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Anti-Retroviral Therapy

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1. Predictors of treatment failure, time to switch and reasons for switching to second line antiretroviral therapy in HIV infected children receiving first line anti-retroviral therapy at a Tertiary Care Hospital in Ethiopia. Full Text available with Trip Pro

Predictors of treatment failure, time to switch and reasons for switching to second line antiretroviral therapy in HIV infected children receiving first line anti-retroviral therapy at a Tertiary Care Hospital in Ethiopia. Treatment failure and delay in switching to second line regimen are major concerns in the treatment of HIV infected children in a resource limited setting. The aim of this study was to determine the prevalence and predictors of first line antiretroviral therapy (ART) regimen (...) failure, reasons and time taken to switch to second line antiretroviral (ARV) medications after treatment failure among HIV-infected children.A retrospective cohort study was conducted February 2003 to May 2018 in HIV-clinic at Tikur Anbessa Specialized Hospital (TASH), Ethiopia. All HIV infected children ≤15 years of age and who were taking first line ART for at least 6 months were included. Data abstraction format was used to collect the data from patients' chart and registry. Binary

2019 BMC Pediatrics

2. Disability and health outcomes – from a cohort of people on long-term anti-retroviral therapy Full Text available with Trip Pro

Disability and health outcomes – from a cohort of people on long-term anti-retroviral therapy Human-immunodeficiency virus (HIV)/Acquired immunodeficiency Syndrome (AIDS) remains a major health problem in South Africa - even after two decades since the introduction of antiretroviral therapy (ART). Long-term survival with HIV is associated with new health-related issues and a risk of functional limitation/disability. The aim of this study was to assess functional limitation associated with HIV

2018 SAHARA J : journal of Social Aspects of HIV/AIDS Research Alliance

3. Microbial Dysbiosis During Simian Immunodeficiency Virus Infection is Partially Reverted with Combination Anti-retroviral Therapy Full Text available with Trip Pro

Microbial Dysbiosis During Simian Immunodeficiency Virus Infection is Partially Reverted with Combination Anti-retroviral Therapy Human immunodeficiency virus (HIV) infection is characterized by a massive loss of CD4 T cells in the gastrointestinal tract (GIT) that is accompanied by changes in the gut microbiome and microbial translocation that contribute to inflammation and chronic immune activation. Though highly active antiretroviral therapy (HAART) has led to better long-term outcomes (...) in HIV infected patients, it has not been as effective at reverting pathogenesis in the GIT. Using the simian immunodeficiency virus (SIV) infection model, we show that combination antiretroviral therapy (c-ART) partially reverted microbial dysbiosis observed during SIV infection. Though the relative abundance of bacteria, their richness or diversity did not significantly differ between infected and treated animals, microbial dysbiosis was evident via multiple beta diversity metrics: Jaccard

2020 Scientific reports

4. Prevalence of polypharmacy amongst HIV positive individuals on anti-retroviral therapy drugs: a systematic review and meta-analysis

Prevalence of polypharmacy amongst HIV positive individuals on anti-retroviral therapy drugs: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record (...) . Not an in vivo animal study 3. No metastases/ only primary tumor 4. No control group 5. Combination therapy or contamination 6. Not about analgesics used in the clinic Full text-screening: As above, with the addition of: 7. No relevant outcome measure reported ">Prioritise the exclusion criteria Example: Two reviewers will independently extract data from each article. We first try to extract numerical data from tables, text or figures. If these are not reported, we will extract data from graphs using digital

2020 PROSPERO

5. The effect of non-injection drug use on sexual risk behaviours and ART adherence among men who have sex with men

was significantly associated with poor anti-retroviral adherence among men who have sex with men and heterosexual men living with HIV (47). Interventions to address sexual risk, drug use, and adherence among men who have sex with men who use drugs A meta-analysis of high-intensity behavioural interventions from 2010 found that interventions for reducing the use of amphetamine-group substances had only a moderate effect size (27). Of the 13 included studies, three were focused on men who have sex with men (...) on erectile dysfunction among men who have sex with men. Journal of Sexual Medicine. 2012;9(4):1106-13. Prestage G, Jin F, Bavinton B, Grulich A, Brown G, Pitts M, et al. Australian gay and bisexual men’s use of erectile dysfunction medications during recent sexual encounters. Journal of Sexual Medicine. 2014;11(3):809-19. De Ryck I, Van Laeken D, Noestlinger C, Platteau T, Colebunders R. The use of erection enhancing medication and party drugs among men living with HIV in Europe. AIDS Care. 2013;25(8

