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Antibiotics in Pregnancy

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141. Oral Vancomycin to Prevent Recurrent C Difficile Infection With Antibiotics

with a suspected or a confirmed bacterial infection requiring antibiotics Exclusion Criteria: Active chronic diarrheal illness (eg, Crohn's disease, ulcerative colitis, short bowel syndrome) Previous adverse reactions to oral vancomycin Requiring metronidazole during hospitalization Known pregnancy Expected survival <72 hours Patients receiving antibiotics only for surgical prophylaxis Patients who received prophylactic oral vancomycin for the current antibiotic course prior to enrollment in the study Contacts (...) Oral Vancomycin to Prevent Recurrent C Difficile Infection With Antibiotics Oral Vancomycin to Prevent Recurrent C Difficile Infection With Antibiotics - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Oral

2018 Clinical Trials

142. 7-days Versus 14 Days of Antibiotics Therapy for Ventilator Associated Pneumonia

7-days Versus 14 Days of Antibiotics Therapy for Ventilator Associated Pneumonia 7-days Versus 14 Days of Antibiotics Therapy for Ventilator Associated Pneumonia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding (...) more. 7-days Versus 14 Days of Antibiotics Therapy for Ventilator Associated Pneumonia The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03477292 Recruitment Status : Recruiting First Posted : March 26, 2018 Last Update

2018 Clinical Trials

143. Antibiotics During Intrauterine Balloon Tamponade Placement

Labor Complications Pregnancy Complications Puerperal Disorders Uterine Hemorrhage Pelvic Inflammatory Disease Adnexal Diseases Genital Diseases, Female Uterine Diseases Anti-Bacterial Agents Clindamycin Clindamycin palmitate Clindamycin phosphate Cefazolin Antibiotics, Antitubercular Anti-Infective Agents Antitubercular Agents Protein Synthesis Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action (...) Antibiotics During Intrauterine Balloon Tamponade Placement Antibiotics During Intrauterine Balloon Tamponade Placement - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Antibiotics During Intrauterine

2018 Clinical Trials

144. Adequate Duration of Antibiotic Treatment in Community-acquired Pneumonia With High Risk Class and Adequate Initial Clinical Response

Adequate Duration of Antibiotic Treatment in Community-acquired Pneumonia With High Risk Class and Adequate Initial Clinical Response Adequate Duration of Antibiotic Treatment in Community-acquired Pneumonia With High Risk Class and Adequate Initial Clinical Response - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You (...) have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Adequate Duration of Antibiotic Treatment in Community-acquired Pneumonia With High Risk Class and Adequate Initial Clinical Response (2017-001406-15) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health

2018 Clinical Trials

145. Prenatal antibiotic exposure and childhood asthma: a population-based study. (Full text)

213 661 mother-child dyads born in Manitoba, Canada between 1996 and 2012. Associations were determined using Cox regression, adjusting for maternal asthma, postnatal antibiotics and other potential confounders. Sensitivity analyses evaluated maternal antibiotic use before and after pregnancy.36.8% of children were exposed prenatally to antibiotics and 10.1% developed asthma. Prenatal antibiotic exposure was associated with an increased risk of asthma (adjusted hazard ratio (aHR) 1.23, 95% CI 1.20 (...) -1.27). There was an apparent dose response (aHR 1.15, 95% CI 1.11-1.18 for one course; aHR 1.26, 95% CI 1.21-1.32 for two courses; and aHR 1.51, 95% CI 1.44-1.59 for three or more courses). Maternal antibiotic use during 9 months before pregnancy (aHR 1.27, 95% CI 1.24-1.31) and 9 months postpartum (aHR 1.32, 95% CI 1.28-1.36) were similarly associated with asthma.Prenatal antibiotic exposure was associated with a dose-dependent increase in asthma risk. However, similar associations were observed

2018 European Respiratory Journal

146. Procalcitonin-guided antibiotic therapy in patients with fever in a general emergency department population: a multicenter noninferiority randomized clinical trial (HiTEMP study). (Full text)

trial, performed in two Dutch hospitals. Adult patients with fever ≥38.2°C (100.8°F) in triage were randomized between standard diagnostic workup (control group) and PCT-guided therapy, defined as standard workup with the addition of one single PCT measurement. The treatment algorithm encouraged withholding antibiotic regimens with PCT <0.5 μg/L, and starting antibiotic regimens at PCT ≥0.5 μg/L. Exclusion criteria were immunocompromised conditions, pregnancy, moribund patients, patients <72 h after (...) Procalcitonin-guided antibiotic therapy in patients with fever in a general emergency department population: a multicenter noninferiority randomized clinical trial (HiTEMP study). Overuse of broad-spectrum antibiotics in emergency departments (EDs) results in antibiotic resistance. We determined whether procalcitonin (PCT) -guided therapy can be used to reduce antibiotic regimens in EDs by investigating efficacy, safety and accuracy.This was a non-inferiority multicentre randomized clinical

