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Antibiotics in Pregnancy

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121. SMFM Consult Series #: Sepsis during pregnancy and the puerperium. (PubMed)

SMFM Consult Series #: Sepsis during pregnancy and the puerperium. Maternal sepsis is a significant cause of maternal morbidity and mortality and is a preventable cause of maternal death. The purpose of this guideline is to summarize what is known about sepsis and to provide guidance for the management of sepsis in pregnancy and the postpartum period. The following are SMFM recommendations: (1) we recommend that sepsis and septic shock be considered medical emergencies and that treatment (...) and resuscitation begin immediately (GRADE 1B); (2) we recommend that providers consider the diagnosis of sepsis in pregnant patients with otherwise unexplained end organ damage in the presence of an infectious process, regardless of the presence of fever (GRADE 1B); (3) we recommend that empiric broad-spectrum antibiotics be administered as soon as possible, ideally within 1 hour, in any pregnant woman in whom sepsis is suspected (GRADE 1B); (4) we recommend obtaining cultures (blood, urine, respiratory

2019 American Journal of Obstetrics and Gynecology

122. Pregnancy Zone Protein is Associated with Airway Infection, Neutrophil Extracellular Trap Formation and Disease Severity in Bronchiectasis. (PubMed)

Pregnancy Zone Protein is Associated with Airway Infection, Neutrophil Extracellular Trap Formation and Disease Severity in Bronchiectasis. Pregnancy zone protein (PZP) is a broad-spectrum immunosuppressive protein believed to suppress T-cell function during pregnancy to prevent fetal rejection. It has not previously been reported in the airway.To characterise PZP in the bronchiectasis airway including its relationship with disease severity.Label free liquid chromatography/mass spectrometry (...) microscopy confirmed the presence of PZP in NETs, while fluorescence and electron microscopy localised PZP to the cytoplasm and nuclei of neutrophils. Effective antibiotic therapy reduced sputum PZP.PZP is released into NETs. We report a novel link between airway infection, NET formation and disease severity in bronchiectasis during chronic airway inflammation.

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2019 American Journal of Respiratory and Critical Care Medicine

123. Chlamydia trachomatis and the Risk of Pelvic Inflammatory Disease, Ectopic Pregnancy, and Female Infertility: A Retrospective Cohort Study Among Primary Care Patients. (PubMed)

antibiotics.This was a retrospective study of women aged 12-25 years at start of follow-up within the Clinical Practice Research Datalink GOLD database linked to index of multiple deprivation quintiles, 2000-2013. CT test status and antibiotic use were determined in a time-dependent manner. Risk of PID, ectopic pregnancy, or female infertility were evaluated using of Cox proportional hazard models.We studied 857 324 women, contributing 6 457 060 person-years. Compared with women who tested CT-negative, women (...) who tested CT-positive had an increased risk of PID (adjusted hazard ratio [aHR], 2.36; 95% confidence interval [CI], 2.01-2.79), ectopic pregnancy (aHR, 1.87; 95% CI, 1.38-2.54), and infertility (aHR, 1.85; 95% CI, 1.27-2.68). The PID risk was higher for women with 2 or more positive CT tests than those with 1 positive test. PID risk increased with the number of previous antibiotic prescriptions, regardless of CT test status.We showed an association between CT-positive tests and 3 adverse

2019 Clinical Infectious Diseases

124. Maternal smoking during pregnancy and offspring utilisation of health care services: A population-based cohort study. (PubMed)

Maternal smoking during pregnancy and offspring utilisation of health care services: A population-based cohort study. Maternal smoking during pregnancy (MSDP) has been associated with a wide range of adverse effects on offspring health, such as low birthweight, behavioural disorders, and asthma. The number of women that smoke during pregnancy in Denmark is still high, making it relevant to study the long-term health outcomes in offspring exposed to maternal smoking in utero.We investigated (...) whether exposure to MSDP is associated with more frequent use of health care services during the first 10 years of life.This population-based cohort study included participants enrolled in the Danish National Birth Cohort between 1996 and 2003. Data on MSDP were obtained from two telephone interviews during pregnancy and one interview after pregnancy. The primary outcome was contacts to the health care system. From Danish national registries, we obtained information on number and type of contacts