2018 Ontario HIV Treatment Network

6. Integrating community pharmacy into community based anti-retroviral therapy program: A pilot implementation in Abuja, Nigeria. Full Text available with Trip Pro

Integrating community pharmacy into community based anti-retroviral therapy program: A pilot implementation in Abuja, Nigeria. The landscape of Human Immunodeficiency Virus (HIV) epidemic control is shifting with the United Nations Programme on HIV/AIDS (UNAIDS) 90-90-90 benchmarks for epidemic control. Community-based Antiretroviral Therapy (CART) models have improved treatment uptake and demonstrated good clinical outcomes. We assessed the feasibility of integrating community pharmacy

2018 PLoS ONE

7. Health-Related Quality of Life in Patients Treated With Antiretroviral Therapy Only Versus Chemotherapy and Antiretroviral Therapy for HIV-Associated Kaposi Sarcoma: A Randomized Control Trial. Full Text available with Trip Pro

alone or with chemotherapy on QOL in treatment-naïve South Africans with HIV-associated KS was assessed.KAART (Kaposi Sarcoma AIDS Anti-Retroviral Therapy) is a randomized, controlled, open-label trial of ART versus ART plus chemotherapy. Crossover between arms was allowed for patients with progressive disease. Eighty-nine percent of patients had advanced tumor burden. Within KAART, QOL measured by European Organization for Research and Treatment of Cancer-QLQ-C30 questionnaire evaluated functional (...) Health-Related Quality of Life in Patients Treated With Antiretroviral Therapy Only Versus Chemotherapy and Antiretroviral Therapy for HIV-Associated Kaposi Sarcoma: A Randomized Control Trial. In sub-Saharan Africa, Kaposi sarcoma (KS) is the most common HIV-associated cancer. KS causes substantial morbidity, and treatment goals should emphasize quality of life (QOL). Antiretroviral therapy (ART) is indicated, and early chemotherapy significantly improves tumor regression. The effect of ART

2018 Journal of global oncology Controlled trial quality: uncertain

8. Emotional and behavioral problems and associated factors among children and adolescents on highly active anti-retroviral therapy in public hospitals of West Gojjam zone, Amhara regional state of Ethiopia, 2018: a cross-sectional study. Full Text available with Trip Pro

Emotional and behavioral problems and associated factors among children and adolescents on highly active anti-retroviral therapy in public hospitals of West Gojjam zone, Amhara regional state of Ethiopia, 2018: a cross-sectional study. Children and adolescents with HIV/AIDS are more likely to have emotional and behavioral problems than the general population. This can result in a continuing negative influence on the quality of life, school performance, immunity and co-morbidity of children (...) and adolescents with HIV/AIDS.To assess the prevalence and associated factors of Emotional and Behavioral Problems among children and adolescents on Highly Active Anti-Retroviral Therapy in the public hospitals of West Gojjam Zone, Amhara regional state of Ethiopia.An institutional based cross sectional study was conducted by screening 411 children and adolescents for emotional and behavioral problems using Pediatric Symptomatology Check List (PSCL). Systematic random sampling technique was used to select

2019 BMC Pediatrics

9. Tooth wear in patients treated with HIV anti-retroviral therapy. Full Text available with Trip Pro

Tooth wear in patients treated with HIV anti-retroviral therapy. The objective of this study was to elucidate the relationship between HIV anti-retroviral therapy and tooth wear.Assessment of tooth wear was conducted both with a survey questionnaire and clinical assessment at Russell Street Dental Clinic in Portland, Oregon. The survey questionnaire comprised of questions on study participant's gender, age, HIV status, current medications, awareness of tooth grinding or clenching, jaw soreness (...)  < 0.05). After controlling for age, years of anti-retroviral therapy use was positively correlated with tooth wear index (B = 0.047, p > 0.05).The findings from this study suggest that HIV + ve patients, who are on anti-retroviral therapy have significant tooth wear, although more studies with larger sample size are needed to confirm this. There is a critical need to initiate a dialogue with medical providers about tooth wear as a possible side effect of antiretroviral therapy and to introduce

2019 BMC Oral Health

10. Perceptions on the feasibility of decentralizing phlebotomy services in community anti-retroviral therapy group model in Lusaka, Zambia. Full Text available with Trip Pro