2018 Clinical Microbiology and Infection Controlled trial quality: uncertain

147. Fetal and early life antibiotics exposure and very early onset inflammatory bowel disease: a population-based study. (Full text)

Fetal and early life antibiotics exposure and very early onset inflammatory bowel disease: a population-based study. Earlier studies on antibiotics exposure and development of IBD (Crohn's disease (CD) and ulcerative colitis (UC)) may have been biased by familial factors and gastroenteritis. We aimed to estimate the association between antibiotics during pregnancy or infantile age and very early onset (VEO) IBD.In this cohort study of 827 239 children born in Sweden between 2006 and 2013, we (...) examined the link between exposure to systemic antibiotics and VEO-IBD (diagnosis <6 years of age), using Cox proportional hazard regression models. Information on antibiotics and IBD was retrieved from the nationwide population-based Swedish Prescribed Drug Register and the National Patient Register. We specifically examined potential confounding from parental IBD and gastroenteritis.Children exposed to antibiotics during pregnancy were at increased risk of IBD compared with general population

2018 Gut

148. Prenatal Exposure to Antibiotics and Risk of Childhood Obesity in a Multi-Center Cohort Study. (Full text)

). Antibiotic use was ascertained for mothers during pregnancy. Modified Poisson regression models were used to estimate risk ratios for obesity (BMI >95th percentile), and linear mixed models were applied to assess the association with BMI z score. Repeated prenatal exposure to antibiotics was associated with childhood obesity at age 7 years, and risk of obesity tended to increase with an increasing number of antibiotic exposures (for 2-3 exposures, risk ratio (RR) = 1.22, 95% confidence interval (CI (...) ): 1.04, 1.44; for ≥4 exposures, RR = 1.34, 95% CI: 1.03, 1.73). The magnitude of association was strongest for repeated exposures in the second trimester (RR = 1.40, 95% CI: 1.16, 1.71). Prenatal antibiotic use was not associated with obesity or BMI z score at age 4 years. These findings support an increased risk of mid-childhood obesity with repeated use of antibiotics during pregnancy.

2018 American Journal of Epidemiology

149. Efficient treatment of chronic endometritis through a novel approach of intrauterine antibiotic infusion: a case series. (Full text)

antibiotic regime was administered based on the infectious agent detected. Re-evaluation concluded slightly improved microbiological environment in the endometrium but persisting inflammation. Antibiotic intrauterine infusion was proposed to the patients as an alternative practice. All our patients achieved a pregnancy shortly following intrauterine treatment with one patient reporting a live birth of twin babies and two patients currently reporting an ongoing pregnancy.The implications of this case (...) Efficient treatment of chronic endometritis through a novel approach of intrauterine antibiotic infusion: a case series. Early diagnosis and efficient management of Chronic Endometritis (CE) in patients seeking fertility treatment are two components every practitioner wishes to address. With respect to endometrial restoration, antibiotic treatment appears to perform well. However, regarding the improvement of In Vitro Fertilization (IVF) success rates, literature evidence is inconclusive

2018 BMC Women's Health

150. Medication use during pregnancy and lactation

can decrease throughout the pregnancy mainly due to increased metabolism in the liver and increased excretion via the kidneys. For medications with a broad therapeutic range this has little clinical significance (i.e. most antibiotics). For other medications (i.e. anticonvulsants, antidepressants, methadone) this may result in reduced therapeutic effect and in some cases necessitate an increased dosage. Because of individual differences, it is advisable to monitor the serum concentration (...) Medication use during pregnancy and lactation Medication use during pregnancy and lactation Hedvig Nordeng Marte Jettestad Prescribing medication to pregnant and lactating women requires that one also takes into consideration the safety of the fetus and breastfed child. The challenge is to provide the woman with an effective medication that does not harm the fetus or breastfed child. Recommendations • Pregnant women should in general be cautious with use of medication, especially in the first

2015 Nordic Federation of Societies of Obstetrics and Gynecology

151. Cardiac Arrest in Pregnancy

Cardiac Arrest in Pregnancy Cardiac Arrest in Pregnancy | Circulation Search Hello Guest! Login to your account Email Password Keep me logged in Search October 2019 September 2019 August 2019 July 2019 June 2019 May 2019 April 2019 March 2019 February 2019 January 2019 This site uses cookies. By continuing to browse this site you are agreeing to our use of cookies. Free Access article Share on Jump to Free Access article Cardiac Arrest in Pregnancy A Scientific Statement From the American Heart (...) are involved in resuscitation and specifically maternal resuscitation. Introduction Cardiac arrest in pregnancy is one of the most challenging clinical scenarios. Although most features of resuscitating a pregnant woman are similar to standard adult resuscitation, several aspects and considerations are uniquely different. The most obvious difference is that there are 2 patients, the mother and the fetus. Caregivers must have a thorough understanding of maternal mortality to best prevent and treat cardiac

