How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

14,413 results for

Antibiotics in Pregnancy

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

101. Preterm Labour, Antibiotics and Cerebral Palsy

Preterm Labour, Antibiotics and Cerebral Palsy Preterm Labour, Antibiotics, and Cerebral Palsy Scientific Impact Paper No. 33 February 2013Preterm Labour, Antibiotics, and Cerebral Palsy 1. Introduction The rate of preterm birth (pregnancy under 37 +0 weeks of gestation) is 5–9% of all births in Europe, and 12–13% in the United States of America (USA); the rates in both continents increased up to 2008, partly due to the higher number of multiple births associated with assisted conceptions. 1 (...) has been demonstrated. 25 4. Short term effect of antenatal antibiotics on preterm birth Subclinical infection is implicated in a large proportion of preterm births, so theoretically, the acute use of antibiotics could eradicate the infection, prolong the pregnancy and improve neonatal outcome. Alternatively, antibiotics might suppress the infection, thus prolonging the pregnancy, but leaving the fetus in a hostile inflammatory environment. 4.1 Asymptomatic women at risk of preterm labour A recent

2013 Royal College of Obstetricians and Gynaecologists

102. Prophylactic antibiotics for inhibiting preterm labour with intact membranes. (PubMed)

benefit or causes harm, prior to membrane rupture.To assess the effects of prophylactic antibiotics administered to women in preterm labour with intact membranes, on maternal and neonatal outcomes.We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 August 2013).Randomised trials that compared antibiotic treatment with placebo or no treatment for women in preterm labour (between 20 and 36 weeks' gestation) with intact membranes.Two review authors independently assessed trial (...) Prophylactic antibiotics for inhibiting preterm labour with intact membranes. The aetiology of preterm birth is complex and there is evidence that subclinical genital tract infection influences preterm labour in some women but the role of prophylactic antibiotic treatment in the management of preterm labour is controversial. Since rupture of the membranes is an important factor in the progression of preterm labour, it is important to see if the routine administration of antibiotics confers any

Full Text available with Trip Pro

2013 Cochrane

103. Antibiotics for mastitis in breastfeeding women. (PubMed)

with mastitis with or without laboratory investigation.We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (30 September 2012), contacted investigators and other content experts known to us for unpublished trials and scanned the reference lists of retrieved articles.We selected randomised controlled trials (RCTs) and quasi-RCTs comparing the effectiveness of various types of antibiotic therapies or antibiotic therapy versus alternative therapies for the treatment of mastitis.Two review (...) Antibiotics for mastitis in breastfeeding women. Mastitis can be caused by ineffective positioning of the baby at the breast or restricted feeding. Infective mastitis is commonly caused by Staphylococcus aureus. The prevalence of mastitis in breastfeeding women may reach 33%. Effective milk removal, pain medication and antibiotic therapy have been the mainstays of treatment.This review aims to examine the effectiveness of antibiotic therapies in relieving symptoms for breastfeeding women

Full Text available with Trip Pro

2013 Cochrane

104. Intrapartum antibiotics for known maternal Group B streptococcal colonization. (PubMed)

Intrapartum antibiotics for known maternal Group B streptococcal colonization. Maternal colonization with group B streptococcus (GBS) during pregnancy increases the risk of neonatal infection by vertical transmission. Administration of intrapartum antibiotic prophylaxis (IAP) during labor has been associated with a reduction in early onset GBS disease (EOGBSD). However, treating all colonized women during labor exposes a large number of women and infants to possible adverse effects without (...) benefit.To assess the effect of IAP for maternal GBS colonization on neonatal: 1) all cause mortality and 2) morbidity from proven and probable EOGBSD, late onset GBS disease (LOD), maternal infectious outcomes and allergic reactions to antibiotics.We updated the search of the Cochrane Pregnancy and Childbirth Group's Trials Register on 10 November 2012.Randomized trials assessing the impact of maternal IAP on neonatal GBS infections were included.We independently assessed eligibility and quality

2013 Cochrane

105. Early clindamycin for bacterial vaginosis in pregnancy (PREMEVA): a multicentre, double-blind, randomised controlled trial. (PubMed)

