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Antibiotic Food Interactions

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61. PK Interaction Between Rifapentine or Rifampicin and a Single Dose of TMC207 in Healthy Subjects (TMC207-CL002)

PK Interaction Between Rifapentine or Rifampicin and a Single Dose of TMC207 in Healthy Subjects (TMC207-CL002) PK Interaction Between Rifapentine or Rifampicin and a Single Dose of TMC207 in Healthy Subjects (TMC207-CL002) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. PK Interaction Between Rifapentine or Rifampicin and a Single Dose of TMC207 in Healthy Subjects (TMC207-CL002) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02216331 Recruitment Status : Completed First Posted : August 13, 2014

2014 Clinical Trials

62. A Drug Interaction Study of Mosapride and Rebamipide

, antibiotics, including study durgs, etc.) or history of clinically significant hypersensitivity reaction. Systolic blood pressure > 150mmHg or <90mmHg, Diastolic blood pressure >100mmHg or <50mmHg(Sitting blood pressure) during the screening procedure Subject has history of drug abuse or tested positive to abused drug in the urine drug screening test. For women, pregnant or breastfeeding woman or woman who was confirmed to be pregnant in the pregnancy test Subject takes caffeine-containing food 5 cups per (...) A Drug Interaction Study of Mosapride and Rebamipide A Drug Interaction Study of Mosapride and Rebamipide - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Drug Interaction Study of Mosapride and Rebamipide

2014 Clinical Trials

63. The Pharmacodynamic/Pharmacokinetic Interaction of Tipranavir and Ritonavir With Loperamide in Healthy Volunteers

of garlic supplements or methylxanthine-containing drinks or food (coffee, tea, cola, energy drinks, chocolate, etc) within 72 hours of PK sampling days (Day 1 [Visit 2], Day 9 [Visit 3], Day 21-22 [Visit 4]) Ingestion of antibiotics within 10 days prior to Day 1 (Visit 2) Inability to comply with investigator's instructions History of gastrointestinal, hepatic, or renal disorders within 60 days of study entry Recent or active alcohol abuse Current use of tobacco products Blood or plasma donations (...) The Pharmacodynamic/Pharmacokinetic Interaction of Tipranavir and Ritonavir With Loperamide in Healthy Volunteers The Pharmacodynamic/Pharmacokinetic Interaction of Tipranavir and Ritonavir With Loperamide in Healthy Volunteers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2014 Clinical Trials

64. Pharmacokinetic Study in Healthy Adult Volunteers to Assess the Interactions Between Steady-State Tipranavir and Atazanavir in the Presence of Ritonavir

Pharmacokinetic Study in Healthy Adult Volunteers to Assess the Interactions Between Steady-State Tipranavir and Atazanavir in the Presence of Ritonavir Pharmacokinetic Study in Healthy Adult Volunteers to Assess the Interactions Between Steady-State Tipranavir and Atazanavir in the Presence of Ritonavir - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail (...) Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Pharmacokinetic Study in Healthy Adult Volunteers to Assess the Interactions Between Steady-State Tipranavir and Atazanavir in the Presence of Ritonavir The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read

2014 Clinical Trials

65. Study to Evaluate the Interaction Potential of Clarithromycin XL on Diltiazem Hydrochloride Cream 2% in Healthy Subjects

Study to Evaluate the Interaction Potential of Clarithromycin XL on Diltiazem Hydrochloride Cream 2% in Healthy Subjects Study to Evaluate the Interaction Potential of Clarithromycin XL on Diltiazem Hydrochloride Cream 2% in Healthy Subjects - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Study to Evaluate the Interaction Potential of Clarithromycin XL on Diltiazem Hydrochloride Cream 2% in Healthy Subjects The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02080780 Recruitment Status : Completed First

2014 Clinical Trials

66. Effect of H2 blockade and food on single-dose pharmacokinetics of GSK1322322, a peptide deformylase inhibitor antibacterial. (PubMed)

