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81. Is the RAPDx Pupillograph Able to Distinguish Between Glaucoma Subjects and Healthy Subjects?

angles on gonioscopy. Exclusion Criteria: Abnormal ocular motility that prevents binocular fixation (e.g. strabismus, nystagmus). Any condition preventing adequate visualization and examination of the pupil or optic nerve (e.g. dense corneal opacities or lens opacities). Active infection of the anterior or posterior segments of the eye. Any intraocular surgical or laser procedure within the previous 4 weeks. Any non-glaucomatous condition that may cause an RAPD, anisocoria or corectopia (ex. optic

2015 Clinical Trials

82. Multiple supratentorial intraparenchymal hemorrhage after posterior fossa surgery (PubMed)

multiple supratentorial hemorrhages. On the ninth day of the postoperative period, there was a sudden neurological worsening and anisocoria. A new brain CT was carried out [Figure 4], which demonstrated a diffuse cerebral edema. In spite of the introduction of clinical measures for the control of diffuse cerebral edema, the patient evolved to brain death.The principal measures in the management of these cases include early diagnosis, detection of possible coagulation disorders, continual monitoring

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2015 Surgical neurology international

83. Cervical lymphadenopathy secondary to rhabdomyosarcoma presenting as Horner syndrome in an infant. (PubMed)

Cervical lymphadenopathy secondary to rhabdomyosarcoma presenting as Horner syndrome in an infant. A 4-week-old boy with left ptosis, anisocoria, and a mass on his left hand was diagnosed with Horner syndrome. The diagnosis precipitated a work-up for a possible malignant etiology. Magnetic resonance imaging demonstrated enlarged left cervical and axillary lymph nodes. A biopsy of the hand lesion confirmed embryonal rhabdomyosarcoma, but a biopsy of the axillary lymph node was negative

2015 JAAPOS - Journal of the American Association for Pediatric Ophthalmology and Strabismus

84. Orbital apex syndrome: an unusual complication of herpes zoster ophthalmicus. (PubMed)

reported case of herpes zoster ophthalmicus complicated by orbital apex syndrome in a patient from Taiwan.A 78-year-old man initially presented with patchy erythema and herpetiform vesicles on his left forehead and upper eyelid. He subsequently developed left-sided ocular complications including reduced visual acuity, anisocoria, ptosis, and complete ophthalmoplegia. Orbital magnetic resonance imaging (MRI) was performed on day 6 of admission to search for signs of the common causes of orbital apex

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2015 BMC Infectious Diseases

85. Predictors for moderate to severe paediatric head injury derived from a surveillance registry in the emergency department. (PubMed)

those with moderate to severe head injury, they were more likely to be involved in road traffic accidents, have a history of difficult arousal, confusion or disorientation and a history of seizure. On physical examination, cases were more likely to have the presence of altered mental status, base of skull fracture, scalp hematoma and anisocoria. On multivariable analysis, the following 4 predictors remained statistically significant: Involvement in road traffic accident (p<0.001), difficult arousal

2015 Injury

86. Risk factors indicating the need for cranial CT scans in elderly patients with head trauma: an Austrian trial and comparison with the Canadian CT Head Rule. (PubMed)

of cranial CT: amnesia, GCS score, age > 65 years, loss of consciousness, nausea or vomiting, hypocoagulation, dementia or a history of ischemic stroke, anisocoria, skull fracture, and development of a focal neurological deficit. Patients requiring neurosurgical intervention were detected with a sensitivity of 90% and a specificity of 67% by using the authors' analysis. In contrast, the use of the CCHR in these patients detected the need for neurosurgical intervention with a sensitivity of only 80

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2014 Journal of Neurosurgery

87. Eye on Children: Acute Work-up for Pediatric Horner's Syndrome. Case Presentation and Review of the Literature. (PubMed)

