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Antibiotic Food Interactions

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1641. A Study To Assess Single Dosage Strength Of GW685698/GW642444 Chronic Obstructive Pulmonary Disease (COPD)

, and day and day by treatment and day by Baseline interactions. par.=participants. Number of Participants With Any Adverse Event (AE) and Any Serious Adverse Event (SAE) Throughout the Study [ Time Frame: From Baseline (Day 1) until Follow-up (up to Study Day 37) ] Co-Primary Endpoint. An AE is defined as any untoward medical occurrence in a participant or clinical investigation participant, temporally associated with the use of a medicinal product, whether or not considered related to the medicinal (...) on Day 1. Change from Baseline was calculated as the Day 29 value minus the Baseline value. Analysis was performed using Mixed Model Repeated Measures (MMRM) with covariates of Baseline FEV1, sex, age, smoking status, treatment and day, and day by treatment and day by Baseline interactions. Mean Change From Baseline (Pre-dose on Day 1) in Weighted Mean FEV1 (0-4 Hours Post-dose) on Days 1 and 28 [ Time Frame: Baseline (pre-dose on Day 1); Day 1 and Day 28 ] FEV1 is a measure of lung function

2008 Clinical Trials

1642. Pharmacokinetic Drug Interaction Between Ezetimibe and Tacrolimus After Single Dose Administration in Healthy Subjects

Pharmacokinetic Drug Interaction Between Ezetimibe and Tacrolimus After Single Dose Administration in Healthy Subjects Pharmacokinetic Drug Interaction Between Ezetimibe and Tacrolimus After Single Dose Administration in Healthy Subjects - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Pharmacokinetic Drug Interaction Between Ezetimibe and Tacrolimus After Single Dose Administration in Healthy Subjects The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00621699 Recruitment Status : Completed First

2008 Clinical Trials

1643. Sulforaphane as an Antagonist to Human PXR-mediated Drug-drug Interactions

activity of CYP3A4 before and following treatment with Rifampin, in the presence or absence of SFN, since midazolam is only eliminated from the bloodstream by CYP3A4. . We predict that SFN will prevent the increase in midazolam clearance (metabolism) that normally follows treatment with the antibiotic, rifampicin. This research is important because it could potentially lead to a simple, cost-effective way of preventing one of the most common causes of adverse drug-drug interactions that occurs today (...) . For example, rifampicin, which is a cheap and effective antibiotic used to treat TB, cannot be used in HIV/AIDS patients because it increases the metabolism of many of the antiretroviral drugs used to treat HIV/AIDS. TB is a major opportunistic infection in AIDS patients, so this is a serious clinical problem, especially in developing countries where more expensive alternative drug therapies are not available. We hypothesize that co-formulation of rifampicin with SFN could block this drug-drug interaction

2008 Clinical Trials

1644. Pharmacokinetic Drug Interaction Between Ezetimibe and Sirolimus After Single Dose Administration in Healthy Subjects

provided by University Medicine Greifswald: pharmacokinetics drug interactions ezetimibe sirolimus human experimentation Additional relevant MeSH terms: Layout table for MeSH terms Hypercholesterolemia Hyperlipidemias Dyslipidemias Lipid Metabolism Disorders Metabolic Diseases Pharmaceutical Solutions Sirolimus Everolimus Ezetimibe Anti-Bacterial Agents Anti-Infective Agents Antibiotics, Antineoplastic Antineoplastic Agents Antifungal Agents Immunosuppressive Agents Immunologic Factors Physiological (...) Pharmacokinetic Drug Interaction Between Ezetimibe and Sirolimus After Single Dose Administration in Healthy Subjects Pharmacokinetic Drug Interaction Between Ezetimibe and Sirolimus After Single Dose Administration in Healthy Subjects - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2008 Clinical Trials