Perceptions on the feasibility of decentralizing phlebotomy services in community anti-retroviral therapy group model in Lusaka, Zambia. The focus of the community anti-retroviral therapy Group model is on drug refill, adherence and support groups. However, laboratory services are completely neglected in this model, and stable patient still have to go to the clinic for blood draws after drugs refills from the community. Due to the introduction of new ART drugs, the guidelines now recommend (...) the use of viral loads to guide decision in switching all patients from NNRTI to dolutegravir based first line ART regimens. But the national viral load testing coverage stands at 37% and and falls short of meeting the global UNAIDS and phlebotomy delivery system is congested. The purpose of this study was to identify the perceptions in decentralizing phlebotomy services into the community anti-retroviral therapy Group model.A qualitative case study design was used. Data were collected through ten

2019 BMC health services research

11. Anti-retroviral therapy scale-up and its impact on sex-stratified tuberculosis notification trends in Uganda. Full Text available with Trip Pro

Anti-retroviral therapy scale-up and its impact on sex-stratified tuberculosis notification trends in Uganda. In order to end the tuberculosis (TB) epidemic by 2035, countries must achieve a 10% annual decline in tuberculosis incidence rates by 2025. Provision of antiretroviral therapy (ART) has been associated with population level decreases in TB notification rates. We aimed to assess whether the progressive scale-up of ART provision over the past nine years has had an effect on population

2019 Journal of the International AIDS Society

12. HIV-related arterial stiffness in Malawian adults is associated with proportion of PD-1 expressing CD8 T-cells and reverses with anti-retroviral therapy. Full Text available with Trip Pro

HIV-related arterial stiffness in Malawian adults is associated with proportion of PD-1 expressing CD8 T-cells and reverses with anti-retroviral therapy. The contribution of immune activation to arterial stiffness and its reversibility in HIV-infected adults in sub-Saharan Africa is unknown.HIV-uninfected and HIV-infected Malawian adults initiating antiretroviral therapy (ART) with CD4 <100 cells/l were enrolled (2-weeks post-ART for HIV-infected) and followed for 44-weeks. We evaluated

2019 Journal of Infectious Diseases

13. The relationship between patient-related factors and medication adherence among Nigerian patients taking highly active anti-retroviral therapy Full Text available with Trip Pro

The relationship between patient-related factors and medication adherence among Nigerian patients taking highly active anti-retroviral therapy Through several initiatives, there are increasingly more people who have access to anti-retroviral therapy. Adherence to therapy is, however, necessary for successful management of disease.The objectives of this study were to describe adherence rates and determine what patient-related factors are related to adherence to anti-retroviral therapy among (...) adult patients in an HIV clinic located in Lagos, Nigeria.Adherence was measured using the two-week self-recall method. Barriers, satisfaction with therapy, and socio-demographic and clinical variables served as independent variables. Data were collected via self-administered surveys.Most of the patients (79.5%) reported 100% adherence. The significant (p<0.05) barriers to adherence were forgetfulness, running out of medication, alcohol use, and medication side effects. For every unit increase

2017 African health sciences

14. Initiation of anti-retroviral therapy before pregnancy reduces the risk of infection-related hospitalization in HIV-exposed uninfected infants born in a high-income country. Full Text available with Trip Pro

Initiation of anti-retroviral therapy before pregnancy reduces the risk of infection-related hospitalization in HIV-exposed uninfected infants born in a high-income country. Epidemiological studies conducted in low and high-income countries showed that infants exposed to maternal HIV but not infected themselves by the virus have a high risk of severe infections. Immune alterations during fetal life have been proposed as a possible mechanism.This prospective study was conducted to assess (...) of this increased risk was associated with time of initiation of maternal anti-retroviral therapy (ART). As compared to HU infants, risk of hospitalization for infection of HEU infants was four-fold higher (3.84, 1.69-8.71) when mothers initiated ART during pregnancy and was not significantly increased (1.42, 0.58-3.48) when ART was initiated before pregnancy. Activation of maternal and newborn monocytes and reduced transfer of maternal antibodies were most intense following ART initiation during pregnancy

2018 Clinical Infectious Diseases

15. Intestinal parasitosis among HIV/AIDS patients who are on anti-retroviral therapy in Kombolcha, North Central, Ethiopia: a cross-sectional study Full Text available with Trip Pro

Intestinal parasitosis among HIV/AIDS patients who are on anti-retroviral therapy in Kombolcha, North Central, Ethiopia: a cross-sectional study Human immunodeficiency virus (HIV) infected patients are highly vulnerable to microbial and parasitic diseases due to the immune-suppression. This study aimed to determine the prevalence and assess the associated risk factors of intestinal parasites in HIV/AIDS patients who are under anti-retroviral therapy in Kombolcha, North-Central Ethiopia.A total