[0·6%] participants) versus none in the placebo group (p=0·034). No severe adverse event was reported in any group. Adverse fetal and neonatal outcomes did not differ significantly between groups in the high-risk subtrial.Systematic screening and subsequent treatment for bacterial vaginosis in women with low-risk pregnancies shows no evidence of risk reduction of late miscarriage or spontaneous very preterm birth. Use of antibiotics to prevent preterm delivery in this patient population should (...) Early clindamycin for bacterial vaginosis in pregnancy (PREMEVA): a multicentre, double-blind, randomised controlled trial. Preterm delivery during pregnancy (<37 weeks' gestation) is a leading cause of perinatal mortality and morbidity. Treating bacterial vaginosis during pregnancy can reduce poor outcomes, such as preterm birth. We aimed to investigate whether treatment of bacterial vaginosis decreases late miscarriages or spontaneous very preterm birth.PREMEVA was a double-blind randomised

2018 Lancet Controlled trial quality: predicted high

106. Management of pregnancy loss in the first trimester: a retrospective audit. (PubMed)

Management of pregnancy loss in the first trimester: a retrospective audit. Early pregnancy loss occurs in 10% of all clinically recognised pregnancies. 80% of pregnancy losses occur in the first trimester. Offering choice and participation in the management decisions is essential to patient-centred care. The aim of this study was to assess the management of first trimester pregnancy loss at the Emirati Hospital in Rafah, Gaza Strip.In this retrospective audit, we compared the management (...) of first trimester pregnancy loss at Emirati Hospital using the American College of Obstetricians and Gynecologists guidelines (ACOG, No. 150, May 2015). Data were obtained from patients' medical records.50 cases were identified in November and December, 2015. 32 (64%) cases were missed miscarriages (an ultrasound finding of a non-viable pregnancy in an asymptomatic patient), 13 (26%) were incomplete miscarriages, and five (10%) were complete miscarriages. All cases were haemodynamically stable. Only

Full Text available with Trip Pro

2018 Lancet

107. In utero exposure to antibiotics and risk of congenital malformations: A population-based study. (PubMed)

In utero exposure to antibiotics and risk of congenital malformations: A population-based study. Antibiotics are commonly prescribed during pregnancy. While the safety of most penicillins are well established, some controversy and uncertainty are associated with the use of other commonly prescribed antibiotics.To determine the risk of congenital malformations following first trimester in utero exposure to 10 commonly prescribed antibiotics in Denmark.This was a cohort study comprising all (...) antibiotics (excluding four penicillins that served as control). In the primary analysis the exposed cohort were compared to a cohort exposed to either of four penicillins considered safe during pregnancy (ampicillin, pivampicillin, benzylpenicillin ad phenoxymethylpenicillin). In sensitivity analysis, the exposed cohort were compared to an unexposed cohort. Covariate adjustments were made for maternal age at delivery, year of delivery, parity, pre-pregnancy BMI, smoking, educational status, employment

2019 American Journal of Obstetrics and Gynecology

108. Antibiotic treatment for patients with amniotic fluid "sludge" to prevent spontaneous preterm birth: a historically controlled observational study. (PubMed)

preterm birth at <34 weeks. The objective of this study was to evaluate routine antibiotic treatment in the presence of amniotic fluid "sludge" for prevention of preterm delivery.A historically-controlled observational study was performed between October 2010 and January 2015, including a total of 86 pregnant women with singleton pregnancies and the presence of amniotic fluid "sludge" at ultrasound. Women admitted from October 2010 to September 2012 received no treatment with antibiotics, whereas (...) Antibiotic treatment for patients with amniotic fluid "sludge" to prevent spontaneous preterm birth: a historically controlled observational study. Amniotic fluid "sludge" has been associated with an increased rate of spontaneous preterm delivery before 35 weeks, a higher frequency of clinical chorioamnionitis, and histologic chorioamnionitis in a high-risk population. Only one study evaluating the use of antibiotics in the presence of amniotic fluid "sludge" showed reduced rates of spontaneous

