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Anaphylaxis

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141. Evaluation of the left venticular systolic function with the measurement of global longitudinal strain by Speckle tracking echocardiography in anaphylaxis (PubMed)

Evaluation of the left venticular systolic function with the measurement of global longitudinal strain by Speckle tracking echocardiography in anaphylaxis It is not known how cardiac functions are affected during anaphylaxis.Our aim was to measure the cardiac functions shortly after an anaphylaxis attack using a new technique that detects subclinical left ventricular dysfunction.Patients in our hospital who experienced anaphylaxis and urticaria (control group) due to any cause were included (...) in the study. Tryptase levels were measured on the third hour of the reaction and 6 weeks later. Left ventricular systolic functions were evaluated with global strain measurement using echocardiography, approximately 4 hours and 6-week post reaction.Twelve patients were included in the anaphylaxis group (83.3% female; mean age, 43.25 ± 9.9 years). The causes of anaphylaxis were drug ingestion (n = 11) and venom immunotherapy. Eight of the anaphylactic reactions (66.7%) were severe and in 9 reactions (75

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2018 Asia Pacific allergy

142. Anaphylaxis management: a survey of school and day care nurses in Lebanon (PubMed)

Anaphylaxis management: a survey of school and day care nurses in Lebanon Children are at a high risk of developing allergic reactions. Since they spend lots of time at the school or day care, the odds of having an allergic event in this setting is high, hence placing the onus of properly managing their event on nurses. In Lebanon, little is known whether a standardised policy for managing allergic and anaphylactic reaction exists, leaving children unsafe and the school personnel liable. Thus (...) , the aim of this study is to describe the current practices in the management of severe allergies and anaphylaxis by Lebanese nurses working in schools and day cares and to explore the perceived need for a protocol to manage anaphylaxis reaction.A cross-sectional survey with nurses working at schools and day cares in Lebanon was conducted.A total of 59 school and day care nurses participated. Eighteen of the school and day care nurses reported having a written policy describing the management steps

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2018 BMJ Paediatrics Open

143. The Rare Anaphylaxis-Associated FcγRIIa3 Exhibits Distinct Characteristics From the Canonical FcγRIIa1 (PubMed)

The Rare Anaphylaxis-Associated FcγRIIa3 Exhibits Distinct Characteristics From the Canonical FcγRIIa1 FcγRIIa is an activating FcγR, unique to humans and non-human primates. It induces antibody-dependent proinflammatory responses and exists predominantly as FcγRIIa1. A unique splice variant, we designated FcγRIIa3, has been reported to be associated with anaphylactic reactions to intravenous immunoglobulins (IVIg) therapy. We aim to define the functional consequences of this FcγRIIa variant (...) acid cytoplasmic insertion and these two FcγRIIa forms responded distinctly to antibody ligation. Whereas FcγRIIa1 was rapidly internalized, FcγRIIa3 was retained longer at the membrane, inducing greater calcium mobilization and cell degranulation. Four FCGR2A SNPs were identified including the previously reported intronic SNP associated with anaphylaxis, but in only 1 of 224 individuals. The unique cytoplasmic element of FcγRIIa3 delays internalization and is associated with enhanced cellular

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2018 Frontiers in immunology

144. Systemic and Local Anaphylaxis is Not Induced by Korean Red Ginseng Mixture in Guinea Pigs (PubMed)

Systemic and Local Anaphylaxis is Not Induced by Korean Red Ginseng Mixture in Guinea Pigs Currently, injuries to customers due to health functional foods are annually increasing. To evaluate the antigenicity of Korean red ginseng mixture (KRGM), we tested for systemic anaphylactic shock and passive cutaneous anaphylaxis in guinea pigs. Based on a comparison of measured body weights, there were no changes in body weight for the KRGM treatment group compared with the control group (...) . In the ovalbumin treated group, however, there was a statistically significant decrease in body weight. For the active systemic anaphylaxis test, after the induction, there were no symptoms that suggested anaphylactic shock in the control and KRGM treatment group. In the ovalbumin treated group, there were symptoms that suggested severe anaphylaxis, and those symptoms included restlessness, piloerection, tremor, rubbing or licking the nose, sneezing, coughing, hyperpnea, dyspnea, staggering gait, jumping

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2018 Toxicological research

145. Food-dependent, exercise-induced anaphylaxis in a patient allergic to peach (PubMed)

Food-dependent, exercise-induced anaphylaxis in a patient allergic to peach Determining the single factor that triggered anaphylactic shock can be challenging. We present an interesting case of a 25-year-old female patient with recurrent anaphylactic reactions developing after eating various foods, particularly in presence of co-factors of allergic reactions. Symptoms occurred after consumption of various kinds of foods - peach, pancakes with cottage cheese and fruit, a meal from a Chinese (...) . ImmunoCAP ISAC test indicated increased levels of IgE specific for the lipid transfer protein (LTP) for walnut (nJug r 3), peach (Pru p 3), wheat (rTri a 14) and plane tree (rPla a 3). The patient was diagnosed with food-dependent, exercise-induced anaphylaxis associated with an allergy to lipid transport proteins (LTPs).

