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Anisometropia

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1. Rapid neuroadaptation to surgically-induced aniseikonia in a 17-year-old patient with high preoperative anisometropia: A case report (PubMed)

Rapid neuroadaptation to surgically-induced aniseikonia in a 17-year-old patient with high preoperative anisometropia: A case report To report a case of rapid neuroadaptation to surgically-induced aniseikonia in a 17-year-old with preoperative anisometropia of 9.5 D.A 17-year-old female with a history of retinopathy of prematurity (ROP) and progressive high myopia with resulting anisometropia secondary to conventional laser photocoagulation in her right eye was found to have diplopia after (...) undergoing cataract surgery in that eye. Other etiologies of diplopia were ruled out and reversal of anisometropia remained the only viable diagnosis. Her diplopia fully resolved without intervention within one month of the surgery.In cases of neuroadaptation to long standing anisometropia, even if that anisometropia develops in infancy, abrupt reversal following surgery can be surprisingly well tolerated.

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2018 American journal of ophthalmology case reports

2. Graft-size selection and anisometropia reduction in penetrating keratoplasty (PKP). (PubMed)

Graft-size selection and anisometropia reduction in penetrating keratoplasty (PKP). To compare the amount of myopia induced by same-size donor-to-host penetrating keratoplasty with that of the amount of myopia induced by over-sized donor-to-host penetrating keratoplasty.Tertiary referral academic center.Retrospective cohort study.Charts from patients who underwent penetrating keratoplasty by the same technique at Bascom Palmer Eye Institute between Nov 1, 2002, and January 1, 2006, were (...) spherical equivalent (SE). The same-size donor graft was used when the intended final refractive target was less than -1.00 diopters SE. The selection of donor graft size was entirely based upon clinical parameters, meaning that the intended final refractive target was determined per each patient's fellow eye refraction, with the intention of reducing anisometropia. All patients received postoperative refraction and corneal topography. These measurements were performed at 6-8 weeks when the initial

2019 PLoS ONE

3. Prevalence and association of refractive anisometropia with near work habits among young schoolchildren: The evidence from a population-based study. (PubMed)

Prevalence and association of refractive anisometropia with near work habits among young schoolchildren: The evidence from a population-based study. Lifestyle behaviour may play a role in refractive error among children, but the association between near work habits and refractive anisometropia remains unclear.We estimated the prevalence of refractive anisometropia and examined its association with near work activities among 23,114 children in the Myopia Investigation Study in Taipei who were (...) grade 2 elementary school students at baseline in 2013 and 2014. Baseline data on demographics, medical history, parental history and near work habits were collected by parent-administered questionnaire survey. Refractive status was determined by cycloplegic autorefraction. Refractive anisometropia was defined as the spherical equivalent difference ≥ 1.0 diopter between eyes.The prevalence of refractive anisometropia was 5.3% (95% confidence interval [CI], 5.0% to 5.6%). The prevalence and severity

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2017 PLoS ONE

4. Mirror image hypermetropic anisometropia in a pair of monozygotic twins. (PubMed)

Mirror image hypermetropic anisometropia in a pair of monozygotic twins. In monozygotic twins two embryos are formed from a single fertilized egg. In "mirror image twins" identical siblings have reverse asymmetric features in the right and left sides of the body. We report the case of twins with mirror-image hypermetropic anisometropia. They were referred to an ophthalmologist at the age of 3.5 years for amblyopia. Cycloplegic refraction of twin 1 was +1.00 in the right eye and +4.50 -0.75 ×180

2018 JAAPOS - Journal of the American Association for Pediatric Ophthalmology and Strabismus

5. ASYMMETRIC DIABETIC RETINOPATHY PROGRESSION IN PATIENTS WITH AXIAL ANISOMETROPIA. (PubMed)

ASYMMETRIC DIABETIC RETINOPATHY PROGRESSION IN PATIENTS WITH AXIAL ANISOMETROPIA. To investigate the differences in the progression of diabetic retinopathy (DR) in both eyes of patients with axial anisometropia.A retrospective review was conducted on diabetic patients who had different axial lengths (difference greater than 1 mm) in each eye. The primary objective of this study was to analyze the differences in the progression of DR in both eyes of patients with axial anisometropia. Fundus (...) ).In patients with axial anisometropia, the longer eye had a lower degree of DR progression than the shorter eye. This result showed that elongation of the axial length had a protective effect against the progression of DR without individual confounding factors.