2019 Paediatric and perinatal epidemiology

125. First trimester termination of pregnancy. (PubMed)

First trimester termination of pregnancy. First trimester termination of pregnancy (TOP) is a safe and effective procedure. The complete abortion rates of surgical and medical abortion are approximately 97% and 95%, respectively. Vacuum aspiration (VA) either by electrical suction or manual aspiration is the method of choice for surgical TOP. Risk of significant bleeding is ≤ 5% in VA, while major complications occur in <1%. The risk of infection after VA can be reduced significantly by using (...) prophylactic antibiotics or by the screen-and-treat strategy. Pre-operative administration of misoprostol can also reduce the risk of complications. The combination of 200 mg mifepristone followed by 800 μg misoprostol 24-48 h later is recommended for first trimester medical TOP. If mifepristone is not available, misoprostol can also be used alone, but repeated doses may be required and the complete abortion rate may be lower. Due to the reduced efficacy in more advanced gestation, repeated doses

2019 Best practice & research. Clinical obstetrics & gynaecology

126. The value of amniopatch in pregnancies associated with spontaneous preterm premature rupture of fetal membranes: a randomized controlled trial. (PubMed)

The value of amniopatch in pregnancies associated with spontaneous preterm premature rupture of fetal membranes: a randomized controlled trial. To evaluate the efficacy and safety of amniopatch in pregnancies associated with spontaneous preterm premature rupture of fetal membranes (PPROM).A randomized controlled trial that involved 100 women diagnosed with PPROM between 24 and 34 weeks of gestational age. Participants were randomized equally into two groups. Group I in which amniopatch was done (...) in addition to the routine management. Group II was treated with routine management including antibiotics and corticosteroids.Amniopatch was successful in complete sealing of the membrane defect in 6/50 (12%) of women while none the control group have undergone similar sealing (p = .0144, RR = 0.88). Women in the amniopatch group showed a significant increase of AFI compared to controls (12 versus 0, p = .0001, RR = 0.56).The amniopatch procedure is a successful technique that safely enhances sealing

2019 The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Controlled trial quality: uncertain

127. Efficient treatment of chronic endometritis through a novel approach of intrauterine antibiotic infusion: a case series. (PubMed)

antibiotic regime was administered based on the infectious agent detected. Re-evaluation concluded slightly improved microbiological environment in the endometrium but persisting inflammation. Antibiotic intrauterine infusion was proposed to the patients as an alternative practice. All our patients achieved a pregnancy shortly following intrauterine treatment with one patient reporting a live birth of twin babies and two patients currently reporting an ongoing pregnancy.The implications of this case (...) Efficient treatment of chronic endometritis through a novel approach of intrauterine antibiotic infusion: a case series. Early diagnosis and efficient management of Chronic Endometritis (CE) in patients seeking fertility treatment are two components every practitioner wishes to address. With respect to endometrial restoration, antibiotic treatment appears to perform well. However, regarding the improvement of In Vitro Fertilization (IVF) success rates, literature evidence is inconclusive

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2018 BMC Women's Health

128. Fetal and early life antibiotics exposure and very early onset inflammatory bowel disease: a population-based study. (PubMed)

Fetal and early life antibiotics exposure and very early onset inflammatory bowel disease: a population-based study. Earlier studies on antibiotics exposure and development of IBD (Crohn's disease (CD) and ulcerative colitis (UC)) may have been biased by familial factors and gastroenteritis. We aimed to estimate the association between antibiotics during pregnancy or infantile age and very early onset (VEO) IBD.In this cohort study of 827 239 children born in Sweden between 2006 and 2013, we (...) examined the link between exposure to systemic antibiotics and VEO-IBD (diagnosis <6 years of age), using Cox proportional hazard regression models. Information on antibiotics and IBD was retrieved from the nationwide population-based Swedish Prescribed Drug Register and the National Patient Register. We specifically examined potential confounding from parental IBD and gastroenteritis.Children exposed to antibiotics during pregnancy were at increased risk of IBD compared with general population

2018 Gut

129. Combined Use of a Respiratory Broad Panel mPCR and Procalcitonin to Reduce Duration of Antibiotics Exposure in Patients With Severe Community-Acquired Pneumonia

Combined Use of a Respiratory Broad Panel mPCR and Procalcitonin to Reduce Duration of Antibiotics Exposure in Patients With Severe Community-Acquired Pneumonia Combined Use of a Respiratory Broad Panel mPCR and Procalcitonin to Reduce Duration of Antibiotics Exposure in Patients With Severe Community-Acquired Pneumonia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study (...) Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Combined Use of a Respiratory Broad Panel mPCR and Procalcitonin to Reduce Duration of Antibiotics Exposure in Patients With Severe Community-Acquired Pneumonia (MULTI-CAP) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated

