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Anti-Retroviral Therapy

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41. Regression of methotrexate-resistant AIDS-related primary central nervous system lymphoma with lenalidomide plus combination anti-retroviral therapy Full Text available with Trip Pro

Regression of methotrexate-resistant AIDS-related primary central nervous system lymphoma with lenalidomide plus combination anti-retroviral therapy 28395565 2018 10 02 2019 01 16 1029-2403 58 11 2017 11 Leukemia & lymphoma Leuk. Lymphoma Regression of methotrexate-resistant AIDS-related primary central nervous system lymphoma with lenalidomide plus combination anti-retroviral therapy. 2748-2751 10.1080/10428194.2017.1312374 Gupta Neel K NK a Division of Hematology/Oncology , University (...) , San Francisco , CA , USA. d Helen Diller Family Comprehensive Cancer Center , San Francisco , CA , USA. eng R01 CA139083 CA NCI NIH HHS United States R21 CA184694 CA NCI NIH HHS United States Letter Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2017 04 10 United States Leuk Lymphoma 9007422 1026-8022 4Z8R6ORS6L Thalidomide F0P408N6V4 Lenalidomide IM Acquired Immunodeficiency Syndrome complications drug therapy Adult Antineoplastic Combined Chemotherapy Protocols adverse

2017 Leukemia & lymphoma

42. The Use of First Line Highly Active Anti-Retroviral Therapy (HAART) is Not Associated with Qtc Prolongation in HIV Patients Full Text available with Trip Pro

The Use of First Line Highly Active Anti-Retroviral Therapy (HAART) is Not Associated with Qtc Prolongation in HIV Patients HAART has improved survival of HIV patients. Its contribution to the development of new cardiovascular abnormalities has generated much interest. This study aimed at determining the prevalence of QTc prolongation among HIV patients and determining the influence if any of the use of HAART on the QTc and on the risk of having QTc prolongation.One hundred and fifty HIV (...) patients with CD4 count <200 cells/mm3 than among those with >200 cells/mm3 0.445 ± 0.03secs vs 0.421 ± 0.03secs (P<0.001). QTc prolongation was commoner among individuals with CD4 count <200 cells/mm3 50% vs 20.5% (P<0.001). On binary logistic regression, none of the HAART medications used by our patients was predictive of the occurrence of QTc prolongation.The QTc is longer, and QTc prolongation occurs more frequently in HAART-naïve HIV patients than patients on HAART and healthy controls. None

2017 Ethiopian journal of health sciences

43. Patients' perceptions of a rural decentralised anti-retroviral therapy management and its impact on direct out-of-pocket spending Full Text available with Trip Pro

Patients' perceptions of a rural decentralised anti-retroviral therapy management and its impact on direct out-of-pocket spending Geographical and financial barriers hamper accessibility to HIV services for rural communities. The government has introduced the nurse initiated management of anti-retroviral therapy at primary health care level, in an effort to improve patient access and reduce patient loads on facilities further up the system.To ascertain the perceptions and satisfaction (...) of patients in terms of the decentralised anti-retroviral policy and the direct out-of-pocket expenses of patients accessing this care in a rural setting.Using a cross-sectional study design, 117 patients from five different primary health care collection points and a hospital anti-retroviral clinic were interviewed using a standard questionnaire.More clinic patients walked to their clinic to collect their medicines as compared to hospital patients (71.2% versus 14.6%). Hospital patients spent more than

2017 African health sciences

44. Effects of a High Protein Food Supplement on Physical Activity, Motor Performance and Health Related Quality of Life of HIV Infected Botswana Children on Anti-Retroviral Therapy (ART) Full Text available with Trip Pro

Effects of a High Protein Food Supplement on Physical Activity, Motor Performance and Health Related Quality of Life of HIV Infected Botswana Children on Anti-Retroviral Therapy (ART) Despite existing evidence about the benefits of nutrition, physical activity (PA) and sport to the overall health and wellbeing of children, knowledge gaps remain on this relationship in children living with chronic conditions like HIV/AIDS. Such knowledge should inform context specific programs that could enhance (...) the quality of life of children. The purpose of this study was to examine the effects of integrating a nutrition intervention (culturally tailored food supplement) into antiretroviral therapy (ART) on psychosocial outcomes and physical activity among HIV-positive children in Botswana.201 HIV-positive children (6-15 years; M = 9.44, SD = 2.40) were recruited and randomly assigned (stratified by age and gender) to two groups. The intervention group (n = 97) received a high protein (bean-sorghum plus

2017 AIMS public health Controlled trial quality: uncertain

45. Determinants of uncontrolled hypertension among clients on anti-retroviral therapy in Kadoma City, Zimbabwe, 2016 Full Text available with Trip Pro

