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Androgenic Alopecia

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181. Clinical practice guidelines for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner Syndrome Meeting

a separate systematic literature search was performed, and for which available evidence was synthesized. For each question, the eligibility criteria, endpoint definition, search strategy and main findings are described below. What is the effect of growth-promoting treatment in TS? (GRADE question 1) Short stature, present in most individuals with TS, is treated with GH, with/without oxandrolone (a non-aromatizable androgen), with the goals of increasing adult height. We systematically searched (...) posterior hairline 40 Broad short-appearing neck 40 Pterygium colli (webbed neck) 25 Thorax Broad chest (shield chest) 30 Inverted nipples 5 Skin, nails, and hair Increased skin ridge count 30 Lymphedema of hands and feet 25 Multiple pigmented naevi 25 Nail hypoplasia/dystrophy 10 Vitiligo 5 Alopecia 5 Skeleton Bone age delay 85 Decreased bone mineral content 50–80 Cubitus valgus 50 Short fourth metacarpal 35 Genu valgum 35 Congenital hip luxation 20 Scoliosis 10 Madelung deformity 5 Heart Bicuspid

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2016 European Society of Human Reproduction and Embryology

182. CRACKCast E128 – Thyroid and Adrenal Disorders

Cold intolerance Coarse, brittle hair Alopecia Dry skin Lethargy Agitation Mononeuropathy Proximal myopathy Signs of hypothyroidism: Vitals – normal or low and slow Refer to box 120.5 in Rosen’s 9 th edition for the symptoms and signs of hypothyroiditis [7] List 5 lab abnormalities, 2 ECG findings, and 1 CXR finding in hypothyroidism An elevated TSH level with a low T4 level is indicative of primary hypothyroidism. Other laboratory findings may include: Mild anemia, Hypercholesterolemia, Elevated (...) mineralocorticoid and glucocorticoid effects. [10] List the hormones produced by the adrenal glands The adrenal glands are responsible for the release of following hormones: aldosterone, corticosteroids, androgens, and catecholamines. *Images from Wikipedia. [11] List 3 effects of aldosterone Aldosterone tends to promote Na + and water retention… Na + and water retention, Lower plasma K + concentration (via renal secretion of K+) Increased Blood pressure It has the opposite effects of Atrial natriuretic peptide

2017 CandiEM

183. Cochrane team criticises the ECDC experts' draft advice on oseltamivir use

he passed away unexpectedly. In a way, it might have been an ideal departure. We pray his soul may rest in peace. In this issue, we featured a new indication “male pattern baldness” of “dutasteride”, 5- a -reductase inhibitor. We have fundamental questions after reviewing it. Based on the package insert, it is indicated for “androgenic alopecia”. However, is “male pattern baldness” really a disease? Does it really need to be treated? TAMIYA, Jiro, an actor who committed suicide at the age of 43 (...) /function/adcs-adl_scale.pdf ReferencesMED CHECK - TIP April 2016 / Vol.2 No.4 · Page 7 Synopsis ? Dutasteride, an ingredient of Zagallo which is newly approved in Sept 2015 for androgenetic alopecia, has been already approved and on the market for prostatic hyperplasia (Avolve®). ? It is an inhibitor of 5- a reductase which converts testosterone into the strongest androgen, dihydrotestosterone (DHT). It also increases estradiol which is the strongest estrogen and is one of the strongest carcinogens

2016 Med Check - The Informed Prescriber

184. Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice Guideline

identity, the prevalence of GD/gender incongruence was much greater in this group than in the general population without a DSD. This supports the concept that there is a role for prenatal/postnatal androgens in gender development ( – ), although some studies indicate that prenatal androgens are more likely to affect gender behavior and sexual orientation rather than gender identity per se ( , ). Researchers have made similar observations regarding the potential role of androgens in the development (...) of gender identity in other individuals with DSD. For example, a review of two groups of 46,XY persons, each with androgen synthesis deficiencies and female raised, reported transgender male (female-to-male) gender role changes in 56% to 63% and 39% to 64% of patients, respectively ( ). Also, in 46,XY female-raised individuals with cloacal exstrophy and penile agenesis, the occurrence of transgender male changes was significantly more prevalent than in the general population ( , ). However, the fact

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2017 Pediatric Endocrine Society