Effect of H2 blockade and food on single-dose pharmacokinetics of GSK1322322, a peptide deformylase inhibitor antibacterial. GSK1322322 is first in a new class of antibiotics, peptide deformylase inhibitors, and is active against multidrug-resistant respiratory and skin pathogens. Part 1 of this phase 1, randomized, single-dose (1,000 mg) study in 20 healthy volunteers compared the relative bioavailability of three different tablet formulations of GSK1322322 (fast release, intermediate release (...) , and slow release) to that of the previously studied powder-in-bottle formulation to assess the optimal formulation for progression into clinical trials. Part 2 assessed the effect of a high-fat meal and drug interaction with an H2 blocker and an H2 blocker plus vitamin C on the pharmacokinetic profile of GSK1322322. Of the three tablet formulations, fast-release GSK1322322 provided pharmacokinetic profiles similar to those of the powder-in-bottle reference formulation (~93% relative bioavailability

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2013 Antimicrobial Agents and Chemotherapy

67. Effect of H2 blockade and food on single-dose pharmacokinetics of GSK1322322, a peptide deformylase inhibitor antibacterial. (PubMed)

Effect of H2 blockade and food on single-dose pharmacokinetics of GSK1322322, a peptide deformylase inhibitor antibacterial. GSK1322322 is first in a new class of antibiotics, peptide deformylase inhibitors, and is active against multidrug-resistant respiratory and skin pathogens. Part 1 of this phase 1, randomized, single-dose (1,000 mg) study in 20 healthy volunteers compared the relative bioavailability of three different tablet formulations of GSK1322322 (fast release, intermediate release (...) , and slow release) to that of the previously studied powder-in-bottle formulation to assess the optimal formulation for progression into clinical trials. Part 2 assessed the effect of a high-fat meal and drug interaction with an H2 blocker and an H2 blocker plus vitamin C on the pharmacokinetic profile of GSK1322322. Of the three tablet formulations, fast-release GSK1322322 provided pharmacokinetic profiles similar to those of the powder-in-bottle reference formulation (~93% relative bioavailability

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2013 Antimicrobial agents and chemotherapy

68. Efficacy and safety testing of mycotoxin-detoxifying agents in broilers following the European Food Safety Authority guidelines. (PubMed)

. The plasma and kidney tissue concentrations of oxytetracycline were significantly higher in broilers receiving a biotransforming agent in the feed compared with control birds. For amoxicillin, the plasma concentrations were significantly higher for broilers receiving an adsorbing agent in comparison to birds receiving the biotransforming agent, but not to the control group. Mycotoxin-detoxifying agents can thus interact with the oral bioavailability of antibiotics depending on the antibiotic (...) Efficacy and safety testing of mycotoxin-detoxifying agents in broilers following the European Food Safety Authority guidelines. Contamination of feeds with mycotoxins is a worldwide problem and mycotoxin-detoxifying agents are used to decrease their negative effect. The European Food Safety Authority recently stated guidelines and end-points for the efficacy testing of detoxifiers. Our study revealed that plasma concentrations of deoxynivalenol and deepoxy-deoxynivalenol were too low to assess

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2012 Poultry science

69. A Drug Interaction Study of GDC-0032 Co-administered With Rifampin or Itraconazole in Healthy Volunteers

A Drug Interaction Study of GDC-0032 Co-administered With Rifampin or Itraconazole in Healthy Volunteers A Drug Interaction Study of GDC-0032 Co-administered With Rifampin or Itraconazole in Healthy Volunteers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. A Drug Interaction Study of GDC-0032 Co-administered With Rifampin or Itraconazole in Healthy Volunteers The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01814709 Recruitment Status : Completed First Posted : March 20, 2013 Last Update Posted

2013 Clinical Trials

70. A Drug Interaction Study of Cilnidipine and Valsartan

A Drug Interaction Study of Cilnidipine and Valsartan A Drug Interaction Study of Cilnidipine and Valsartan - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Drug Interaction Study of Cilnidipine (...) Description Go to Brief Summary: The investigators investigate the potential pharmacokinetic drug-drug interaction between Cilnidipine 10 mg and Valsartan 160 mg in healthy male volunteers who receive Cilnidipine 10 mg alone, Valsartan 160 mg , and both together in a 3 period repeatedly. Condition or disease Intervention/treatment Phase Healthy Drug: C - V - C+V Drug: C - C+V - V Drug: V - C - C+V Drug: V - C+V - C Drug: C+V - C - V Drug: C+V - V - C Phase 1 Detailed Description: To evaluate the safety

2013 Clinical Trials

71. A Phase 1 Study to Examine the Drug-Drug Interaction of Ciprofloxacin, Itraconazole, and Rifampin on the Combination of Lumacaftor With Ivacaftor in Healthy Adult Subjects

