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Antibiotics in Pregnancy

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1. Antibiotics for treating gonorrhoea in pregnancy. Full Text available with Trip Pro

on antibiotics for treating this infectious condition.To assess the clinical effectiveness and harms of antibiotics for treating gonorrhoea in pregnant women.We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 May 2017), LILACS database (1982 to April 5, 2017), the WHO International Clinical Trials Registry Platform (ICTRP; April 5, 2017), ClinicalTrials.gov (April 5, 2017), the ISRCTN Registry (April 5, 2017), and Epistemonikos (April 5, 2017). We also searched reference lists (...) Antibiotics for treating gonorrhoea in pregnancy. Gonorrhoea is a sexually transmitted infection that is caused by Neisseria gonorrhoeae, and is a major public health challenge today. N gonorrhoeae can be transmitted from the mother's genital tract to the newborn during birth, and can cause gonococcal ophthalmia neonatorum as well as systemic neonatal infections. It can also cause endometritis and pelvic sepsis in the mother. This review updates and replaces an earlier Cochrane Review

2018 Cochrane

2. Associations between macrolide antibiotics prescribing during pregnancy and adverse child outcomes in the UK: population based cohort study. Full Text available with Trip Pro

Associations between macrolide antibiotics prescribing during pregnancy and adverse child outcomes in the UK: population based cohort study. To assess the association between macrolide antibiotics prescribing during pregnancy and major malformations, cerebral palsy, epilepsy, attention deficit hyperactivity disorder, and autism spectrum disorder in children.Population based cohort study.The UK Clinical Practice Research Datalink.The study cohort included 104 605 children born from 1990 to 2016 (...) , 1.14 to 2.19, mainly hypospadias). Erythromycin in the first trimester was associated with an increased risk of any major malformation (27.39 v 17.65 per 1000, 1.50, 1.13 to 1.99). No statistically significant associations were found for other system specific malformations or for neurodevelopmental disorders. Findings were robust to sensitivity analyses.Prescribing macrolide antibiotics during the first trimester of pregnancy was associated with an increased risk of any major malformation

2020 BMJ

3. Antibiotic use during pregnancy increases offspring asthma severity in a dose-dependent manner. Full Text available with Trip Pro

Antibiotic use during pregnancy increases offspring asthma severity in a dose-dependent manner. The use of antibiotics during pregnancy is associated with increased allergic asthma risk in the offspring, and given that approximately 25% of pregnant women are prescribed antibiotics, it is important to understand the mechanisms contributing to this phenomenon. Currently, there are no studies that directly test this association experimentally. Our objective was to develop a mouse model in which (...) antibiotic treatment during pregnancy results in increased offspring asthma susceptibility.Pregnant mice were treated daily from gestation day 8-17 with an oral solution of the antibiotic vancomycin, and three concentrations were tested. At weaning, offspring were subjected to an adjuvant-free experimental asthma protocol using ovalbumin as an allergen. The composition of the gut microbiome was determined in mothers and offspring with samples collected from five different time points; short-chain fatty

2020 Allergy

4. COVID-19 rapid guideline: antibiotics for pneumonia in adults in hospital

and dosing in specific populations, for example, for hepatic impairment, renal impairment, pregnancy and breast-feeding, and when administering intravenous antibiotics. There are no validated tools to assess the severity of hospital-acquired pneumonia in the context of the COVID-19 pandemic; severity should be based on clinical judgement. Consult a local microbiologist for alternative options, including for pregnant women. If there is a penicillin allergy, avoid using co-amoxiclav and piperacillin (...) that bacterial co-infection occurs in less than about 10% of patients with COVID-19. But patients in critical care have an increased likelihood of bacterial infection compared with patients in other hospital wards or settings. • Because COVID-19 pneumonia is caused by a virus, antibiotics are ineffective unless there is a bacterial co-infection. • Inappropriate antibiotic use may reduce their availability, and indiscriminate use may lead to Clostridioides difficile infection and antimicrobial resistance

2020 National Institute for Health and Clinical Excellence - Clinical Guidelines

5. Urinary tract infections and antibiotic use in pregnancy - qualitative analysis of online forum content. Full Text available with Trip Pro

