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Antepartum Depression

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41. Prevalence and determinants of antenatal depression among women attending primary health care centers in Western Saudi Arabia Full Text available with Trip Pro

2017 and February 15th 2017 were interviewed. A self-administered questionnaire used for data collection asked about socio-demographic variables and included the Edinburgh Postnatal Depression Scale.  The most common contributor was the  harming herself (mean±SD, 2.7±0.60). Factors significantly associated with depression among participants were the number of daughters, previous diagnosis of depression, and financial problems.The prevalence of antepartum depression among pregnant women in Jeddah (...) Prevalence and determinants of antenatal depression among women attending primary health care centers in Western Saudi Arabia To measure the prevalence of antenatal depression among pregnant women attending the primary health care (PHC) antenatal care clinics in Jeddah, Saudi Arabia and to determine associated factors.Following a cross-sectional study design, 320 pregnant women attending the antenatal care clinics in the Ministry of Health PHC Centers in Jeddah, Saudi Arabia between January 1st

2017 Saudi medical journal

42. Understanding the relationship between cesarean birth and stress, anxiety, and depression after childbirth: A nationwide cohort study. (Abstract)

on postpartum stress, anxiety, and depression.This nationwide population-based cohort study was conducted using the Taiwan National Health Insurance Database. A total of 12 619 women who underwent cesarean birth and 12 619 control women who underwent vaginal birth were matched by propensity score based on age, socioeconomic status, residential urbanicity, antepartum comorbidity, and index year of delivery. We compared the incidence of stress, anxiety, and depression during the first postpartum year between (...) Understanding the relationship between cesarean birth and stress, anxiety, and depression after childbirth: A nationwide cohort study. Women who undergo cesarean birth might have an increased risk for poor mental health after childbirth, possibly because of maternal and neonatal physical problems, low parental confidence, and decreased levels of oxytocin. However, this relationship remains controversial and requires further examination. The study aimed to examine the effect of cesarean birth

2017 Birth

43. Effects of Two In-hospital Antepartum Interventions on Functional Ability and Quality of Life in Early Postpartum Women.

Effects of Two In-hospital Antepartum Interventions on Functional Ability and Quality of Life in Early Postpartum Women. Effects of Two In-hospital Antepartum Interventions on Functional Ability and Quality of Life in Early Postpartum Women. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Effects of Two In-hospital Antepartum Interventions on Functional Ability and Quality of Life in Early Postpartum Women. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02239341 Recruitment Status : Completed First

2014 Clinical Trials

44. Psychometric properties of the 7-item Generalized Anxiety Disorder scale in antepartum women from Ghana and Côte d'Ivoire. (Abstract)

Psychometric properties of the 7-item Generalized Anxiety Disorder scale in antepartum women from Ghana and Côte d'Ivoire. To explore the psychometric properties of the 7-item Generalized Anxiety Disorder scale (GAD-7) in West African pregnant women.In a cross-sectional study, the GAD-7, the PHQ-9 (depression module of the Patient Health Questionnaire) and the WHO-DAS II (12-item World Health Organization Disability Scale) were administered to n=647 Ivorian and n=395 Ghanaian antepartum women

2014 Journal of Affective Disorders

45. Association of Antenatal Depression Symptoms and Antidepressant Treatment With Preterm Birth. Full Text available with Trip Pro

); the primary predictor was an Edinburgh Postnatal Depression Scale antepartum score of 10 or greater, indicating symptoms of depression. Logistic regression models were used with and without consideration of antidepressant exposure during pregnancy.Among 7,267 women, 831 (11%) screened positive for depression. In multivariable analyses adjusting for maternal age, race, income, body mass index, tobacco use, lifetime diagnosis of major depression and anxiety, diabetes, hypertension, and preeclampsia, women (...) who screened negative), depressive symptoms were not associated with a significantly increased risk of preterm and very preterm birth or an SGA neonate.In a large cohort of women screened for depression antepartum, those with depressive symptoms had an increased likelihood of preterm and very preterm delivery as well having an SGA neonate. Such risk was not apparent among women who were treated with an antidepressant medication.

