How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

106,394 results for

Anti-Retroviral Therapy

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

61. Comparison of sequential, incremental and concomitant reintroduction regimens of anti-tubercular therapy after initial episode of anti-tubercular therapy induced hepatitis: a systematic review and network meta-analysis

Comparison of sequential, incremental and concomitant reintroduction regimens of anti-tubercular therapy after initial episode of anti-tubercular therapy induced hepatitis: a systematic review and network meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete (...) . Not an original full research paper (e.g. review, editorial) 2. Not an in vivo animal study 3. No metastases/ only primary tumor 4. No control group 5. Combination therapy or contamination 6. Not about analgesics used in the clinic Full text-screening: As above, with the addition of: 7. No relevant outcome measure reported ">Prioritise the exclusion criteria Example: Two reviewers will independently extract data from each article. We first try to extract numerical data from tables, text or figures

2019 PROSPERO

62. Determinants of anti-retroviral regimen changes among HIV/AIDS patients of east and west Wollega zone health institutions, Oromia region, west Ethiopia: a cross-sectional study (PubMed)

Determinants of anti-retroviral regimen changes among HIV/AIDS patients of east and west Wollega zone health institutions, Oromia region, west Ethiopia: a cross-sectional study Human Immunodeficiency Virus (HIV) is one of the main causes of morbidity and mortality; because of this it continues to be a major global public health concern. It has believed to kill more than 34 million lives so far. Sub Saharan Africa constitutes about 70% of people living with HIV among the 37 million on the globe (...) . This region, accounted for more than two third of the global new HIV infections and about 15 million (40%) were receiving antiretroviral therapy (ART) at the end of 2014 throught the world. ART has fundamentally changed the treatment of HIV and transformed this infection from a disease of high mortality to chronic and medically managed disease. The issues of drug induced toxicities & complexity of current highly active antiretroviral therapy (HAART) regimens has remained of great concern. The aim

Full Text available with Trip Pro

2018 BMC pharmacology & toxicology

63. Body Compartment Pharmacokinetics of Anti- Retroviral Agents That May be Used for Future HIV Post- Exposure Prophylaxis.

Body Compartment Pharmacokinetics of Anti- Retroviral Agents That May be Used for Future HIV Post- Exposure Prophylaxis. Body Compartment Pharmacokinetics of Anti- Retroviral Agents That May be Used for Future HIV Post- Exposure Prophylaxis. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Body Compartment Pharmacokinetics of Anti- Retroviral Agents That May be Used for Future HIV Post- Exposure Prophylaxis. (PEP2) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our

2018 Clinical Trials

64. Sleeve Gastrectomy in Morbidly Obese HIV Patients: Focus on Anti-retroviral Treatment Absorption After Surgery. (PubMed)

Sleeve Gastrectomy in Morbidly Obese HIV Patients: Focus on Anti-retroviral Treatment Absorption After Surgery. Anti-retroviral therapy (ART) dramatically reduced AIDS development, thus enabling patients to live as long as the general population. New challenges have emerged particularly cardiometabolic diseases and weight gain, with some HIV patients seeking bariatric surgery (BS). However, BS outcomes during HIV remain poorly described, with scarce data on ART pharmacokinetic post

2018 Obesity Surgery

65. Are Nonsteroidal Anti-inflammatory Drugs Safe and Effective for Treatment of Acute Renal Colic (SRS Therapy)

Are Nonsteroidal Anti-inflammatory Drugs Safe and Effective for Treatment of Acute Renal Colic (SRS Therapy) TAKE-HOME MESSAGE For patients presenting with acute renal colic, treatment with nonsteroidal anti- in?ammatory drugs offers effective pain relief with fewer adverse effects than opioids or paracetamol. Are Nonsteroidal Anti-in?ammatory Drugs Safe and Effective for Treatment of Acute Renal Colic? EBEM Commentators Katie Pettit, MD Julie L. Welch, MD Department of Emergency Medicine (...) Indiana University School of Medicine Indianapolis, IN Results A total of 36 randomized controlled trials (including 4,887 patients) from 16 countries were included in this systematic review and meta-analysis. Outcomes for reduction in pain at 30 minutes found that nonsteroidal anti- in?ammatory drugs had bene?t over opioids (mean difference –5.58 on a 100-point scale; 95% con?dence interval [CI]–10.22 to –0.95); however, there was sub- stantial heterogeneity across studies (I 2 ¼81%), and subgroup

