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Antibiotics in Pregnancy

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14341. Pharmacokinetics and Pharmacodynamics and Selected Antibiotics During Pregnancy

Pharmacokinetics and Pharmacodynamics and Selected Antibiotics During Pregnancy Pharmacokinetics and Pharmacodynamics and Selected Antibiotics During Pregnancy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Pharmacokinetics and Pharmacodynamics and Selected Antibiotics During Pregnancy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00214331 Recruitment Status : Completed First Posted : September 21, 2005 Last Update Posted : October 27, 2016 Sponsor: University of Wisconsin, Madison Collaborator: Food and Drug

2005 Clinical Trials

14342. Antibiotics for treating bacterial vaginosis in pregnancy. (PubMed)

Antibiotics for treating bacterial vaginosis in pregnancy. Bacterial vaginosis is an imbalance of the normal vaginal flora with an overgrowth of anaerobic bacteria and a lack of the normal lactobacillary flora. Bacterial vaginosis during pregnancy has been associated with poor perinatal outcome and, in particular, preterm birth (PTB). Identification and treatment may reduce the risk of PTB and its consequences.To assess the effects of antibiotic treatment of bacterial vaginosis in pregnancy.We (...) searched the Cochrane Pregnancy and Childbirth Group's Trials Register (May 2006).Randomized trials comparing antibiotic treatment with placebo or no treatment, or comparing two or more antibiotic regimens in pregnant women with bacterial vaginosis or intermediate vaginal flora.Two review authors assessed trials and extracted data independently. We contacted study authors for additional information.We included fifteen trials of good quality, involving 5888 women. Antibiotic therapy was effective

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2007 Cochrane database of systematic reviews (Online)

14343. Antibiotics for bacterial vaginosis or Trichomonas vaginalis in pregnancy: a systematic review. (PubMed)

Antibiotics for bacterial vaginosis or Trichomonas vaginalis in pregnancy: a systematic review. To determine whether antibiotic treatment for bacterial vaginosis or Trichomonas vaginalis during pregnancy decreases the risk of preterm birth and associated adverse outcomes.Pre-MEDLINE and MEDLINE (1966-2003), EMBASE (1980-2003), and the Cochrane Library were searched using the keywords "bacterial vaginosis", "Trichomonas", "Trichomonas vaginalis", "Trichomonas vaginitis", "Trichomonas infections (...) ", "pregnancy", "pregnant", "antibiotics", and "antibiotic prophylaxis".The search produced 1,888 titles, of which 1,256 abstracts were reviewed further. Of these, 1,217 were ineligible. Inclusion criteria were the following: randomized controlled trials in which antibiotics were compared with no antibiotic or placebo, for women in the second or third trimester of pregnancy with symptomatic or asymptomatic bacterial vaginosis or Trichomonas vaginalis, intact membranes, and not in labor. Exclusion criteria

2005 Obstetrics and Gynecology

14344. Antibiotic treatment of bacterial vaginosis in pregnancy: a meta-analysis. (PubMed)

Antibiotic treatment of bacterial vaginosis in pregnancy: a meta-analysis. The purpose of this study was to evaluate the effectiveness of antibiotic treatment of bacterial vaginosis in pregnancy to reduce preterm delivery.We performed a meta-analysis of published, English-language, randomized, placebo-controlled clinical trials of antibiotic treatment of bacterial vaginosis in pregnant women with intact amniotic membranes at <37 weeks of gestation. Primary outcomes included preterm delivery (...) , perinatal or neonatal death, and neonatal morbidity.Ten studies with results for 3969 patients were included. In patients without preterm labor, antibiotic treatment did not significantly decrease preterm delivery at <37 weeks of gestation, in all patients combined (odds ratio, 0.83; 95% CI, 0.57-1.21) nor in high-risk patients with a previous preterm delivery (odds ratio, 0.50; 95% CI, 0.22-1.12). In both groups, significant statistical heterogeneity was observed. A significant reduction in preterm

