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Antepartum Depression

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321. A randomized trial of intrapartum electronic fetal heart rate monitoring versus intermittent auscultation. (PubMed)

in terms of maternal age, gravidity, parity, gestational age, and number of antepartum high-risk factors. More patients monitored electronically received oxytocin for either augmentation (52.4 versus 38.1%; P = .0001) or induction (15.6 versus 7%; P = .0001). The length of labor was longer in the EFM group (first stage 6.1 +/- 4.3 versus 5.5 +/- 3.7 hours; P = .006; second stage 29.4 +/- 18.6 versus 26.9 +/- 16.9 minutes; P = .01). There was a higher incidence of nonreassuring fetal heart rate patterns (...) neonatal complications. Two neonatal deaths occurred in the EFM group and nine perinatal deaths in the auscultation group (two intrapartum and seven neonatal deaths). The perinatal mortality rates were 2.6 per 1000 and 13 per 1000 total births, respectively (P = .04). The two deaths in the EFM group and three of the neonatal deaths in the auscultation group may not have been prevented by intrapartum monitoring; however, four neonatal deaths from the auscultation group occurred in depressed (5-minute

1993 Obstetrics and Gynecology Controlled trial quality: uncertain

322. Psychosocial and psychological interventions for treating antenatal depression. (PubMed)

fetal and infant health outcomes, non-pharmacological treatment options are needed.The primary objective of this review is to assess the effects, on mothers and their families, of psychosocial and psychological interventions compared with usual antepartum care in the treatment of antenatal depression.We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (September 2006), the Cochrane Collaboration Depression Anxiety and Neurosis Group's Trials Registers (CCDANCTR-Studies (...) Psychosocial and psychological interventions for treating antenatal depression. Although pregnancy was once thought of as a time of emotional wellbeing for many women, conferring 'protection' against psychiatric disorders, a recent meta-analysis of 21 studies suggests the mean prevalence rate for depression across the antenatal period is 10.7%, ranging from 7.4% in the first trimester to a high of 12.8% in the second trimester. Due to maternal treatment preferences and potential concerns about

2007 Cochrane

323. Psychosocial and psychological interventions for prevention of postnatal depression: systematic review. (PubMed)

Psychosocial and psychological interventions for prevention of postnatal depression: systematic review. To assess the effects of psychosocial and psychological interventions compared with usual antepartum, intrapartum, or postpartum care on the risk of postnatal depression.Medline, Embase, CINAHL, Cochrane central register of controlled trials, Cochrane pregnancy and childbirth group trials register, Cochrane depression, anxiety, and neurosis trials register, secondary references and review (...) articles, and experts in the field.All published and unpublished randomised controlled trials of preventive psychosocial or psychological interventions in which the primary or secondary aim was a reduction in the risk of postnatal depression. All trials recruited pregnant women or new mothers less than six weeks postpartum. Eligible studies were abstracted, assessed for methodological quality, and pooled with relative risk for categorical data and weighted mean difference for continuous data.Fifteen

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2005 BMJ

324. Psychosocial and psychological interventions for preventing postpartum depression. (PubMed)

and the early postpartum period to prevent postpartum depression.Primary: to assess the effect of diverse psychosocial and psychological interventions compared with usual antepartum, intrapartum, or postpartum care to reduce the risk of developing postpartum depression. Secondary: to examine (1) the effectiveness of specific types of psychosocial and psychological interventions, (2) the effectiveness of individual versus group-based interventions, (3) the effects of intervention onset and duration, and (4 (...) Psychosocial and psychological interventions for preventing postpartum depression. The cause of postpartum depression remains unclear, with extensive research suggesting a multi-factorial aetiology. However, epidemiological studies and meta-analyses of predictive studies have consistently demonstrated the importance of psychosocial and psychological variables. While interventions based on these variables may be effective treatment strategies, theoretically they may also be used in pregnancy

2004 Cochrane database of systematic reviews (Online)

325. Screening depressive patients in pregnancy with the pregnancy mood profile. (PubMed)

Screening depressive patients in pregnancy with the pregnancy mood profile. Depression and related psychopathologies have turned into a modern bubonic plague. World Health Organization figures signal a worldwide epidemic, affecting > or = 15% of the population and probably > 22% of women of childbearing age. Antepartum and postpartum depression are medical conditions that negatively affect mother and child and that need to be detected as early as possible to avoid or limit the use (...) of pharmacologic treatments, with their possible side effects. The obstetrician should regularly test for depression with simple means from the very first moment of planning for a child and should use the test results for a pregnancy mood profile. This profile could assist in determining the risk of postpartum depression and serve as an early alert for postpartum suicide.

