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Anti-Retroviral Therapy

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21. Transmission dynamics among participants initiating anti-retroviral therapy upon diagnosis of early acute HIV-1 infection in Thailand. (PubMed)

Transmission dynamics among participants initiating anti-retroviral therapy upon diagnosis of early acute HIV-1 infection in Thailand. To assess transmission characteristics in a predominantly MSM cohort initiating antiretroviral therapy (ART) immediately following diagnosis of acute HIV-1infection (AHI).A longitudinal study (2009-2017) was performed in participants with AHI (n = 439) attending a single clinic in Bangkok. Plasma samples obtained prior to ART were used to obtain HIV-1 pol

2018 AIDS

22. Harmful alcohol drinking among HIV-positive people in Nepal: an overlooked threat to anti-retroviral therapy adherence and health-related quality of life (PubMed)

Harmful alcohol drinking among HIV-positive people in Nepal: an overlooked threat to anti-retroviral therapy adherence and health-related quality of life People living with Human Immunodeficiency Virus (HIV) often suffer from alcohol-use disorders resulting in their poor health and treatment outcomes. Little is known about the association of harmful alcohol drinking with their adherence to anti-retroviral therapy (ART) and health-related quality of life (QOL) in low-resource settings.This study

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2018 Global health action

23. Dolutegravir-based anti-retroviral therapy is effective and safe in HIV–infected paediatric patients (PubMed)

Dolutegravir-based anti-retroviral therapy is effective and safe in HIV–infected paediatric patients Treatment of HIV infection in adolescents is challenging due to long duration of therapy and poor adherence. Recently, the integrase strand transfer inhibitor dolutegravir (DTG) has been approved for the use in adolescents with HIV, but evidence in clinical practice is very limited.We describe six cases of HIV-infected children/adolescents successfully treated with DTG-based regimen. Data (...) relative to children/adolescents managed at the Referral Center for Pediatric HIV/AIDS of the University of Naples were reviewed. Patients were tested before introduction of DTG, after 1 month and every 3 months in the first 2 years to assess virologic and immunological response, tolerance and development of side effects. Families were asked to report any suspected adverse events.Six patients (2 male, median age 17 years, range 12-18) were started on DTG-based anti-retroviral regimen due to low

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2018 Italian journal of pediatrics

24. Initiation of anti-retroviral therapy before pregnancy reduces the risk of infection-related hospitalization in HIV-exposed uninfected infants born in a high-income country. (PubMed)

Initiation of anti-retroviral therapy before pregnancy reduces the risk of infection-related hospitalization in HIV-exposed uninfected infants born in a high-income country. Epidemiological studies conducted in low and high-income countries showed that infants exposed to maternal HIV but not infected themselves by the virus have a high risk of severe infections. Immune alterations during fetal life have been proposed as a possible mechanism.This prospective study was conducted to assess (...) of this increased risk was associated with time of initiation of maternal anti-retroviral therapy (ART). As compared to HU infants, risk of hospitalization for infection of HEU infants was four-fold higher (3.84, 1.69-8.71) when mothers initiated ART during pregnancy and was not significantly increased (1.42, 0.58-3.48) when ART was initiated before pregnancy. Activation of maternal and newborn monocytes and reduced transfer of maternal antibodies were most intense following ART initiation during pregnancy

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2018 Clinical Infectious Diseases

25. Gender difference in health related quality of life and associated factors among people living with HIV/AIDS attending anti-retroviral therapy at public health facilities, western Ethiopia: comparative cross sectional study. (PubMed)

Gender difference in health related quality of life and associated factors among people living with HIV/AIDS attending anti-retroviral therapy at public health facilities, western Ethiopia: comparative cross sectional study. Though HIV/AIDS has multidimensional consequences on quality of life, there is a gap in measuring and monitoring health related quality of life of HIV/AIDS patients. Hence, this study intended to measure health related quality of life domains and associated determinants (...) among people living with HIV/AIDS in western Ethiopia.A comparative cross-sectional study was conducted among 520 HIV/AIDS patients on anti-retroviral therapy in public health facilities in West Shoa Zone, Western Ethiopia from April to May, 2016. Participants were selected using simple random sampling method. Quality of life was measured using WHOQOL-HIV BREF and depression was assessed using Beck Depression Inventory, Second Edition (BDI-II). Data were analyzed using SPSS version 22

