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Antibiotics in Pregnancy

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161. DiagNostic Study of Low-dose CT and multipleX PCR on Antibiotic Treatment and Outcome of Community-Acquired Pneumonia

DiagNostic Study of Low-dose CT and multipleX PCR on Antibiotic Treatment and Outcome of Community-Acquired Pneumonia DiagNostic Study of Low-dose CT and multipleX PCR on Antibiotic Treatment and Outcome of Community-Acquired Pneumonia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. DiagNostic Study of Low-dose CT and multipleX PCR on Antibiotic Treatment and Outcome of Community-Acquired Pneumonia (CAP-NEXT) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details

2017 Clinical Trials

162. INtravesical Antimicrobial Agents v STANDard Oral Antibiotics for the Treatment of Acute UTI in Women With rUTI

INtravesical Antimicrobial Agents v STANDard Oral Antibiotics for the Treatment of Acute UTI in Women With rUTI INtravesical Antimicrobial Agents v STANDard Oral Antibiotics for the Treatment of Acute UTI in Women With rUTI - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. INtravesical Antimicrobial Agents v STANDard Oral Antibiotics for the Treatment of Acute UTI in Women With rUTI (INSTANT) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov

2017 Clinical Trials

163. Serum Concentration of CEFOxitin Used for Antibiotic Prophylaxis in Obese Patients Undergoing BARiatric Surgery

to social security, The patient is able to consent to clinical research and has received all information on the study design/protocol, Signed/written informed consent Exclusion Criteria: Refuse to consent to the study or the patient is unable to consent, Allergy/Anaphylaxis to beta-lactam (ß-lactam) antibiotics either proven or suspected, Pregnancy, Persons deprived of their liberty by judicial or administrative decision, Urgent or emergent surgery. Contacts and Locations Go to Information from (...) Serum Concentration of CEFOxitin Used for Antibiotic Prophylaxis in Obese Patients Undergoing BARiatric Surgery Serum Concentration of CEFOxitin Used for Antibiotic Prophylaxis in Obese Patients Undergoing BARiatric Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2017 Clinical Trials

164. Antibiotic stewardship in perinatal and neonatal care. (PubMed)

Antibiotic stewardship in perinatal and neonatal care. The spread of antibiotic resistance due to the use and misuse of antibiotics around the world is now a major health crisis. Neonates are exposed to antibiotics both before and after birth, often empirically because of risk factors for infection, or for non-specific signs which may or may not indicate sepsis. There is increasing evidence that, apart from antibiotic resistance, the use of antibiotics in pregnancy and in the neonatal period (...) alters the microbiome in the fetus and neonate with an increased risk of immediate and long-term adverse effects. Antibiotic stewardship is a co-ordinated program that promotes the appropriate use of antibiotics, improves patient outcomes, reduces microbial resistance, and decreases the spread of infections caused by multidrug-resistant organisms. This review addresses some of the controversies in antibiotic use in the perinatal period, examines opportunities for reduction of unnecessary antibiotic

2017 Seminars in fetal & neonatal medicine

165. Associations of prenatal and childhood antibiotic use with child body mass index at age 3 years. (PubMed)

. Antibiotic orders were ascertained for mothers during pregnancy and for children through their age-3 BMI measurement. Linear mixed-effects regression models evaluated associations of prenatal and childhood antibiotic use with child BMIz.Prenatal antibiotic orders were not associated with child BMIz. Children in the three largest categories of lifetime antibiotic orders had higher BMIz compared with children with no orders; associations persisted when controlling for prenatal antibiotics (β [95 (...) Associations of prenatal and childhood antibiotic use with child body mass index at age 3 years. Early-life antibiotic exposure, whether through prenatal or childhood antibiotic use, may contribute to increased child body mass. Associations of prenatal and childhood antibiotic use with body mass index z-score (BMIz) were evaluated at age 3 years.Electronic health records were utilized from 8,793 mothers and singleton children delivered at Geisinger Clinic in Pennsylvania between 2006 and 2012