2019 Acta Obstetricia et Gynecologica Scandinavica

109. Evidence that antibiotic administration is effective in the treatment of a subset of patients with intra-amniotic infection/inflammation presenting with cervical insufficiency. (PubMed)

cerclage is performed. The use of prophylactic antibiotics is predicated largely on the basis that they reduce the rate of complications during the course of vaginal surgery. However, it is possible that antibiotic administration can also eradicate intra-amniotic infection/inflammation and improve pregnancy outcome.To describe the outcome of antibiotic treatment of patients with cervical insufficiency with either intra-amniotic infection/inflammation.The study population consisted of 22 women who met (...) the following criteria: 1) singleton pregnancy; 2) painless cervical dilatation of >1cm between 16.0-27.9 weeks of gestation; 3) intact membranes and absence of uterine contractions; 4) transabdominal amniocentesis performed for the evaluation of the microbiologic and inflammatory status of the amniotic cavity; 5) presence of intra-amniotic infection/inflammation; and 6) antibiotic treatment (regimen consisted of ceftriaxone, clarithromycin, and metronidazole). Amniotic fluid was cultured for aerobic

2019 American Journal of Obstetrics and Gynecology

110. The influence of timing of Maternal administration of Antibiotics during cesarean section on the intestinal Microbial colonization in Infants (MAMI-trial): study protocol for a randomised controlled trial. (PubMed)

during pregnancy and delivery. Recent revisions to international obstetric guidelines have resulted in the exposure of all infants born by caesarean section (CS) to broad-spectrum antibiotics perinatally. To date, the consequences of these new guidelines on neonatal gut colonisation and the associated short- and long-term health implications have not yet been addressed. The aim of this study is to investigate the influence of the timing of antibiotic administration during CS to the mother (...) The influence of timing of Maternal administration of Antibiotics during cesarean section on the intestinal Microbial colonization in Infants (MAMI-trial): study protocol for a randomised controlled trial. A disturbance in the early colonisation of the gut by microorganisms is associated with an aberrant innate immune system and a variety of clinical conditions later in life. Several factors are considered to influence this initial colonisation, including maternally administered antibiotics

Full Text available with Trip Pro

2019 Trials Controlled trial quality: uncertain

111. The Effect of Non-penicillin Antibiotic Regimens on Neonatal Outcomes in Preterm Premature Rupture of Membranes. (PubMed)

The Effect of Non-penicillin Antibiotic Regimens on Neonatal Outcomes in Preterm Premature Rupture of Membranes. Objective  A 7-day course of a penicillin (PCN) and macrolide is standard of care (SAR) in preterm premature rupture of membranes (PPROM). Data regarding alternative antibiotic regimens are limited. We sought to assess the impact of non-PCN regimens on neonatal outcomes. Study Design  Secondary analysis of randomized controlled trial of antenatal magnesium sulfate. Singleton (...) , nonanomalous pregnancies complicated by PPROM at > 24 weeks of gestation receiving the SAR were compared with women receiving a non- β -lactam regimen and a macrolide (NPCR). Primary outcome was a neonatal composite. Secondary outcomes included pregnancy latency, endometritis, and chorioamnionitis. Results  A total of 949 women met inclusion criteria; 821(56%) received the SAR and 128(8.8%) received NPCR. Adjusted models did not demonstrate worse outcomes (AOR [adjusted odds ratio] = 0.50; 95% CI

Full Text available with Trip Pro

2019 AJP Reports Controlled trial quality: predicted high

112. Impact of Azithromycin-Based Extended-Spectrum Antibiotic Prophylaxis on Noninfectious Cesarean Wound Complications. (PubMed)

. This is a secondary analysis of the C/SOAP (Cesarean Section Optimal Antibiotic Prophylaxis) randomized controlled trial, which enrolled women with singleton pregnancies ≥24 weeks who were undergoing nonelective cesarean. Women were randomized to adjunctive azithromycin or identical placebo up to 1 hour preincision. All wound complications occurring within 6 weeks were adjudicated into infection and noninfectious wound complications (seroma, hematoma, local cellulitis, and other noninfectious wound breakdown (...) Impact of Azithromycin-Based Extended-Spectrum Antibiotic Prophylaxis on Noninfectious Cesarean Wound Complications.  Adding azithromycin to standard antibiotic prophylaxis for unscheduled cesarean delivery has been shown to reduce postcesarean infections. Because wound infection with ureaplasmas may not be overtly purulent, we assessed the hypothesis that azithromycin-based extended-spectrum antibiotic prophylaxis also reduces wound complications that are identified as noninfectious