2018 Retina

6. Photorefractive Keratectomy for Severe Anisometropia and Isoametropia Associated With Amblyopia

Photorefractive Keratectomy for Severe Anisometropia and Isoametropia Associated With Amblyopia Photorefractive Keratectomy for Severe Anisometropia and Isoametropia Associated With Amblyopia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Photorefractive Keratectomy for Severe Anisometropia and Isoametropia Associated With Amblyopia The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03610997 Recruitment Status : Recruiting

2018 Clinical Trials

7. Missense mutation in SLIT2 associated with congenital myopia, anisometropia, connective tissue abnormalities, and obesity (PubMed)

Missense mutation in SLIT2 associated with congenital myopia, anisometropia, connective tissue abnormalities, and obesity SLIT2 is a protein ligand for the Roundabout (ROBO) receptor and was found to play a major role in repulsive midline axon guidance in central nervous system development. Based on studies utilizing knockout models, it has been postulated that SLIT2 is important for preventing inappropriate axonal routing during mammalian optic chiasm development.Case report.Here, we report (...) a case of congenital myopia, anisometropia, and obesity in a patient with a SLIT2 point mutation. Examination of the patient's skin biopsy revealed abnormalities in elastin and collagen fibrils that suggest an underlying connective tissue disorder. Structural modeling placed the novel mutation (p.D1407G) in the EGF-like domain 8 and was predicted to affect interactions with SLIT2 binding partners.To the authors' knowledge, this is the first report of a SLIT2 variant in the context of these ocular

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2018 Orphanet journal of rare diseases

8. Comparison of perceptual eye positions among patients with different degrees of anisometropia. (PubMed)

Comparison of perceptual eye positions among patients with different degrees of anisometropia. The aim of this study is to compare the perceptual eye positions (PEPs) among patients with different degrees of anisometropia.A total of 157 patients were recruited into this retrospective study. A detailed ophthalmic examination was conducted on each patient. The degree of refractive errors in the presence of astigmatism was converted into the degree of spherical equivalent (SE). Patients were (...) divided into 3 groups according to the interocular SE difference: severe anisometropia group with interocular SE difference ≥2.50D, mild anisometropia group with interocular SE difference ≥1.00D and <2.50D, and non-anisometropia group with interocular SE difference <1.00D. The vertical and horizontal PEP were measured by a computer-controlled perceptual examination evaluation system. The results obtained from the 3 groups were compared and analyzed.A total of 157 patients were enrolled including 32

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2017 Medicine

9. Exome sequencing identifies a novel UNC5D mutation in a severe myopic anisometropia family: A case report. (PubMed)

Exome sequencing identifies a novel UNC5D mutation in a severe myopic anisometropia family: A case report. Severe myopic anisometropia has been identified to have heritability, but the pathogenesis of anisometropia still remains obscure.Here, we presented a Chinese severe myopic anisometropia family with 5 members affected. Though using the exome sequencing, we identified a novel mutation in the UNC5D gene (c.1297C>T, p.R433C), which was predicted to have a damage effect on the protein function (...) and kept highly conserved throughout evolution across species. As previously described, the UNC5D gene belongs to the UNC5 protein family and may have functions to regulate neuronal migration, axon guidance, and cell survival. The expression of UNC5D was also co-located at the visual areas of the mouse cortical regions at early postnatal ages.Our data provide the first evidence for involvement of UNC5D gene in the severe myopic anisometropia.

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2017 Medicine

10. Measurement of peripapillary retinal nerve fiber layer thickness and macular thickness in anisometropia using spectral domain optical coherence tomography: a prospective study (PubMed)

Measurement of peripapillary retinal nerve fiber layer thickness and macular thickness in anisometropia using spectral domain optical coherence tomography: a prospective study To study whether there is a difference in central macular thickness (CMT) and peripapillary retinal nerve fiber layer (RNFL) thickness between the two eyes of individuals having anisometropia >1 diopter (D) using spectral domain optical coherence tomography (OCT).One hundred and one subjects, 31 with myopic anisometropia (...) , 28 with astigmatic anisometropia, and 42 with hypermetropic anisometropia, were enrolled in the study. After informed consent, detailed ophthalmological examination was performed for every patient including cycloplegic refraction, best corrected visual acuity, slit lamp, and fundus examination. After routine ophthalmic examination peripapillary RNFL and CMT were measured using spectral domain OCT and the values of the two eyes were compared in the three types of anisometropia. Axial length

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2017 Clinical ophthalmology (Auckland, N.Z.)