2016 Obstetrics and Gynecology

46. Serum brain-derived neurotrophic factor (BDNF) concentrations in pregnant women with post-traumatic stress disorder and co-morbid depression Full Text available with Trip Pro

concentrations among women with PTSD with and without depression. A total of 2928 women attending prenatal care clinics in Lima, Peru, were recruited. Antepartum PTSD and depression were evaluated using PTSD Checklist-Civilian Version (PCL-C) and Patient Health Questionnaire-9 (PHQ-9) scales, respectively. BDNF concentrations were measured in a subset of the cohort (N = 944) using a competitive enzyme-linked immunosorbent assay (ELISA). Logistic regression procedures were used to estimate odds ratios (...) (OR) and 95 % confidence intervals (95 % CI). Antepartum PTSD (37.4 %) and depression (27.6 %) were prevalent in this cohort of low-income pregnant Peruvian women. Approximately 19.9 % of participants had comorbid PTSD-depression. Median serum BDNF concentrations were lower among women with comorbid PTSD-depression as compared with women without either condition (median [interquartile range], 20.44 [16.97-24.30] vs. 21.35 [17.33-26.01] ng/ml; P = 0.06). Compared to the referent group (those without PTSD

2016 Archives of women's mental health

47. Epidemiology of maternal depression, risk factors, and child outcomes in low-income and middle-income countries Full Text available with Trip Pro

Epidemiology of maternal depression, risk factors, and child outcomes in low-income and middle-income countries Maternal depression, a non-psychotic depressive episode of mild to major severity, is one of the major contributors of pregnancy-related morbidity and mortality. Maternal depression (antepartum or post partum) has been linked to negative health-related behaviours and adverse outcomes, including psychological and developmental disturbances in infants, children, and adolescents. Despite (...) its enormous burden, maternal depression in low-income and middle-income countries remains under-recognised and undertreated. In this Series paper, we systematically review studies that focus on the epidemiology of perinatal depression (ie, during antepartum and post-partum periods) among women residing in low-income and middle-income countries. We also summarise evidence for the association of perinatal depression with infant and childhood outcomes. This review is intended to summarise findings

2016 The Lancet. Psychiatry

48. Cortisol Response to the Trier Social Stress Test in Pregnant Women at Risk for Postpartum Depression Full Text available with Trip Pro

Cortisol Response to the Trier Social Stress Test in Pregnant Women at Risk for Postpartum Depression Antepartum depression and anxiety are risk factors for postpartum depression (PPD). Postpartum abnormalities in hypothalamic-pituitary-adrenal (HPA) reactivity are associated with PPD. It is not known if antepartum HPA abnormalities exist in women at risk for PPD (AR-PPD). We measured salivary cortisol response to the Trier Social Stress Test (TSST) in 44 (24 AR-PPD, 20 healthy comparison (...) ) pregnant women. Depression and anxiety were measured using the Edinburgh Postnatal Depression Scale (EPDS) and Spielberger State-Trait Anxiety Inventory-State (STAI-S). We analyzed longitudinal changes in cortisol using generalized estimating equation methods to control for the correlation within subjects at the six TSST time points. Group differences in area under the curve (AUC) were examined. A majority (70.8 %) of the AR-PPD had prior depression. EPDS total score was higher in AR-PPD vs. comparison

2016 Archives of women's mental health

49. Trajectories of Perinatal Depressive and Anxiety Symptoms in a Community Cohort. (Abstract)

belonging to each trajectory. Model fit was evaluated using the Bayesian information criterion. Multinomial logistic regression analysis was conducted to compare characteristics across the trajectories.Five distinct trajectory groups with constant and variable patterns were identified for both depressive and anxiety symptoms: minimal, mild, antepartum, postpartum, and chronic. Common risk factors of depression and anxiety across groups with elevated symptoms were history of mental health issues (odds (...) Trajectories of Perinatal Depressive and Anxiety Symptoms in a Community Cohort. The evidence on trajectories of perinatal depression is mostly based on studies composed of women at high risk for poor mental health. Research on maternal anxiety trajectories is also scarce. Using a large community cohort, the All Our Babies study, in Alberta, Canada, we examined trajectories of perinatal depressive and anxiety symptoms and compared characteristics of women across trajectories.Anxiety