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2018 BMC Public Health

26. Clinico-pathological characteristics among South African women with breast cancer receiving anti-retroviral therapy for HIV. (PubMed)

Clinico-pathological characteristics among South African women with breast cancer receiving anti-retroviral therapy for HIV. Breast cancer is the most common cancer in women and a leading cause of cancer-related mortality worldwide. South Africa has the largest global burden of HIV infection and the largest anti-retroviral treatment (ART) program. This study aimed to analyse the association of HIV and ART use with breast cancer clinico-pathological characteristics.Study participants were

2018 Breast

27. Health related quality of life of HIV/AIDS patients on highly active anti-retroviral therapy at a university referral hospital in Ethiopia. (PubMed)

Health related quality of life of HIV/AIDS patients on highly active anti-retroviral therapy at a university referral hospital in Ethiopia. Highly active antiretroviral therapy improves the longevity of patients living with HIV/AIDS. We conducted the study in order to assess health related quality of life of HIV/AIDS patients and the association of socio-demographic and disease related variables with health related quality of life.Health facility based cross-sectional study among 400 HIV/AIDS (...) patients taking highly active anti-retroviral therapy from Gondar University referral hospital was conducted. A pre-tested semi-structured questionnaire, which was adopted from World Health Organization Quality of life brief instrument, was used. The data were then analyzed using SPSS version 20 software for Windows.The majority of the respondents reported to to have a good physical health (15.55). The World Health Organization clinical stage was found to be significantly associated with all

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2017 BMC health services research

28. HDL Cholesterol Efflux Capacity in Newly Diagnosed HIV and Effects of Anti-Retroviral Therapy. (PubMed)

HDL Cholesterol Efflux Capacity in Newly Diagnosed HIV and Effects of Anti-Retroviral Therapy. In the general population, high-density lipoprotein (HDL) cholesterol efflux capacity (HCEC) relates inversely to incident cardiovascular events. Previous studies have suggested that HCEC is decreased in HIV and that antiretroviral therapy (ART) initiation might improve HCEC.To evaluate HCEC in the context of ART initiation and immune activation in HIV.Baseline HCEC from 10 ART-naive HIV-infected (...) males and 12 prospectively matched non-HIV-infected males were analyzed. In the HIV cohort, HCEC 6 months after elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate (E/C/F/TDF) therapy was evaluated. HCEC served as the primary outcome and was measured by the ability of J774 mouse macrophages to efflux cholesterol. Our ex vivo assay used two cholesterol acceptors [apolipoprotein B (apoB)-depleted sera or purified HDL] and modulation of cellular efflux pathways using a liver X receptor

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2017 Journal of Clinical Endocrinology and Metabolism

29. Impact of Protease Inhibitor based Anti-Retroviral Therapy on Outcomes for HIV+ Kidney Transplant Recipients. (PubMed)

Impact of Protease Inhibitor based Anti-Retroviral Therapy on Outcomes for HIV+ Kidney Transplant Recipients. Excellent outcomes have been demonstrated among select HIV-positive kidney transplant (KT) recipients with well-controlled infection, but to date, no national study has explored outcomes among HIV+ KT recipients by antiretroviral therapy (ART) regimen. Intercontinental Marketing Services (IMS) pharmacy fills (1/1/01-10/1/12) were linked with Scientific Registry of Transplant Recipients

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2017 American Journal of Transplantation

30. Ten-year trends in anti-retroviral therapy persistence among US medicaid beneficiaries, 2001-2010. (PubMed)

Ten-year trends in anti-retroviral therapy persistence among US medicaid beneficiaries, 2001-2010.

