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Antibiotics in Pregnancy

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21. Routine antibiotic prophylaxis after normal vaginal birth for reducing maternal infectious morbidity. (PubMed)

administration of prophylactic antibiotics to women after normal (uncomplicated) vaginal birth, compared with placebo or no antibiotic prophylaxis, reduces postpartum maternal infectious morbidities and improves outcomes.We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 August 2017), LILACS, ClinicalTrials.gov, the WHO International Clinical Trials Registry Platform (ICTRP) (22 August 2017) and reference lists of retrieved studies.We planned to include randomised or quasi (...) Routine antibiotic prophylaxis after normal vaginal birth for reducing maternal infectious morbidity. Infectious morbidities contribute to considerable maternal and perinatal morbidity and mortality, including women at no apparent increased risk of infection. To reduce the incidence of infections, antibiotics are often administered to women after uncomplicated childbirth, particularly in settings where women are at higher risk of puerperal infectious morbidities.To assess whether routine

2017 Cochrane

22. Antibiotic prophylaxis for episiotomy repair following vaginal birth. (PubMed)

of infection after vaginal birth is high. However, available evidence is unclear concerning the role of prophylactic antibiotics in preventing infections after an episiotomy.To assess whether routine antibiotic prophylaxis before or immediately after incision or repair of episiotomy for women with an uncomplicated vaginal birth, compared with either placebo or no antibiotic prophylaxis, prevents maternal infectious morbidities and improves outcomes.We searched the Cochrane Pregnancy and Childbirth's Trials (...) Antibiotic prophylaxis for episiotomy repair following vaginal birth. Bacterial infections occurring during labour, childbirth, and the puerperium may be associated with considerable maternal and perinatal morbidity and mortality. Antibiotic prophylaxis might reduce wound infection incidence after an episiotomy, particularly in situations associated with a higher risk of postpartum perineal infection, such as midline episiotomy, extension of the incision, or in settings where the baseline risk

2017 Cochrane

23. Antibiotics for neonates born through meconium-stained amniotic fluid. (PubMed)

Antibiotics for neonates born through meconium-stained amniotic fluid. Approximately 1 in 10 pregnancies is affected by meconium passage at delivery, which can result in meconium aspiration syndrome (MAS). MAS can cause respiratory complications and, very rarely, death. Antibiotics have been prescribed for neonates exposed to meconium in amniotic fluid, with the intention of preventing infection due to potential bacterial contaminants.We conducted this review to assess the efficacy and safety (...) of antibiotics for:1. prevention of infection, morbidity, and mortality among infants born through meconium-stained amniotic fluid (MSAF) who are asymptomatic at birth; and2. prevention of infection, morbidity, and mortality among infants born through MSAF who have signs and symptoms compatible with meconium aspiration syndrome (MAS).We performed a literature search using the following databases: MEDLINE (1966 to July 2016); Embase (1980 to July 2016); the Cumulative Index to Nursing and Allied Health

2017 Cochrane

24. Antibiotic prophylaxis for operative vaginal delivery. (PubMed)

infectious puerperal morbidities in women undergoing operative vaginal deliveries including vacuum or forceps deliveries, or both.We searched Cochrane Pregnancy and Childbirth's Trials Register (12 July 2017), ClinicalTrials.gov, the WHO International Clinical Trials Registry Platform (ICTRP) (12 July 2017) and reference lists of retrieved studies.All randomised trials comparing any prophylactic antibiotic regimens with placebo or no treatment in women undergoing vacuum or forceps deliveries were (...) Antibiotic prophylaxis for operative vaginal delivery. Vacuum and forceps assisted vaginal deliveries are reported to increase the incidence of postpartum infections and maternal readmission to hospital compared to spontaneous vaginal delivery. Prophylactic antibiotics may be prescribed to prevent these infections. However, the benefit of antibiotic prophylaxis for operative vaginal deliveries is still unclear.To assess the effectiveness and safety of antibiotic prophylaxis in reducing