Determinants of uncontrolled hypertension among clients on anti-retroviral therapy in Kadoma City, Zimbabwe, 2016 Clients on anti-retroviral therapy (ART) are living longer and have risk of hypertension. Side effects of medicines and aging increase this risk. Hypertension prevalence among clients on ART in Kadoma City was estimated to be 30% in 2015. Of these, 61% had uncontrolled hypertension. This was high compared to 46% of hypertensives in the general population who had uncontrolled (...) hypertension. We determined factors associated with uncontrolled hypertension among clients on ART.A 1.1 unmatched case control study was conducted. Interviews, anthropometric measurements and record reviews were to collect data on demography and medical history. Epi Info 7 was used for univariate, bivariate analysis and logistic regression.One hundred and fifty-two cases and 152 controls were recruited into the study. Adding salt to dishes regularly aOR = 5.69 (3.19-10.16), body mass index (BMI) above 25

2017 Clinical hypertension

46. Factors associated with HIV-1 low level viraemia in patients on effective anti-retroviral therapy

Factors associated with HIV-1 low level viraemia in patients on effective anti-retroviral therapy Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external (...) tumor 4. No control group 5. Combination therapy or contamination 6. Not about analgesics used in the clinic Full text-screening: As above, with the addition of: 7. No relevant outcome measure reported ">Prioritise the exclusion criteria Example: Two reviewers will independently extract data from each article. We first try to extract numerical data from tables, text or figures. If these are not reported, we will extract data from graphs using digital ruler software. In case data are not reported

2019 PROSPERO

47. The safety and side effect profile of metformin use in HIV-infected persons on anti-retroviral therapy

The safety and side effect profile of metformin use in HIV-infected persons on anti-retroviral therapy Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files (...) tumor 4. No control group 5. Combination therapy or contamination 6. Not about analgesics used in the clinic Full text-screening: As above, with the addition of: 7. No relevant outcome measure reported ">Prioritise the exclusion criteria Example: Two reviewers will independently extract data from each article. We first try to extract numerical data from tables, text or figures. If these are not reported, we will extract data from graphs using digital ruler software. In case data are not reported

2019 PROSPERO

48. Risk of acute coronary syndrome in people living with HIV on anti-retroviral therapy

Risk of acute coronary syndrome in people living with HIV on anti-retroviral therapy Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Timing (...) of the eligible articles for final inclusion. In each phase, 2 observers will independently assess each article. Discrepancies will be resolved through discussion, or by consulting a third investigator. ">Procedure for study selection Example : Title-abstract screening: 1. Not an original full research paper (e.g. review, editorial) 2. Not an in vivo animal study 3. No metastases/ only primary tumor 4. No control group 5. Combination therapy or contamination 6. Not about analgesics used in the clinic Full

2019 PROSPERO

49. Ten-year trends in anti-retroviral therapy persistence among US medicaid beneficiaries, 2001-2010. (Abstract)

Ten-year trends in anti-retroviral therapy persistence among US medicaid beneficiaries, 2001-2010.

2017 AIDS

50. A Drug-drug Interaction (DDI) Study of Morphothiadine Mesilate/Ritonavir in Healthy Subjects

Subjects Actual Study Start Date : June 26, 2018 Actual Primary Completion Date : July 31, 2018 Estimated Study Completion Date : January 2019 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Part A:Group A Subjects will receive GLS4+RTV on Day 1,followed by ETV on Day11-21 and co-administration with GLS4+RTV on Day 21. Drug: GLS4 Administered GLS4 120 mg orally three times daily in fed state (...) Infections DNA Virus Infections Virus Diseases Hepatitis, Viral, Human Ritonavir Tenofovir Entecavir HIV Protease Inhibitors Protease Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Anti-HIV Agents Anti-Retroviral Agents Antiviral Agents Anti-Infective Agents Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 Enzyme Inhibitors Reverse Transcriptase Inhibitors Nucleic Acid Synthesis Inhibitors

2018 Clinical Trials

51. A Comparison of Electronic Medical Record Data to Paper Records in Antiretroviral Therapy Clinic in Ethiopia: What is affecting the Quality of the Data? Full Text available with Trip Pro