2016 Journal of Clinical Psychiatry

50. Bright light therapy in pregnant women with major depressive disorder: study protocol for a randomized, double-blind, controlled clinical trial. Full Text available with Trip Pro

of antepartum depression is necessary. Both psychotherapy and antidepressant medication, first choice treatments in a non-pregnant population, have limitations in treating depression during pregnancy. Therefore, it is urgent and relevant to investigate alternative treatments for antepartum depression. Bright light therapy (BLT) is a promising treatment for pregnant women with depressive disorder, for it combines direct availability, sufficient efficacy, low costs and high safety, taking the safety (...) , in maternal sleep quality and gestational age, birth weight, infant behaviour, infant cortisol exposure and infant cortisol stress response.If BLT reduces depressive symptoms in pregnant women, it will provide a safe, cheap, non-pharmacological and efficacious alternative treatment for psychotherapy and antidepressant medication in treating antepartum depression, without any expected adverse reactions for the unborn child.Netherlands Trial Register NTR5476 . Registered 5 November 2015.

2016 BMC Psychiatry Controlled trial quality: predicted high

51. Implementation of universal screening for depression during pregnancy: Feasibility and impact on obstetric care. (Abstract)

in prenatal care at the participating sites, 8840 women (98%) were screened for depression antepartum, and 7780 women (86%) were screened postpartum. A total of 576 women (6.5%) screened positive for probable depression; of these, 69% screened positive antepartum, and 31% screened positive postpartum (P < .01). All women who screened positive were referred for an evaluation by a mental health professional; 79% of the women were evaluated, which was more common antepartum than postpartum (83% vs 71%; P (...) with an antidepressant medication, which was more frequent during the postpartum period than during the antepartum period (54% vs 28%; P < .001). After adjustment for maternal age, parity, race, and household income, women who screened positive antepartum were significantly more likely to link to mental health services compared with women who screened positive postpartum (adjusted odds ratio, 2.09; 95% CI, 1.24-3.24; P = .001).This study demonstrates the feasibility of universal depression screening during both

2016 American Journal of Obstetrics and Gynecology

52. Screening for depression in pregnant women from Côte d׳Ivoire and Ghana: Psychometric properties of the Patient Health Questionnaire-9. (Abstract)

Screening for depression in pregnant women from Côte d׳Ivoire and Ghana: Psychometric properties of the Patient Health Questionnaire-9. Major depression in antepartum women is a considerable health problem. This article aims at exploring the psychometric properties of the 9-item Patient Health Questionnaire (PHQ-9) in West African pregnant women.In a cross-sectional survey, the PHQ-9 was administered to n=639 Ivorian and n=389 Ghanaian women in their last trimester of pregnancy (gestational age (...) disability.Both samples were quite homogenous regarding residence in urban areas and gestational age.In our samples of African pregnant women, depression measured with the PHQ-9 does not appear as an entirely homogenous construct. However, the use of the sum score of the PHQ-9 is appropriate for depression screening purposes.Copyright © 2015 Elsevier B.V. All rights reserved.

