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Antepartum Depression

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161. Chronic Medical Conditions and Perinatal Mental Illness: A Systematic Review and Meta-Analysis. (PubMed)

using DerSimonian and Laird random effects models. The review included 16 papers representing 12 studies and 1,626,260 women. CMCs overall were associated with peripartum mental illness overall (adjusted pooled odds ratios (aPOR) = 1.43, 95% confidence interval (CI): 1.25, 1.63). CMCs overall were associated with antepartum (aPOR = 1.41, 95% CI: 1.10, 1.81) and postpartum mental illness separately (aPOR = 1.44, 95% CI: 1.13, 1.85) and with peripartum depression (aPOR = 1.45, 95% CI: 1.25, 1.67

2018 American Journal of Epidemiology

162. Is partners’ mental health and well-being affected by holding the baby after stillbirth? Mothers’ accounts from a national survey (PubMed)

to have held their baby. Higher gestational age, shorter time interval between antepartum death and delivery, and mother's holding the baby all predicted a higher rate of partner's holding. There was a consistent negative effect of holding the baby across mental health and well-being outcomes, although after adjustment only higher odds of depression (OR 2.72, 95% CI 1.35-5.50) and post-traumatic stress type symptoms (OR 1.95, 95% CI 1.01-3.78) at 3 months were significantly associated with having held (...) the baby following stillbirth.This study is the first to assess the impact of holding the baby on partners' mental health and well-being. The prevalence of depression and anxiety were high, and the negative effects of holding the baby were significant 3 months later.

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2018 Journal of Reproductive and Infant Psychology

163. Tranexamic Acid in Pregnancies With Vaginal Bleeding

Description Go to Brief Summary: Tranexamic acid has been proposed and used for prevention and management of antepartum and postpartum hemorrhage. Condition or disease Intervention/treatment Phase Vaginal Bleeding During Pregnancy Drug: Tranexamic Acid Not Applicable Detailed Description: Bleeding during pregnancy is associated with a three- to fourfold increase in perinatal mortality. Hemorrhage in pregnancy is characterized by activation of the fibrinolytic system. Tranexamic acid is a potent (...) Model: Single Group Assignment Intervention Model Description: Tranexamic acid was prescribed for women with abnormal vaginal bleeding in the first trimester less than 20 weeks gestation (threatened and recurrent miscarriage) and Antepartum hemorrhage (abruption , placenta previa, and unknown causes for vaginal bleeding) Masking: None (Open Label) Primary Purpose: Treatment Official Title: Tranexamic Acid in Pregnancies With Early and Late Onset Vaginal Bleeding:One Arm Clinical Trial Actual Study

2018 Clinical Trials

164. Evaluation of Copeptin Levels in Elective Cesarean Section With Different Anesthetic Technique

Inclusion Criteria: 18-40 years of age ASA I-II 36-40 gestational weeks BMI ≤ 40 Undergoing elective cesarean section Exclusion Criteria: Coagulopathy Known central or peripheral nerve disease fetal anomalies birth weight less than 2000 grams and above 4500 grams, infants with a risk of meconium or amniotic fluid aspiration kidney failure, diabetes mellitus, hypertension, cardiac disease, antepartum hemorrhage, asthma bronchiole, Rh incompatibility, congenital malformations Contacts and Locations Go (...) Device Product: No Keywords provided by Ece YAMAK ALTINPULLUK, Istanbul University: copeptin levels Cesarean section general anesthesia spinal anesthesia Additional relevant MeSH terms: Layout table for MeSH terms Diabetes Insipidus Fetal Distress Kidney Diseases Urologic Diseases Pituitary Diseases Endocrine System Diseases Signs and Symptoms Anesthetics Arginine Vasopressin Central Nervous System Depressants Physiological Effects of Drugs Hemostatics Coagulants Vasoconstrictor Agents Antidiuretic