11. A Prospective Study of Anterior Segment Ocular Parameters in Anisometropia (PubMed)

A Prospective Study of Anterior Segment Ocular Parameters in Anisometropia The aim of this study was to investigate the differences in anterior segment ocular parameters in anisometropia >1 D.This study included 202 eyes of 101 subjects ranging from 10 to 40 years of age with anisometropia of 1 D or more. The subjects were divided into groups according to anisomyopia, anisoastigmatism, and anisohypermetropia. After providing informed consent, each patient underwent a detailed ophthalmological (...) anisomyopia; 42 had anisohypermetropia; and 28 had anisoastigmatism. A predisposition toward greater myopia in right eyes was noted in anisomyopia (24 of 31 subjects, 77%). The inter-ocular acuity difference was significant in all three groups (p < 0.01). As the degree of anisometropia increased, there was significant positive correlation in the difference in AL in myopes (r = 0.863, p < 0.01) and hypermetropes (r = 0.669, p < 0.01) and the difference in corneal curvature in anisoastigmatism (r = 0.564, p

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2017 Korean journal of ophthalmology : KJO

12. Observations on the Relationship between Anisometropia, Amblyopia and Strabismus (PubMed)

Observations on the Relationship between Anisometropia, Amblyopia and Strabismus We investigated the potential causal relationships between anisometropia, amblyopia and strabismus, specifically to determine whether either amblyopia or strabismus interfered with emmetropization. We analyzed data from non-human primates that were relevant to the co-existence of anisometropia, amblyopia and strabismus in children. We relied on interocular comparisons of spatial vision and refractive development (...) in animals reared with 1) monocular form deprivation; 2) anisometropia optically imposed by either contact lenses or spectacle lenses; 3) organic amblyopia produced by laser ablation of the fovea; and 4) strabismus that was either optically imposed with prisms or produced by either surgical or pharmacological manipulation of the extraocular muscles. Hyperopic anisometropia imposed early in life produced amblyopia in a dose-dependent manner. However, when potential methodological confounds were taken

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2017 Vision Research

13. Retina and Optic Disc Characteristics in Amblyopic and Non-amblyopic Eyes of Patients with Myopic or Hyperopic Anisometropia (PubMed)

Retina and Optic Disc Characteristics in Amblyopic and Non-amblyopic Eyes of Patients with Myopic or Hyperopic Anisometropia To compare retinal and optic disc characteristics between amblyopic and non-amblyopic eyes in patients with myopic and hyperopic anisometropia measured with optical coherence tomography (OCT).Patients with myopic (25 patients: 17 female, 8 male; median age 27 years, range 16-40 years) and hyperopic (31 patients: 19 female, 12 male; median age 20 years, range 13-41 years

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2017 Turkish Journal of Ophthalmology

14. Visual outcome in 879 children treated for strabismus: insufficient accommodation and vision deprivation, deficient emmetropisation and anisometropia. (PubMed)

Visual outcome in 879 children treated for strabismus: insufficient accommodation and vision deprivation, deficient emmetropisation and anisometropia. To identify the effect of infant hypermetropia on residual amblyopia in children remaining after treatment.879 strabismic children had cycloplegic retinoscopy at the age of 6 months and later when strabismus was diagnosed. A total of 26 hypermetropes consistently wore glasses from the age of 6 months, and 305 other hypermetropes had (...) their accommodation periodically assessed by dynamic retinoscopy before strabismus was diagnosed. The relation between the last known visual acuity after treatment and all other clinical findings was analysed using t-tests and regression analysis.Vision less than 6/12 in nonfixing eyes was associated with infantile hypermetropia > +5.0D, and in rare instances in excess of -3.0D of myopia. In hypermetropes only, anisometropia was associated with worse amblyopia. Astigmatism was associated with myopia and low

2017 Strabismus

15. Anisometropia at Age 5 Years after Unilateral Intraocular Lens Implantation During Infancy in the Infant Aphakia Treatment Study (IATS). (PubMed)

Anisometropia at Age 5 Years after Unilateral Intraocular Lens Implantation During Infancy in the Infant Aphakia Treatment Study (IATS). To report the prevalence of anisometropia at age 5 years after unilateral intraocular lens (IOL) implantation in infants.Prospective randomized clinical trial.Fifty-seven infants in the Infant Aphakia Treatment Study (IATS) with a unilateral cataract were randomized to IOL implantation with an initial targeted postoperative refractive error of either +8 (...) diopters (D) (infants 28 to <48 days of age) or +6 D (infants 48-210 days of age). Anisometropia was calculated at age 5 years. Six patients were excluded from the analyses.Median age at cataract surgery was 2.2 months (interquartile range [IQR], 1.2, 3.5 months). The mean age at the age 5 years follow-up visit was 5.0 ± 0.1 years (range, 4.9-5.4 years). The median refractive error at the age 5 years visit of the treated eyes was -2.25 D (IQR -5.13, +0.88 D) and of the fellow eyes +1.50 D (IQR +0.88

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2017 American Journal of Ophthalmology Controlled trial quality: uncertain

16. Anisometropia of spherical equivalent and astigmatism among myopes: a 23-year follow-up study of prevalence and changes from childhood to adulthood. (PubMed)