2003 Journal of Reproductive Medicine

326. Serotonin 1A receptor reductions in postpartum depression: a positron emission tomography study. (PubMed)

controls and nine postpartum depressed (PD) subjects with perinatal (antepartum or postpartum) depression onset. Of the nine PD subjects, five had unipolar depression, and four had bipolar disorder.None.5HT1A receptor BP.Age, time since delivery, and reproductive hormones did not differ between groups. Postsynaptic 5HT1A receptor binding in postpartum depression was reduced 20%-28% relative to controls, with most significant reductions in anterior cingulate and mesiotemporal cortices.Postsynaptic 5HT1A (...) Serotonin 1A receptor reductions in postpartum depression: a positron emission tomography study. To measure brain serotonin-1A (5HT1A) receptor binding potential (BP) in healthy and depressed postpartum women.5HT1A receptor BP was measured with positron emission tomography by using [(11)C]WAY100635 a single time. Multivariate analysis of variance was used to determine depression effects on 5HT1A receptor BP in relevant brain regions.An academic research environment.Seven postpartum healthy

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2007 Fertility and Sterility

327. Universal perinatal depression screening in an Academic Medical Center. (PubMed)

Universal perinatal depression screening in an Academic Medical Center. To develop a department-based program to identify and treat women at risk for perinatal depression.Private and employed physician groups were engaged to conduct antepartum maternal depression screening using the Edinburgh Postnatal Depression Scale. A comprehensive program was established to ensure that patients identified as being at risk would receive appropriate care. The program 1) developed a network of existing (...) community mental health providers to accommodate screen-positive referrals, 2) created a 24/7 hotline staffed by mental health workers to respond to urgent/emergent patient needs, 3) provided nursing and physician education via a comprehensive curriculum on perinatal depression, and 4) facilitated outpatient depression screening that included a centralized scoring and referral system.A total of 4,322 women completed 4,558 screens during the initial 24 months (June 2003-May 2005). Although initial uptake

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2006 Obstetrics and Gynecology

328. Controlled clinical trial of interpersonal psychotherapy versus parenting education program for depressed pregnant women. (PubMed)

regarding this topic, to the authors' knowledge. APA has identified treatment of depression during pregnancy as a priority for clinical guidelines.A 16-week bilingual controlled clinical trial compared a group receiving interpersonal psychotherapy for antepartum depression to a parenting education control program. Fifty outpatient antepartum women who met DSM-IV criteria for major depressive disorder were randomly assigned to interpersonal psychotherapy or a didactic parenting education program. Thirty (...) criteria were met in 60% of the women treated with interpersonal psychotherapy, according to a CGI score of < or = 2. In addition, there was a significant correlation between maternal mood and mother-infant interaction.Interpersonal psychotherapy is an effective method of antidepressant treatment during pregnancy and should be a first-line treatment in the hierarchy of treatment for antepartum depression.

2003 American Journal of Psychiatry Controlled trial quality: uncertain

329. Interpersonal Psychotherapy Adapted for the Group Setting in the Treatment of Postpartum Depression (PubMed)

Interpersonal Psychotherapy Adapted for the Group Setting in the Treatment of Postpartum Depression Interpersonal psychotherapy (IPT) has demonstrated efficacy in the individual treatment of antepartum and postpartum depression. The current investigation extends prior work by examining the efficacy of a group IPT approach for the treatment of postpartum depression. Depression scores of 17 women diagnosed with postpartum depressive disorder (DSM-IV criteria) decreased significantly from pre (...) - to post-treatment. Follow-up assessments at 6 months revealed continuation of the treatment effect. Results indicate that IPT adapted for a group model has positive implications for the treatment of postpartum depression, demonstrating both short-term and longer-term effects in the reduction of depressive symptomatology. Study limitations include the small sample size, absence of control group, possible bias in therapist's assessments, and lack of monitoring adherence, which may have jeopardized

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2001 The Journal of psychotherapy practice and research

330. Antepartum Chronic Epidural Therapy (ACET) to Improve Blood Flow to the Uterus, Placenta and Baby in Pre-Eclampsia and Intrauterine Growth Restriction

Antepartum Chronic Epidural Therapy (ACET) to Improve Blood Flow to the Uterus, Placenta and Baby in Pre-Eclampsia and Intrauterine Growth Restriction Antepartum Chronic Epidural Therapy (ACET) to Improve Blood Flow to the Uterus, Placenta and Baby in Pre-Eclampsia and Intrauterine Growth Restriction - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved (...) Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Antepartum Chronic Epidural Therapy (ACET) to Improve Blood Flow to the Uterus, Placenta and Baby in Pre-Eclampsia and Intrauterine Growth Restriction The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our