2018 BMC research notes

16. Assessing the level of institutionalization of donor-funded anti-retroviral therapy (ART) programs in health facilities in Uganda: implications for program sustainability Full Text available with Trip Pro

Assessing the level of institutionalization of donor-funded anti-retroviral therapy (ART) programs in health facilities in Uganda: implications for program sustainability In the context of declining international assistance for ART scale-up in Sub-Saharan Africa, the institutionalization of ART programs through integrating them in the organizational routines of health facilities is gaining importance as a program sustainability strategy.The aims of this study were; (i) to compare the level

2018 Global health action

17. Malnutrition and Opportunistic Infections among People Living with HIV Receiving Anti-retroviral Therapy in Aceh, Indonesia Full Text available with Trip Pro

Malnutrition and Opportunistic Infections among People Living with HIV Receiving Anti-retroviral Therapy in Aceh, Indonesia 29922623 2018 11 14 2251-6085 47 5 2018 May Iranian journal of public health Iran. J. Public Health Malnutrition and Opportunistic Infections among People Living with HIV Receiving Anti-retroviral Therapy in Aceh, Indonesia. 762-764 Llf Putri Cut C Medical Research Unit, School of Medicine, Syiah Kuala University, Banda Aceh, Indonesia. Siregar Masra L ML Dept. of Internal (...) Medicine, School of Medicine, Syiah Kuala University, Banda Aceh, Indonesia. Dept. of Internal Medicine, Dr. Zainoel Abidin Hospital, Syiah Kuala University, Banda Aceh, Indonesia. Harapan Harapan H Medical Research Unit, School of Medicine, Syiah Kuala University, Banda Aceh, Indonesia. Tropical Disease Centre, School of Medicine, Syiah Kuala University, Banda Aceh, Indonesia. Dept. of Microbiology, School of Medicine, Syiah Kuala University, Banda Aceh, Indonesia. Husnah Husnah H Dept. of Nutrition

2018 Iranian journal of public health

18. Harmful alcohol drinking among HIV-positive people in Nepal: an overlooked threat to anti-retroviral therapy adherence and health-related quality of life Full Text available with Trip Pro

Harmful alcohol drinking among HIV-positive people in Nepal: an overlooked threat to anti-retroviral therapy adherence and health-related quality of life People living with Human Immunodeficiency Virus (HIV) often suffer from alcohol-use disorders resulting in their poor health and treatment outcomes. Little is known about the association of harmful alcohol drinking with their adherence to anti-retroviral therapy (ART) and health-related quality of life (QOL) in low-resource settings.This study

2018 Global health action

19. Barriers to tuberculosis and human immunodeficiency virus treatment guidelines adherence among nurses initiating and managing anti-retroviral therapy in KwaZulu-Natal and North West provinces Full Text available with Trip Pro

Barriers to tuberculosis and human immunodeficiency virus treatment guidelines adherence among nurses initiating and managing anti-retroviral therapy in KwaZulu-Natal and North West provinces  Nurses, as front-line care providers in the South Africa's health care system, are called upon to deliver integrated interventions for tuberculosis and human immunodeficiency virus (TB and HIV) including nurse-initiated management of anti-retroviral therapy (NIMART) and anti-TB treatment. Adherence (...) to treatment guidelines and factors associated with non-adherence to treatment guidelines among nurses remain under explored. To explore and describe barriers to treatment guidelines adherence among nurses initiating and managing anti-retroviral therapy and anti-TB treatment in KwaZulu-Natal and North West provinces. This study employed a qualitative exploratory descriptive design. Four semi-structured focus group interviews were conducted during 2014 each consisting of four to eight NIMART trained nurses

2018 Curationis

20. Transmission dynamics among participants initiating anti-retroviral therapy upon diagnosis of early acute HIV-1 infection in Thailand. (Abstract)

Transmission dynamics among participants initiating anti-retroviral therapy upon diagnosis of early acute HIV-1 infection in Thailand. To assess transmission characteristics in a predominantly MSM cohort initiating antiretroviral therapy (ART) immediately following diagnosis of acute HIV-1infection (AHI).A longitudinal study (2009-2017) was performed in participants with AHI (n = 439) attending a single clinic in Bangkok. Plasma samples obtained prior to ART were used to obtain HIV-1 pol

2018 AIDS

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