A Phase 1 Study to Examine the Drug-Drug Interaction of Ciprofloxacin, Itraconazole, and Rifampin on the Combination of Lumacaftor With Ivacaftor in Healthy Adult Subjects A Phase 1 Study to Examine the Drug-Drug Interaction of Ciprofloxacin, Itraconazole, and Rifampin on the Combination of Lumacaftor With Ivacaftor in Healthy Adult Subjects - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search (...) for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Phase 1 Study to Examine the Drug-Drug Interaction of Ciprofloxacin, Itraconazole, and Rifampin on the Combination of Lumacaftor With Ivacaftor in Healthy Adult Subjects The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has

2013 Clinical Trials

72. The Effect of Fiber Snack Foods on Dietary Intake in Healthy Adults

on how to record your dietary intake using the ASA24. The ASA24 is a web-based interactive program that asks you to record the foods you ate during the previous day Randomization: Measure weight, waist circumference, and body composition. We will use the BodPod to measure your body composition. The BodPod uses air displacement to measure body volume Receive dietary counseling on how to incorporate the study foods into your current diet. You will be asked to use these foods to replace foods you (...) or either or greater than 4000 kcal per day, consuming on average greater than 10 g dietary fiber/1000 kcal Unwilling to discontinue any prebiotic and fiber supplements, or probiotic supplement Antibiotic use within 2 months from study start Known food allergies Physician-diagnosed gastrointestinal disease or condition (such as ulcerative colitis, Crohn's disease, gastroparesis, cancer, peptic ulcer disease, Celiac disease, short bowel disease, ileostomy, colostomy other than GERD, constipation

2011 Clinical Trials

73. A Clinical Trial to Investigate the Pharmacokinetic Drug-drug Interaction of Clevudine and Adefovir Dipivoxil After Oral Administration in Healthy Male Subjects

A Clinical Trial to Investigate the Pharmacokinetic Drug-drug Interaction of Clevudine and Adefovir Dipivoxil After Oral Administration in Healthy Male Subjects A Clinical Trial to Investigate the Pharmacokinetic Drug-drug Interaction of Clevudine and Adefovir Dipivoxil After Oral Administration in Healthy Male Subjects - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study (...) Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Clinical Trial to Investigate the Pharmacokinetic Drug-drug Interaction of Clevudine and Adefovir Dipivoxil After Oral Administration in Healthy Male Subjects (BKP-1003-101) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated

2012 Clinical Trials

74. Cerebral palsy in adults

, language or sensory needs, consider referring them to services providing information, assessment and provision of electronic assistive technology. 1.2.15 Be aware that using electronic assistive technology may mean that the person with cerebral palsy needs less contact with their carers, which may reduce their social interaction. 1.2.16 If adults with cerebral palsy are already using electronic assistive technology, discuss at every review any: problems or concerns they have with their equipment (...) health problems and emotional difficulties to the needs and abilities of the person with cerebral palsy, in particular take into account communication difficulties or learning disabilities. 1.4.12 At every review, explore with the adult with cerebral palsy (and their family and carers, if agreed) if they have any concerns about, for example, their: mood irritability behaviour social interaction Cerebral palsy in adults (NG119) © NICE 2019. All rights reserved. Subject to Notice of rights (https

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

75. MR-proADM test for use with clinical deterioration scores in cases of suspected infection

are not influenced by food or water intake and there are no significant gender-related differences. It reports that the biomarker is stable, with no degradation seen up to 72 hours at room temperature. The assay performance has been established in accordance with Clinical and Laboratory Standards Institute Guidelines. The test is for use with other clinical scores, such as the National Early Warning Score (NEWS) or NEWS2 for people with suspected infection or sepsis. Innovations The company claims (...) alone. This increased the AUC to 0.61 (95% CI 0.54 to 0.69) from 0.55 (95% CI 0.48 to 0.62). When the confounding effects of chronic obstructive pulmonary disease or heart failure and interaction with MR-proADM were included, the prognostic accuracy further increased the area under the curve to 0.69 (95% CI 0.63 to 0.76). MR-proADM test for use with clinical deterioration scores in cases of suspected infection (MIB195) © NICE 2019. All rights reserved. Subject to Notice of rights (https