Urinary tract infections and antibiotic use in pregnancy - qualitative analysis of online forum content. Antibiotics are standard treatment for asymptomatic and symptomatic urinary tract infections (UTIs) in pregnancy. Their overuse, however, can contribute to antimicrobial resistance (AMR) and expose the foetus to drugs that might affect its development. Preventative behaviours are currently the best option to reduce incidences of UTIs and to avoid the use of antibiotics in pregnancy. The aim (...) thematic analysis.Women's perceptions of UTIs and antibiotic use in pregnancy were driven by their pre-natal attachment to the foetus. UTIs were thought to be common and high risk in pregnancy, which meant that antibiotics were viewed as essential in the presence of suspected symptoms. The dominant view about antibiotics was that their use was safe and of little concern in pregnancy. Women reported an emotional reaction to developing a UTI. They coped by seeking information about behaviour change

2019 BMC Pregnancy and Childbirth

6. Association between antibiotic treatment during pregnancy & infancy and the development of allergic diseases. Full Text available with Trip Pro

Association between antibiotic treatment during pregnancy & infancy and the development of allergic diseases. Allergies are a serious public health issue, and prevalences are rising worldwide. The role of antibiotics in the development of allergies has repeatedly been discussed, as results remain inconsistent. The aim of this study was to investigate the association between pre- and post-natal antibiotic exposure and subsequent development of allergies (atopic dermatitis, food allergy, asthma (...) , atopic sensitization and allergic rhinitis).A total of 1080 children who participated in a European birth cohort study (PASTURE) were included in this analysis. Data on antibiotic exposure during pregnancy and/or first year of life and allergic diseases were collected by questionnaires from pregnancy up to 6 years of age and analysed by performing logistic regressions. To take into account reverse causation, we included models, where children with diagnosis or symptoms of the respective disease

2019 Pediatric Allergy and Immunology

7. Maternal antibiotic use during pregnancy and childhood obesity at age 5 years. Full Text available with Trip Pro

Maternal antibiotic use during pregnancy and childhood obesity at age 5 years. The benefits of antibiotic treatment during pregnancy are immediate, but there may be long-term risks to the developing child. Prior studies show an association between early life antibiotics and obesity, but few have examined this risk during pregnancy.To evaluate the association of maternal antibiotic exposure during pregnancy on childhood BMI-z at 5 years, we conducted a retrospective cohort analysis. Using (...) electronic health record data from seven health systems in PCORnet, a national distributed clinical research network, we included children with same-day height and weight measures who could be linked to mothers with vital measurements during pregnancy. The primary independent variable was maternal outpatient antibiotic prescriptions during pregnancy (any versus none). We examined dose response (number of antibiotic episodes), spectrum and class of antibiotics, and antibiotic episodes by trimester

2019 International Journal of Obesity

8. Use of antibiotics during pregnancy and risk of spontaneous abortion Full Text available with Trip Pro

Use of antibiotics during pregnancy and risk of spontaneous abortion Although antibiotics are widely used during pregnancy, evidence regarding their fetal safety remains limited. Our aim was to quantify the association between antibiotic exposure during pregnancy and risk of spontaneous abortion.We conducted a nested case-control study within the Quebec Pregnancy Cohort (1998-2009). We excluded planned abortions and pregnancies exposed to fetotoxic drugs. Spontaneous abortion was defined (...) as having a diagnosis or procedure related to spontaneous abortion before the 20th week of pregnancy. The index date was defined as the calendar date of the spontaneous abortion. Ten controls per case were randomly selected and matched by gestational age and year of pregnancy. Use of antibiotics was defined by filled prescriptions between the first day of gestation and the index date and was compared with (a) non-exposure and (b) exposure to penicillins or cephalosporins. We studied type of antibiotics

2017 EvidenceUpdates

9. Systematic review on the use of D-mannose and its combinations with other non-antibiotic and antibiotic agents for the prevention and treatment of urinary tract infections in non-pregnant women

Systematic review on the use of D-mannose and its combinations with other non-antibiotic and antibiotic agents for the prevention and treatment of urinary tract infections in non-pregnant women Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears

2020 PROSPERO

10. Antibiotic treatment of uncomplicated pyelonephritis in non-pregnant women

Antibiotic treatment of uncomplicated pyelonephritis in non-pregnant women Prescrire IN ENGLISH - Spotlight ''Antibiotic treatment of uncomplicated pyelonephritis in non-pregnant women'', 1 December 2014 {1} {1} {1} | | > > > Antibiotic treatment of uncomplicated pyelonephritis in non-pregnant women Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight (...) Antibiotic treatment of uncomplicated pyelonephritis in non-pregnant women The choice of antibiotic treatment for acute uncomplicated pyelonephritis in women should take resistance to antibiotics into account. Acute uncomplicated pyelonephritis is a bacterial kidney infection. It is more frequent in women than in men and is generally caused by the Escherichia coli bacterium. Pyelonephritis is suspected in cases of spontaneous lumbar pain or tenderness during palpation, combined with a high fever