1645. Flaxseed, Aromatase Inhibitors and Breast Tumor Characteristics

Center for Complementary and Integrative Health (NCCIH) AstraZeneca Information provided by (Responsible Party): Roswell Park Cancer Institute Study Details Study Description Go to Brief Summary: The proposed study plans to examine the effect of flaxseed consumption, a phytoestrogen rich food, compared to aromatase inhibitors as a complementary approach to treating estrogen receptor positive breast cancer, as well as the effect of combined flaxseed and aromatase inhibitor therapy on breast cancer (...) treatment. Because of the increasing use of both complementary and alternative approaches to treatment, and the use of aromatase inhibitors in the treatment of breast cancer, the proposed study has potential to provide important clinical information about the effect of foods high in phytoestrogens on a common endocrine therapy used in breast cancer. Condition or disease Intervention/treatment Phase Breast Cancer Drug: Anastrozole Dietary Supplement: flaxseed Drug: Placebo Not Applicable Detailed

2008 Clinical Trials

1646. Study of the Ability of Clarithromycin to Induce Oxidative Stress

in the development of cardiovascular complications [5], and it could be such an oxidative stress that had led to the increased mortality in the above study. Especially because a recent american study found evidence that bactericidal antibiotics induce oxidative stress in bacteria, leading to cell death [6]. This oxidative stress contributes significantly to the impact of the bactericidal antibiotics, which was thought to be primarily attributed to their specific drug/target interactions. The same study also (...) of cardiovascular complications, suggesting that Chlamydophila pneumoniae could exacerbate the development of atherosclerosis [1]. It has therefore been tried to treat atherosclerotic AMI- patients prophylactically with macrolide antibiotics (which is used to treat Chlamydia infections), to halt development of the atherosclerosis and the accompanying risk of a new acute myocardial infarction. Two minor studies have demonstrated a positive effect of macrolide-treatment, why a major Danish study of Clarithromycin

2008 Clinical Trials

1647. Multicenter, Randomized, Double-Blind, Double-Dummy, Phase 3 Study of the Safety and Efficacy of Elvitegravir Versus Raltegravir

protease inhibitor (PI) plus 1 or 2 additional antiretroviral (ARV) agents) in HIV-1 infected, ARV treatment-experienced adults who have documented resistance, or at least six months experience prior to screening with two or more different classes of ARV agents. Participants will be randomized in a 1:1 ratio to receive EVG plus background regimen (Elvitegravir group), or raltegravir plus background regimen (Raltegravir group). Due to known drug interactions, participants in the Elvitegravir group (...) analysis. For phenotypic susceptibility, fully active is defined as being below the lower clinical or biological cutoff. Participants are required to take their ritonavir dose based on the dosing schedule indicated in the prescribing information for the PI; no additional ritonavir is required to be taken with EVG. No other marketed PIs are allowed as part of the background regimen due to unknown drug interactions. The second agent can be one nucleoside or nucleotide reverse transcriptase inhibitor

2008 Clinical Trials

1648. Equol status modifies the association of soy intake and mammographic density in a sample of postmenopausal women. (PubMed)

therapy). Of 325 enrolled, 232 (71%) participants completed study assessments and are included in the present analysis. Mean percent density was 34% (+/-18%). Seventy-five (30%) participants were producers of equol. Forty-three (19%) participants reported regularly eating >1 soy food or supplement/wk. There were no significant independent associations of equol status or soy intake with percent density, but the interaction between these factors was significant (P < 0.01). Among equol producers, those (...) Equol status modifies the association of soy intake and mammographic density in a sample of postmenopausal women. Only 30% to 50% of people produce the daidzein-metabolite equol after eating soy. We conducted a cross-sectional study of the associations between equol status, intake of soy foods, and mammographic density in a sample of postmenopausal women recruited at a radiology clinic near Buffalo, New York. Participants were 48 to 82 years old, had no history of cancer or breast reduction

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2008 Cancer Epidemiology & Biomarkers and Prevention