2015 Journal of Affective Disorders

53. Disagreement between Therapist Raters and Independent Evaluators in a Controlled Clinical Trial of Interpersonal Psychotherapy for Depressed Pregnant Women. (Abstract)

, controlled clinical treatment trial compared interpersonal psychotherapy for antepartum depression (IPT-P) with a parenting education program (PEP) provided to a control group. An outpatient sample of 142 women who met DSM-IV criteria for major depressive disorder was randomly assigned to IPT-P or PEP between September 2005 and May 2011. Only 110 cases were assessed at baseline and had at least 1 other treatment week of paired ratings by a therapist and a blinded independent evaluator (IE). The 17-item (...) Disagreement between Therapist Raters and Independent Evaluators in a Controlled Clinical Trial of Interpersonal Psychotherapy for Depressed Pregnant Women. The randomized controlled trial in which both the patient and the treating clinician are kept blinded to the treatment is the "gold standard" for treatment research assignment. However, in psychotherapy research, evaluations can only be single blind; thus, such studies are inherently more limited.A 12-week, bilingual, parallel-design

2015 Journal of psychiatric practice Controlled trial quality: uncertain

54. Suicide Risk Among Perinatal Women Who Report Thoughts of Self-Harm on Depression Screens. Full Text available with Trip Pro

campuses. Suicidal ideation on the Edinburgh Postnatal Depression Scale and prediction of suicide risk were examined through multivariable modeling and qualitative analysis of clinical assessments.Among 22,118 Edinburgh Postnatal Depression Scale questionnaires studied, suicidal ideation was reported on 842 (3.8%, 95% confidence interval [CI] 3.5-4.1%) and was positively associated with younger maternal age (antepartum mean age 30.9 compared with 31.9 years, P=.001), unpartnered relationship status (...) Suicide Risk Among Perinatal Women Who Report Thoughts of Self-Harm on Depression Screens. To estimate the incidence and clinical significance of suicidal ideation revealed during perinatal depression screening and estimate the associated suicide risk.Retrospective cohort study of women completing the Edinburgh Postnatal Depression Scale at 24-28 weeks of gestation and 6 weeks postpartum through a suburban integrated health system with approximately 5,000 annual deliveries on two hospital

2015 Obstetrics and Gynecology

55. Maternal depression is associated with DNA methylation changes in cord blood T lymphocytes and adult hippocampi Full Text available with Trip Pro

lymphocytes isolated from 38 antepartum maternal and 44 neonatal cord blood samples were analyzed using Illumina Methylation 450 K microarrays. Previously obtained methylation data sets using methylated DNA immunoprecipitation and array-hybridization of 62 postmortem hippocampal samples of adult males were re-analyzed to test associations with history of maternal depression. We found 145 (false discovery rate (FDR) q<0.05) and 2520 (FDR q<0.1) differentially methylated CG-sites in cord blood T lymphocytes (...) of neonates from the maternal depression group as compared with the control group. However, no significant DNA methylation differences were detected in the antepartum maternal T lymphocytes of our preliminary data set. We also detected 294 differentially methylated probes (FDR q<0.1) in hippocampal samples associated with history of maternal depression. We observed a significant overlap (P=0.002) of 33 genes with changes in DNA methylation in T lymphocytes of neonates and brains of adult offspring. Many

2015 Translational psychiatry

56. Breastfeeding and postpartum depression Full Text available with Trip Pro

to the early 1990s. How such factors shape breastfeeding intentions and beliefs is not really considered in the paper, so although the sample is from the United Kingdom, how well it relates to the UK population today is unclear. Data have been analysed from approximately 8,000 women completing the Edinburgh Postnatal Depression Scale at two antepartum and four postpartum time points. 86% of the sample were married and 45% were carrying their first child. Women were asked at an unspecified point during (...) Breastfeeding and postpartum depression Breastfeeding and postpartum depression Search National Elf Service Search National Elf Service » » » » Breastfeeding and postpartum depression Oct 28 2014 Posted by Breastfeeding never seems to be far from the attention of the press, be it the medical journals, the tabloids, the public health printers or those of the placard-wielding persuasion. Issues of freedom of choice versus beliefs about ‘what’s best for baby and for mum’ seem to be perennial

2014 The Mental Elf

57. A randomized, double-blind, placebo-controlled study of light therapy for antepartum depression. Full Text available with Trip Pro