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2017 Cochrane

25. Pregnancy and lower urinary tract infection: opt for cefuroxime

antibiotics are cefuroxime and the combination of amoxicillin + clavulanic acid, because a large amount of data on short-term exposure is available. This includes around 400 pregnancies exposed from the first trimester to cefuroxime, and 500 exposed to the combination of amoxicillin + clavulanic acid, in which no problem was identified. In mid-2017, proprietary drugs based on single-dose fosfomycin trometamol were authorised in France for urinary tract infections in pregnant women, after having been (...) recommended by a range of institutions. This recommendation was based on a few clinical trials which showed similar efficacy to that of standard antibiotic treatment. Fosfomycin trometamol crosses the placenta and is widely distributed in the body. During the first trimester, assessment of the consequences for the unborn child of exposure to fosfomycin trometamol is based on around 150 pregnancies. No worrying safety alert has appeared, but these data are too few in number to exclude a significant risk

2019 Prescrire

26. Pregnancy and Renal Disease

Pregnancy and Renal Disease Clinical Practice Guideline Pregnancy and Renal Disease Authors: Kate Wiles - Chair NIHR Doctoral Research Fellow in Obstetric Nephrology, Guy’s and St. Thomas’ NHS Foundation Trust and King's College London Lucy Chappell Professor of Obstetrics, King's College London and Consultant Obstetrician, Guy’s and St. Thomas’ NHS Foundation Trust Katherine Clark Specialist Midwife, King’s College Hospital NHS Foundation Trust Louise Elman Expert Patient Matt Hall Consultant (...) Nephrologist, King’s College Hospital NHS Foundation Trust and King’s College London Final Version: September 2019 Review Date: September 2024 Renal Association Clinical Practice Guideline Pregnancy and Renal Disease – September 2019 2 Endorsements The National Institute for Health and Care Excellence (NICE) has accredited the process used by the Renal Association to produce its Clinical Practice Guidelines. Accreditation is valid for 5 years from January 2017. More information on accreditation can

2019 Renal Association

27. Appendicitis during pregnancy in a Greenlandic Inuit woman; antibiotic treatment as a bridge-to-surgery in a remote area (PubMed)

Appendicitis during pregnancy in a Greenlandic Inuit woman; antibiotic treatment as a bridge-to-surgery in a remote area Appendicitis during pregnancy causes severe diagnostic problems, and is associated with an increase in perforation rate and morbidity compared to that in the normal population. In addition, it may cause preterm birth and fetal loss. In remote areas, appendicitis during pregnancy, besides presenting diagnostic problems, also creates treatment difficulties. In Northern (...) Greenland, geographical distances are vast, and weather conditions can be extreme. We report a case of a Greenlandic Inuit woman who presented with appendicitis during pregnancy. The nearest hospital with surgical and anaesthetic care was located nearly 1200 km away, and, due to extreme weather conditions, she could not be transferred immediately. She was treated with intravenous antibiotic treatment, and after weather conditions had improved, she was transferred by aeroplane and underwent

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2016 BMJ case reports

28. Control Cross Sectional Study Evaluating an Antibiotic Prevention Strategy in 30 Pregnancies Under Clean Intermittent Self-Catheterization and Review of Literature. (PubMed)

Control Cross Sectional Study Evaluating an Antibiotic Prevention Strategy in 30 Pregnancies Under Clean Intermittent Self-Catheterization and Review of Literature. To assess the efficacy and safety of a weekly oral cycling antibiotic (WOCA) strategy to prevent UTI in women.We performed a monocentric, comparative, retrospective, cross-sectional study on pregnant women under clean intermittent self catheterization between January 2008 and December 2014. WOCA consisted the administration (...) of a single-dose antibiotic, alternating antibiotic A and B once every 2 weeks, according to previous urine cultures.Twenty-five women carried out 30 pregnancies. Thirteen pregnancies (43.3%) were in the WOCA group (WCG) strategy and 17 were in the non-WOCA group (NWCG) (56.7%). In the 19 (63.3%) pregnancies with urinary tract infection (UTI), 5 (38.4%) were in WCG, 14 (82.3%) were not (P = .023). There were more cystitis in NWCG (76.5% vs 23.1% P = .009) but more colonization in WCG (46.2% vs 5.8% P

