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Antibiotics in Pregnancy

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161. Nausea/vomiting in pregnancy

is it? Most women feel nauseated or vomit in early pregnancy [ ]. This is defined as nausea and vomiting in pregnancy when there are no other causes [ ]. These symptoms are commonly referred to as 'morning sickness', but symptoms can occur at any time during the day [ ]. A UK study found that nausea and vomiting occur throughout the day in many pregnant women; of 292 women with symptoms, only 3.8% experienced nausea only in the morning. A similar pattern was observed for women with vomiting (...) and vomiting are a mechanism to prevent the woman eating potentially harmful foods. Gastric dysfunction In pregnant women, oesophageal, gastric, and small-bowel motility are impaired because of smooth-muscle relaxation due to increased levels of progesterone. Delayed gastric emptying in pregnancy may also contribute to nausea and vomiting. Vestibular and olfactory system It is postulated that a pregnancy stimulus may lower the threshold for vestibular-mediated nausea and vomiting in some women. Hyperacuity

2018 NICE Clinical Knowledge Summaries

162. Impact of intrapartum antimicrobial prophylaxis upon the intestinal microbiota and the prevalence of antibiotic resistance genes in vaginally delivered full-term neonates Full Text available with Trip Pro

Impact of intrapartum antimicrobial prophylaxis upon the intestinal microbiota and the prevalence of antibiotic resistance genes in vaginally delivered full-term neonates Disturbances in the early establishment of the intestinal microbiota may produce important implications for the infant's health and for the risk of disease later on. Different perinatal conditions may be affecting the development of the gut microbiota. Some of them, such as delivery mode or feeding habits, have been (...) extensively assessed whereas others remain to be studied, being critical to identify their impact on the microbiota and, if any, to minimize it. Antibiotics are among the drugs most frequently used in early life, the use of intrapartum antimicrobial prophylaxis (IAP), present in over 30% of deliveries, being the most frequent source of exposure. However, our knowledge on the effects of IAP on the microbiota establishment is still limited. The aim of the present work was to evaluate the impact of IAP

2017 Microbiome

163. INtravesical Antimicrobial Agents v STANDard Oral Antibiotics for the Treatment of Acute UTI in Women With rUTI

INtravesical Antimicrobial Agents v STANDard Oral Antibiotics for the Treatment of Acute UTI in Women With rUTI INtravesical Antimicrobial Agents v STANDard Oral Antibiotics for the Treatment of Acute UTI in Women With rUTI - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. INtravesical Antimicrobial Agents v STANDard Oral Antibiotics for the Treatment of Acute UTI in Women With rUTI (INSTANT) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov

2017 Clinical Trials

164. Hyperbaric Oxygen Therapy for Antibiotic Refractory Pouchitis

Hyperbaric Oxygen Therapy for Antibiotic Refractory Pouchitis Hyperbaric Oxygen Therapy for Antibiotic Refractory Pouchitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Hyperbaric Oxygen Therapy (...) for Antibiotic Refractory Pouchitis (HBOT-pouch) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03526796 Recruitment Status : Not yet recruiting First Posted : May 16, 2018 Last Update Posted : May 16, 2018 See Sponsor: Jinling

2018 Clinical Trials

165. Oral Vancomycin to Prevent Recurrent C Difficile Infection With Antibiotics

with a suspected or a confirmed bacterial infection requiring antibiotics Exclusion Criteria: Active chronic diarrheal illness (eg, Crohn's disease, ulcerative colitis, short bowel syndrome) Previous adverse reactions to oral vancomycin Requiring metronidazole during hospitalization Known pregnancy Expected survival <72 hours Patients receiving antibiotics only for surgical prophylaxis Patients who received prophylactic oral vancomycin for the current antibiotic course prior to enrollment in the study Contacts (...) Oral Vancomycin to Prevent Recurrent C Difficile Infection With Antibiotics Oral Vancomycin to Prevent Recurrent C Difficile Infection With Antibiotics - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Oral

2018 Clinical Trials

166. Mechanical Bowel Preparation and Oral Antibiotics Before Colon Cancer Surgery

Mechanical Bowel Preparation and Oral Antibiotics Before Colon Cancer Surgery Mechanical Bowel Preparation and Oral Antibiotics Before Colon Cancer Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Mechanical Bowel Preparation and Oral Antibiotics Before Colon Cancer Surgery (COLONPREP) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03475680 Recruitment Status : Not yet recruiting First Posted : March 23, 2018 Last

2018 Clinical Trials

167. GRam Stain-guided Antibiotics ChoicE for Ventilator-Associated Pneumonia (GRACE-VAP) Trial

: Patients having an allergy to study medications Pregnant patients Patients discharged from ICU Patients diagnosed as having heart failure or atelectasis Patients administered antibiotics for more than 24 hours when they meet the inclusion criteria Patients declined to provide full life support Patients judged as inappropriate at the discretion of the study physician. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may (...) GRam Stain-guided Antibiotics ChoicE for Ventilator-Associated Pneumonia (GRACE-VAP) Trial GRam Stain-guided Antibiotics ChoicE for Ventilator-Associated Pneumonia (GRACE-VAP) Trial - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2018 Clinical Trials