2015 American Heart Association

152. Early Pregnancy Loss

pregnancy loss should be similar to that after suction curettage for induced abortion. Therefore, despite the lack of data, antibiotic prophylaxis also should be considered for patients with early pregnancy loss ( , ). The use of a single preoperative dose of doxycycline is recommended to prevent infection after surgical management of early pregnancy loss. Some experts have recommended administration of a single 200-mg dose of doxycycline 1 hour before surgical management of early pregnancy loss (...) to prevent postoperative infection. The use of antibiotics based only on the diagnosis of incomplete early pregnancy loss has not been found to reduce infectious complications as long as unsafe induced abortion is not suspected ( ). The benefit of antibiotic prophylaxis for the medical management of early pregnancy loss is unknown. How do the different treatment approaches to early pregnancy loss differ with respect to cost? Studies have consistently shown that surgical management in an operating room

2015 American College of Obstetricians and Gynecologists

153. Management of AML in Pregnancy

. & Chapman, S.W. ( 1998 ) Antifungal therapy during pregnancy . Clinical Infectious Diseases , 27 , 1151 – 1160 . Lynch, C.M. , Sinnott, J.T. , Holt, D.A. & Herold, A.H. ( 1991 ) Use of antibiotics during pregnancy . American Family Physician , 43 , 1365 – 1368 . Meyer‐Wittkopf, M. , Barth, H. , Emons, G. & Schmidt, S. ( 2001 ) Fetal cardiac effects of doxorubicin therapy for carcinoma of the breast during pregnancy: case report and review of the literature . Ultrasound in Obstetrics & Gynecology , 18 (...) Management of AML in Pregnancy Guidelines for the diagnosis and management of acute myeloid leukaemia in pregnancy - Ali - 2015 - British Journal of Haematology - Wiley Online Library By continuing to browse this site, you agree to its use of cookies as described in our . Search within Search term Search term The full text of this article hosted at iucr.org is unavailable due to technical difficulties. Guideline Free Access Guidelines for the diagnosis and management of acute myeloid leukaemia

2015 British Committee for Standards in Haematology

154. Management of Beta Thalassaemia in Pregnancy

(chorionic villus sampling, amniocentesis or cell-free fetal DNA) if appropriate. Take a clinical history to establish the extent of thalassaemia complications. Women with diabetes to be referred to joint diabetes pregnancy clinic with haematology input. Review medications e.g. chelators such as deferiprone or deferasirox. Women should be taking 5 mg folic acid. Women who have had a splenectomy should receive antibiotic prophylaxis. Discuss vaccinations with those women who have had a splenectomy. Offer (...) Management of Beta Thalassaemia in Pregnancy Management of Beta Thalassaemia in Pregnancy Green-top Guideline No. 66 March 2014RCOG Green-top Guideline No. 66 2of 17 © Royal College of Obstetricians and Gynaecologists Management of Beta Thalassaemia in Pregnancy This is the first edition of this guideline. 1. Purpose and scope The purpose of this guideline is to produce evidence-based guidance on the management of women with beta ( ß) thalassaemia major and intermedia in pregnancy

2014 Royal College of Obstetricians and Gynaecologists

155. General principles and prescription recommendations for antibiotics in primary care

function (creatinine clearance in elderly patients), fragility (diabetes, immunodeficiency), pregnancy and breastfeeding; • the choice of an antibiotic with the narrowest possible spectrum; • the shortest possible duration of treatment to avoid selection of resistant strains. ´ It is recommended to: • give preference to oral administration; • comply with the recommended dosages and treatment durations; • evaluate the efficacy of the antibiotic treatment on the symptoms between 48 and 72 hours after (...) (without obstruction); • acute exacerbation of a mild or moderate chronic obstructive pulmonary disease, in the absence of purulent secretions; • bronchiolitis and tracheobronchitis of favourable progress within 72 hours, in the absence of an associated AOM; • maxillary sinusitis in a child or adult when progress under symptomatic treatment is favourable. ´ There is no need to prescribe an antibiotic in asymptomatic bacteriuria (urinary colonisation) outside of pregnancy , including catheterisation

2014 HAS Guidelines

156. Differentiating Streptococcus pseudoporcinus from GBS: Could this have implications in pregnancy? (Full text)

Differentiating Streptococcus pseudoporcinus from GBS: Could this have implications in pregnancy? Streptococcus agalactiae (GBS) is a common pathogen known to cause neonatal and maternal infectious morbidity. Streptococcus pseudoporcinus (S. pseudoporcinus) is a separate, recently identified beta-hemolytic gram positive coccus that can cause false positive results on standard GBS agglutination testing assays.To determine the prevalence and clinical implications of S. pseudoporcinus colonization (...) in pregnancy.This is a 2-year retrospective cohort study comparing pregnant women colonized with GBS to those colonized with S. pseudoporcinus. We used a proteomics method of identification, matrix assisted laser desorption ionization time of flight mass spectrometry, to distinguish between S. pseudoporcinus and GBS colonization. Antibiotic susceptibility testing was carried out on all specimens. Maternal and neonatal chart reviews were conducted to identify predictors of S. pseudoporcinus colonization