2003 American journal of obstetrics and gynecology

14345. Antibiotics for treating bacterial vaginosis in pregnancy. (PubMed)

Antibiotics for treating bacterial vaginosis in pregnancy. Bacterial vaginosis is an imbalance of the normal vaginal flora with an overgrowth of anaerobic bacteria and a lack of the normal lactobacillary flora. Bacterial vaginosis during pregnancy has been associated with poor perinatal outcome and, in particular, preterm birth. Identification and treatment may reduce the risk of preterm birth and its consequences.To assess the effects of antibiotic treatment of bacterial vaginosis (...) in pregnancy.We searched the Cochrane Pregnancy and Childbirth Group trials register (May 2004).Randomized trials comparing antibiotic treatment with placebo or no treatment, or comparing two or more antibiotic regimens in pregnant women with bacterial vaginosis or intermediate vaginal flora.Two reviewers assessed trials and extracted data independently. We contacted study authors for additional information.Thirteen trials involving 5300 women were included; all were of good quality. Antibiotic therapy

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2005 Cochrane database of systematic reviews (Online)

14346. Antibiotics and the Prolongation of Pregnancy in Preterm Labor With an Advanced Cervical Exam

Antibiotics and the Prolongation of Pregnancy in Preterm Labor With an Advanced Cervical Exam Antibiotics and the Prolongation of Pregnancy in Preterm Labor With an Advanced Cervical Exam - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Antibiotics and the Prolongation of Pregnancy in Preterm Labor With an Advanced Cervical Exam The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00589329 Recruitment Status : Terminated (published data suggest potential harm in other investigations.) First Posted

2007 Clinical Trials

14347. The NICHD-MFMU antibiotic treatment of preterm PROM study: impact of initial amniotic fluid volume on pregnancy outcome. (PubMed)

The NICHD-MFMU antibiotic treatment of preterm PROM study: impact of initial amniotic fluid volume on pregnancy outcome. The purpose of this study was to evaluate the associations between measured amniotic fluid volume and outcome after preterm premature rupture of membranes (PROM).This was a secondary analysis of 290 women, with singleton pregnancies, who participated in a trial of antibiotic therapy for preterm PROM at 24(0) to 32(0) weeks. Each underwent assessment of the 4 quadrant amniotic (...) fluid index (AFI) and a maximum vertical fluid pocket (MVP) before randomization. The impact of low AFI (< 5.0 cm) and low MVP (< 2.0 cm) on latency, amnionitis, neonatal morbidity, and composite morbidity (any of death, RDS, early sepsis, stage 2-3 necrotizing enterocolitis, and/or grade 3-4 intraventricular hemorrhage) was assessed. Logistic regression controlled for confounding factors including gestational age at randomization, GBS carriage, and antibiotic study group.Low AFI and low MVP were

2006 American Journal of Obstetrics and Gynecology

14348. Antibiotic use in pregnancy and lactation: what is and is not known about teratogenic and toxic risks. (PubMed)

Antibiotic use in pregnancy and lactation: what is and is not known about teratogenic and toxic risks. Over ten million women are either pregnant or lactating in the United States at any time. The risks of medication use for these women are unique. In addition to normal physiologic changes that alter the pharmacokinetics of drugs, there is the concern of possible teratogenic and toxic effects on the developing fetus and newborn. This article reviews the risks and pharmacokinetic considerations (...) for 11 broad-spectrum antibiotics that can be used to treat routine and life-threatening infections during pregnancy and lactation.Information from the U.S. Food and Drug Administration (FDA) product labels, the Teratogen Information Service, REPROTOX, Shepard's Catalog of Teratogenic Agents, Clinical Pharmacology, and the peer-reviewed medical literature was reviewed concerning the use of 11 antibiotics in pregnant and lactating women. The PubMed search engine was used with the search terms