185. European Society of Endocrinology Clinical practice guidelines for the care of girls and women with Turner syndrome

a separate systematic literature search was performed, and for which available evidence was synthesized. For each question, the eligibility criteria, endpoint definition, search strategy and main findings are described below. What is the effect of growth-promoting treatment in TS? (GRADE question 1) Short stature, present in most individuals with TS, is treated with GH, with/without oxandrolone (a non-aromatizable androgen), with the goals of increasing adult height. We systematically searched (...) posterior hairline 40 Broad short-appearing neck 40 Pterygium colli (webbed neck) 25 Thorax Broad chest (shield chest) 30 Inverted nipples 5 Skin, nails, and hair Increased skin ridge count 30 Lymphedema of hands and feet 25 Multiple pigmented naevi 25 Nail hypoplasia/dystrophy 10 Vitiligo 5 Alopecia 5 Skeleton Bone age delay 85 Decreased bone mineral content 50–80 Cubitus valgus 50 Short fourth metacarpal 35 Genu valgum 35 Congenital hip luxation 20 Scoliosis 10 Madelung deformity 5 Heart Bicuspid

2017 European Society of Endocrinology

186. 4th ESO?ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 4)

these regimens as (neo)adju- vant treatment and for whom ChT is ap- propriate. Other options are, however, available and effective, such as capecita- bine and vinorelbine, particularly if avoiding alopecia is a priority for the patient. I/A 71% In patients with taxane-naive and anthracy- cline-resistant ABC or with anthracycline maximum cumulative dose or toxicity (i.e. cardiac) who are being considered for further ChT, taxane-based therapy, preferably as single agent, would usually be considered (...) by an important expression of androgen receptor (AR; luminal AR subtype). The fact that bicalutamide, an anti- androgen approved for the treatment of prostate cancer, is avail- able, has led to some off-label use in advanced TNBC. However, the panel believes that this type of agent should not be used in routine clinical practice, in view of the very limited data that exist [46–48] and until the determination of the AR is optimised and standardised. Unfortunately, the development of enzaluta- mide, another

2018 European Society for Medical Oncology

187. Endocrine Therapy for Hormone Receptor-Positive Metastatic Breast Cancer

Event (%) TRM Bone Pain Hypercalcemia Rashes Hot Flashes Thromboembolism Uterine Bleeding Nausea Vomiting Diarrhea Infections Fatigue Hypertension Cardiomyopathy Pulmonary Toxicity Neutropenia Stomatitis Anemia Alopecia Peripheral Neuropathy Single-agent

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2016 American Society of Clinical Oncology Guidelines

188. Drugs for male- and female-pattern baldness: Just a hair bit more effective than doing nothing?

care research. www.acfp.ca October 11, 2016 Drugs for male- and female-pattern baldness: Just a hair bit more effective than doing nothing? Clinical Question: What is the effect of approved medications for androgenic alopecia in men and women? Bottom-line: For men using finasteride or minoxidil, one in 4-8 more than placebo will notice at least slight improvement in hair count over 6-12 months, with no clear evidence one is better. For every 84 men taking finasteride for hair loss, one extra (...) outcome. o Minoxidil 1-5% versus placebo: ? Patient-rated moderate improvement or better (26% versus 14%, NNT=8) ? Increase in hair count, +13 hairs/cm 2 , at 6-12 months. Context: • Prevalence of androgenic alopecia increases with age, with approximately ½ of men and ? of women balding after age 70. 10 • Numerous other interventions (like nutritional supplements or Handi-Dome Comb) have low quality evidence with inconsistent results. 9,11 • Only minoxidil for women or men, and finasteride for men

2016 Tools for Practice

189. Acne clinical guideline

, A. Hormonal profiles and prevalence of polycystic ovary syndrome in women with acne. J Dermatol . 1997 ; 24 : 223–229 | | , x 53 Lucky, A.W. Endocrine aspects of acne. Pediatr Clin North Am . 1983 ; 30 : 495–499 | , x 54 Lucky, A.W., McGuire, J., Rosenfield, R.L., Lucky, P.A., and Rich, B.H. Plasma androgens in women with acne vulgaris. J Invest Dermatol . 1983 ; 81 : 70–74 | | | , x 55 Abulnaja, K.O. Changes in the hormone and lipid profile of obese adolescent Saudi females with acne vulgaris. Braz J Med (...) : 25–33 | | | | | Spironolactone B II, III x 102 Shaw, J.C. Low-dose adjunctive spironolactone in the treatment of acne in women: a retrospective analysis of 85 consecutively treated patients. J Am Acad Dermatol . 2000 ; 43 : 498–502 | | | | , x 103 Sato, K., Matsumoto, D., Iizuka, F. et al. Anti-androgenic therapy using oral spironolactone for acne vulgaris in Asians. Aesthetic Plast Surg . 2006 ; 30 : 689–694 | | | Flutamide C III x 104 Wang, H.S., Wang, T.H., and Soong, Y.K. Low dose flutamide