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2017 Obesity

166. The Jarisch-Herxheimer Reaction After Antibiotic Treatment of Spirochetal Infections: A Review of Recent Cases and Our Understanding of Pathogenesis. (PubMed)

in patients' blood and inhibition by anti-TNF antibodies. Accelerated phagocytosis of spirochetes by polymorphonuclear (PMN) leukocytes before rise in cytokines is responsible for removal of organisms from the blood, suggesting an early inflammatory signal from PMNs. Rarely fatal, except in neonates and in pregnancy for African women whose babies showed high perinatal mortality because of low birth weight, the JHR can be regarded as an adverse effect of antibiotics, necessary for achieving a cure (...) The Jarisch-Herxheimer Reaction After Antibiotic Treatment of Spirochetal Infections: A Review of Recent Cases and Our Understanding of Pathogenesis. Within 24 hours after antibiotic treatment of the spirochetal infections syphilis, Lyme disease, leptospirosis, and relapsing fever (RF), patients experience shaking chills, a rise in temperature, and intensification of skin rashes known as the Jarisch-Herxheimer reaction (JHR) with symptoms resolving a few hours later. Case reports indicate

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2017 American Journal of Tropical Medicine & Hygiene

167. Antibiotic Overconsumption in Pregnant Women With Urinary Tract Symptoms in Uganda. (PubMed)

Antibiotic Overconsumption in Pregnant Women With Urinary Tract Symptoms in Uganda. Urinary tract infections (UTIs) are one of the most common bacterial infections in women. During pregnancy physiological changes, like frequency, mimic UTI symptoms, and therefore bacteriological cultures are needed to confirm the diagnosis. However, in developing countries antibiotic therapy is commonly initiated without culture confirmation.We investigated the prevalence of bacteriuria among pregnant women (...) with and without UTI symptoms in Uganda. In total 2 562 urine samples were evaluated with nitrite and leukocyte esterase tests, using urine culture and/or dipslide with species identification as reference.The prevalence of culture-proven UTI among pregnant women with UTI symptoms was 4%. Since treatment is initiated based only on the presence of symptoms, 96% were erroneously given antibiotics. Further, there is a high prevalence of resistance to commonly used antibiotics, with 18 % ESBL and 36 % multidrug

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2017 Clinical Infectious Diseases

168. Drug interactions between rifamycin antibiotics and hormonal contraception: A systematic review. (PubMed)

Drug interactions between rifamycin antibiotics and hormonal contraception: A systematic review. Rifamycin antibiotics are commonly used for treatment of tuberculosis, but may reduce the effectiveness of hormonal contraception (HC).To determine whether interactions between rifamycins and HC result in decreased effectiveness or increased toxicity of either therapy.We searched MEDLINE, Embase, Cochrane and clinicaltrials.gov through May 2017.We included trials, cohort, and case-control studies (...) addressing pregnancy rates, pharmacodynamics or pharmacokinetic (PK) outcomes when HC and rifamycins were administered together versus apart. Of 7291 original records identified, 11 met inclusion criteria after independent review by two authors.Two authors independently abstracted study details and assessed study quality using the United States Preventive Services Task Force grading system. Findings are reported descriptively.Studies only addressed combined oral contraceptives (COCs) and none reported

2017 BJOG : an international journal of obstetrics and gynaecology

169. Drug interactions between non-rifamycin antibiotics and hormonal contraception: A systematic review. (PubMed)

language that addressed pregnancy rates, pharmacodynamics, or pharmacokinetic outcomes when any hormonal contraceptive and non-rifamycin antibiotic were administered together vs apart. Of 7291 original records that were identified, 29 met criteria for inclusion.Two authors independently assessed study quality and risk of bias using the United States Preventive Services Task Force evidence grading system. Findings were tabulated by drug class.Study quality ranged from good to poor and addressed only (...) oral contraceptive pills, emergency contraception pills, and the combined vaginal ring. Two studies demonstrated no difference in pregnancy rates in women who used oral contraceptives with and without non-rifamycin antibiotics. No differences in ovulation suppression or breakthrough bleeding were observed in any study that combined hormonal contraceptives with any antibiotic. No significant decreases in any progestin pharmacokinetic parameter occurred during co-administration with any antibiotic

2017 American Journal of Obstetrics and Gynecology

170. Old habits die hard: retrospective analysis of outcomes with use of corticosteroids and antibiotics before embryo transfer. (PubMed)

Old habits die hard: retrospective analysis of outcomes with use of corticosteroids and antibiotics before embryo transfer. To evaluate clinical pregnancy rates in embryo transfer (ET) cycles with and without peri-implantation corticosteroid and oral antibiotic administration.Retrospective cohort study.University-affiliated in vitro fertilization (IVF) clinic.Eight hundred and seventy-six ETs with or without the routine use of methylprednisolone and doxycycline.Embryo transfer (...) procedures.Clinical pregnancy rates (CPR).The CPR with the routine use of methylprednisolone and doxycycline was 56.1% compared with 61.5% after discontinuation of these medications. Ongoing pregnancy rates were 49.5% with medications versus 53.2% without medications. Of the cleavage-stage embryos, 79% underwent assisted hatching; among these, the CPR was 28.7% when treated with corticosteroids and antibiotics compared with 47.4% without medications.No statistically significant difference in overall IVF outcomes