2006 Obstetrics and Gynecology

14349. [Antibiotic prophylaxis in limited gynecological surgeries for pregnancy termination]. (PubMed)

[Antibiotic prophylaxis in limited gynecological surgeries for pregnancy termination]. The authors attempted with this trial to confirm the necessity of periabortal antibiotic prophylaxis after spontaneous and induced abortion. The trial included 172 patients with abortion; 53 of them with induced abortion and 119 with spontaneous abortion. The term of gestation was between 5 and 22 week. Three therapeutic groups were compared to a control no-treatment group. The first group was given (...) Ampicillin orally 4 x 500 mg for 5 consecutive days. The second group was administered a combination of Ampicillin orally 4 x 500 mg plus Gentamycin 2 x 80 mg i.m. for 3 to 5 days postoperatively. The third group was given 3 x 2 g i.v. Cefazolin intraoperatively and 24 hours following the manipulation. The trial aimed at establishing the efficiency and cost-effectiveness of the antibiotic prophylaxis. The results tend to prove the perioperative prophylaxis with Cefazolin is preferable since it is most

2003 Akusherstvo i ginekologii͡a Controlled trial quality: uncertain

14350. Prophylactic antibiotic administration in pregnancy to prevent infectious morbidity and mortality. (PubMed)

Prophylactic antibiotic administration in pregnancy to prevent infectious morbidity and mortality. Some previous studies suggested that prophylactic antibiotics given during pregnancy improved maternal and perinatal outcomes, some did not show any benefit and some even reported adverse effects.To determine the effect of prophylactic antibiotics during second and third trimester of pregnancy on maternal and perinatal outcomes.The Cochrane Pregnancy and Childbirth Group trials register (April (...) 2002), the Cochrane Controlled Trials Register (The Cochrane Library, Issue 1, 2002) and reference lists of articles were searched.Randomized controlled trials comparing prophylactic antibiotic treatment with placebo or no treatment for women in the second or third trimester of pregnancy before labour.Trial quality assessment and data extraction were done by the reviewers.There were six randomized controlled trials which recruited 2184 women to detect the effect of prophylactic antibiotic

2002 Cochrane database of systematic reviews (Online)

14351. Antibiotics, the pill, and pregnancy. (PubMed)

Antibiotics, the pill, and pregnancy. To establish if advice concerning risks of pregnancy when taking oral contraceptive pill and antibiotics is being offered.A retrospective audit of notes of 100 female patients aged 15-39 who were prescribed antibiotics.Documentation of use of contraception was noted in 3% of patients. Advice concerning risks and further precautions was noted in this 3% but not in any other records.The audit identified a gap in documentation and/or clinical practice (...) in advising women of childbearing age of the risk of conceiving when using oral contraceptive pill and antibiotics. Recommendations are given as to how this may be addressed.

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1999 Journal of accident & emergency medicine

14352. Metronidazole is used for antibiotic associated diarrhoea in pregnancy in UK (PubMed)

Metronidazole is used for antibiotic associated diarrhoea in pregnancy in UK 12386050 2002 11 22 2018 11 13 1756-1833 325 7369 2002 Oct 19 BMJ (Clinical research ed.) BMJ Metronidazole is used for antibiotic associated diarrhoea in pregnancy in UK. 903 Pegler Scott S McElhatton Patricia P eng Comment Letter England BMJ 8900488 0959-8138 0 Anti-Bacterial Agents 0 Anti-Infective Agents 140QMO216E Metronidazole AIM IM BMJ. 2002 Jun 8;324(7350):1345-6 12052785 Anti-Bacterial Agents adverse effects (...) Anti-Infective Agents therapeutic use Diarrhea chemically induced prevention & control Female Humans Metronidazole therapeutic use Pregnancy Pregnancy Complications chemically induced prevention & control 2002 10 19 4 0 2002 11 26 4 0 2002 10 19 4 0 ppublish 12386050 PMC1124393 Br J Clin Pharmacol. 1997 Aug;44(2):179-82 9278206 BMJ. 2002 Jun 8;324(7350):1345-6 12052785 Mayo Clin Proc. 1988 Feb;63(2):147-53 3339906 Am J Obstet Gynecol. 1994 Aug;171(2):345-7; discussion 348-9 8059811