2019 National Institute for Health and Clinical Excellence - Advice

76. British guideline on the management of asthma

This guideline will be of particular interest to healthcare professionals involved in the care of people with asthma including general practitioners, consultants and specialists in respiratory medicine, nurses, pharmacists and other allied health professionals with an interest in respiratory care. The guideline will also be of interest to people with asthma, their parents and carers; those who interact with people with asthma outside of the NHS, such as teachers; voluntary organisations with an interest (...) 25 Table 5: Clinical clues to alternative diagnoses in adults Clinical clue Possible diagnosis Without airflow obstruction Predominant cough without lung function abnormalities Chronic cough syndromes; pertussis Prominent dizziness, light-headedness, peripheral tingling Dysfunctional breathing Recurrent severe ‘asthma attacks’ without objective confirmatory evidence Vocal cord dysfunction Predominant nasal symptoms without lung function abnormalities Rhinitis Postural and food-related symptoms

2019 SIGN

77. Antimicrobial stewardship: changing risk-related behaviours in the general population

up this process. Inadequate infection prevention and control practices, poor sanitary conditions and inappropriate food handling encourage the spread of infections that may need the use of antibiotics. Improvements in nutrition, hygiene and sanitation, and reductions in overcrowded housing, have all helped prevent and decrease the transmission of infectious diseases (Davies 2013 [1] ). The World Health Organization estimates that, along with these broad environmental factors, antimicrobials add (...) Behavioural strategies and programmes 42 3 High-risk groups 42 4 Workplace 43 5 Older people in day and residential care 43 Antimicrobial stewardship: changing risk-related behaviours in the general population (NG63) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 4 of 44Ov Overview erview This guideline covers making people aware of how to correctly use antimicrobial medicines (including antibiotics) and the dangers

2017 National Institute for Health and Clinical Excellence - Clinical Guidelines

78. Cerebral palsy in under 25s: assessment and management

of functional impairment than other causes. 1.2.5 Recognise that the clinical syndrome of neonatal encephalopathy can result from various pathological events, such as a hypoxic–ischaemic brain injury or sepsis, and if there has been more than 1 such event they may interact to damage the developing brain. 1.2.6 When assessing the likely cause of cerebral palsy, recognise that neonatal encephalopathy has been reported at the following approximate prevalences in Cerebral palsy in under 25s: assessment (...) videofluoroscopy if any of the following apply: There is uncertainty about the safety of eating, drinking and swallowing after specialist clinical assessment. The child or young person has recurrent chest infection without overt clinical signs of aspiration. There is deterioration in eating, drinking and swallowing ability with increasing age (particularly after adolescence). There is uncertainty about the impact of modifying food textures (for example, use of thickeners or pureeing). Parents or carers need

2017 National Institute for Health and Clinical Excellence - Clinical Guidelines

79. Antibiotic resistance

of two antibiotics in poultry feeds, became effective. In Scandinavia, there is evidence that the ban has led to a lower of antibiotic resistance in (nonhazardous) animal bacterial populations. As of 2004, several European countries established a decline of antimicrobial resistance in humans through limiting the usage antimicrobials in agriculture and food industries without jeopardizing animal health or economic cost. United States [ ] The (USDA) and the (FDA) collect data on antibiotic use (...) linking it to the emergence of fluoroquinolone-resistant infections in humans. Legal challenges from the food animal and pharmaceutical industries delayed the final decision to do so until 2006. Fluroquinolones have been banned from extra-label use in food animals in the USA since 2007. However, they remain widely used in companion and exotic animals. Global action plans and awareness [ ] The increasing interconnectedness of the world and the fact that new classes of antibiotics have not been

2012 Wikipedia

80. Antibiotic misuse

representative livestock data for the key organisms under surveillance. “NARMS partners at CDC and USDA have published over 150 peer-reviewed research articles examining the nature and magnitude of antimicrobial resistance hazards associated with antibiotic use in food-producing animals.” In 2014, the FDA began working with the United States Department of Agriculture (USDA) and the Centers of Disease Control and Prevention (CDC) to explore additional mechanisms to obtain data that is representative (...) of antibiotic use in food-producing animals. In 2015, the FDA issues the (VFD) final rule. Under this rule veterinarians must authorize the use of antimicrobials within feed for the animals they serve. Instances of antibiotic misuse [ ] Health advocacy messages such as this one encourage patients to talk with their doctor about safety in using antibiotics. Common situations in which antibiotics are overused include the following: Apparent viral in children should not be treated with antibiotics

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2012 Wikipedia

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