A Comparison of Electronic Medical Record Data to Paper Records in Antiretroviral Therapy Clinic in Ethiopia: What is affecting the Quality of the Data? Anti-Retroviral Therapy (ART) care is a lifelong treatment, which needs accurate and reliable data collected for long period of time. Poor quality of medical records data remains a challenge and is directly related to the quality of care of patients. To improve this, there is an increasing trend to implement electronic medical record (EMR (...) ) in hospitals. However, there is little evidence on the impact of EMR on the quality of health data in low- resource setting hospitals like Ethiopia. This comparative study aims to fill this evidence gap by assessing the completeness and reliability of paper-based and electronic medical records and explore the challenges of ensuring data quality at the Anti-Retroviral Therapy (ART) clinic at the University of Gondar Referral Hospital in Northwest Ethiopia.An institution-based comparative cross-sectional

2018 Online journal of public health informatics

52. Pilot evaluation of a second-generation electronic pill box for adherence to Bedaquiline and antiretroviral therapy in drug-resistant TB/HIV co-infected patients in KwaZulu-Natal, South Africa. Full Text available with Trip Pro

Pilot evaluation of a second-generation electronic pill box for adherence to Bedaquiline and antiretroviral therapy in drug-resistant TB/HIV co-infected patients in KwaZulu-Natal, South Africa. The introduction of Bedaquiline, the first new antimycobacterial drug in over 40 years, has highlighted the critical importance of medication adherence in drug-resistant tuberculosis (DR-TB) treatment to prevent amplified drug-resistance and derive sustained benefit. Real-time electronic dose monitoring (...) (EDM) accurately measures adherence and allows for titration of adherence support for anti-retroviral therapy (ART). The goal of this study was to evaluate the accuracy and acceptability of a next-generation electronic pillbox (Wisepill RT2000) for Bedaquiline-containing TB regimens.Eligible patients were DR-TB/HIV co-infected adults hospitalized for the initiation of Bedaquiline-containing treatment regimens in KwaZulu-Natal, South Africa. A one-way crossover design was used to evaluate levels

2018 BMC Infectious Diseases

53. Research on the treatment effects and drug resistances of long-term second-line antiretroviral therapy among HIV-infected patients from Henan Province in China. Full Text available with Trip Pro

Research on the treatment effects and drug resistances of long-term second-line antiretroviral therapy among HIV-infected patients from Henan Province in China. HIV/AIDS patients who fail to respond to first-line treatment protocols are switched to second-line ART. Identifying factors that influence effective second-line treatment can improve utilization of limited medical resources. We investigated the efficacy of long-term second-line anti-retroviral therapy (ART) after first-line virologic (...) failure as well as the impact of non-nucleotide reverse transcriptase inhibitor (NNRTI), nucleotide reverse transcriptase inhibitor (NRTI), and protease inhibitor (PI) resistance mutations and medication adherence on ineffective viral suppression.A total of 120 patients were evaluated at 6, 12, 18, 24, and 48 months after initiation of second-line ART; a paper questionnaire was administered via a face-to-face interview and venous blood samples were collected. CD4+ T cell count, viral load, and drug

2018 BMC Infectious Diseases

54. A Couple-based Antiretroviral Therapy Adherence Intervention for People Who Inject Drugs

A Couple-based Antiretroviral Therapy Adherence Intervention for People Who Inject Drugs A Couple-based Antiretroviral Therapy Adherence Intervention for People Who Inject Drugs - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. A Couple-based Antiretroviral Therapy Adherence Intervention for People Who Inject Drugs The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03555396 Recruitment Status : Not yet recruiting First Posted

2018 Clinical Trials

55. A Drug Interaction Study to Assess the Pharmacokinetics of Narlaprevir and Antiretroviral Drugs

2018 Layout table for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Keywords provided by R-Pharm: hepatitis C chronic pharmacokinetics HIV coinfection concomitant therapy Additional relevant MeSH terms: Layout table for MeSH terms Ritonavir Tenofovir Raltegravir Potassium Anti-Retroviral Agents HIV Protease Inhibitors Protease Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Anti-HIV Agents Antiviral (...) ) Actual Enrollment : 36 participants Allocation: Randomized Intervention Model: Crossover Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: A Drug Interaction Study to Assess the Pharmacokinetics of Narlaprevir and Antiretroviral Drugs Actual Study Start Date : April 24, 2017 Actual Primary Completion Date : June 24, 2017 Actual Study Completion Date : June 30, 2017 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go

2018 Clinical Trials

56. Poor outcomes in recurrent tuberculosis: More than just drug resistance? Full Text available with Trip Pro

hospital in Malawi. Participants were evaluated at baseline, after completion of the intensive phase at 2-months, and at the end of the 8-month treatment course. Patients were assessed for respiratory co-morbidity; anaemia; renal impairment; diabetes; Anti-retroviral (ART) failure; and drug toxicity. Amongst 158 patients entering TB care at the point of a recurrent episode, only 92 (58%) had a microbiologically confirmed diagnosis. The prevalence of drug resistance was low (9.6%). Of the 158 patients (...) Poor outcomes in recurrent tuberculosis: More than just drug resistance? Approximately 11% of people reported to have tuberculosis (TB) have previously received treatment. Clinical outcomes are consistently poor on retreatment regimens, however reasons for this are unclear. This study aimed to explore factors which may contribute to unsuccessful outcomes in retreatment TB.A prospective cohort of consecutive patients starting WHO Category II retreatment regimen was recruited at a central