2016 Urology

29. Antibiotic use during pregnancy: how bad is it? (PubMed)

Antibiotic use during pregnancy: how bad is it? Our microbial companions (the "microbiota") are extremely important for the preservation of human health. Although changes in bacterial communities (dysbiosis) are commonly associated with disease, such changes have also been described in healthy pregnancies, where the microbiome plays an essential role in maternal and child health outcomes, including normal immune and metabolic function in later life. Nevertheless, this new understanding (...) of the importance of the microbiome has not yet influenced contemporary clinical practice regarding antibiotic use during pregnancy.Antibiotic treatment during pregnancy is widespread in Western countries, and accounts for 80 % of prescribed medications in pregnancy. However, antibiotic treatment, while at times lifesaving, can also have detrimental consequences. A single course of antibiotics perturbs bacterial communities, with evidence that the microbial ecosystem does not return completely to baseline

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2016 BMC Medicine

30. A New, Potent, and Placenta-Permeable Macrolide Antibiotic, Solithromycin, for the Prevention and Treatment of Bacterial Infections in Pregnancy (PubMed)

A New, Potent, and Placenta-Permeable Macrolide Antibiotic, Solithromycin, for the Prevention and Treatment of Bacterial Infections in Pregnancy Intrauterine infection-inflammation is a major cause of early preterm birth and subsequent neonatal mortality and acute or long-term morbidity. Antibiotics can be administered in pregnancy to prevent preterm birth either prophylactically to women at high risk for preterm delivery, or to women with diagnosed intrauterine infection, prelabor rupture (...) of membranes, or in suspected preterm labor. The therapeutic goals of each of these scenarios are different, with different pharmacological considerations, although effective antimicrobial therapy is an essential requirement. An ideal antibiotic for these clinical indications would be (a) one that is easily administered and orally bioactive, (b) has a favorable adverse effect profile (devoid of reproductive toxicity or teratogenicity), (c) is effective against the wide range of microorganisms known

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2016 Frontiers in immunology

31. Antibiotics in Pregnancy

Antibiotics in Pregnancy Antibiotics in Pregnancy Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Antibiotics in Pregnancy Antibiotics (...) in Pregnancy Aka: Antibiotics in Pregnancy , Antifungal Medications in Pregnancy , Antiparasitic Medications in Pregnancy , Antiviral Medications in Pregnancy II. Background Pregnancy Categories will be replaced on medication bottles with specific warnings and precautions by 2020 in U.S. Although are no longer FDA designated, they are included here As of 2018, succinct guidance (to replace ABCDX) on specific drugs in pregnancy is lacking III. Class B: No risk in controlled animal studies Topical Agents

2018 FP Notebook

32. Maternal Infections, Antibiotics and Paracetamol in Pregnancy and Offspring Celiac Disease: A Cohort Study. (PubMed)

Maternal Infections, Antibiotics and Paracetamol in Pregnancy and Offspring Celiac Disease: A Cohort Study. Infections in pregnancy are common, may affect fetal development, and have been linked to offspring autoimmunity. We aimed to determine whether maternal infections, the use of antibiotics, and use of paracetamol in pregnancy are associated with the risk of offspring celiac disease (CD).The nationwide Norwegian Mother and Child Cohort Study includes 84,274 children born in the period from (...) increased for categories 1 infection (1.01 [95% CI = 0.82-1.25]) and ≥2 infections (1.22 [95% CI = 1.00-1.49]) versus no infection. We found the same pattern for respiratory tract infections, but not for gastrointestinal infections. The aORs were broadly consistent across pregnancy periods of exposure. The use of antibiotics and paracetamol was, compared with no use, not associated with offspring CD (aOR = 1.16 [95% CI = 0.94-1.43] and aOR = 1.13 [95% CI = 0.96-1.33], respectively; P values for trend