1649. Telithromycin-associated hepatotoxicity: Clinical spectrum and causality assessment of 42 cases. (PubMed)

Telithromycin-associated hepatotoxicity: Clinical spectrum and causality assessment of 42 cases. Telithromycin is the first of a new class of ketolide antibiotics with increased activity against penicillin-resistant and erythromycin-resistant pneumococci. This agent received approval by the United States Food and Drug Administration (FDA) in 2004 for treatment of upper and lower respiratory infections. Following market introduction, spontaneous reports of telithromycin-associated hepatotoxicity (...) of causality increased after agreement on definitions of categories and interactive discussions.Telithromycin is a rare cause of drug-induced liver injury that may have a distinctive clinical signature and associated high mortality rate. Consensus for attribution of liver injury to a selected drug exposure by individual experts can be aided by careful definition of terminology and discussion.

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2008 Hepatology

1650. Salmonella Gastroenteritis

; Public Health England ; Salmonella Interaction with and Passage through the Intestinal Mucosa: Through the Lens of the Organism. Front Microbiol. 20112:88. doi: 10.3389/fmicb.2011.00088. Epub 2011 Apr 29. ; Egg Info ; Advisory Committee on the Microbiological Safety of Food (ACMSF). February 2016 ; World Health Organization (WHO) August 2013 ; Development and evaluation of a multiplex real-time polymerase chain reaction procedure to clinically type prevalent Salmonella enterica serovars. J Mol Diagn (...) Salmonella Gastroenteritis Salmonella Gastroenteritis. Information on food poisoning | Patient TOPICS Try our Symptom Checker TREATMENT RESOURCES Try our Symptom Checker PROFESSIONAL Upgrade to Patient Pro / / Search Salmonella Gastroenteritis Authored by , Reviewed by | Last edited 25 May 2016 | Certified by This article is for Medical Professionals Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based on research evidence, UK

2008 Mentor

1651. Reflexology - Level of Evidence

, lemon, lemon grass (unless greatly diluted with a carrier oil), turmeric and valerian. Skin patch testing can be carried out beforehand if there are concerns. Care should be taken in those with a history of allergy or atopic conditions such as asthma, eczema or hay fever. Oestrogen-dependent tumours such as breast cancer or ovarian cancer, are a contra-indication to the use of oils with oestrogen-like compounds, such as fennel, aniseed, sage, and clary sage. There may be possible interactions (...) of essential oils, with antibiotics, antihistamines and sedatives. Cinnamon, turmeric, valerian, laurel, juniper, aniseed, coriander and eucalyptus should not be used for longer than two weeks at a time because of concerns about toxicity. Bitter almond, red thyme, common sage, rue, wormwood, tansy, savory, wintergreen and sassafras oils should be avoided at all times by everyone as they can be poisonous. There is no evidence to suggest that aromatherapy can cure or prevent any illnesses; however, some

2008 Mentor

1652. Zinc Supplements

and calcium absorption. Interactions [ ] Quinolone and tetracycline antibiotics may interact with zinc supplements, leading to reduced absorption of the supplement and the antibiotic. Zinc supplementation can reduce the absorption of penicillamine. Prolonged use of thiazide diuretics increases urinary excretion of zinc and so can reduce tissue levels. Side-effects Irritability, headache, lethargy. [ ] Unpleasant taste in the mouth. There have been reports of anosmia with intranasal zinc preparations (...) intake of zinc is needed to maintain adequate body levels. The recommended daily zinc intake (reference nutrient intake) for an adult man in the UK is 9.5 mg. [ ] The recommended daily zinc intake for an adult woman in the UK is 7 mg. [ ] The Food Standards Agency and the Department of Health in the UK advise that intake of zinc should not exceed 25 mg per day. Dietary sources of zinc Zinc rich foods: Red meat and poultry (these are the main sources of zinc for many). Oysters, crab, lobster and other