Anisometropia of spherical equivalent and astigmatism among myopes: a 23-year follow-up study of prevalence and changes from childhood to adulthood. To study anisometropia of spherical equivalent and astigmatism from the onset of myopia at school age to adulthood.A total of 240 myopic schoolchildren (mean age 10.9 years), with no previous spectacles, were recruited during 1983-1984 to a randomized 3-year clinical trial of bifocal treatment of myopia. Examinations with subjective cyclopedic (...) refraction were repeated 3 years later (follow-up 1) for 238 subjects and thereafter at the mean ages of 23.2 (follow-up 2) and 33.9 years (follow-up 3) for 178 and 134 subjects. After exclusions, the 102 subjects who attended all three follow-ups were included in the analyses. Corneal refractive power and astigmatism and anterior chamber depth was measured with Pentacam topography and axial length with IOL master at study end. Prevalence and changes in anisometropia of spherical equivalent (AnisoSE

2017 Acta ophthalmologica Controlled trial quality: uncertain

17. Ocular Myasthenia Gravis in Monozygotic Twins with Mirror-image Myopic Anisometropia (PubMed)

Ocular Myasthenia Gravis in Monozygotic Twins with Mirror-image Myopic Anisometropia 27729761 2017 03 22 2018 11 13 2092-9382 30 5 2016 Oct Korean journal of ophthalmology : KJO Korean J Ophthalmol Ocular Myasthenia Gravis in Monozygotic Twins with Mirror-image Myopic Anisometropia. 392-393 Chung Seung Ah SA Department of Ophthalmology, Ajou University School of Medicine, Suwon, Korea. Jang Seran S Department of Ophthalmology, Ajou University School of Medicine, Suwon, Korea. eng Case Reports (...) Letter Twin Study 2016 09 29 Korea (South) Korean J Ophthalmol 8804513 1011-8942 IM Adult Anisometropia diagnosis etiology physiopathology Diseases in Twins Female Humans Myasthenia Gravis complications diagnosis Myopia diagnosis etiology physiopathology Refraction, Ocular physiology Twins, Monozygotic No potential conflict of interest relevant to this article was reported. 2016 10 13 6 0 2016 10 13 6 0 2017 3 23 6 0 ppublish 27729761 10.3341/kjo.2016.30.5.392 PMC5057017 Acta Neurol Scand. 2009 Mar

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2016 Korean journal of ophthalmology : KJO

18. HIGH MYOPIA AND DIABETIC RETINOPATHY: A Contralateral Eye Study in Diabetic Patients With High Myopic Anisometropia. (PubMed)

HIGH MYOPIA AND DIABETIC RETINOPATHY: A Contralateral Eye Study in Diabetic Patients With High Myopic Anisometropia. To examine an association between high myopia and diabetic retinopathy (DR) in diabetic patients with high myopic anisometropia.A total of 116 white diabetic patients (232 eyes) with high myopia (spherical equivalent > -5.00 diopters, D) anisometropia (difference ≥ -6 D) were enrolled in this cross-sectional, contralateral eye study. The frequency of DR was compared between

2016 Retina

19. Longitudinal Development of Refractive Error in Children With Accommodative Esotropia: Onset, Amblyopia, and Anisometropia. (PubMed)

Longitudinal Development of Refractive Error in Children With Accommodative Esotropia: Onset, Amblyopia, and Anisometropia. We investigated longitudinal changes of refractive error in children with accommodative esotropia (ET) throughout the first 12 years of life, its dependence on age at onset of ET, and whether amblyopia or anisometropia are associated with defective emmetropization.Longitudinal refractive errors in children with accommodative ET were analyzed retrospectively. Eligibility

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2016 Investigative Ophthalmology & Visual Science

20. Prevalence and Associations of Anisometropia in Children. (PubMed)

Prevalence and Associations of Anisometropia in Children. To describe prevalence and associations of anisometropia in children.The cross-sectional school-based study included children aged 4 to 18 years.The study included 6025 (94.7%) of 6364 eligible children. Mean refractive anisometropia was 0.37 ± 0.57 diopters (median: 0.25 diopters; range: 0-7.88 diopters; prevalence [≥1 diopter]: 7.0% ± 0.3%). In multivariate analysis (regression coefficient r: 0.66), higher refractive anisometropia (...) (BCVA) (P < 0.001; β: 0.14; B: 1.83; 95% CI: 1.54-2.12), and lower stereoacuity (P < 0.001; β: 0.08; B: 0.31; 95% CI: 0.22-0.39). Refractive anisometropia showed a U-shaped correlation with refractive error. Higher anisomyopia was associated (r: 0.57) with older age (P = 0.001; β: 0.05; B: 0.006; 95% CI: 0.002-0.009), higher level of paternal education (P = 0.001; β: 0.01; B: 0.01; 95% CI: 0.01-0.02), more total time spent indoors reading or writing (P = 0.01; β: 0.03; B: 0.01; 95% CI: 0.00-0.01

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2016 Investigative Ophthalmology & Visual Science

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