidepressant therapy is as effective for PLWH as the general population.To (...) assess the efficacy of antidepressant therapy for treatment of depression in PLWH.We searched The Cochrane Common Mental Disorders Group's specialised register (CCMD-CTR), the Cochrane Library, PubMed, Embase and ran a cited reference search on the Web of Science for reports of all included studies. We conducted additional searches of the international trial registers including; ClinicalTrials.gov, World Health Organization Trials Portal (ICTRP), and the HIV and AIDS - Clinical trials register. We

2018 Cochrane

7. Antidepressants for preventing postnatal depression. (PubMed)

Antidepressants for preventing postnatal depression. Depression is common in the postnatal period and can lead to adverse effects on the infant and wider family, in addition to the morbidity for the mother. It is not clear whether antidepressants are effective for the prevention of postnatal depression and little is known about possible adverse effects for the mother and infant, particularly during breastfeeding. This is an update of a Cochrane Review last published in 2005.To assess (...) the effectiveness of antidepressant medication for the prevention of postnatal depression, in comparison with any other treatment, placebo or standard care.We searched the Cochrane Common Mental Disorders Controlled Trials Register (CCMDCTR ‒ both Studies and References), CENTRAL (Wiley), MEDLINE (OVID), Embase (OVID), PsycINFO (OVID), on 13 February 2018. We also searched the World Health Organization (WHO) trials portal (ICTRP) and ClinicalTrials.gov on 13 February 2018 to identify any additional unpublished

2018 Cochrane

8. Antidepressants versus placebo for panic disorder in adults. (PubMed)

Antidepressants versus placebo for panic disorder in adults. Panic disorder is characterised by repeated, unexpected panic attacks, which represent a discrete period of fear or anxiety that has a rapid onset, reaches a peak within 10 minutes, and in which at least four of 13 characteristic symptoms are experienced, including racing heart, chest pain, sweating, shaking, dizziness, flushing, stomach churning, faintness and breathlessness. It is common in the general population with a lifetime (...) prevalence of 1% to 4%. The treatment of panic disorder includes psychological and pharmacological interventions. Amongst pharmacological agents, the National Institute for Health and Care Excellence (NICE) and the British Association for Psychopharmacology consider antidepressants, mainly selective serotonin reuptake inhibitors (SSRIs), as the first-line treatment for panic disorder, due to their more favourable adverse effect profile over monoamine oxidase inhibitors (MAOIs) and tricyclic

2018 Cochrane

14. Antidepressants for treating depression in dementia. (PubMed)

Antidepressants for treating depression in dementia. The use of antidepressants in dementia accompanied by depressive symptoms is widespread, but their clinical efficacy is uncertain. This review updates an earlier version, first published in 2002.To determine the efficacy and safety of any type of antidepressant for patients who have been diagnosed as having dementia of any type and depression as defined by recognised criteria.We searched ALOIS, the Cochrane Dementia and Cognitive Improvement (...) Group's Specialised Register, on 16 August 2017. ALOIS contains information on trials retrieved from databases and from a number of trial registers and grey literature sources.We included all relevant double-blind, randomised trials comparing any antidepressant drug with placebo, for patients diagnosed as having dementia and depression.Two review authors selected studies for inclusion and extracted data independently. We assessed risk of bias in the included studies using the Cochrane 'Risk of bias

2018 Cochrane

15. Tricyclic antidepressant overdose

Tricyclic antidepressant overdose Tricyclic antidepressant overdose - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Tricyclic antidepressant overdose Last reviewed: February 2019 Last updated: March 2018 Summary Tricyclic antidepressants have a narrow therapeutic index and therefore become potent cardiovascular and central nervous system toxins in moderate doses. Complications include effects of prolonged hypotension (...) toxicologist or intensive care specialist . Benzodiazepines are the first-line treatment for seizures. Definition An antidepressant overdose occurs when a person ingests an amount of medication that is more than a reasonable and normal dose. Henry JA, Alexander CA, Sener EK. Relative mortality from overdose of antidepressants. BMJ. 1995;310:221-224. http://www.bmj.com/cgi/content/full/310/6974/221 http://www.ncbi.nlm.nih.gov/pubmed/7866123?tool=bestpractice.com Tricyclic antidepressants (TCAs) are the main