A randomized, double-blind, placebo-controlled study of light therapy for antepartum depression. Affective disorder during pregnancy is a common condition requiring careful judgment to treat the depression while minimizing risk to the fetus. Following up on promising pilot trials, we studied the efficacy of light therapy.Twenty-seven pregnant women with nonseasonal major depressive disorder according to DSM-IV (outpatients, university polyclinic) were randomly assigned to 7,000 lux fluorescent (...) bright white or 70 lux dim red (placebo) light administered at home in the morning upon awakening for 1 h/d in a 5-week double-blind trial carried out between October 2004 and October 2008. Clinical state was monitored weekly with the 29-item Structured Interview Guide for the Hamilton Depression Rating Scale (HDRS) with Atypical Depression Supplement (SIGH-ADS). Changes of rating scale scores over time were analyzed with the general linear model. Differences from baseline of SIGH-ADS and 17-item

2011 Journal of Clinical Psychiatry Controlled trial quality: predicted high

58. Using the Patient Health Questionnaire (PHQ-9) and the Edinburgh Postnatal Depression Scale (EPDS) to Assess Suicidal Ideation among Pregnant Women in Lima, Peru Full Text available with Trip Pro

Using the Patient Health Questionnaire (PHQ-9) and the Edinburgh Postnatal Depression Scale (EPDS) to Assess Suicidal Ideation among Pregnant Women in Lima, Peru We sought to examine the concordance of two suicidal ideation items from the Patient Health Questionnaire-9 (PHQ-9) and the Edinburgh Postnatal Depression Scale (EPDS), to evaluate the prevalence of suicidal ideation among pregnant women, and to assess the co-occurrence of suicidal ideation with antepartum depressive symptoms. A cross (...) -9, 51 % of participants with suicidal ideation had probable depression. In prenatal care clinics, screening for suicidal ideation is needed for women with and without depressive symptoms. Future studies are needed to identify additional predictors of antepartum suicidality, determine the appropriate duration of reporting period for suicidal ideation screening, and assess the percentage of individuals with positive responses to the two suicidal ideation items at high risk of planning

2014 Archives of women's mental health

59. Prophylactic Use of Postpartum Sertraline to Prevent Postpartum Depression

in the third trimester of the pregnancy to rule-out current depressive illness. If there was no evidence of depression at the antepartum evaluation, patients delivering a liveborn singleton fetus at 34 0/7 weeks or greater would be re-evaluated prior to discharge and, if scoring Depression scale, would then be enrolled in the trial. Patients would be assigned to either sertraline 50 mg daily or identical appearing placebo for 12 weeks. Group allocation would be determined (...) gestation No current clinical evidence of depression Able to read and understand written English language Exclusion Criteria: Multiple gestation Delivery prior to 34 weeks Delivery outside of Cooper University Hospital Major fetal anomaly or fetal demise Current use of antidepressants Evidence of active depression at antepartum evaluation Edinburgh Postpartum Depression scale of >12 prior to discharge from the hospital Maternal age < 18 years Infant in Neonatal Intensive Care Unit (NICU) at time

2014 Clinical Trials

60. Mode of Delivery and Postpartum Depression: The Role of Patient Preferences. (Abstract)

was measured by the standard gamble metric. Depression was assessed antepartum and at 8-10 weeks and 6-8 months after delivery by using the Patient Health Questionnaire (PHQ-9). The primary outcome was PHQ-9 score at 8-10 weeks after delivery. We used multivariable regression analysis to assess the effect of strength of preference for vaginal delivery and delivery mode undergone on postpartum depression.Of 160 participants, 33.1% were nulliparous, and 30.6% had a previous cesarean delivery. Most (...) cesarean delivery (P = .027) but not among women who underwent vaginal delivery (P = .761). The interaction between delivery mode and vaginal delivery preference score was no longer significant at 6-8 months after delivery.Women who have a strong antepartum preference for vaginal delivery and deliver by cesarean may be at increased risk for depression in the early postpartum period.Published by Elsevier Inc.

2014 American Journal of Obstetrics and Gynecology

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