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2018 International journal of immunopathology and pharmacology

146. Anaphylaxis in atypical cold urticaria: case report and review of literature (PubMed)

Anaphylaxis in atypical cold urticaria: case report and review of literature Cold-induced urticaria is a kind of physical urticaria characterized by the appearance of wheals after exposure to cold. The atypical form is a rare sub-type characterized by appearance of hives even in areas not directly exposed to the cold and by a negative cold stimulation test. Its diagnosis is often challenging because of the lack of specific tests and it is usually based on the patient's clinical history (...) to cold and a negative response to the cold stimulation test, are the characteristic features of this rare form of cold urticaria.Atypical cold urticaria should be suspected in all cases of anaphylaxis related to cold exposure (i.e. contact with water) with a negative cold stimulation test.

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2018 Italian journal of pediatrics

147. First-reported pediatric cases of American ginseng anaphylaxis and allergy (PubMed)

First-reported pediatric cases of American ginseng anaphylaxis and allergy Ginseng is a perennial herb used in traditional Chinese medicine, which has become increasingly popular world-wide due to its proposed medicinal effects. There are two major species of ginseng, Panax ginseng (Korean or Asian ginseng), and Panax quinquefolius (American ginseng). Although cases of allergy due to Korean ginseng have been reported in adults, there are no reported cases of allergy to American ginseng (...) , and no reported cases of ginseng allergy in pediatric patients.We present two unique cases of pediatric patients with suspected allergic reactions to American ginseng. The first patient is a 6-year-old girl who presented to the emergency department in anaphylaxis (urticaria and respiratory symptoms) minutes after inhaling powdered American ginseng. There was evidence of sensitization to American ginseng on skin prick testing (SPT) (13 × 12 mm wheal) and evidence of allergy to American ginseng on basophil

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2018 Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology

148. Aetiology of anaphylaxis in patients referred to an immunology clinic in Colombo, Sri Lanka (PubMed)

Aetiology of anaphylaxis in patients referred to an immunology clinic in Colombo, Sri Lanka The aetiology of anaphylaxis differs according to types of foods consumed, fauna and foliage and cultural practices. Although the aetiology of anaphylaxis in Western countries are well known, the causes in South Asian countries have not been reported. We sought to determine the causes of anaphylaxis in patients referred to an immunology clinic in Colombo, Sri Lanka.238 episodes of anaphylaxis were (...) reviewed in 188 patients who were referred and skin prick tests and in vitro tests (ImmunoCap) were carried out to assess the presence of allergen specific IgE. Clinical features and severity of anaphylaxis was also recorded along with treatment received.Anaphylaxis to food either following direct exposure 90/238 (37.5%) or after exercise in the form of food dependent exercise induced anaphylaxis 29/238 (12.2%) was the predominant cause of anaphylaxis. Allergy to cow's milk and red meat, after

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2018 Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology

149. Anaphylaxis with midazolam in pediatric hematology-oncology unit: a case report (PubMed)

Anaphylaxis with midazolam in pediatric hematology-oncology unit: a case report 30459522 2018 12 07 1306-0015 53 3 2018 Sep Turk pediatri arsivi Turk Pediatri Ars Anaphylaxis with midazolam in pediatric hematology-oncology unit: a case report. 200-201 10.5152/TurkPediatriArs.2018.6176 Çakmakcı Selma S Department of Pediatric Hematology and Oncology, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey. Bayhan Turan T Department of Pediatric Hematology

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2018 Turkish Archives of Pediatrics/Türk Pediatri Arşivi

150. Anaphylaxis (PubMed)

Anaphylaxis Anaphylaxis is an acute, potentially fatal systemic allergic reaction with varied mechanisms and clinical presentations. Although prompt recognition and treatment of anaphylaxis are imperative, both patients and healthcare professionals often fail to recognize and diagnose early signs and symptoms of the condition. Clinical manifestations vary widely; however, the most common signs are cutaneous symptoms, including urticaria, angioedema, erythema and pruritus. Immediate (...) intramuscular administration of epinephrine into the anterolateral thigh is first-line therapy, even if the diagnosis is uncertain. The mainstays of long-term management include specialist assessment, avoidance measures, and the provision of an epinephrine auto-injector and an individualized anaphylaxis action plan. This article provides an overview of the causes, clinical features, diagnosis and acute and long-term management of this serious allergic reaction.