2018 Clinical Trials

165. Fetal Doppler Indices in Predicting Perinatal Outcome Among Severely Hypertensive Pregnant Patients.

hypertension (gestational hypertension, preeclampsia, chronic hypertension and chronic hypertension with superimposed preeclampsia). Singleton living fetus. Exclusion Criteria: Maternal medical disorders rather than hypertension. Fetal congenital anomalies. Rupture of membrane. Antepartum hemorrhage (placenta previa or accidental hemorrhage). The maternal administration of respiratory depressants within 2 hours from the delivery of the fetus (e. g., opioid analgesic ) Contacts and Locations Go

2018 Clinical Trials

166. Nifedipine Versus Magnesium Sulfate for Prevention of Preterm Labor in Symptomatic Placenta Previa

: Not yet recruiting First Posted : May 31, 2018 Last Update Posted : May 31, 2018 See Sponsor: Assiut University Information provided by (Responsible Party): ramy nasser, Assiut University Study Details Study Description Go to Brief Summary: Antepartum hemorrhage is defined as bleeding from or within the female genital tract, occurring from 28+0 weeks of pregnancy and till delivery of the fetus. it occurs in 3-5% of pregnancies and is an important cause of perinatal and maternal morbidity and mortality (...) : No Additional relevant MeSH terms: Layout table for MeSH terms Obstetric Labor, Premature Placenta Previa Obstetric Labor Complications Pregnancy Complications Placenta Diseases Magnesium Sulfate Nifedipine Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Anesthetics Central Nervous System Depressants Anti-Arrhythmia Agents Anticonvulsants Calcium Channel Blockers Membrane Transport Modulators Molecular Mechanisms of Pharmacological Action Calcium-Regulating

2018 Clinical Trials

167. Buprenorphine vs Buprenorphine/Naloxone on the Effects of Maternal Symptomatology

to Primary Outcome Measures : Compliance antepartum [ Time Frame: From entry into the study until delivery (through study completion, an average of 9 months which is duration of the pregnancy) ] To compare compliance with buprenorphine versus buprenorphine/naloxone medication-assisted treatment (MAT) in pregnant women. Compliance will include the incidence of urine toxicology testing positive for illicit substances during prenatal care and at the time of admission for delivery. Compliance postpartum (...) [ Time Frame: 2 month period postpartum ] To compare compliance with buprenorphine versus buprenorphine/naloxone medication-assisted treatment (MAT) in the postpartum period. Compliance will include the incidence of urine toxicology testing positive for illicit substances from the time of discharge from the hospital following the delivery over a 2 month period postpartum (postpartum period). Dosing antepartum [ Time Frame: From entry into the study until delivery (through study completion, an average

2018 Clinical Trials

168. Prevalence and risk factors of gestational diabetes mellitus: findings from a universal screening feasibility program in Lima, Peru. (PubMed)

and was associated with maternal obesity, family history of diabetes and antepartum depression among Peruvian women. Intervention programs aimed at early diagnoses and management of GDM need to take maternal obesity, family history of diabetes and antepartum depression into account. (...) was conducted among 1300 pregnant women attending a prenatal clinic in Lima, Peru. GDM was diagnosed using an Oral Glucose Tolerance Test (OGTT) performed between 24 and 28 gestational weeks using the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria. Depression status was assessed using the Patient Health Questionnaire-9. Multivariate logistic regression models were used to identify risk factors of GDM.Approximately 16% of pregnant women were diagnosed with GDM

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2018 BMC Pregnancy and Childbirth

169. HIV Exposure and Formula Feeding Predict Under-2 Mortality in HIV-Uninfected Children, Botswana. (PubMed)

zidovudine, and 1% took <2 weeks of any antiretrovirals antepartum. Twenty four-month vital status was available for 888 (99.4%) children. HIV-exposed uninfected children had a significantly higher risk of death compared with children of HIV-uninfected mothers (5.0% vs 1.8%) (adjusted hazard ratio 3.27, 95% CI 1.44-7.40). High collinearity between maternal HIV status and child feeding method precluded analysis of these factors as independent predictors of mortality. Preterm birth, low birth weight (...) , and congenital anomaly were also associated with mortality (in separate analyses), but maternal socioeconomic factors, depression, substance use, and social support were not significant predictors.The strongest predictors of 24-month mortality among children in Botswana were HIV exposure and formula feeding, although the relative contribution of these factors to child health could not be separated.Copyright © 2018 Elsevier Inc. All rights reserved.