2019 PLoS ONE

57. HIV-attributable causes of death in the medical ward at the Chris Hani Baragwanath Hospital, South Africa. Full Text available with Trip Pro

HIV-positive ranging from 3 to 8. Most of the deaths attributable to HIV were among those dying of TB or of other respiratory conditions.The high prevalence of HIV among those that died, peaking at 70% in those aged 30 years but still 7% in those aged 80 years, demonstrates the impact of the HIV epidemic on adult mortality and on hospital services and the extent to which early anti-retroviral treatment would have reduced the burden of both. These data make it possible to better assess mortality (...) HIV-attributable causes of death in the medical ward at the Chris Hani Baragwanath Hospital, South Africa. Data on the association between HIV infection and deaths from underlying medical conditions are needed to understand and assess the impact of HIV on mortality. We present data on mortality in the Chris Hani Baragwanath Hospital (CHBH) South Africa and analyse the relationship between each cause of death and HIV.From 2006 to 2009 data were collected on 15,725 deaths including age, sex, day

2019 PLoS ONE

58. Effect of antiretroviral therapy on longitudinal lung function trends in older children and adolescents with HIV-infection. Full Text available with Trip Pro

Effect of antiretroviral therapy on longitudinal lung function trends in older children and adolescents with HIV-infection. Chronic respiratory disease is a common cause of morbidity in children with HIV infection. We investigated longitudinal lung function trends among HIV-infected children, to describe the evolution of lung disease and assess the effect of anti-retroviral therapy (ART).Prospective follow-up of two cohorts of HIV-infected children, aged 6 to 16 years, in Harare, Zimbabwe; one

2019 PLoS ONE

59. Study With Dual Therapy Including Lamivudine (300 mg QD) Plus Raltegravir (1200 mg QD) in Virologically Suppressed HIV-1 Infected Patients Experiencing Inconvenience, Toxicity, Negative Impact on Co-morbidities or Risk of Drug-drug Interactions With Their

Study With Dual Therapy Including Lamivudine (300 mg QD) Plus Raltegravir (1200 mg QD) in Virologically Suppressed HIV-1 Infected Patients Experiencing Inconvenience, Toxicity, Negative Impact on Co-morbidities or Risk of Drug-drug Interactions With Their Study With Dual Therapy Including Lamivudine (300 mg QD) Plus Raltegravir (1200 mg QD) in Virologically Suppressed HIV-1 Infected Patients Experiencing Inconvenience, Toxicity, Negative Impact on Co-morbidities or Risk of Drug-drug (...) Official Title: Phase 3b, Single Arm, Simplification Study With Dual Therapy Including Lamivudine (300 mg QD) Plus Raltegravir (1200 mg QD) in Virologically Suppressed HIV-1 Infected Patients Experiencing Inconvenience, Toxicity, Negative Impact on Co-morbidities or Risk of Drug-drug Interactions With Their Current Regimen. RALAM-II Study Actual Study Start Date : May 3, 2018 Estimated Primary Completion Date : March 30, 2020 Estimated Study Completion Date : March 30, 2020 Resource links provided

2017 Clinical Trials

60. Anti-Retroviral Therapy

-Retroviral Therapy Aka: Anti-Retroviral Therapy , Anti-Retroviral Agents , HIV Treatment , HIV Medication , Antiretroviral , Anti-retroviral , Combination Antiretroviral Therapy , CART , Highly Active Antiretroviral Therapy From Related Chapters II. Precautions Obtain (GART) before starting therapy (and if failing therapy) See Compliance is critical to suppress viral load (<500 c/ml) Adherence of 95% to drug regimen: 81% success rate Adherence of 90-95% to drug regimen: 64% success rate Adherence of 80 (...) Guidelines for use of Antiretroviral agents in HIV-1 Infected Adults and Adolescents Updated 1/10/11 and accessed 10/8/2011 HIV- Treatment Information Service Website Stanford HIV Drug Resistance Database UCSF National HIV/ Clinicians Center Phone (warmline): 800-933-3413 NIH Info Site Perinatal HIV/ XV. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Anti-Retroviral Therapy." Click on the image (or right click) to open

2018 FP Notebook

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