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2018 Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology

151. A New Diagnostic Criteria of Wheat-Dependent, Exercise-Induced Anaphylaxis in China (PubMed)

A New Diagnostic Criteria of Wheat-Dependent, Exercise-Induced Anaphylaxis in China Wheat-dependent, exercise-induced anaphylaxis (WDEIA) is an allergic reaction induced by intense exercise combined with wheat ingestion. The gold standard for diagnosis of WDEIA is a food exercise challenge; however, this test is unacceptable for Chinese WDEIA patients and unable to be approved by the Ethics Committee of Chinese hospitals due to substantial risk. There are no diagnostic criteria for Chinese (...) WDEIA patients. The aim of present study was to propose new practical diagnosis criteria for Chinese WDEIA patients.We prospectively included 283 clinically diagnosed WDEIA patients from January 1, 2010 to June 30, 2014, and in the meanwhile, three groups were enrolled which included 133 patients with the history of anaphylaxis induced by food other than wheat, 186 recurrent urticaria patients, and 94 healthy participants. Clinical comprehensive evaluation by allergists used as the reference gold

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2018 Chinese medical journal

152. Anaphylaxis triggers in a large tertiary care hospital in Qatar: a retrospective study (PubMed)

Anaphylaxis triggers in a large tertiary care hospital in Qatar: a retrospective study Anaphylaxis is a serious allergic disease that may lead to death if not immediately recognized and treated. Triggers of anaphylaxis including food, drugs, and insect stings can vary widely. The incidence of anaphylaxis seems to be affected by age, sex, atopy, and geographic location. This study aims to examine the common triggers of anaphylaxis in Qatar.A total of 1068 electronic medical records were audited (...) using power chart system: 446 from the medical coding system of anaphylaxis and 622 from the epinephrine auto-injectors (EAIs) dispensed during January 2012-December 2017.Of 1068 patients, 574 (53.5%) had anaphylaxis; male to female ratio was 1.2, and 300 patients (77.9%) were less than 10 years old. The common triggers were food (n = 316, 55.0%), insect stings (n = 161, 28.0%), and drugs (n = 103, 17.9%). Common anaphylaxis food triggers were nuts (n = 173, 30.1%), eggs (n = 89, 15.5%), and seafood

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2018 The World Allergy Organization journal

153. Reply to “Acute Myocardial Infarction Induced by Anaphylaxis in China: The Kounis Syndrome” (PubMed)

Reply to “Acute Myocardial Infarction Induced by Anaphylaxis in China: The Kounis Syndrome” 30246739 2018 11 14 2542-5641 131 19 2018 Oct 05 Chinese medical journal Chin. Med. J. Reply to "Acute Myocardial Infarction Induced by Anaphylaxis in China: The Kounis Syndrome". 2394 10.4103/0366-6999.241811 Tang Rui R Department of Allergy, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China. Sun Jin-Lu JL Department

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2018 Chinese medical journal

154. Acute Myocardial Infarction Induced by Anaphylaxis in China: The Kounis Syndrome (PubMed)

Acute Myocardial Infarction Induced by Anaphylaxis in China: The Kounis Syndrome 30246738 2018 11 14 2542-5641 131 19 2018 Oct 05 Chinese medical journal Chin. Med. J. Acute Myocardial Infarction Induced by Anaphylaxis in China: The Kounis Syndrome. 2392-2393 10.4103/0366-6999.241810 Kounis Nicholas G NG Department of Cardiology, Patras University General Hospital, Rion, Patras, Achaia 26504, Greece. Koniari Ioanna I Department of Electrophysiology, Queen Elizabeth Hospital, Birmingham B15 2TH

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2018 Chinese medical journal

155. Emergency anaphylaxis protocols: A cross-sectional analysis of general practice surgeries and pharmacies in both the urban and rural setting in Ireland (PubMed)

Emergency anaphylaxis protocols: A cross-sectional analysis of general practice surgeries and pharmacies in both the urban and rural setting in Ireland The incidence of anaphylaxis appears to be increasing worldwide with cases in the community outnumbering those in the hospital setting. General practice (GP) surgeries and pharmacies, based in the community, are often the first point of contact for many patients suffering from anaphylaxis.To determine if studied GP surgeries and pharmacies have (...) an anaphylaxis protocol on site and have access to an anaphylaxis kit; to explore GP's and pharmacists' personal experiences with management of anaphylaxis.A cross-sectional, questionnaire-based study was performed examining anaphylaxis protocols in a sample of general practices and pharmacies from some counties in Ireland. This consisted of a sample from rural and urban settings. The study commenced in October 2014.Nineteen of 24 GPs (79%) and 9 (29%) pharmacies had an anaphylaxis protocol (P < 0.001