2017 AIDS

31. Non-adherence to anti-retroviral therapy among HIV infected adults in Mon State of Myanmar. (PubMed)

Non-adherence to anti-retroviral therapy among HIV infected adults in Mon State of Myanmar. The provision of Anti-Retroviral Therapy (ART) was started in Myanmar in 2005 in collaboration with the National AIDS Program and the private sector. Successful clinical management of HIV-infected patients is subject to optimal adherence. The aim of the study was to determine the prevalence of adherence to ART and identify factors associated with non-adherence to ART among HIV infected adults registered

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2017 BMC Public Health

32. Anthropometric Improvement among HIV Infected Pre-School Children Following Initiation of First Line Anti-Retroviral Therapy: Implications for Follow Up. (PubMed)

Anthropometric Improvement among HIV Infected Pre-School Children Following Initiation of First Line Anti-Retroviral Therapy: Implications for Follow Up. Antiretroviral therapy (ART) is a lifesaving intervention for HIV infected children. There is a scarcity of data on immunological recovery and its relation with growth indicators among HIV infected young children. The current study aims to assess the pattern of anthropometric Z-score improvement following initiation of first-line ART among

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2016 PLoS ONE

33. Single-Dose Study of MK-4250 Monotherapy in Anti-Retroviral Therapy-Naive, Human Immunodeficiency Virus (HIV)-1 Infected Participants (MK-4250-002)

Single-Dose Study of MK-4250 Monotherapy in Anti-Retroviral Therapy-Naive, Human Immunodeficiency Virus (HIV)-1 Infected Participants (MK-4250-002) Single-Dose Study of MK-4250 Monotherapy in Anti-Retroviral Therapy-Naive, Human Immunodeficiency Virus (HIV)-1 Infected Participants (MK-4250-002) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies (...) Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Single-Dose Study of MK-4250 Monotherapy in Anti-Retroviral Therapy-Naive, Human Immunodeficiency Virus (HIV)-1 Infected Participants (MK-4250-002) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details

2017 Clinical Trials

34. The Use of First Line Highly Active Anti-Retroviral Therapy (HAART) is Not Associated with Qtc Prolongation in HIV Patients (PubMed)

The Use of First Line Highly Active Anti-Retroviral Therapy (HAART) is Not Associated with Qtc Prolongation in HIV Patients HAART has improved survival of HIV patients. Its contribution to the development of new cardiovascular abnormalities has generated much interest. This study aimed at determining the prevalence of QTc prolongation among HIV patients and determining the influence if any of the use of HAART on the QTc and on the risk of having QTc prolongation.One hundred and fifty HIV

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2017 Ethiopian journal of health sciences

35. Regression of methotrexate-resistant AIDS-related primary central nervous system lymphoma with lenalidomide plus combination anti-retroviral therapy (PubMed)

Regression of methotrexate-resistant AIDS-related primary central nervous system lymphoma with lenalidomide plus combination anti-retroviral therapy 28395565 2018 10 02 2019 01 16 1029-2403 58 11 2017 11 Leukemia & lymphoma Leuk. Lymphoma Regression of methotrexate-resistant AIDS-related primary central nervous system lymphoma with lenalidomide plus combination anti-retroviral therapy. 2748-2751 10.1080/10428194.2017.1312374 Gupta Neel K NK a Division of Hematology/Oncology , University (...) , San Francisco , CA , USA. d Helen Diller Family Comprehensive Cancer Center , San Francisco , CA , USA. eng R01 CA139083 CA NCI NIH HHS United States R21 CA184694 CA NCI NIH HHS United States Letter Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2017 04 10 United States Leuk Lymphoma 9007422 1026-8022 4Z8R6ORS6L Thalidomide F0P408N6V4 Lenalidomide IM Acquired Immunodeficiency Syndrome complications drug therapy Adult Antineoplastic Combined Chemotherapy Protocols adverse

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2017 Leukemia & lymphoma

36. Fluticasone furoate induced iatrogenic Cushing syndrome in a pediatric patient receiving anti-retroviral therapy (PubMed)