2018 BMJ Best Practice

16. Antidepressants for the treatment of depression in people with cancer. (PubMed)

Antidepressants for the treatment of depression in people with cancer. Major depression and other depressive conditions are common in people with cancer. These conditions are not easily detectable in clinical practice, due to the overlap between medical and psychiatric symptoms, as described by diagnostic manuals such as the Diagnostic and Statistical Manual of Mental Disorders (DSM) and International Classification of Diseases (ICD). Moreover, it is particularly challenging to distinguish (...) between pathological and normal reactions to such a severe illness. Depressive symptoms, even in subthreshold manifestations, have been shown to have a negative impact in terms of quality of life, compliance with anti-cancer treatment, suicide risk and likely even the mortality rate for the cancer itself. Randomised controlled trials (RCTs) on the efficacy, tolerability and acceptability of antidepressants in this population are few and often report conflicting results.To assess the efficacy

2018 Cochrane

17. Antidepressants for insomnia in adults. (PubMed)

Antidepressants for insomnia in adults. Insomnia disorder is a subjective condition of unsatisfactory sleep (e.g. sleep onset, maintenance, early waking, impairment of daytime functioning). Insomnia disorder impairs quality of life and is associated with an increased risk of physical and mental health problems including anxiety, depression, drug and alcohol abuse, and increased health service use. hypnotic medications (e.g. benzodiazepines and 'Z' drugs) are licensed for sleep promotion (...) , but can induce tolerance and dependence, although many people remain on long-term treatment. Antidepressant use for insomnia is widespread, but none is licensed for insomnia and the evidence for their efficacy is unclear. This use of unlicensed medications may be driven by concern over longer-term use of hypnotics and the limited availability of psychological treatments.To assess the effectiveness, safety and tolerability of antidepressants for insomnia in adults.This review incorporated the results

Full Text available with Trip Pro

2018 Cochrane

18. Antidepressants for the treatment of people with co-occurring depression and alcohol dependence. (PubMed)

Antidepressants for the treatment of people with co-occurring depression and alcohol dependence. Alcohol dependence is a major public health problem characterized by recidivism, and medical and psychosocial complications. The co-occurrence of major depression in people entering treatment for alcohol dependence is common, and represents a risk factor for morbidity and mortality, which negatively influences treatment outcomes.To assess the benefits and risks of antidepressants for the treatment (...) -English language literature. We handsearched references of topic-related systematic reviews and the included studies.Randomized controlled trials and controlled clinical trials comparing antidepressants alone or in association with other drugs or psychosocial interventions (or both) versus placebo, no treatment, and other pharmacological or psychosocial interventions.We used standard methodological procedures as expected by Cochrane.We included 33 studies in the review (2242 participants

2018 Cochrane

19. The depressing evidence for antidepressants in the elderly

The depressing evidence for antidepressants in the elderly Tools for Practice is proudly sponsored by the Alberta College of Family Physicians (ACFP). ACFP is a provincial, professional voluntary organization, representing more than 5,000 family physicians, family medicine residents, and medical students in Alberta. Established over sixty years ago, the ACFP strives for excellence in family practice through advocacy, continuing medical education and primary care research. www.acfp.ca February 4 (...) , 2019 The depressing evidence for antidepressants in the elderly Clinical Question: How effective are antidepressants for treating depression in the elderly? Bottom Line: The efficacy of antidepressants in the elderly is inconsistent and may decrease as patients age. From 80% to 40% of elderly patients will recover with antidepressants, with some studies showing no difference from placebo response rates. Harms of antidepressants are common, with ~20% stopping due to adverse effects. Evidence: • 5

2019 Tools for Practice

20. Antidepressants for Adults with Depression using Opioid Medications: Clinical Effectiveness and Guidelines

Antidepressants for Adults with Depression using Opioid Medications: Clinical Effectiveness and Guidelines Antidepressants for Adults with Depression using Opioid Medications: Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Antidepressants for Adults with Depression using Opioid Medications: Clinical Effectiveness and Guidelines Antidepressants for Adults with Depression using Opioid Medications: Clinical Effectiveness and Guidelines Last updated: February 16 (...) , 2018 Project Number: RB1196-000 Product Line: Research Type: Drug Report Type: Summary of Abstracts Result type: Report Question What is the clinical effectiveness of antidepressants in adults with depression using opioid medications? What are the evidence-based guidelines informing the use of antidepressants in adults with depression using opioid medications? Key Message Two systematic reviews, one meta-analysis, four randomized controlled trials, and one evidence-based guideline was identified

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>