2018 Clinical Trials

130. Antibiotic and Probiotic Therapies in the Adjuvant Treatment of the Chronic Periodontitis.

Antibiotic and Probiotic Therapies in the Adjuvant Treatment of the Chronic Periodontitis. Antibiotic and Probiotic Therapies in the Adjuvant Treatment of the Chronic Periodontitis. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Antibiotic and Probiotic Therapies in the Adjuvant Treatment of the Chronic Periodontitis. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03692819 Recruitment Status : Recruiting First Posted

2018 Clinical Trials

131. Prenatal Exposure to Antibiotics and Risk of Childhood Obesity in a Multi-Center Cohort Study. (PubMed)

). Antibiotic use was ascertained for mothers during pregnancy. Modified Poisson regression models were used to estimate risk ratios for obesity (BMI >95th percentile), and linear mixed models were applied to assess the association with BMI z score. Repeated prenatal exposure to antibiotics was associated with childhood obesity at age 7 years, and risk of obesity tended to increase with an increasing number of antibiotic exposures (for 2-3 exposures, risk ratio (RR) = 1.22, 95% confidence interval (CI (...) ): 1.04, 1.44; for ≥4 exposures, RR = 1.34, 95% CI: 1.03, 1.73). The magnitude of association was strongest for repeated exposures in the second trimester (RR = 1.40, 95% CI: 1.16, 1.71). Prenatal antibiotic use was not associated with obesity or BMI z score at age 4 years. These findings support an increased risk of mid-childhood obesity with repeated use of antibiotics during pregnancy.

2018 American Journal of Epidemiology

132. The Effect of Chinese Herbal Medicine for Reducing the Application of Antibiotics in the Treatment of Acute Mastitis

: No Keywords provided by Xiaohua Pei, Beijing University of Chinese Medicine: Pugongying Herba Taraxaci Acute Mastitis Cefdinir Randomized controlled trial Postpartum Breastfeeding Lactation multicenter Chinese herb Traditional Chinese medicine Cephalosporin Antibiotics Additional relevant MeSH terms: Layout table for MeSH terms Mastitis Puerperal Disorders Pregnancy Complications Breast Diseases Skin Diseases Anti-Bacterial Agents Cefdinir Antibiotics, Antitubercular Anti-Infective Agents Antitubercular (...) The Effect of Chinese Herbal Medicine for Reducing the Application of Antibiotics in the Treatment of Acute Mastitis The Effect of Chinese Herbal Medicine for Reducing the Application of Antibiotics in the Treatment of Acute Mastitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2018 Clinical Trials

133. Antibiotics Dispensed to Privately Insured Pregnant Women with Urinary Tract Infections — United States, 2014 (PubMed)

Antibiotics Dispensed to Privately Insured Pregnant Women with Urinary Tract Infections — United States, 2014 Urinary tract infections (UTIs) occur in about 8% of pregnant women, and untreated UTIs can have serious consequences, including pyelonephritis, preterm labor, low birth weight, and sepsis (1). Pregnant women are typically screened for UTIs during early pregnancy, and those with bacteriuria are treated with antibiotics (1,2). Antibiotic stewardship is critical to improving patient (...) safety and to combating antibiotic resistance. Because of the potential risk for birth defects, including anencephaly, heart defects, and orofacial clefts, associated with use of sulfonamides and nitrofurantoin during pregnancy (3), a 2011 committee opinion from the American College of Obstetricians and Gynecologists (ACOG) recommended that sulfonamides and nitrofurantoin may be prescribed in the first trimester of pregnancy only when other antimicrobial therapies are deemed clinically inappropriate

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2018 Morbidity and Mortality Weekly Report

134. Prenatal sonography of placental abscess and prolonged antibiotic treatment for Serratia marcescens bacteremia (PubMed)

Prenatal sonography of placental abscess and prolonged antibiotic treatment for Serratia marcescens bacteremia Termination of pregnancy is indicated for Serratia marcescens bacteremia, a major cause of mortality. Our present case was highly challenging because the patient wished to continue with her pregnancy, and the ultrasonography showed features of a placental abscess. Although the outcomes were good after prolonged antibiotic treatment, this was an exceptional case.