Eye on Children: Acute Work-up for Pediatric Horner's Syndrome. Case Presentation and Review of the Literature. Ptosis and anisocoria in a child may be subtle indications of occult pathology, and making the observation acutely in the emergency department (ED) is important in guiding patient management and treatment. Emergency physicians must evaluate patients to exclude serious or life-threatening emergencies and ensure correct disposition of patients. Horner syndrome in children may

2014 Journal of Emergency Medicine

88. Presenting Symptoms of Pediatric Brain Tumors Diagnosed in the Emergency Department. (PubMed)

%), altered mental status (16.1%), back/neck pain (16.1%), papilledema (12.6%), facial asymmetry (10.3%), sensory deficits (8.0%), focal motor weakness (6.9%), cranial nerve 6 deficit (6.9%), ptosis (5.7%), macrocephaly (4.6%), asymptomatic (3.4%), and anisocoria (1.1%). The frequencies of location of headache were diffuse (24.1%), frontal (12.1%), occipital (8.6%), and parietal/temporal (6.9%). The severity was described as severe (37.9%) followed by moderate and mild (10.3% and 5.2%, respectively). Most

2014 Pediatric Emergency Care

89. Mutations in HAO1 encoding glycolate oxidase cause isolated glycolic aciduria. (PubMed)

of type 1 primary hyperoxaluria. The genetic basis of isolated glycolic aciduria is reported here.Two brothers, born to consanguineous healthy parents of Arab descent, were evaluated for psychomotor delay associated with triple-A-like syndrome (anisocoria, alacrima and achalasia). The proband showed markedly increased urinary glycolic acid excretion with normal excretion of oxalate, citrate and glycerate. Abdominal ultrasound showed normal-sized kidneys with normal echotexture. The genetic nature

2014 Journal of Medical Genetics

90. Small incision iris tumour biopsy using a cavernous sampling forceps. (PubMed)

diagnosis was achieved. Complications were limited to minute bleeding at the biopsy site and one case of relative pupil enlargement (anisocoria) without further refractive issues.Iris tumour biopsies can be successfully approached using a cavernous 23G intraocular forceps with a low risk for procedure-related complications. The conical interior design allows for removal of whole tissue pieces with minimal manipulative artefacts. An optional bimanual access through a second corneal incision and use

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2014 British Journal of Ophthalmology

91. Impact of Herniation on WFNS Grading in Spontaneous Subarachnoid Hemorrhage

will be treated according to the local protocol. Upon admission the patient is clinically evaluated for occurrence of clinical signs of brain herniation syndromes (anisocoria, bilateral dilated pupils, posturing). Usually first line treatment includes neurological resuscitation (placement external cerebrospinal fluid drainage in case of hydrocephalus, treatment of seizure, and general intensive care measures). Hereafter, the patient is clinically evaluated for a second time. The patients will be graded

2014 Clinical Trials

92. DAILIES® AquaComfort Plus® Multifocal (MF)

be contraindicated as determined by the investigator Eye injury or surgery within 12 weeks immediately prior to enrollment in this trial Any moderate or severe ocular condition observed during the slitlamp examination at the enrollment visit History of herpetic keratitis, ocular surgery or irregular cornea Prior refractive surgery (e.g. LASIK, PRK, etc) Monocular (only 1 eye with functional vision) or fit with only 1 lens Habitually uncorrected anisometropia >2.00D Clinically significant anisocoria Participation

2014 Clinical Trials

93. Study to Assess the Influence of Three Different α-antagonists and Placebo on the Extent of Weekly Phenylephrine-induced Mydriasis at Three Different Concentrations of Phenylephrine in Healthy Male Volunteers

for this study: Hypersensitivity to any alpha agonist, or to phenylephrine Supine blood pressure at screening of systolic < 110 mmHg and diastolic < 60 mmHg Ophthalmological criteria: Corrected visual acuity < 0.5 Refractive Error with a spherical equivalent > +6 or smaller - 6 D Elevated intraocular pressure (higher than 22 mmHg) Relevant anisocoria or pupil deformation History of eye surgery apart from laser trabeculoplasty less than three months previously or extraocular surgery such as strabismus surgery