2016 American Academy of Dermatology

190. Guideline on the management of premature ovarian insufficiency

with POI and endometriosis 123 12.5.d Women with POI and other medical issues 123 12.6. Treatment with androgens 127 12.6.a Indications 128 12.6.b Risks of androgen therapy 129 12.6.c Routes of administration, dose, duration, monitoring 129 13. Puberty induction 138 14. Complementary treatments in POI 144 Appendix 1: Abbreviations 148 Appendix 2: Glossary 150 Appendix 3: Guideline group 152 Appendix 4: Research recommendations 154 Appendix 5: Methodology 156 Appendix 6: Reviewers of the guideline draft (...) to compliance. GPP No routine monitoring tests are required but may be prompted by specific symptoms or concerns. GPP Treatment with androgens Women should be informed that androgen treatment is only supported by limited data, and that long-term health effects are not clear yet. C If androgen therapy is commenced, treatment effect should be evaluated after 3-6 months and should possibly be limited to 24 months. GPP 18 HRT in women with POI and special issues Turner Syndrome Girls and women with POI due

2015 European Society of Human Reproduction and Embryology

191. Breast Cancer Treatment (PDQ®): Health Professional Version

al.: Postmenopausal serum androgens, oestrogens and breast cancer risk: the European prospective investigation into cancer and nutrition. Endocr Relat Cancer 12 (4): 1071-82, 2005. [ ] Kaaks R, Berrino F, Key T, et al.: Serum sex steroids in premenopausal women and breast cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). J Natl Cancer Inst 97 (10): 755-65, 2005. [ ] Collaborative Group on Hormonal Factors in Breast Cancer: Menarche, menopause, and breast

2018 PDQ - NCI's Comprehensive Cancer Database

192. Jarilla-Coffea extract: a natural cosmetic product that improves eyelash and eyebrow growth in women. (PubMed)

Jarilla-Coffea extract: a natural cosmetic product that improves eyelash and eyebrow growth in women. A combination of extracts, from two plant species, ie, Coffea arabica and Larrea divaricata (Jarilla) (ECOHAIR®), is being successfully used in Argentina as a cosmetic for hair recovery in androgenic and areata alopecia, and for eyelash and eyebrow growth. The objectives of this prospective study were to evaluate the capacity of Jarilla-Coffea extract gel of improving hair growth in relation

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2019 Clinical, cosmetic and investigational dermatology

193. A retrospective feasibility study of biweekly docetaxel in patients with high-risk metastatic castration-naïve prostate cancer. (PubMed)

A retrospective feasibility study of biweekly docetaxel in patients with high-risk metastatic castration-naïve prostate cancer. Results from randomized phase III trials have shown that thrice-weekly docetaxel added to androgen-deprivation therapy (ADT) has a significant impact on the survival of patients with metastatic castration-naïve prostate cancer (mCNPC) and established early chemotherapy as part of the standard of care for high-risk disease. Controversy remains, however, because some (...) occurred. High-risk was defined as bone metastases beyond axial skeleton and/or visceral disease.The included patients' median age was 68 years (range: 31-86 years) and 17 (49%) had visceral metastases. Biweekly docetaxel was generally well-tolerated; the most commonly observed adverse events, considering those of all grades, included alopecia (74%), nail changes (42%), and constipation (31%). Hematologic adverse events were infrequent, and no patient received hematopoietic growth factors. One patient

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2019 BMC Urology

194. Evaluating hair growth promoting effects of candidate substance: A review of research methods. (PubMed)

Evaluating hair growth promoting effects of candidate substance: A review of research methods. Androgenetic alopecia (AGA) is the most common form of hair loss disorder. As the prevalence of AGA rises, the demand for AGA treatments is rising accordingly, prompting research to identify therapeutic candidates to treat AGA. Because AGA is caused by crosstalk among multiple hair follicle (HF) cell components, understanding the effects of candidate molecules on HF cells is essential to determining (...) . The main outcomes used to evaluate the effects of candidate substances are 1) changes in HF growth rates in vitro, 2) anagen induction capabilities, and 3) the effects of androgen modulation. This article reviews a series of methods used to evaluate the hair growth-promoting effects of candidate substances, providing an overview of cell assays, organs, and animal models used in AGA research in order to facilitate AGA research moving forward.Copyright © 2019 The Author(s). Published by Elsevier B.V. All