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2018 Clinical Case Reports

135. A survey of the views and capabilities of community pharmacists in Western Australia regarding the rescheduling of selected oral antibiotics in a framework of pharmacist prescribing (PubMed)

A survey of the views and capabilities of community pharmacists in Western Australia regarding the rescheduling of selected oral antibiotics in a framework of pharmacist prescribing Antibiotic misuse in the community contributes to antimicrobial resistance. One way to address this may be by better utilizing community pharmacists' skills in antibiotic prescribing. The aims of this study were to examine the level of support for "down-scheduling" selected antibiotics and to evaluate factors (...) of the seven vignettes.Of the 240 pharmacists surveyed, 90 (37.5%) responded, yielding 630 responses to seven different case vignettes. There was more than 60% respondent support for expanded prescribing (rescheduling) of commonly prescribed antibiotics. Overall 426/630 (67.6%) chose to treat the patient while the remaining 204/630 (32.4%) referred the patient to a doctor. Of those electing to treat, 380/426 (89.2%) opted to use oral antibiotics, with 293/380 (77.2%) treating with an appropriate selection

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2018 PeerJ

136. A diagnosis of late-onset Myasthenia gravis unmasked by topical antibiotics (PubMed)

A diagnosis of late-onset Myasthenia gravis unmasked by topical antibiotics Myasthenia Gravis (MG) is a disorder of the neuromuscular junction (NMJ) that manifests as fluctuating fatiguable weakness of the muscles. There are many factors that can exacerbate myasthenia symptoms including a variety medications and drugs, systemic illness, and pregnancy. A number of medications have been implicated in exacerbating MG symptoms, including aminoglycosides. We present a case of an elderly female

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2018 Journal of community hospital internal medicine perspectives

137. Adequate Duration of Antibiotic Treatment in Community-acquired Pneumonia With High Risk Class and Adequate Initial Clinical Response

Adequate Duration of Antibiotic Treatment in Community-acquired Pneumonia With High Risk Class and Adequate Initial Clinical Response Adequate Duration of Antibiotic Treatment in Community-acquired Pneumonia With High Risk Class and Adequate Initial Clinical Response - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You (...) have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Adequate Duration of Antibiotic Treatment in Community-acquired Pneumonia With High Risk Class and Adequate Initial Clinical Response (2017-001406-15) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health

2018 Clinical Trials

138. Antibiotics During Intrauterine Balloon Tamponade Placement

Labor Complications Pregnancy Complications Puerperal Disorders Uterine Hemorrhage Pelvic Inflammatory Disease Adnexal Diseases Genital Diseases, Female Uterine Diseases Anti-Bacterial Agents Clindamycin Clindamycin palmitate Clindamycin phosphate Cefazolin Antibiotics, Antitubercular Anti-Infective Agents Antitubercular Agents Protein Synthesis Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action (...) Antibiotics During Intrauterine Balloon Tamponade Placement Antibiotics During Intrauterine Balloon Tamponade Placement - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Antibiotics During Intrauterine

2018 Clinical Trials

139. 7-days Versus 14 Days of Antibiotics Therapy for Ventilator Associated Pneumonia

7-days Versus 14 Days of Antibiotics Therapy for Ventilator Associated Pneumonia 7-days Versus 14 Days of Antibiotics Therapy for Ventilator Associated Pneumonia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding (...) more. 7-days Versus 14 Days of Antibiotics Therapy for Ventilator Associated Pneumonia The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03477292 Recruitment Status : Recruiting First Posted : March 26, 2018 Last Update

2018 Clinical Trials

140. Oral Vancomycin to Prevent Recurrent C Difficile Infection With Antibiotics

with a suspected or a confirmed bacterial infection requiring antibiotics Exclusion Criteria: Active chronic diarrheal illness (eg, Crohn's disease, ulcerative colitis, short bowel syndrome) Previous adverse reactions to oral vancomycin Requiring metronidazole during hospitalization Known pregnancy Expected survival <72 hours Patients receiving antibiotics only for surgical prophylaxis Patients who received prophylactic oral vancomycin for the current antibiotic course prior to enrollment in the study Contacts (...) Oral Vancomycin to Prevent Recurrent C Difficile Infection With Antibiotics Oral Vancomycin to Prevent Recurrent C Difficile Infection With Antibiotics - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Oral

2018 Clinical Trials

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