2005 Clinical Trials

331. Antepartum Study on Use of Interpersonal Psychotherapy at 3 New York City Site

of antepartum depression (APD) increases twofold in women with poor social supports, low socioeconomic status (SES), and negative life events. APD may cause low birth weight, premature labor, and eclampsia. APD is also one of the best predictors of postpartum depression (PPD), which in turn may lead to impaired emotional and cognitive development of the infant. Therefore, early treatment of APD is important for the well-being of both the woman and her infant. Forms of psychotherapy have been successful (...) Behavioral: Parenting education program (PEP) PEP will include 45-minute weekly sessions for 12 weeks. During sessions, participants will learn about the stages of pregnancy, childbirth, and early infant development. Other Name: PEP Outcome Measures Go to Primary Outcome Measures : Depression [ Time Frame: Measured weekly for 12 weeks antepartum and Weeks 4, 8, 12, 16, and 24 postpartum ] Secondary Outcome Measures : Mother-infant bonding [ Time Frame: Measured at Weeks 4, 8, 12, 16, and 24 postpartum

2005 Clinical Trials

332. From antepartum to postpartum: a prospective study on the prevalence of peripartum depression in a semiurban Turkish community. (PubMed)

From antepartum to postpartum: a prospective study on the prevalence of peripartum depression in a semiurban Turkish community. To examine the prevalence of depression in the last trimester of pregnancy and within the first 6 months postpartum, to determine whether there is an association between antepartum and postpartum depression and to investigate the risk factors prospectively in a cohort of Turkish women.In a prospective, community-based, cohort study, 125 women who expected to give birth (...) during the first 6 months of 2002 (January 1, 2002-June 30, 2002) were included. Depression was measured at 36-38 weeks antepartum and then again at 5-8, 10-14 and 20-26 weeks postpartum using the Edinburgh Postnatal Depression Scale. A questionnaire that was devised to collect data on sociodemographic and clinical information on the women was applied.The prevalence of depression was highest in pregnancy (21.6%) and declined gradually in the follow-up period (respectively, 16.8%, 14.4% and 9.6

2006 Journal of Reproductive Medicine

333. Health, sociodemographic data, and pregnancy outcome in women with antepartum depressive symptoms. (PubMed)

Health, sociodemographic data, and pregnancy outcome in women with antepartum depressive symptoms. To study whether women with antepartum depression have an increased risk for adverse perinatal outcome.From a sample of 1,489 women, an index group (n = 259) of all women with depressive symptoms on the Edinburgh Postnatal Depression Scale in gestational week 35-36 was selected. Two hundred fifty-nine women with no depressive symptoms on the Edinburgh Postnatal Depression Scale antepartum (...) or postpartum were randomly chosen as the reference group. Medical, gynecologic, and obstetric history, socioeconomic status, pregnancy, and perinatal data were collected from standardized medical records for all women.Women with antepartum depressive symptoms were more often multiparas with a history of earlier obstetric complications. Complications during the present pregnancy were more frequent in the antepartum-depressed group of women. There were no differences concerning outcome of delivery

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2004 Obstetrics and Gynecology

334. Randomized clinical trial of bright light therapy for antepartum depression: preliminary findings. (PubMed)

Randomized clinical trial of bright light therapy for antepartum depression: preliminary findings. Bright light therapy was shown to be a promising treatment for depression during pregnancy in a recent open-label study. In an extension of this work, we report findings from a double-blind placebo-controlled pilot study.Ten pregnant women with DSM-IV major depressive disorder were randomly assigned from April 2000 to January 2002 to a 5-week clinical trial with either a 7000 lux (active) or 500 (...) trial, it was not statistically significant. However, in the longer 10-week trial, the presence of active versus placebo light produced a clear treatment effect (p =.001) with an effect size (0.43) similar to that seen in antidepressant drug trials. Successful treatment with bright light was associated with phase advances of the melatonin rhythm.These findings provide additional evidence for an active effect of bright light therapy for antepartum depression and underscore the need for an expanded

2004 Journal of Clinical Psychiatry Controlled trial quality: uncertain

335. An open trial of morning light therapy for treatment of antepartum depression. (PubMed)

An open trial of morning light therapy for treatment of antepartum depression. About 5% of pregnant women meet criteria for major depression. No pharmacotherapy is specifically approved for antepartum depression; novel treatment approaches may be welcome. The authors explored the use of morning bright light therapy for antepartum depression.An open trial of bright light therapy in an A-B-A design was conducted for 3-5 weeks in 16 pregnant patients with major depression. The Hamilton Depression (...) Rating Scale, Seasonal Affective Disorders Version, was administered to assess changes in mood. A follow-up questionnaire was used to assess outcome after delivery.After 3 weeks of treatment, mean depression ratings improved by 49%. Benefits were seen through 5 weeks of treatment. There was no evidence of adverse effects of light therapy on pregnancy.These data provide evidence that morning light therapy has an antidepressant effect during pregnancy. A randomized controlled trial is warranted to test

2002 American Journal of Psychiatry

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