2019 American journal of perinatology Controlled trial quality: predicted high

113. Procalcitonin and lung ultrasonography point-of-care testing to decide on antibiotic prescription in patients with lower respiratory tract infection in primary care: protocol of a pragmatic cluster randomized trial. (PubMed)

, pregnancy, inability to provide informed consent and unavailability of the GP. Patients will fill in a 28 day-symptom diary and will be contacted by phone on days 7 and 28. The primary outcome is the proportion of patients prescribed any antibiotic up to day 28. Secondary outcomes include clinical failure by day 7 (death, admission to hospital, absence of amelioration or worsening of relevant symptoms) and by day 28, duration of restricted daily activities, episode duration as defined by symptom score (...) Procalcitonin and lung ultrasonography point-of-care testing to decide on antibiotic prescription in patients with lower respiratory tract infection in primary care: protocol of a pragmatic cluster randomized trial. A minority of patients presenting with lower respiratory tract infection (LRTI) to their general practitioner (GP) have community-acquired pneumonia (CAP) and require antibiotic therapy. Identifying them is challenging, because of overlapping symptomatology and low diagnostic

Full Text available with Trip Pro

2019 BMC pulmonary medicine Controlled trial quality: predicted high

114. Association of the Eukaryotic Vaginal Virome with Prophylactic Antibiotic Exposure and Reproductive Outcomes in a Subfertile Population Undergoing In Vitro Fertilization: A Prospective Exploratory Study. (PubMed)

, viral diversity was higher in the group that did not achieve clinical pregnancy compared to those who did (p=0.06).We demonstrate the vaginal eukaryotic virome in women undergoing IVF is associated with antibiotic exposure. Additionally, we demonstrate an inverse trend between viral diversity and pregnancy, with a higher number of viruses detected associated with failure to achieve clinical pregnancy in the azithromycin group.© 2019 Royal College of Obstetricians and Gynaecologists. (...) Association of the Eukaryotic Vaginal Virome with Prophylactic Antibiotic Exposure and Reproductive Outcomes in a Subfertile Population Undergoing In Vitro Fertilization: A Prospective Exploratory Study. The objective of this study was to use high-throughput sequencing to describe the vaginal eukaryotic DNA virome in patients undergoing in vitro fertilization (IVF) to examine associations between the vaginal virome, antibiotic exposure, and IVF outcomes.Prospective exploratory study SETTING

Full Text available with Trip Pro

2019 BJOG

115. An Integrated Safety Summary of Omadacycline, a Novel Aminomethylcycline Antibiotic. (PubMed)

An Integrated Safety Summary of Omadacycline, a Novel Aminomethylcycline Antibiotic. Omadacycline is a semisynthetic tetracycline antibiotic. Phase III clinical trial results have shown that omadacycline has an acceptable safety profile in the treatment of acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia. Similar to most tetracyclines, transient nausea and vomiting and low-magnitude increases in liver aminotransferases were the most frequent (...) treatment-emergent adverse events in phase III studies but were not treatment limiting. Package insert warnings and precautions for omadacycline include tooth discoloration; enamel hypoplasia; inhibition of bone growth following use in late pregnancy, infancy, or childhood up to 8 years of age; an imbalance in mortality (2%, compared with 1% in moxifloxacin-treated patients) was observed in the phase III study in patients with community-acquired bacterial pneumonia. Omadacycline has no effect on the QT

Full Text available with Trip Pro

2019 Clinical Infectious Diseases

116. The association between antibiotics in the first year of life and child growth trajectory. (PubMed)

) and 6 year follow-up study (6YFU) were included. Antibiotic exposures, weight and height measurements were collected from birth through the first 12 months, and then again at 6 years. Linear mixed effects growth modeling, controlling for exclusive breastfeeding, socio-demographic factors, smoking during pregnancy, gestational diabetes, and maternal pre-pregnancy weight status, was used to examine the association between antibiotic exposure and child growth trajectories through age 6 years.The (...) The association between antibiotics in the first year of life and child growth trajectory. Antibiotics are frequently prescribed to children, and may be an environmental influence that contributes to the increasing prevalence of childhood obesity. The aim of this study was to examine the effect of antibiotic use in the first year of life on child growth trajectories from birth to age 6 years including significant covariates.Data from 586 children in the Infant Feeding Practices II (IFPS II