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2016 Journal of Pediatric Gastroenterology and Nutrition

33. Prophylactic Antibiotics in Twin Pregnancies Complicated by Previable Preterm Premature Rupture of Membranes (PubMed)

Prophylactic Antibiotics in Twin Pregnancies Complicated by Previable Preterm Premature Rupture of Membranes This study aims to determine if antibiotics given for latency to women with twins and previable preterm premature rupture of membranes (PPROM) affect the duration from membrane rupture to delivery.A retrospective cohort study of twin pregnancies at a single center from 2000 to 2015 with previable (14 (0/7)-22 (6/7) weeks) PPROM was conducted. Women who were not candidates for expectant (...) management or who elected for immediate delivery were excluded. Pregnancy complications, delivery data, and neonatal outcomes were compared between women who did and did not receive latency antibiotics. The primary outcome was latency.Of 52 eligible women, 30 (64%) elected expectant management; 17 women received antibiotics and 13 did not. No demographic differences existed between the groups. The median gestational age of rupture was 20 and 20.3 weeks in the antibiotic group and no antibiotic group

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2016 AJP Reports

34. Antibiotic use during pregnancy and asthma in preschool children: the influence of confounding. (PubMed)

Antibiotic use during pregnancy and asthma in preschool children: the influence of confounding. A recent study suggested that early-life intestinal microbiota may play an important role in the development of childhood asthma, indicating that antibiotics taken during early life or in late pregnancy may be associated with childhood asthma.This study aims to assess the association between prenatal antibiotic use and asthma in preschool children using data from the prescription database IADB.nl (...) regression was used to estimate crude and adjusted odds ratios (aORs).In both the case-sibling and case-control analysis, the use of antibiotics in the third trimester of pregnancy was associated with an increased risk of asthma in preschool children (aOR 1.37; 95% CI 1.02-1.83 and aOR 1.40; 95% CI 1.15-1.47). Time-trend analyses showed that results were not influenced by a time trend in antibiotic exposure. A significant association between exposure to antibiotics in any trimester of pregnancy

2016 Clinical and Experimental Allergy

35. Antibiotic Therapy in Preterm Premature Rupture of the Membranes

PPROM at 32 weeks' gestation, antibiotics should be administered to women who are not in labour in order to prolong pregnancy and to decrease maternal and neonatal morbidity (I-A). 2. The use of antibiotics should be gestational-age dependent. The evidence for benefit is greater at earlier gestational ages (<32 weeks) (I-A). 3. For women with PPROM at >32 weeks' gestation, administration of antibiotics to prolong pregnancy is recommended if fetal lung maturity cannot be proven and/or delivery (...) Antibiotic Therapy in Preterm Premature Rupture of the Membranes No. 233-Antibiotic Therapy in Preterm Premature Rupture of the Membranes - Journal of Obstetrics and Gynaecology Canada Email/Username: Password: Remember me Search Terms Search within Search Volume 39, Issue 9, Pages e207–e212 No. 233-Antibiotic Therapy in Preterm Premature Rupture of the Membranes x Mark H. Yudin , MD Toronto, ON x Julie van Schalkwyk , MD Vancouver, BC x Nancy Van Eyk , MD Halifax, NS No. 233, September 2017

2017 Society of Obstetricians and Gynaecologists of Canada

36. Interventions during pregnancy to prevent preterm birth: an overview of Cochrane systematic reviews. (PubMed)

, bedrest for women with singleton pregnancy and antibiotic prophylaxis during the second and third trimester were of no effect or equivalent to a comparator.Possible benefitFour SRs found possible benefit in: group antenatal care for all pregnant women; antibiotics for pregnant women with asymptomatic bacteriuria; pharmacological interventions for smoking cessation for pregnant women who smoke; and vitamin D supplements alone for women without pre-existing conditions such as diabetes.Possible harmOne (...) ; and fetal and umbilical Doppler for high-risk pregnant women.Clear evidence of harmNo included SR reported clear evidence of harm.No effect or equivalenceFor pregnant women at high risk of PTB, antibiotic prophylaxis during the second and third trimester was of no effect or equivalent to a comparator.Possible benefitOne SR reported possible benefit with cervical cerclage for women with singleton pregnancy and high risk of PTB.Possible harmOne SR reported possible harm associated with a reduced schedule