Fluticasone furoate induced iatrogenic Cushing syndrome in a pediatric patient receiving anti-retroviral therapy We present a case of iatrogenic Cushing's syndrome, induced by treatment with fluticasone furoate (1-2 dd, 27.5 µg in each nostril) in a pediatric patient treated for congenital HIV. The pediatric patient described in this case report is a young girl of African descent, treated for congenital HIV with a combination therapy of Lopinavir/Ritonavir (1 dd 320/80 mg), Lamivudine (1 dd 160 (...) treated for HIV due to the strong inhibition of CYP3 enzymes by Ritonavir. Upon discontinuation of fluticasone treatment, the pediatric patient improved both clinically and biochemically with normalisation of cortisol and ACTH within a couple of weeks.Fluticasone therapy may induce iatrogenic Cushing's syndrome in a patient treated with anti-retroviral therapy.Pharmacogenetic analysis, in particular CYP3A genotyping, provides useful information in patients treated for HIV with respect to possible

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2017 Endocrinology, diabetes & metabolism case reports

37. Effects of a High Protein Food Supplement on Physical Activity, Motor Performance and Health Related Quality of Life of HIV Infected Botswana Children on Anti-Retroviral Therapy (ART) (PubMed)

Effects of a High Protein Food Supplement on Physical Activity, Motor Performance and Health Related Quality of Life of HIV Infected Botswana Children on Anti-Retroviral Therapy (ART) Despite existing evidence about the benefits of nutrition, physical activity (PA) and sport to the overall health and wellbeing of children, knowledge gaps remain on this relationship in children living with chronic conditions like HIV/AIDS. Such knowledge should inform context specific programs that could enhance (...) the quality of life of children. The purpose of this study was to examine the effects of integrating a nutrition intervention (culturally tailored food supplement) into antiretroviral therapy (ART) on psychosocial outcomes and physical activity among HIV-positive children in Botswana.201 HIV-positive children (6-15 years; M = 9.44, SD = 2.40) were recruited and randomly assigned (stratified by age and gender) to two groups. The intervention group (n = 97) received a high protein (bean-sorghum plus

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2017 AIMS public health

38. The relationship between patient-related factors and medication adherence among Nigerian patients taking highly active anti-retroviral therapy (PubMed)

The relationship between patient-related factors and medication adherence among Nigerian patients taking highly active anti-retroviral therapy Through several initiatives, there are increasingly more people who have access to anti-retroviral therapy. Adherence to therapy is, however, necessary for successful management of disease.The objectives of this study were to describe adherence rates and determine what patient-related factors are related to adherence to anti-retroviral therapy among (...) adult patients in an HIV clinic located in Lagos, Nigeria.Adherence was measured using the two-week self-recall method. Barriers, satisfaction with therapy, and socio-demographic and clinical variables served as independent variables. Data were collected via self-administered surveys.Most of the patients (79.5%) reported 100% adherence. The significant (p<0.05) barriers to adherence were forgetfulness, running out of medication, alcohol use, and medication side effects. For every unit increase

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2017 African health sciences

39. Patients' perceptions of a rural decentralised anti-retroviral therapy management and its impact on direct out-of-pocket spending (PubMed)

Patients' perceptions of a rural decentralised anti-retroviral therapy management and its impact on direct out-of-pocket spending Geographical and financial barriers hamper accessibility to HIV services for rural communities. The government has introduced the nurse initiated management of anti-retroviral therapy at primary health care level, in an effort to improve patient access and reduce patient loads on facilities further up the system.To ascertain the perceptions and satisfaction (...) of patients in terms of the decentralised anti-retroviral policy and the direct out-of-pocket expenses of patients accessing this care in a rural setting.Using a cross-sectional study design, 117 patients from five different primary health care collection points and a hospital anti-retroviral clinic were interviewed using a standard questionnaire.More clinic patients walked to their clinic to collect their medicines as compared to hospital patients (71.2% versus 14.6%). Hospital patients spent more than

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2017 African health sciences

40. A cluster randomized controlled trial of extending ART refill intervals to six-monthly for anti-retroviral adherence clubs. (PubMed)

A cluster randomized controlled trial of extending ART refill intervals to six-monthly for anti-retroviral adherence clubs. The antiretroviral therapy (ART) adherence club (AC) differentiated service delivery model, where clinically stable ART patients receive their ART refills and psychosocial support in groups has supported clinically stable patients' retention and viral suppression. Patients and health systems could benefit further by reducing visit frequency and increasing ART refills. We

2019 BMC Infectious Diseases

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