2018 Annals of Emergency Medicine Systematic Review Snapshots

66. Are Corticosteroids Superior to Nonsteroidal Anti-inflammatory Drugs in the Treatment of Acute Gout? (SRS Therapy)

Are Corticosteroids Superior to Nonsteroidal Anti-inflammatory Drugs in the Treatment of Acute Gout? (SRS Therapy) TAKE-HOME MESSAGE Corticosteroids provide pain relief similar to that of nonsteroidal anti- in?ammatory drugs for acute gout, with fewer adverse effects. Are Corticosteroids Superior to Nonsteroidal Anti-in?ammatory Drugs in the Treatment of Acute Gout? EBEM Commentators Joseph W. Watkins IV, MD Rawle A. Seupaul, MD Department of Emergency Medicine University of Arkansas (...) for Medical Sciences Little Rock, AR Results The search identi?ed 529 refer- ences; 6 trials evaluating 817 pa- tients met inclusion criteria. The overallriskofbiaswaslowinthese trials, whereas the quality of the evidence was rated as low to mod- erate according to GRADE criteria. Themeta-analysisdemonstratedno difference between corticosteroids and nonsteroidal anti-in?ammatory drugs for the following outcomes: short-term pain relief ( 7days), time to resolution of pain, and requirement for additional

2018 Annals of Emergency Medicine Systematic Review Snapshots

67. Anti-IL5 therapies for asthma. (PubMed)

Anti-IL5 therapies for asthma. This review is the first update of a previously published review in The Cochrane Library (Issue 7, 2015). Interleukin-5 (IL-5) is the main cytokine involved in the activation of eosinophils, which cause airway inflammation and are a classic feature of asthma. Monoclonal antibodies targeting IL-5 or its receptor (IL-5R) have been developed, with recent studies suggesting that they reduce asthma exacerbations, improve health-related quality of life (HRQoL) and lung (...) function. These are being incorporated into asthma guidelines.To compare the effects of therapies targeting IL-5 signalling (anti-IL-5 or anti-IL-5Rα) with placebo on exacerbations, health-related qualify of life (HRQoL) measures, and lung function in adults and children with chronic asthma, and specifically in those with eosinophilic asthma refractory to existing treatments.We searched the Cochrane Airways Trials Register, clinical trials registries, manufacturers' websites, and reference lists

Full Text available with Trip Pro

2017 Cochrane

68. Anti-adhesion therapy following operative hysteroscopy for treatment of female subfertility. (PubMed)

Anti-adhesion therapy following operative hysteroscopy for treatment of female subfertility. Observational evidence suggests a potential benefit with several anti-adhesion therapies in women undergoing operative hysteroscopy (e.g. insertion of an intrauterine device or balloon, hormonal treatment, barrier gels or human amniotic membrane grafting) for decreasing intrauterine adhesions (IUAs).To assess the effectiveness of anti-adhesion therapies versus placebo, no treatment or any other anti (...) in the field. We also searched reference lists of appropriate papers.Randomised controlled trials (RCTs) of anti-adhesion therapies versus placebo, no treatment or any other anti-adhesion therapy following operative hysteroscopy in subfertile women. The primary outcome was live birth. Secondary outcomes were clinical pregnancy, miscarriage and IUAs present at second-look hysteroscopy, along with mean adhesion scores and severity of IUAs.Two review authors independently selected studies, assessed risk

Full Text available with Trip Pro

2017 Cochrane

69. Oral anti-diabetic pharmacological therapies for the treatment of women with gestational diabetes. (PubMed)

Oral anti-diabetic pharmacological therapies for the treatment of women with gestational diabetes. Gestational diabetes mellitus (GDM) is a major public health issue with rates increasing globally. Gestational diabetes, glucose intolerance first recognised during pregnancy, usually resolves after birth and is associated with short- and long-term complications for the mother and her infant. Treatment options can include oral anti-diabetic pharmacological therapies.To evaluate the effects of oral (...) anti-diabetic pharmacological therapies for treating women with GDM.We searched Cochrane Pregnancy and Childbirth's Trials Register (14 May 2016), ClinicalTrials.gov, WHO ICTRP (14 May 2016) and reference lists of retrieved studies.We included published and unpublished randomised controlled trials assessing the effects of oral anti-diabetic pharmacological therapies for treating pregnant women with GDM. We included studies comparing oral anti-diabetic pharmacological therapies with 1) placebo