168. Combined Use of a Respiratory Broad Panel mPCR and Procalcitonin to Reduce Duration of Antibiotics Exposure in Patients With Severe Community-Acquired Pneumonia

Combined Use of a Respiratory Broad Panel mPCR and Procalcitonin to Reduce Duration of Antibiotics Exposure in Patients With Severe Community-Acquired Pneumonia Combined Use of a Respiratory Broad Panel mPCR and Procalcitonin to Reduce Duration of Antibiotics Exposure in Patients With Severe Community-Acquired Pneumonia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study (...) Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Combined Use of a Respiratory Broad Panel mPCR and Procalcitonin to Reduce Duration of Antibiotics Exposure in Patients With Severe Community-Acquired Pneumonia (MULTI-CAP) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated

2018 Clinical Trials

169. Antibiotic Outbreak, Risk Factors for Never Event, Prediction of Inappropriate Use

that never events also cluster over time. Using electronic data capture strategies, an algorithm will be developed to quickly and accurately identify areas of antibiotic use concern. Secondly, a framework will be developed, utilizing antimicrobial consumption data and captured signals of inappropriate antimicrobial use to provide targets for antimicrobial stewardship efforts. Condition or disease Infectious Disease Detailed Description: Appropriateness in antimicrobial prescribing has become a focal (...) except when using time and resource intense chart reviews. Even the largest contemporary antibiotic consumption studies have not assessed appropriateness as it was 'outside of study scope'. Further, there is no consensus or agreement on what constitutes inappropriate use. These apparent omissions underscore the difficulty and complexity in attributing appropriateness of use for antimicrobials. Importantly, this study will focus on the MOST inappropriate use, which are defined as 'never events

2018 Clinical Trials

170. Mechanical Bowel Preparation and Oral Antibiotics Before Rectal Cancer Surgery

Mechanical Bowel Preparation and Oral Antibiotics Before Rectal Cancer Surgery Mechanical Bowel Preparation and Oral Antibiotics Before Rectal Cancer Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Mechanical Bowel Preparation and Oral Antibiotics Before Rectal Cancer Surgery (PREPACOL2) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03491540 Recruitment Status : Not yet recruiting First Posted : April 9, 2018 Last

2018 Clinical Trials

171. Antibiotic De-escalation in Onco-hematology Patients for Sepsis or Septic Shock

Posted : February 5, 2019 See Sponsor: Institut Paoli-Calmettes Information provided by (Responsible Party): Institut Paoli-Calmettes Study Details Study Description Go to Brief Summary: De-escalation aims at reducing the use of broad-spectrum antibiotics and therefore the emergence of multidrug-resistant (MDR) pathogens. Observational studies suggested that this strategy seems to be safe. However, there is no adequate, direct evidence showing de-escalation of antimicrobial agents to be effective (...) of broad-spectrum antibiotics in terms of hospital mortality. The secondary aims are to compare the two strategies in terms of mortality, duration of antimicrobial therapy, durations of mechanical ventilation, vasopressor use, numbers of superinfections, organ failure. Antimicrobial de-escalation (ADE) of antimicrobial therapy is a strategy proposed to allow for the rational use of broad-spectrum antimicrobial therapy as the empiric treatment for infections and minimize the overall exposure

2018 Clinical Trials

172. Short Compared With Standard Duration of Antibiotic Treatment for AECOPD

antimicrobial agents. Antibiotic treatment duration was not based on a strong scientific rationale. Yet at the time of the dramatic emergence of bacterial resistance, reducing the selection pressure by reducing the exposure to antibiotic should be a major issue. In addition, the decrease in costs and associated side effects reinforces the interest of short treatments. Unfortunately, few studies with a satisfactory methodology are available in the literature. In fact, we present the rational and the interest (...) using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: patients having COPD (according to the definition of the American Thoracic Society) in acute exacerbation Exclusion Criteria: Pneumonia Antibiotic treatment in the previous days Pregnancy Immunodeficiency Concomitant infection intubation

2018 Clinical Trials

173. Clearance and Pharmacokinetics of Antibiotics in Renal Replacement Therapy

Clearance and Pharmacokinetics of Antibiotics in Renal Replacement Therapy Clearance and Pharmacokinetics of Antibiotics in Renal Replacement Therapy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Clearance and Pharmacokinetics of Antibiotics in Renal Replacement Therapy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03714789 Recruitment Status : Recruiting First Posted : October 22, 2018 Last Update Posted : October

2018 Clinical Trials

174. suPAR to Guide Antibiotics in Emergency Department

suPAR to Guide Antibiotics in Emergency Department suPAR to Guide Antibiotics in Emergency Department - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. suPAR to Guide Antibiotics in Emergency Department (...) Information provided by (Responsible Party): Hellenic Institute for the Study of Sepsis Study Details Study Description Go to Brief Summary: The aim of the current study is to evaluate suPAR - guided medical intervention, consisting of early antibiotic administration at the emergency room for presumed infection and sepsis and evaluate the impact of this intervention to the patients' final outcome. Since the traditionally used biomarkers (PCT, CRP) and scores (SOFA score) for early recognition of severity