2008 Mentor

1653. Zinc Excess and Zinc Toxicity

and calcium absorption. Interactions [ ] Quinolone and tetracycline antibiotics may interact with zinc supplements, leading to reduced absorption of the supplement and the antibiotic. Zinc supplementation can reduce the absorption of penicillamine. Prolonged use of thiazide diuretics increases urinary excretion of zinc and so can reduce tissue levels. Side-effects Irritability, headache, lethargy. [ ] Unpleasant taste in the mouth. There have been reports of anosmia with intranasal zinc preparations (...) intake of zinc is needed to maintain adequate body levels. The recommended daily zinc intake (reference nutrient intake) for an adult man in the UK is 9.5 mg. [ ] The recommended daily zinc intake for an adult woman in the UK is 7 mg. [ ] The Food Standards Agency and the Department of Health in the UK advise that intake of zinc should not exceed 25 mg per day. Dietary sources of zinc Zinc rich foods: Red meat and poultry (these are the main sources of zinc for many). Oysters, crab, lobster and other

2008 Mentor

1654. Zinc Deficiency

and calcium absorption. Interactions [ ] Quinolone and tetracycline antibiotics may interact with zinc supplements, leading to reduced absorption of the supplement and the antibiotic. Zinc supplementation can reduce the absorption of penicillamine. Prolonged use of thiazide diuretics increases urinary excretion of zinc and so can reduce tissue levels. Side-effects Irritability, headache, lethargy. [ ] Unpleasant taste in the mouth. There have been reports of anosmia with intranasal zinc preparations (...) of zinc is needed to maintain adequate body levels. The recommended daily zinc intake (reference nutrient intake) for an adult man in the UK is 9.5 mg. [ ] The recommended daily zinc intake for an adult woman in the UK is 7 mg. [ ] The Food Standards Agency and the Department of Health in the UK advise that intake of zinc should not exceed 25 mg per day. Dietary sources of zinc Zinc rich foods: Red meat and poultry (these are the main sources of zinc for many). Oysters, crab, lobster and other

2008 Mentor

1655. Typhoid Vaccination

so if exposed to large doses of S. typhi . Attention should be paid to personal, food and water hygiene at all times. Interactions The oral vaccine Vivotif® is inactivated when antibacterials and some antimalarials are taken at the same time. Antibacterials should not be taken for the three-day period before and the three-day period following oral vaccination. Mefloquine: the oral vaccination should ideally be completed at least three days before the first dose of mefloquine (...) antibody levels to those reached after the primary immunisation. Because of the limited protection offered by the vaccine, scrupulous attention to personal, food and water hygiene must be emphasised to travellers. Polysaccharide typhoid vaccine is also available as a combined vaccination with hepatitis A, for adults and for adolescents aged 15 years and over. If boosted within 6-12 months of the first dose, it confers immunity against hepatitis A for ten years, but against typhoid for only three years

2008 Mentor

1656. Hypersensitivity Vasculitis

revised in 2012 [ ] . Aetiology [ ] No cause is found in a third to half of all cases. Many drugs have been reported to cause the condition. Examples include: Antibiotics. Non-steroidal anti-inflammatory drugs (NSAIDs). Letrozole [ ] . Orlistat [ ] . Other implicated causes include: Upper respiratory tract infections. As symptoms do not present until after the illness, if an antibiotic is used, it is often impossible to know if it was the illness or the medication that caused them. Severe bacterial (...) infection, especially bacterial endocarditis. Food and food additives. Hepatitis C has been implicated, especially when there is cryoglobulinaemia. Collagen diseases. Inflammatory bowel disease. Malignancy probably accounts for around 1% of cases [ ] . Granulomatosis with polyangiitis (Wegener's granulomatosis) and hairy cell leukaemia are the most common. Polyarteritis nodosa and Churg-Strauss syndrome have also been implicated [ ] . Epidemiology The disease is in many ways similar to Henoch-Schönlein