2017 Cochrane

70. Insulators to Improve the Safety of Retroviral Vectors for HIV Gene Therapy (PubMed)

Insulators to Improve the Safety of Retroviral Vectors for HIV Gene Therapy Retroviral vector gene therapy is a promising approach to treating HIV-1. However, integrated vectors are mutagens with the potential to dysregulate nearby genes and cause severe adverse side effects. Leukemia has already been a documented severe adverse event in gene therapy clinical trials for the treatment of primary immunodeficiencies. These side effects will need to be reduced or avoided if retroviral vectors (...) are to be used clinically for HIV-1 treatment. The addition of chromatin insulators to retroviral vectors is a potential strategy for reducing adverse side effects. Insulators have already been effectively used in retroviral vectors to reduce genotoxicity in pre-clinical studies. Here, we will review how insulators function, genotoxicity in gene therapy clinical trials, the design of insulated retroviral vectors, promising results from insulated retroviral vector studies, and considerations

Full Text available with Trip Pro

2016 Biomedicines

71. Metastatic uveal melanoma showing durable response to anti-CTLA-4 and anti-PD-1 combination therapy after experiencing progression on anti-PD-1 therapy alone (PubMed)

Metastatic uveal melanoma showing durable response to anti-CTLA-4 and anti-PD-1 combination therapy after experiencing progression on anti-PD-1 therapy alone Uveal melanoma accounts for 85% of the ocular melanomas and has an increased risk of hematogenous spread, most commonly to the liver. After curative intent therapy like surgery and radiation, fifty percent of patients present with distant metastasis. Metastatic uveal melanoma (MUM) does not harbor typically targetable mutations, e.g., BRAF (...) nivolumab showed PR and continuous shrinkage of the metastatic lesions with no hypermetabolic activity even on PET/CT. He is 22 months' post-treatment and continues to do well without any evidence of active disease.Although, limited response has been shown to single agent immune checkpoint inhibitors and chemotherapy, our patient showed durable response with anti-CTLA-4 and anti-PD-1 combination therapy in MUM.

Full Text available with Trip Pro

2018 Journal for immunotherapy of cancer

72. Optimal Anti-Retroviral Prophylaxis in Infants At High-Risk of Acquiring Human Immunodeficiency Virus: A Systematic Review. (PubMed)

Optimal Anti-Retroviral Prophylaxis in Infants At High-Risk of Acquiring Human Immunodeficiency Virus: A Systematic Review. The risk of perinatal HIV infection can be dramatically reduced through maternal antiretroviral therapy (ART) and infant antiretroviral (ARV) postnatal prophylaxis. The 2013 WHO guidelines recommended four to six weeks of nevirapine or zidovudine as post-natal prophylaxis, with possible extension to 12 weeks for high-risk breastfed infants. A systematic review

2017 The Pediatric infectious disease journal

73. HCV viremia associates with NK cell activation and dysfunction in anti retroviral HIV/HCV co-infected subjects. (PubMed)

HCV viremia associates with NK cell activation and dysfunction in anti retroviral HIV/HCV co-infected subjects. The impact of hepatitis C virus (HCV) RNA levels on immune status in chronically HCV mono-infected when compared to HIV/HCV co-infected on antiretroviral therapy (ART) remains poorly understood. A total of 78 African American subjects HCV viraemic/naïve to HCV treatment (33 HCV genotype 1 mono-infected, 45 ART-treated HIV/HCV genotype 1 co-infected) were studied. Clinical and liver

Full Text available with Trip Pro

2017 Journal of viral hepatitis

74. The effect of interrupted anti-retroviral treatment on the reconstitution of memory and naive T cells during tuberculosis treatment in HIV patients with active pulmonary tuberculosis (PubMed)

The effect of interrupted anti-retroviral treatment on the reconstitution of memory and naive T cells during tuberculosis treatment in HIV patients with active pulmonary tuberculosis The reconstitution of cellular immune components contributes to clinical outcome of HIV and Mycobacterium tuberculosis (MTB) infection. Interruption of anti-retroviral therapy (ART) could lead to perturbations in reconstitution of T cells in HIV/ tuberculosis (TB) patients.To ascertain the effect of interrupted ART

Full Text available with Trip Pro

2017 African health sciences

75. Activity of MK-8504 in Anti-retroviral-naïve, Human Immunodeficiency Virus 1 (HIV-1) Infected Participants (MK-8504-002)

Posted : June 15, 2017 Last Update Posted : July 13, 2018 Sponsor: Merck Sharp & Dohme Corp. Information provided by (Responsible Party): Merck Sharp & Dohme Corp. Study Details Study Description Go to Brief Summary: This study aims to evaluate the safety, tolerability, pharmacokinetics (PK), and anti-retroviral therapy (ART) activity of MK-8504 monotherapy, a tenofovir (TFV) pro-drug, in ART-naïve, HIV-1 infected participants. The primary hypothesis is that MK-8504 has superior antiretroviral (...) Official Title: A Single-Dose Clinical Trial to Study the Safety, Tolerability, Pharmacokinetics, and Anti-Retroviral Activity of MK-8504 Monotherapy in Anti-Retroviral Therapy (ART)-Naïve, HIV-1 Infected Patients Actual Study Start Date : September 8, 2017 Actual Primary Completion Date : May 21, 2018 Actual Study Completion Date : June 4, 2018 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: Panel A: MK