2017 Fertility and Sterility

171. FFA2 Contribution to Gestational Glucose Tolerance Is Not Disrupted by Antibiotics. (PubMed)

FFA2 Contribution to Gestational Glucose Tolerance Is Not Disrupted by Antibiotics. During the insulin resistant phase of pregnancy, the mRNA expression of free fatty acid 2 receptor (Ffar2) is upregulated and as we recently reported, this receptor contributes to insulin secretion and pancreatic beta cell mass expansion in order to maintain normal glucose homeostasis during pregnancy. As impaired gestational glucose levels can affect metabolic health of offspring, we aimed to explore the role (...) of maternal Ffar2 expression during pregnancy on the metabolic health of offspring and also the effects of antibiotics, which have been shown to disrupt gut microbiota fermentative activity (the source of the FFA2 ligands) on gestational glucose homeostasis. We found that maternal Ffar2 expression and impaired glucose tolerance during pregnancy had no effect on the growth rates, ad lib glucose and glucose tolerance in the offspring between 3 and 6 weeks of age. To disrupt short chain fatty acid production

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2016 PLoS ONE

172. Antibiotic Prevention for Maternal Group B Streptococcal Colonization on Neonatal GBS-Related Adverse Outcomes: A Meta-Analysis. (PubMed)

Antibiotic Prevention for Maternal Group B Streptococcal Colonization on Neonatal GBS-Related Adverse Outcomes: A Meta-Analysis. Maternal colonization with group B Streptococcus (GBS) during pregnancy increases the risk of neonatal infection by vertical transmission. However, it remains unclear whether treating all colonized women during labor exposes a large number of their neonates to possible adverse effects without benefit. We performed a meta-analysis to assess the effect of intrapartum (...) antibiotic prophylaxis on neonatal adverse outcomes. We identified studies by searching several English and Chinese electronic databases and reviewing relevant articles. Data were pooled using fixed-effects or random-effects meta-analysis, and for each outcome both risk ratio (RR) and 95% confidence intervals (95% CIs) were calculated. Fourteen studies (2,051 pregnant women and 2,063 neonates) were included, comprising 13 randomized clinical trials and 1 cohort study. Antibiotic prophylaxis is associated

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2017 Frontiers in microbiology

173. Prenatal antibiotics and atopic dermatitis among 18-month old children in the Danish National Birth Cohort. (PubMed)

different definitions of atopic dermatitis.Prenatal exposure to antibiotics throughout pregnancy was associated with an increased risk of atopic dermatitis but only within the first 18 months of life among children born by atopic mothers. The clinical usefulness of this finding must rest on corroboration in independent data sources.© 2017 John Wiley & Sons Ltd. (...) Prenatal antibiotics and atopic dermatitis among 18-month old children in the Danish National Birth Cohort. Despite extensive research, the aetiology of atopic dermatitis remains largely unknown, but reduced intestinal microbiota diversity in neonates has been linked to subsequent atopic dermatitis. Consequently, postnatal antibiotics have been proposed as a risk factor, but a potential association between prenatal antibiotics and atopic dermatitis is not well studied. Overall, the current

2017 Clinical and Experimental Allergy

174. Obtaining antibiotics online from within the UK: a cross-sectional study. (PubMed)

; and (iii) identify resulting AS and patient safety issues.Searches were conducted for 'buy antibiotics online' using Google and Yahoo. For each search engine, data from the first 10 web sites with unique URL addresses were reviewed. Analysis was conducted on evidence of appropriate pharmacy registration, prescription requirement, whether antibiotic choice was 'prescriber-driven' or 'consumer-driven', and whether specific information was required (allergies, comorbidities, pregnancy) or given (adverse (...) Obtaining antibiotics online from within the UK: a cross-sectional study. Improved antibiotic stewardship (AS) and reduced prescribing in primary care, with a parallel increase in personal internet use, could lead citizens to obtain antibiotics from alternative sources online.A cross-sectional analysis was performed to: (i) determine the quality and legality of online pharmacies selling antibiotics to the UK public; (ii) describe processes for obtaining antibiotics online from within the UK

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2017 Journal of Antimicrobial Chemotherapy