2019 American Journal of Obstetrics and Gynecology

157. SMFM Consult Series #: Sepsis during pregnancy and the puerperium. (Full text)

SMFM Consult Series #: Sepsis during pregnancy and the puerperium. Maternal sepsis is a significant cause of maternal morbidity and mortality and is a preventable cause of maternal death. The purpose of this guideline is to summarize what is known about sepsis and to provide guidance for the management of sepsis in pregnancy and the postpartum period. The following are SMFM recommendations: (1) we recommend that sepsis and septic shock be considered medical emergencies and that treatment (...) and resuscitation begin immediately (GRADE 1B); (2) we recommend that providers consider the diagnosis of sepsis in pregnant patients with otherwise unexplained end organ damage in the presence of an infectious process, regardless of the presence of fever (GRADE 1B); (3) we recommend that empiric broad-spectrum antibiotics be administered as soon as possible, ideally within 1 hour, in any pregnant woman in whom sepsis is suspected (GRADE 1B); (4) we recommend obtaining cultures (blood, urine, respiratory

2019 American Journal of Obstetrics and Gynecology

158. Pregnancy Zone Protein is Associated with Airway Infection, Neutrophil Extracellular Trap Formation and Disease Severity in Bronchiectasis. (Full text)

Pregnancy Zone Protein is Associated with Airway Infection, Neutrophil Extracellular Trap Formation and Disease Severity in Bronchiectasis. Pregnancy zone protein (PZP) is a broad-spectrum immunosuppressive protein believed to suppress T-cell function during pregnancy to prevent fetal rejection. It has not previously been reported in the airway.To characterise PZP in the bronchiectasis airway including its relationship with disease severity.Label free liquid chromatography/mass spectrometry (...) microscopy confirmed the presence of PZP in NETs, while fluorescence and electron microscopy localised PZP to the cytoplasm and nuclei of neutrophils. Effective antibiotic therapy reduced sputum PZP.PZP is released into NETs. We report a novel link between airway infection, NET formation and disease severity in bronchiectasis during chronic airway inflammation.

2019 American Journal of Respiratory and Critical Care Medicine

159. Asymptomatic bacteriuria in pregnancy: systematic reviews of screening and treatment effectiveness and patient preferences. (PubMed)

. For treatment with antibiotics, we searched three databases for systematic reviews and obtained search results of the Cochrane Pregnancy and Childbirth Group's Trials Register to update a Cochrane review. Study selection, risk of bias assessment and evaluation of the quality for each outcome using Grading of Recommendations Assessment, Development and Evaluation was completed independently by two reviewers with consensus. Meta-analysis was conducted when appropriate as were analyses based on planned (...) opinions about antibiotic use during pregnancy. Fifteen trials compared antibiotic treatment with no treatment or placebo in women with confirmed bacteriuria. Low-quality evidence found that treatment lowered rates of pyelonephritis (12 trials, relative risk [RR] 0.24; 95% CI 0.13 to 0.42; absolute risk reduction [ARR] 17.6%; number needed to treat [NNT] 6, 95% CI 5 to 7) and low birth weight (seven trials, RR 0.63; 95% CI 0.45 to 0.90; ARR 4.4%; NNT 23, 95% CI 15 to 85).Antibiotic treatment for women

2019 BMJ open

160. The value of amniopatch in pregnancies associated with spontaneous preterm premature rupture of fetal membranes: a randomized controlled trial. (PubMed)

The value of amniopatch in pregnancies associated with spontaneous preterm premature rupture of fetal membranes: a randomized controlled trial. To evaluate the efficacy and safety of amniopatch in pregnancies associated with spontaneous preterm premature rupture of fetal membranes (PPROM).A randomized controlled trial that involved 100 women diagnosed with PPROM between 24 and 34 weeks of gestational age. Participants were randomized equally into two groups. Group I in which amniopatch was done (...) in addition to the routine management. Group II was treated with routine management including antibiotics and corticosteroids.Amniopatch was successful in complete sealing of the membrane defect in 6/50 (12%) of women while none the control group have undergone similar sealing (p = .0144, RR = 0.88). Women in the amniopatch group showed a significant increase of AFI compared to controls (12 versus 0, p = .0001, RR = 0.56).The amniopatch procedure is a successful technique that safely enhances sealing

2019 The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Controlled trial quality: uncertain

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