Full Text available with Trip Pro

2019 BMC Pediatrics

117. WITHDRAWN: Antibiotic prophylaxis regimens and drugs for cesarean section. (PubMed)

WITHDRAWN: Antibiotic prophylaxis regimens and drugs for cesarean section. Prophylactic antibiotics for cesarean section have been shown to reduce the incidence of maternal postoperative infectious morbidity. Many different antibiotic regimens have been reported to be effective.The objective of this review was to determine which antibiotic regimen is most effective in reducing the incidence of infectious morbidity in women undergoing cesarean section.We searched the Cochrane Pregnancy (...) and Childbirth Group trials register and the Cochrane Controlled Trials Register. The date of the most recent search was October 1998.Randomized trials that included women undergoing cesarean section were included. Trials were required to compare at least two different antibiotic regimens. Trials that compared placebo with a single antibiotic regimen were not included as these are studies which have been analyzed in another Cochrane review.Data were extracted from each publication independently

2012 Cochrane

118. Antibiotics prior to embryo transfer in ART. (PubMed)

Antibiotics prior to embryo transfer in ART. Embryo transfer (ET) involves the placement of one or more embryos into the uterine cavity, usually by passing a catheter through the cervical os. ET is the final step in an assisted reproductive technology (ART) cycle, where a woman has undergone controlled ovarian stimulation, egg retrieval and in vitro fertilisation of her eggs. Despite the transfer of high quality embryos, many ETs do not result in a pregnancy. There are many factors which may (...) affect the success of ET, including the presence of upper genital tract microbial colonisation. The administration of antibiotics prior to ET has been suggested as an intervention to reduce levels of microbial colonisation and hence improve pregnancy rates.To evaluate the effectiveness and safety of antibiotic administration prior to ET during ART cycles.We searched the Menstrual Disorders and Subfertility Group Specialised Register, Cochrane Central Register of Controlled Trials (CENTRAL

Full Text available with Trip Pro

2012 Cochrane

119. Nausea/vomiting in pregnancy

Nausea/vomiting in pregnancy Nausea/vomiting in pregnancy - NICE CKS Share Nausea/vomiting in pregnancy: Summary The majority of women vomit or feel nauseated in early pregnancy. Symptoms usually begin between the fourth and seventh weeks of gestation and usually resolve around the 20th week of pregnancy. Hyperemesis gravidarum is a diagnosis of exclusion characterized by prolonged and severe nausea and vomiting, dehydration, electrolyte imbalance, ketonuria, and body weight loss of more than 5 (...) % of pre-pregnancy weight. Findings which may suggest an alternative diagnosis include: Onset of symptoms after 11 weeks of gestation. Abdominal pain or tenderness (more than mild epigastric tenderness after retching). Fever. Headache or abnormal neurological examination. Goitre. Complications are more likely in women with severe vomiting and include: Maternal — weight loss, dehydration, hyponatraemia, vitamin deficiencies, Mallory-Weiss tear or oesophageal rupture, increased risk of venous

2018 NICE Clinical Knowledge Summaries

120. Use of Antibiotic Therapy for Pediatric Dental Patients

and chro- nic recurrent submandibular sialadenitis, antibiotic therapy is included as part of the treatment. 27 Oral contraceptive use Whenever an antibiotic is prescribed to a female patient taking oral contraceptives to prevent pregnancy, the patient must be advised to use additional techniques of birth control during antibiotic therapy and for at least one week beyond the last dose, as the antibiotic may render the oral contraceptive ineffective. 28,29 Rifampicin has been documented to decrease (...) Use of Antibiotic Therapy for Pediatric Dental Patients AMERICAN ACADEMY OF PEDIATRIC DENTISTRY RECOMMENDATIONS: BEST PRACTICES 383 Purpose The American Academy of Pediatric Dentistry ( AAPD) recognizes the increasing prevalence of antibiotic-resistant microorganisms. These recommendations are intended to provide guidance in the proper and judicious use of anti- biotic therapy in the treatment of oral conditions. 1 Methods Recommendations on the use of antiobiotic therapy were developed

2014 American Academy of Pediatric Dentistry

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>