2018 Journal of Pediatrics

171. Reduced Fetal Movements

and depressed Apgar scores. However, further evaluation of this technology is required before clinical recommendations can be made. 65 © Royal College of Obstetricians and Gynaecologists 7 of 16 RCOG Green-top Guideline No. 57 B B Evidence level 2+ B Evidence level 3 PSeveral studies have concluded that if the term fetus does not experience a fetal heart rate acceleration for more than 80 minutes, fetal compromise is likely to be present. 66–68 However, a systematic review in the Cochrane Database (...) . The study reported no increase in the number of preterm births, infants requiring transfer to neonatal care or infants with severe neonatal depression or FGR. There was more than a doubling in the number of ultrasound scans RCOG Green-top Guideline No. 57 8 of 16 © Royal College of Obstetricians and Gynaecologists Evidence level 2– Evidence level 2+ P B C A Evidence level 2+ Evidence level 2–(OR 2.64; 95% CI 2.02–3.45), but this seemed to be compensated by a reduction in additional follow-up

2011 Royal College of Obstetricians and Gynaecologists

172. Maternal Collapse in Pregnancy and the Puerperium

as a reference point. The common causes of maternal collapse are discussed below, but this is not an exhaustive list, as this is beyond the scope of this guideline. 4.2.1 Haemorrhage This is the most common cause of maternal collapse, and was responsible for 17 maternal deaths in the last triennium. 1 Major obstetric haemorrhage has an estimated incidence of 3.7/1000 maternities. 20 Causes of major obstetric haemorrhage include postpartum haemorrhage, major antepartum haemorrhage from placenta praevia (...) fluid embolism Haemorrhage: splenic artery rupture hepatic rupture uterine (antepartum haemorrhage/ postpartum haemorrhage) Pulmonary embolism Eclampsia Intracranial haemorrhage Cardiac causes: arrhythmias myocardial infarction cardiomyopathy Sepsis Drugs: magnesium sulphate local anaesthetic illicit drugs Hypoglycaemia Aortic dissection Figure 1. Causes of maternal collapse Reversible cause Cause in pregnancy 4 H’s Hypovolaemia Bleeding (may be concealed) (obstetric/other) or relative hypovolaemia

2011 Royal College of Obstetricians and Gynaecologists

174. Group Versus Traditional Prenatal Care for Diabetes

Detailed Description: Long term, the investigator aims to test the central hypothesis that group prenatal care, compared to traditional prenatal care, will improve, 1.) glycemic control and, 2.) postpartum weight retention in women with type 2 and gestational diabetes. The objective of this proposal is to conduct a randomized trial in two phases to determine the effect of Diabetes Group Care (GC) on glycemic control in pregnant women with T2DM and GDM (Antepartum Phase) and the impact on postpartum (...) Activities Scale (a measure of the number of days during the prior week in which the subject followed diet, exercise, blood sugar testing, and medication adherence recommendations) Effect of Diabetes Group Care on number of blood glucose values [ Time Frame: Initial study visit (22-34 weeks) through 39 weeks gestation ] Determine the effect of Diabetes Group care by measuring the percentage of recommended blood glucose values entered on logs since initial study visit Maternal Antepartum Compliance [ Time

2017 Clinical Trials

175. Interventions to treat mental disorders during pregnancy: A systematic review and multiple treatment meta-analysis. (PubMed)

Interventions to treat mental disorders during pregnancy: A systematic review and multiple treatment meta-analysis. For women suffering from an antepartum mental disorder (AMD), there is lack of evidence-based treatment algorithms due to the complicated risk-benefit analysis for both mother and unborn child. We aimed to provide a comprehensive overview of pharmacological and non-pharmacological interventions to treat AMD and performed a meta-analysis of the estimated treatment effect (...) on the psychiatric symptoms during pregnancy.MedLine, PsycINFO and Embase databases were searched by two independent reviewers for clinical trials with a control condition on treatment of women with AMD, i.e. major depressive (MDD), anxiety, psychotic, eating, somatoform and personality disorders. We inventoried the effect of the treatment, i.e. decrease of psychiatric symptoms at the end of the treatment or postpartum. We adhered to the PRISMA-protocol.Twenty-nine trials were found involving 2779 patients