2014 Clinical Trials

94. Fibrinogen in the Initial Resuscitation of Severe Trauma (FiiRST)

pneumothorax and massive pulmonary emboli). Severe head injury, defined as any of the following: i. Glasgow coma scale (GCS) of 3 due to severe traumatic brain injury (TBI); ii. TBI with clear indication of immediate neurosurgical intervention based on clinical findings (mechanism of trauma associated with focal signs such as anisocoria with fixed pupil) or on CT results (bleeding causing mass effect); iii. Unsalvageable head injury such as through-through gunshot wound to the head, open skull fracture

2014 Clinical Trials

95. Infrared Pupillometry During General Anesthesia to Predict Pain

or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years to 99 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Patients older than 18 years undergoing arthroscopic knee surgery of any type Exclusion Criteria: Blindness Anisocoria

2014 Clinical Trials

96. Multifocal High ADD Contact Lens Proof of Concept Trial

millimeter) anisocoria; History of intolerance or hypersensitivity to any component of the investigational products; Concurrent participation in a contact lens or contact lens care product clinical trial within the previous 30 days; Eye injury or ocular or intra-ocular surgery within 6 months prior to enrollment; Any ocular or systemic medical condition that may, in the opinion of the Investigator, preclude safe administration of the study lenses or affect the results of this study; Other protocol

2014 Clinical Trials

97. Hemifacial hyperhidrosis associated with ipsilateral/contralateral cervical disc herniation myelopathy. Functional considerations on how compression pattern determines the laterality (PubMed)

anisocoria or blepharoptosis. Sweat function testing and thermography confirmed hyperhidrosis of hemifacial and adjacent areas. Neck MRI showed cervical disc herniation. Three of the patients had lateral compression with welldemarcated hypohidrosis below the hyperhidrosis on the same side as the cervical lesion. The rest had paramedian compression with poorly demarcated hyperhidrosis and hypohidrosis on the contralateral side. Although MRI showed no intraspinal pathological signal intensity, lateral

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2014 Functional Neurology

98. Post-tussive carotid artery dissection: Could it be whooping cough? (PubMed)

Post-tussive carotid artery dissection: Could it be whooping cough? 24914229 2014 08 26 2018 12 02 1488-2329 186 9 2014 Jun 10 CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne CMAJ Post-tussive carotid artery dissection: could it be whooping cough? 697 10.1503/cmaj.114-0045 Carey Colleen C University of Calgary, Calgary, Alta. eng Letter Comment Canada CMAJ 9711805 0820-3946 AIM IM CMAJ. 2014 Jan 7;186(1):57-61 24218537 Anisocoria etiology Carotid

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2014 CMAJ : Canadian Medical Association Journal

99. Neurosyphilis (Overview)

proprioception, loss of vibratory sense, otosclerosis, vertigo, sensory ataxia, chorioretinitis) - 48% Pupillary changes (anisocoria, Argyll Robertson pupils, skew deviation) - 43% Cranial neuropathy - 36% Dementia, mania, or paranoia - 35% Romberg sign - 24% Charcot joint - 13% Hypotonia - 10% Optic atrophy 7% Neurosyphilis is divided into 2 general categories: (1) early involvement of the CNS limited to the meninges and (2) parenchymal involvement. The 6 delineated groups are as follows: Asymptomatic Acute


100. Neurological History and Physical Examination (Overview)

error of metabolism typically associated with mental retardation (usually severe) and intimal thickening and necrosis of the media of blood vessels, resulting in strokes and coronary artery disease. See the image below. Pes cavus deformity can be associated with many conditions including spina bifida, other spinal dysraphisms, and homocystinuria. Ancillary Signs Anisocoria This refers to pupillary asymmetry, which may result from sympathetic or parasympathetic dysfunction. Sympathetic dysfunction


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