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2002 BMJ : British Medical Journal

14353. [Single-dose antibiotic therapy of asymptomatic bacteriuria in pregnancy. Results and complications]. (PubMed)

[Single-dose antibiotic therapy of asymptomatic bacteriuria in pregnancy. Results and complications]. 3601207 1987 07 29 2006 11 15 0026-4784 39 4 1987 Apr Minerva ginecologica Minerva Ginecol [Single-dose antibiotic therapy of asymptomatic bacteriuria in pregnancy. Results and complications]. 289-92 Pregazzi R R Mazzatenta E E Bouchè C C ita Clinical Trial English Abstract Journal Article Randomized Controlled Trial Antibioticoterapia in dose singola della batteriuria asintomatica (...) in gravidanza. Risultati e complicanze. Italy Minerva Ginecol 0400731 0026-4784 0 Anti-Bacterial Agents IM Adolescent Adult Anti-Bacterial Agents administration & dosage adverse effects Drug Administration Schedule Female Humans Pregnancy Pregnancy Complications, Infectious drug therapy Random Allocation Urinary Tract Infections drug therapy 1987 4 1 1987 4 1 0 1 1987 4 1 0 0 ppublish 3601207

1987 Minerva ginecologica Controlled trial quality: uncertain

14354. Acute pyelonephritis in pregnancy: a prospective study of oral versus intravenous antibiotic therapy. (PubMed)

Acute pyelonephritis in pregnancy: a prospective study of oral versus intravenous antibiotic therapy. Ninety pregnant women admitted to the high-risk pregnancy unit with a diagnosis of acute pyelonephritis were randomized to receive either oral (cephalexin 500 mg every 6 hours) or intravenous (IV) (cephalothin 1 g every 6 hours) antibiotic therapy. All patients were initially hydrated with 1 L of normal saline IV over 4 hours. Neither parenteral analgesics nor antiemetics were used. Bacteremia (...) was noted in 13 (14.4%) of the 90 patients and mandated IV therapy. There was no difference between the oral and IV groups concerning predefined criteria for successful therapy (91.4 versus 92.9% successful therapy, respectively). No characteristic available at presentation predicted bacteremia or ultimate failure of therapy. Two patients (2.2%) experienced significant complications. These data suggest that in nonbacteremic patients, oral antibiotics are both safe and effective for the treatment

1990 Obstetrics and Gynecology Controlled trial quality: uncertain

14355. A randomized trial of three antibiotic regimens for the treatment of pyelonephritis in pregnancy. (PubMed)

A randomized trial of three antibiotic regimens for the treatment of pyelonephritis in pregnancy. To compare the effectiveness of three antibiotic regimens for the treatment of acute pyelonephritis in pregnancy.One hundred seventy-nine pregnant women earlier than 24 weeks' gestation who had acute pyelonephritis were randomized to 1) intravenous (i.v.) ampicillin and gentamicin, 2) i.v. cefazolin, or 3) intramuscular ceftriaxone. All participants then completed 10-day courses of oral cephalexin (...) after primary treatment. A urine culture was performed on admission and 5-14 days after completion of therapy. Surveillance for persistent or recurrent infection and obstetric complications continued until delivery. On the basis of a two-sided hypothesis test and with alpha = .025, 60 subjects were needed in each group for statistical power greater than 80% to detect a difference between ceftriaxone and other antibiotics if hospital length of stay differed by 1 or more days.The treatment groups were

1998 Obstetrics and Gynecology Controlled trial quality: uncertain

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