2018 Cochrane

37. Different antibiotic regimens for treating asymptomatic bacteriuria in pregnancy. (PubMed)

Different antibiotic regimens for treating asymptomatic bacteriuria in pregnancy. Asymptomatic bacteriuria occurs in 5% to 10% of pregnancies and, if left untreated, can lead to serious complications.To assess which antibiotic is most effective and least harmful as initial treatment for asymptomatic bacteriuria in pregnancy.We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (March 2010) and reference lists of retrieved studies.Randomized controlled trials comparing two (...) . Comparing cycloserine with sulphadimidine, no significant differences in symptomatic, persistent, or recurrent infections were noted.We cannot draw any definite conclusion on the most effective and safest antibiotic regimen for the initial treatment of asymptomatic bacteriuria in pregnancy. One study showed advantages with a longer course of nitrofurantoin, and another showed better tolerability with ampicillin compared with pivmecillinam; otherwise, there was no significant difference demonstrated

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2010 Cochrane

38. Routes of administration of antibiotic prophylaxis for preventing infection after caesarean section. (PubMed)

of antibiotic prophylaxis for preventing infection after caesarean section.The aim of this review was to assess the benefits and harms of different routes of prophylactic antibiotics given for preventing infectious morbidity in women undergoing caesarean section.We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 January 2016), ClinicalTrials.gov, the WHO International Clinical Trials Registry Platform (ICTRP) (6 January 2016) and reference lists of retrieved studies.We included (...) Routes of administration of antibiotic prophylaxis for preventing infection after caesarean section. Post-caesarean section infection is a cause of maternal morbidity and mortality. Administration of antibiotic prophylaxis is recommended for preventing infection after caesarean delivery. The route of administration of antibiotic prophylaxis should be effective, safe and convenient. Currently, there is a lack of synthesised evidence regarding the benefits and harms of different routes

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2016 Cochrane

39. Management of Group B Streptococcal Bacteriuria in Pregnancy

, and Costs The recommendations in this guideline are designed to help clinicians identify pregnancies in which it is appropriate to treat GBS bacteriuria to optimize maternal and perinatal outcomes, to reduce the occurrences of antibiotic anaphylaxis, and to prevent increases in antibiotic resistance to GBS and non-GBS pathogens. No cost-benefit analysis is provided. Recommendations 1. Treatment of any bacteriuria with colony counts ≥100 000 CFU/mL in pregnancy is an accepted and recommended strategy (...) and includes treatment with appropriate antibiotics (II-2A). 2. Women with documented group B streptococcal bacteriuria (regardless of level of colony-forming units per mL) in the current pregnancy should be treated at the time of labour or rupture of membranes with appropriate intravenous antibiotics for the prevention of early-onset neonatal group B streptococcal disease (II-2A). 3. Asymptomatic women with urinary group B streptococcal colony counts <100 000 CFU/mL in pregnancy should not be treated

2018 Society of Obstetricians and Gynaecologists of Canada

40. Pregnancy

cause serious adverse pregnancy outcomes for both mother and child including preterm birth and small-for-gestational-age babies. Interventions used to prevent RUTI in women who are pregnant can be pharmacological (antibiotics) or non-pharmacological (cranberry products, acupuncture, probiotics and behavioural (...) modifications). So far little is known about the best way to prevent RUTI in pregnant women. OBJECTIVES: To assess the effects of interventions for preventing RUTI in pregnant women.The (...) Pregnancy Top results for pregnancy - Trip Database or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4

2018 Trip Latest and Greatest

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