2014 Prescrire

11. Antibiotics after incision and drainage for uncomplicated skin abscesses Full Text available with Trip Pro

of adverse effects including nausea and diarrhoea We suggest TMP-SMX rather than clindamycin because TMP-SMX has a lower risk of diarrhoea Cephalosporins in addition to incision and drainage are probably not more effective than incision and drainage alone in most settings From a societal perspective, the modest benefits from adjuvant antibiotics may not outweigh the harms from increased antimicrobial resistance in the community, although this is speculative Box 1 Linked articles in this BMJ Rapid (...) are likely to prefer TMP-SMX. Person-centred versus societal perspective (impact on antibiotic resistance) The recommendations explicitly take a person-centred perspective rather than a public health or societal perspective. The use of antibiotics is associated with the emergence of antibiotic resistance within the community and may increase the risk of antibiotic resistant infections in community members. The increasing rates of antimicrobial resistance are a public health priority. From a societal

2018 BMJ Rapid Recommendations

12. COVID-19: Antibiotic Management in Ambulatory Patients

April 3 The CDC offers no guidance specific to the use of antibiotics in COVID+ patients in the outpatient setting. Professional society guidance on antibiotic indications in COVID+ patients or patients under investigation (PUI) Source Recommendations IDSA April 13 The IDSA offers no guidance specific to the use of antibiotics in COVID+ patients in the outpatient setting. ASP April 2 For patients in an ambulatory setting, antibacterial therapy (including azithromycin) is not routinely recommended (...) practices Source Recommendations NICE April 3 When starting antibiotic treatment, the first-choice oral antibiotic is: doxycycline 200 mg on the first day, then 100 mg once a day for 5 days in total (not in pregnancy). Alternative: amoxicillin 500 mg 3 times a day for 5 days [specific to ambulatory setting]. WHO March 13 Empiric antibiotic treatment should be based on the clinical diagnosis (community acquired pneumonia, health care-associated pneumonia [if infection was acquired in health care setting

2020 Centre for Evidence-Based Practice, Penn Medicine

13. Antibacterial-coated sutures versus non-antibacterial-coated sutures for the prevention of abdominal, superficial and deep, surgical site infection (SSI)

low risk of bias RCTs 83 Table 19: The length of hospital stay in triclosan-coated vs non-antibacterial coated sutures patient groups 85 Table 20: The proportion of patients requiring secondary surgery for wound-related complications of surgery 86 Table 21: The incidence of complete abdominal wound dehiscence within 30 days of surgery and incisional hernia during the period of study follow-up 87 Table 22: Causative microorganism of SSI and the use of systemic antibiotic therapy within 30 days (...) Controlled Trial REA Relative Effectiveness Assessment RoB Risk of Bias RR Relative risk SAE Serious Adverse Event SAF Safety domain Antibacterial-coated sutures for the prevention of abdominal SSI Version 1.4, March 2017 EUnetHTA Joint Action 3 WP4 10 SAP Surgical antibiotic prophylaxis SDGC Study Center of the German Surgical Society SHEA The Society for Healthcare Epidemiology of America SHEA/IDSA Society for Healthcare Epidemiology of America/Infectious Diseases Society of America SI Superficial

2017 EUnetHTA

15. Use of antibiotics during pregnancy and the risk of major congenital malformations: a population based cohort study Full Text available with Trip Pro

Use of antibiotics during pregnancy and the risk of major congenital malformations: a population based cohort study Few studies have investigated the link between individual antibiotics and major congenital malformations (MCMs) including specific malformations owing to small sample size. We aimed to quantify the association between exposure to gestational antibiotic and the risk of MCMs.Using the Quebec pregnancy cohort (1998-2008), we included a total of 139 938 liveborn singleton alive whose (...) mothers were covered by the "Régie de l'assurance maladie du Québec" drug plan for at least 12 months before and during pregnancy. Antibiotic exposure was assessed in the first trimester and MCMs were identified within the first year of life.After adjusting for potential confounders, clindamycin exposure was associated with an increased risk of MCMs (aOR 1.34, 95% CI 1.02-1.77, 60 exposed cases), musculoskeletal system malformations (aOR 1.67, 95% CI 1.12-2.48, 29 exposed cases) and ventricular/atrial