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2017 PloS one

176. Subcutaneous Bupivacaine Decrease Post-op Pain in Patients Undergoing C-Section

consecutive minutes)] Chronic antepartum opioid use History of substance abuse (alcohol or drug) Current tobacco use Chronic steroid use Contacts and Locations Go to No Contacts or Locations Provided More Information Go to Layout table for additonal information Responsible Party: Jeffrey Bernstein, Professor, Montefiore Medical Center ClinicalTrials.gov Identifier: Other Study ID Numbers: 2017- 8094 First Posted: December 26, 2017 Last Update Posted: July 23, 2018 Last Verified: July 2018 Individual (...) Epinephrine Racepinephrine Epinephryl borate Anesthetics, Local Anesthetics Central Nervous System Depressants Physiological Effects of Drugs Sensory System Agents Peripheral Nervous System Agents Analgesics, Opioid Narcotics Analgesics Adjuvants, Anesthesia Anesthetics, Intravenous Anesthetics, General Adrenergic alpha-Agonists Adrenergic Agonists Adrenergic Agents Neurotransmitter Agents

2017 Clinical Trials

177. Correlates of early pregnancy serum brain-derived neurotrophic factor in a Peruvian population (PubMed)

concentrations. Participants with moderate antepartum depressive symptoms (Patient Health Questionnaire-9 (PHQ-9) score ≥ 10) had lower serum BDNF concentrations compared with participants with no/mild antepartum depressive symptoms (PHQ-9 score < 10). Maternal age, early pregnancy BMI, gestational age, and the presence of moderate antepartum depressive symptoms were statistically significantly associated with early pregnancy serum BDNF concentrations in low-income Peruvian women. Biological changes of CRP

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2017 Archives of women's mental health

178. Breastfeeding-Friendly Physician?s Office: Optimizing Care for Infants and Children

, of?ce staff, and families. (For the purposes of thisdocument‘‘physician’’referstoanyonewhoisrendering the primary medical care to the breastfeeding dyad, both the mother antepartum and the dyad postpartum. In differ- ent countries and cultures that could be a doctor, a midwife, or another healthcare professional. All should strive for a ‘‘Breastfeeding-Friendly Practice’’ in which to care for these families.) Breastmilk substitutes Infant formula, glucose water, or other liquids given in place (...) , re?ux, normal stool and voiding patterns, maintaining lactation when separated from the infant (for example, during illness, prematurity, or return to work), breastfeeding in public, postpartum depression, maternal medication use, and maternal illness during breastfeeding). (I) 8. Allow and encourage breastfeeding in the waiting room. Display signs in the waiting area encouraging mothers to breastfeed (Figs. 1 and 2). Provide a com- fortable private area to breastfeed for those mothers who prefer

2013 Academy of Breastfeeding Medicine

180. Obstetric Anaesthetic Services

and the emergency workload) should be audited and monitored, and any necessary action taken to correct recurrence. Postoperative analgesia Intrathecal or epidural diamorphine or morphine can provide adequate analgesia after caesarean section without the addition of intravenous PCA opioid. The administration of parenteral opioids to women who have received neuraxial opioids is discouraged as it increases the risk of respiratory 13 depression. In the absence of contra-indications, women should be prescribed (...) intention • All decisions regarding regional analgesia must rest with the anaesthetist. Anaesthetists and obstetricians • Anaesthetists should encourage and facilitate consultation in the antepartum period by making themselves available when antenatal clinics are in progress and by ensuring clear lines of referral. A system for the antenatal assessment of high-risk mothers should be in place with 24-hour access to the information on the delivery suite • Good communication on the delivery suite is vital

2013 Association of Anaesthetists of GB and Ireland

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