2017 Clinical Trials

76. Determinants of uncontrolled hypertension among clients on anti-retroviral therapy in Kadoma City, Zimbabwe, 2016 (PubMed)

Determinants of uncontrolled hypertension among clients on anti-retroviral therapy in Kadoma City, Zimbabwe, 2016 Clients on anti-retroviral therapy (ART) are living longer and have risk of hypertension. Side effects of medicines and aging increase this risk. Hypertension prevalence among clients on ART in Kadoma City was estimated to be 30% in 2015. Of these, 61% had uncontrolled hypertension. This was high compared to 46% of hypertensives in the general population who had uncontrolled

Full Text available with Trip Pro

2017 Clinical hypertension

77. Single versus combination intravenous anti-pseudomonal antibiotic therapy for people with cystic fibrosis. (PubMed)

Single versus combination intravenous anti-pseudomonal antibiotic therapy for people with cystic fibrosis. Choice of antibiotic, and the use of single or combined therapy are controversial areas in the treatment of respiratory infection due to Pseudomonas aeruginosa in cystic fibrosis (CF). Advantages of combination therapy include wider range of modes of action, possible synergy and reduction of resistant organisms; advantages of monotherapy include lower cost, ease of administration (...) and reduction of drug-related toxicity. Current evidence does not provide a clear answer and the use of intravenous antibiotic therapy in cystic fibrosis requires further evaluation. This is an update of a previously published review.To assess the effectiveness of single compared to combination intravenous anti-pseudomonal antibiotic therapy for treating people with cystic fibrosis.We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register, comprising references identified from

Full Text available with Trip Pro

2016 Cochrane

78. Anti-tuberculous therapy for maintenance of remission in Crohn's disease. (PubMed)

Anti-tuberculous therapy for maintenance of remission in Crohn's disease. There have been a number of studies with conflicting results which have examined the effect of anti-tuberculous therapy in Crohn's disease. A meta-analysis was performed to evaluate the use of anti-tuberculous therapy for the maintenance of remission in Crohn's disease.To evaluate the effects of anti-tuberculous therapy for the maintenance of remission in patients with Crohn's disease.We searched MEDLINE, EMBASE (...) , the Cochrane LIbrary, and the Cochrane IBD Group Specialized Register from inception to June 22, 2015.Randomized controlled trials (RCTs) of anti-tuberculous therapy compared to placebo or another active therapy in patients with quiescent Crohn's disease were considered for inclusion.At least two authors independently extracted data and assessed the quality of included studies using the Cochrane risk of bias tool. We calculated the risk ratio (RR) and corresponding 95% confidence interval (CI

Full Text available with Trip Pro

2016 Cochrane

79. Oral non-steroidal anti-inflammatory drug therapy for lung disease in cystic fibrosis. (PubMed)

Oral non-steroidal anti-inflammatory drug therapy for lung disease in cystic fibrosis. Progressive lung damage causes most deaths in cystic fibrosis. Non-steroidal anti-inflammatory drugs (such as ibuprofen) may prevent progressive pulmonary deterioration and morbidity in cystic fibrosis.To assess the effectiveness of treatment with non-steroidal anti-inflammatory drugs in cystic fibrosis.We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register comprising references (...) identified from comprehensive electronic database searches, hand searches of relevant journals and abstract books of conference proceedings. We contacted manufacturers of non-steroidal anti-inflammatory drugs.Latest search of the Group's Trials Register: 04 February 2016.Randomized controlled trials comparing oral non-steroidal anti-inflammatory drugs, at any dose for at least two months, to placebo in people with cystic fibrosis.Two authors independently assessed trials for inclusion the review

Full Text available with Trip Pro

2016 Cochrane

80. Risk of acute coronary syndrome in people living with HIV on anti-retroviral therapy

Risk of acute coronary syndrome in people living with HIV on anti-retroviral therapy Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Timing (...) of the eligible articles for final inclusion. In each phase, 2 observers will independently assess each article. Discrepancies will be resolved through discussion, or by consulting a third investigator. ">Procedure for study selection Example : Title-abstract screening: 1. Not an original full research paper (e.g. review, editorial) 2. Not an in vivo animal study 3. No metastases/ only primary tumor 4. No control group 5. Combination therapy or contamination 6. Not about analgesics used in the clinic Full

2019 PROSPERO

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>