2018 Clinical Trials

175. Short 3-week Antibiotic Treatment Versus 6 Weeks in Adults With Septic Arthritis of Native Joint

infections. Moreover, no consensus prevails on the administration route and duration of antimicrobial therapy. Although most clinicians acknowledge the interest of oral antibiotics and shorter treatment duration, randomized controlled trials are necessary to evaluate this practice. The SHASAR project aims to evaluate whether a shorter antibiotic treatment (3 week treatment) is safe and not inferior to the conventional 6 week treatment in native joint infections. If successful, this would represent (...) Short 3-week Antibiotic Treatment Versus 6 Weeks in Adults With Septic Arthritis of Native Joint Short 3-week Antibiotic Treatment Versus 6 Weeks in Adults With Septic Arthritis of Native Joint - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2018 Clinical Trials

176. Assessment of Pain and Antibacterial Activity of Chitosan Versus Sodium Hypochlorite as Irrigant in Infected Canal

in biomedical application due to its antimicrobial properties and biocompatibility and ability to resist aging for longer periods provide antibacterial effect in root canal disinfection.10ml of cs-np will be used during instrumentation in intervention group Drug: chitosan nanoparticles Chitosan is a bioactive polymer obtained from deacetylation of chitin and is used in biomedical application due to its antimicrobial properties and biocompatibility and ability to resist aging for longer periods provide (...) Assessment of Pain and Antibacterial Activity of Chitosan Versus Sodium Hypochlorite as Irrigant in Infected Canal Assessment of Pain and Antibacterial Activity of Chitosan Versus Sodium Hypochlorite as Irrigant in Infected Canal - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2018 Clinical Trials

177. Antibiotic and Probiotic Therapies in the Adjuvant Treatment of the Chronic Periodontitis.

Antibiotic and Probiotic Therapies in the Adjuvant Treatment of the Chronic Periodontitis. Antibiotic and Probiotic Therapies in the Adjuvant Treatment of the Chronic Periodontitis. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Antibiotic and Probiotic Therapies in the Adjuvant Treatment of the Chronic Periodontitis. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03692819 Recruitment Status : Recruiting First Posted

2018 Clinical Trials

178. The Value of Post-operative Antibiotic Therapy After Laparoscopic Appendectomy for Complicated Acute Appendicitis (Other Than for Generalized Peritonitis)

The Value of Post-operative Antibiotic Therapy After Laparoscopic Appendectomy for Complicated Acute Appendicitis (Other Than for Generalized Peritonitis) The Value of Post-operative Antibiotic Therapy After Laparoscopic Appendectomy for Complicated Acute Appendicitis (Other Than for Generalized Peritonitis) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail (...) Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Value of Post-operative Antibiotic Therapy After Laparoscopic Appendectomy for Complicated Acute Appendicitis (Other Than for Generalized Peritonitis) (ABAP) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal

2018 Clinical Trials

179. Relationship between Maternal and First Year of Life Dispensations of Antibiotics and Antiasthmatics Full Text available with Trip Pro

Relationship between Maternal and First Year of Life Dispensations of Antibiotics and Antiasthmatics Antibiotics are the most frequent prescription drugs used by pregnant women. Our objective was to investigate if the dispensation of antibiotics and antiasthmatics in children less than 1 year of age is associated with prenatal antibiotic exposure. A secondary aim was to explore the incidence of dispensed antibiotics in pregnancy and dispensed antibiotics and antiasthmatics in children. We (...) conducted an observational study using the Peer Academic Detailing study database to select patients eligible for match in the Medical Birth Registry of Norway, a total of 7747 mother-and-child pairs. Details on antibiotic and antiasthmatic pharmacy dispensations were obtained from the Norwegian Prescription Database. One quarter (1948 of 7747) of the mothers in the study had been dispensed antibiotics during pregnancy. In their first year of life, 17% (1289) of the children had had an antibiotic

2018 Antibiotics

180. Probiotic supplementation restores normal microbiota composition and function in antibiotic-treated and in caesarean-born infants Full Text available with Trip Pro

Probiotic supplementation restores normal microbiota composition and function in antibiotic-treated and in caesarean-born infants Infants born by caesarean section or receiving antibiotics are at increased risk of developing metabolic, inflammatory and immunological diseases, potentially due to disruption of normal gut microbiota at a critical developmental time window. We investigated whether probiotic supplementation could ameliorate the effects of antibiotic use or caesarean birth on infant (...) microbiota in a double blind, placebo-controlled randomized clinical trial. Mothers were given a multispecies probiotic, consisting of Bifidobacterium breve Bb99 (Bp99 2 × 108 cfu) Propionibacterium freundenreichii subsp. shermanii JS (2 × 109cfu), Lactobacillus rhamnosus Lc705 (5 × 109 cfu) and Lactobacillus rhamnosus GG (5 × 109 cfu) (N = 168 breastfed and 31 formula-fed), or placebo supplement (N = 201 breastfed and 22 formula-fed) during pregnancy, and the infants were given the same supplement

2018 Microbiome Controlled trial quality: predicted high

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