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2019 Journal of dermatological science

195. Cholesterol homeostasis: links to hair follicle biology and hair disorders. (PubMed)

Cholesterol homeostasis: links to hair follicle biology and hair disorders. Lipids and lipid metabolism are critical factors in hair follicle (HF) biology and cholesterol has long been suspected of influencing hair growth. Altered cholesterol homeostasis is involved in the pathogenesis of primary cicatricial alopecia, mutations in a cholesterol transporter are associated with congenital hypertrichosis and dyslipidaemia has been linked to androgenic alopecia. The underlying molecular mechanisms

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2019 Experimental Dermatology

196. Bacillus/Trapa japonica Fruit Extract Ferment Filtrate enhances human hair follicle dermal papilla cell proliferation via the Akt/ERK/GSK-3β signaling pathway. (PubMed)

fibroblast in the hair bulb, play an essential role in controlling hair growth and in conditions such as androgenic alopecia. We examined the effect of Bacillus/Trapa japonica fruit ferment filtrate extracts (TJFs) on HDP cells to determine whether activation of the Akt/ERK/GSK-3β signaling pathway improved HDP cell proliferation.We prepared TJFs using various methods. The extract properties were analyzed using WST-1, Lowry, and cell migration assays as well as immunofluorescence staining. We also (...) Bacillus/Trapa japonica Fruit Extract Ferment Filtrate enhances human hair follicle dermal papilla cell proliferation via the Akt/ERK/GSK-3β signaling pathway. Despite advances in medical treatments, the proportion of the population suffering from alopecia is increasing, creating a need for new treatments to control hair loss and prevent balding. Treatments based on plant-derived compounds could potentially prevent hair loss. Human hair follicle dermal papilla (HDP) cells, a type of specialized

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2019 BMC Complementary and Alternative Medicine

199. Menopause Chapter 2: Midlife Body Changes

salons. (Level I) HAIR Key Points Hair changes, including hair loss and excessive hair growth, are common during the menopause transition and postmenopause. Multiple factors, including hormonal changes at menopause, genetic predisposition, and stress, contribute to midlife hair changes. Female pattern hair loss (FPHL), also known as androgenetic alopecia, and telogen effluvium are the most common patterns of hair loss. It has been postulated that the increase in the ratio of androgen to estrogen (...) . Testing for androgen excess, chronic iron deficiency, or thyroid disorders may be indicated. (Level I) Topical minoxidil 5% used once daily is an FDA-approved treatment of FPHL. Minoxidil combined with an antiandrogen such as spironolactone is commonly used in women with FPHL, although there is limited evidence to support this approach. (Level II) Women with FPHL and measurable androgen excess respond differently to antiandrogen therapy compared with women with FPHL and normal androgen levels

2014 The North American Menopause Society

200. Naturally Occurring Hair Growth Peptide: Water-Soluble Chicken Egg Yolk Peptides Stimulate Hair Growth Through Induction of Vascular Endothelial Growth Factor Production. (PubMed)

Naturally Occurring Hair Growth Peptide: Water-Soluble Chicken Egg Yolk Peptides Stimulate Hair Growth Through Induction of Vascular Endothelial Growth Factor Production. Alopecia is divided into two categories: androgenic alopecia and nonandrogenic alopecia. An androgen-dependent abnormality of biological functions causes alopecia in males, but the role of androgens is not yet elucidated in female pattern hair loss (FPHL). Modulation of androgenic activity is not effective in certain kinds (...) of androgenic alopecia in females, as well as in cases of nonandrogenic alopecia in males and females. The hair growth drug, minoxidil, stimulates vascular endothelial growth factor (VEGF) production as well as vascularization and hair growth in females. Yet, because minoxidil has side effects with long-term use, a safe alternative hair growth agent is needed. Whereas hair develops after birth in mammalian species, hair mostly grows in a precocial bird, in the chicken, between hatching days 14 and 15

2018 Journal of medicinal food

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