2008 Mentor

1657. Homeopathy

, lemon, lemon grass (unless greatly diluted with a carrier oil), turmeric and valerian. Skin patch testing can be carried out beforehand if there are concerns. Care should be taken in those with a history of allergy or atopic conditions such as asthma, eczema or hay fever. Oestrogen-dependent tumours such as breast cancer or ovarian cancer, are a contra-indication to the use of oils with oestrogen-like compounds, such as fennel, aniseed, sage, and clary sage. There may be possible interactions (...) of essential oils, with antibiotics, antihistamines and sedatives. Cinnamon, turmeric, valerian, laurel, juniper, aniseed, coriander and eucalyptus should not be used for longer than two weeks at a time because of concerns about toxicity. Bitter almond, red thyme, common sage, rue, wormwood, tansy, savory, wintergreen and sassafras oils should be avoided at all times by everyone as they can be poisonous. There is no evidence to suggest that aromatherapy can cure or prevent any illnesses; however, some

2008 Mentor

1658. Complementary and Alternative Medicine

be possible interactions of essential oils, with antibiotics, antihistamines and sedatives. Cinnamon, turmeric, valerian, laurel, juniper, aniseed, coriander and eucalyptus should not be used for longer than two weeks at a time because of concerns about toxicity. Bitter almond, red thyme, common sage, rue, wormwood, tansy, savory, wintergreen and sassafras oils should be avoided at all times by everyone as they can be poisonous. There is no evidence to suggest that aromatherapy can cure or prevent any (...) The medicinal properties of herbs have been exploited for many centuries. The druids and the Ancient Egyptians are amongst the best-known exponents of herbal medicine. The concern is that many herbal remedies that are for sale have not been thoroughly tested for efficacy, toxicity, drug interactions and teratogenicity. In addition, there are often problems of variation in potency between batches and correct doses are not carefully established. The Medicines and Healthcare products Regulatory Agency (MHRA

2008 Mentor

1659. Acupuncture

, lemon, lemon grass (unless greatly diluted with a carrier oil), turmeric and valerian. Skin patch testing can be carried out beforehand if there are concerns. Care should be taken in those with a history of allergy or atopic conditions such as asthma, eczema or hay fever. Oestrogen-dependent tumours such as breast cancer or ovarian cancer, are a contra-indication to the use of oils with oestrogen-like compounds, such as fennel, aniseed, sage, and clary sage. There may be possible interactions (...) of essential oils, with antibiotics, antihistamines and sedatives. Cinnamon, turmeric, valerian, laurel, juniper, aniseed, coriander and eucalyptus should not be used for longer than two weeks at a time because of concerns about toxicity. Bitter almond, red thyme, common sage, rue, wormwood, tansy, savory, wintergreen and sassafras oils should be avoided at all times by everyone as they can be poisonous. There is no evidence to suggest that aromatherapy can cure or prevent any illnesses; however, some

2008 Mentor

1660. Aromatherapy

, lemon, lemon grass (unless greatly diluted with a carrier oil), turmeric and valerian. Skin patch testing can be carried out beforehand if there are concerns. Care should be taken in those with a history of allergy or atopic conditions such as asthma, eczema or hay fever. Oestrogen-dependent tumours such as breast cancer or ovarian cancer, are a contra-indication to the use of oils with oestrogen-like compounds, such as fennel, aniseed, sage, and clary sage. There may be possible interactions (...) of essential oils, with antibiotics, antihistamines and sedatives. Cinnamon, turmeric, valerian, laurel, juniper, aniseed, coriander and eucalyptus should not be used for longer than two weeks at a time because of concerns about toxicity. Bitter almond, red thyme, common sage, rue, wormwood, tansy, savory, wintergreen and sassafras oils should be avoided at all times by everyone as they can be poisonous. There is no evidence to suggest that aromatherapy can cure or prevent any illnesses; however, some

2008 Mentor

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