175. Antibiotic Prophlaxis for High-risk Laboring Women in Low Income Countries

Antibiotic Prophlaxis for High-risk Laboring Women in Low Income Countries Antibiotic Prophlaxis for High-risk Laboring Women in Low Income Countries - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Antibiotic Prophlaxis for High-risk Laboring Women in Low Income Countries The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03248297 Recruitment Status : Recruiting First Posted : August 14, 2017 Last Update Posted : February

2017 Clinical Trials

176. Optimizing the Antibiotic Treatment of Uncomplicated Acute Appendicitis

Volunteers: No Criteria Inclusion Criteria: Age 18-60 years CT confirmed uncomplicated acute appendicitis Ability to give consent to participate in the study Exclusion Criteria: Age under 18 years or over 60 years Pregnancy or lactation Allergy to contrast media or iodine Allergy or contraindication to antibiotic therapy Renal insufficiency Metformin medication Severe systemic illness (for example malignancy, medical condition requiring immunosuppressant medication) CT confirmed complicated acute (...) Optimizing the Antibiotic Treatment of Uncomplicated Acute Appendicitis Optimizing the Antibiotic Treatment of Uncomplicated Acute Appendicitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Optimizing

2017 Clinical Trials

177. The Antibiotic Rifampin to Reduce High Levels of Blood and Urine Calcium in IIH

The Antibiotic Rifampin to Reduce High Levels of Blood and Urine Calcium in IIH The Antibiotic Rifampin to Reduce High Levels of Blood and Urine Calcium in IIH - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . The Antibiotic Rifampin to Reduce High Levels of Blood and Urine Calcium in IIH The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03384121 Recruitment Status : Recruiting First Posted : December 27, 2017 Last Update Posted

2017 Clinical Trials

178. Prophylactic Antibiotics Prior to Embryo Transfer (PAPET): RCT

University School of Medicine Information provided by (Responsible Party): Ashley Eskew, Washington University School of Medicine Study Details Study Description Go to Brief Summary: The objective of this study is to determine the impact on clinical pregnancy rate of withholding routine prophylactic antibiotic therapy during IVF. The hypothesis is that withholding antibiotic prophylaxis will be non-inferior to routine administration. To test this hypothesis, the investigators will conduct a randomized (...) is universal antibiotic prophylaxis, even in low risk populations. Our intervention will be withholding antibiotic prophylaxis in low risk populations. Outcome Measures Go to Primary Outcome Measures : Clinical pregnancy rate [ Time Frame: Our primary outcome measure will be obtained at 5-8 weeks gestational age following embryo transfer ] Defined as a gestational sac, with fetal pole and cardiac activity, on ultrasound Secondary Outcome Measures : Miscarriage rate [ Time Frame: Prior to 20 weeks gestation

2017 Clinical Trials

179. Use of Perioperative Antibiotics in Endoscopic Sinus Surgery

(amoxicillin-clavulanate, doxycycline, clarithromycin), immunodeficiency, cystic fibrosis, pregnancy, or diabetes with nasal polyposis (inability to receive systemic steroids) will be excluded, as will patients who lack capacity to provide informed consent. Patients undergoing active treatment for malignancy will be excluded. Patients undergoing unilateral ESS or with nonabsorbable packing placed at the time of surgery will be excluded. Patients who have been on antibiotics within 2 weeks of the surgery (...) Use of Perioperative Antibiotics in Endoscopic Sinus Surgery Use of Perioperative Antibiotics in Endoscopic Sinus Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Use of Perioperative Antibiotics

2017 Clinical Trials

180. Intrapartum antibiotics for GBS prophylaxis alter colonization patterns in the early infant gut microbiome of low risk infants (PubMed)

Intrapartum antibiotics for GBS prophylaxis alter colonization patterns in the early infant gut microbiome of low risk infants Early life microbial colonization and succession is critically important to healthy development with impacts on metabolic and immunologic processes throughout life. A longitudinal prospective cohort was recruited from midwifery practices to include infants born at full term gestation to women with uncomplicated pregnancies. Here we compare bacterial community succession (...) in infants born vaginally, with no exposure to antibiotics (n = 53), with infants who were exposed to intrapartum antibiotic prophylaxis (IAP) for Group B Streptococcus (GBS; n = 14), and infants born by C-section (n = 7). Molecular profiles  of the 16 S rRNA genes indicate that there is a delay in the expansion of Bifidobacterium, which was the dominate infant gut colonizer, over the first 12 weeks and a persistence of Escherichia when IAP for GBS exposure is present during vaginal labour. Longer

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2017 Scientific reports

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