2017 British journal of clinical pharmacology

16. Antibiotic use during pregnancy: a retrospective study of prescription patterns and birth outcomes at an antenatal clinic in rural Ghana Full Text available with Trip Pro

defects.Sixty five percent of pregnant women were administered antibiotics at some stage during pregnancy. Beta Lactam antibiotics accounted for more than 67% of all antibiotics prescribed. There was a statistically significant association between antibiotic exposure and pregnancy factors such as stage of pregnancy, parity and mode of delivery but not with socio-economic status of the mother. Intrapartum antibiotic exposure did not significantly affect the birthweight, incidence of congenital birth defect (...) Antibiotic use during pregnancy: a retrospective study of prescription patterns and birth outcomes at an antenatal clinic in rural Ghana Babies are increasingly being exposed to antibiotics intrapartum in the bid to reduce neonatal and maternal deaths. Intrapartum antibiotic exposure, including even those considered safe in pregnancy, have been associated with childhood obesity and compromised immunity. Data on the extent of antibiotic use, safety and its impact on birth outcomes and neonatal

2017 Journal of pharmaceutical policy and practice

17. Optimal levels of DHEA for pregnancy may be reduced by antibiotics Full Text available with Trip Pro

Optimal levels of DHEA for pregnancy may be reduced by antibiotics 28760838 2017 10 16 2018 12 02 1488-2329 189 30 2017 07 31 CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne CMAJ Optimal levels of DHEA for pregnancy may be reduced by antibiotics. E999 10.1503/cmaj.733105 Howard James M JM Independent biologist, Fayetteville, Ark. eng Letter Comment Canada CMAJ 9711805 0820-3946 0 Anti-Bacterial Agents 459AG36T1B Dehydroepiandrosterone AIM IM CMAJ. 2017 (...) May 1;189(17 ):E625-E633 28461374 CMAJ. 2017 Jul 31;189(30):E1000 28760839 Anti-Bacterial Agents Dehydroepiandrosterone Female Fertilization in Vitro Humans Pregnancy Competing interests: None declared. 2017 8 2 6 0 2017 8 2 6 0 2017 10 17 6 0 ppublish 28760838 189/30/E999 10.1503/cmaj.733105 PMC5536992 Reprod Biol Endocrinol. 2009 Oct 07;7:108 19811650 Riv Biol. 2001 Jan-Apr;94(1):177-83 11445999 Gynecol Endocrinol. 2013 Oct;29(10):940-3 23889217 CMAJ. 2017 May 1;189(17 ):E625-E633 28461374 Brain

2017 CMAJ : Canadian Medical Association Journal

18. Prevalence of time-related bias in pharmacoepidemiology studies on the use of anti-emetics, antifungal, and antibiotic medications during pregnancy: a systematic review

Prevalence of time-related bias in pharmacoepidemiology studies on the use of anti-emetics, antifungal, and antibiotic medications during pregnancy: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability

2019 PROSPERO

19. Antibiotics in Pregnancy Increase Children's Risk of Otitis Media and Ventilation Tubes. (Abstract)

Antibiotics in Pregnancy Increase Children's Risk of Otitis Media and Ventilation Tubes. To study the association between antibiotic intake in pregnancy and the development of otitis media and placement of ventilation tubes (VTs) in the offspring under the hypothesis that antibiotics in pregnancy may alter the offspring's propensity for disease.Data from the 700 children in the Copenhagen Prospective Studies on Asthma in Childhood 2010 unselected birth cohort study were used. Information (...) on maternal antibiotic use and other exposures during pregnancy was collected prospectively from interviews and validated in national registries. Otitis media episodes were registered in a prospective diary for 3 years. Information regarding children's VTs was obtained from national registries.There were 514 children who had diary information and were included in the analysis regarding otitis media episodes. For VTs analysis, 699 children were included. Thirty-seven percent of the mothers received

2017 Journal of Pediatrics

20. Outcomes of antibiotic therapy for uncomplicated appendicitis in pregnancy. (Abstract)

Outcomes of antibiotic therapy for uncomplicated appendicitis in pregnancy. The aim of the present study is to determine the feasibility and safety of antibiotics for uncomplicated simple appendicitis in pregnancy.We conducted a 6-year prospective observational study on 20 pregnant women in whom uncomplicated simple appendicitis (appendiceal diameter ≤11 mm and with no signs of appendicoliths, perforation, or abscess) was radiologically verified and managed with a 4-day course of antibiotics (...) . Treatment failure rate, defined as the need for an appendectomy during hospitalization and recurrence in the follow-up period (median 25 months), and maternal or fetal complications during the pregnancy were evaluated.Mean age of patients was 33.4 years, and gestational age was 17.8 weeks. Three patients failed to respond to antibiotic therapy during hospitalization and underwent subsequent appendectomy (2 suppurative and 1 perforated appendicitis). There was 1 wound infection postoperatively. During

2017 American Journal of Medicine

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