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2018 The European journal of general practice

156. Anaphylaxis to diphenylcyclopropenone during sensitization for wart treatment—A case report (PubMed)

Anaphylaxis to diphenylcyclopropenone during sensitization for wart treatment—A case report 30306114 2019 02 26 2352-5126 4 9 2018 Oct JAAD case reports JAAD Case Rep Anaphylaxis to diphenylcyclopropenone during sensitization for wart treatment-A case report. 872-873 10.1016/j.jdcr.2018.07.003 Venkatesh Kavya K St. Vincent's Hospital, Sydney, Australia. Yun James J Department of Allergy and Immunology, Royal North Shore Hospital, Sydney, Australia. The University of Sydney, Sydney, Australia (...) . Bakis-Petsoglou Sophie S Hills Dermatology (Private Practice), Sydney, Australia. eng Case Reports 2018 10 03 United States JAAD Case Rep 101665210 2352-5126 DPCP, diphenylcyclopropenone SPT, skin prick testing anaphylaxis diphencyprone diphenylcyclopropenone hypersensitivity verruca verrucae warts 2018 10 12 6 0 2018 10 12 6 0 2018 10 12 6 1 epublish 30306114 10.1016/j.jdcr.2018.07.003 S2352-5126(18)30183-8 PMC6172440 Australas J Dermatol. 1988 Apr;29(1):33-6 2977943 Allergy. 2001 Sep;56(9):850-6

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2018 JAAD Case Reports

157. Low Incidence of Biphasic Allergic Reactions in Patients Admitted to Intensive Care after Anaphylaxis. (PubMed)

Low Incidence of Biphasic Allergic Reactions in Patients Admitted to Intensive Care after Anaphylaxis. Recurrent manifestations of anaphylaxis after treatment, termed biphasic reactions, are estimated to occur in 1 to 23% of reactionsHowever, little is known about the incidence, triggers, symptoms, and management of biphasic reactions WHAT THIS ARTICLE TELLS US THAT IS NEW: In 83 cases of patients admitted to intensive care units in Denmark after anaphylaxis, suspected biphasic reactions (...) occurred in 4 (4.8%) of patientsThe incidence of biphasic reactions was low, 3 out of 4 were considered possible, and only 1 considered a probable biphasic allergic reaction BACKGROUND:: Biphasic allergic reactions-recurrence of allergy symptoms after a symptom-free period-are reported to occur in 1 to 23% of allergic reactions. Patients admitted to an intensive care unit after anaphylaxis potentially have more severe reactions and a higher risk of biphasic allergic reactions. The purpose of this study

2018 Anesthesiology

158. Massive release of the histamine-degrading enzyme diamine oxidase during severe anaphylaxis in mastocytosis patients. (PubMed)

Massive release of the histamine-degrading enzyme diamine oxidase during severe anaphylaxis in mastocytosis patients. Histaminolytic activity mediated by diamine oxidase (DAO) is present in plasma after induction of severe anaphylaxis in rats, guinea pigs, and rabbits. Heparin released during mast cell degranulation in the gastrointestinal tract might liberate DAO from heparin-sensitive storage sites. DAO release during anaphylaxis has not been demonstrated in humans.Plasma DAO, tryptase (...) , and histamine concentrations of four severe anaphylaxis events were determined at multiple serial time points in two patients with systemic mastocytosis. The histamine degradation rates were measured in anaphylaxis samples and in pregnancy sera and plasma with comparable DAO concentrations.Mean DAO (132 ng/mL) and tryptase (304 ng/mL) concentrations increased 187- and 4.0-fold, respectively, over baseline values (DAO 0.7 ng/mL, tryptase 76 ng/mL) during severe anaphylaxis. Under non-anaphylaxis conditions

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2018 Allergy

159. Anaesthesia for a biopsy of corpus callosum in patient with a recent intra-operative anaphylaxis to an unknown anaesthetic allergen: a case report. (PubMed)

Anaesthesia for a biopsy of corpus callosum in patient with a recent intra-operative anaphylaxis to an unknown anaesthetic allergen: a case report. Anaphylaxis in general anaesthesia occurs with a frequency of 1:5000-1:20000. This clinical summary reports on the use of an effective risk management strategy employing second line anaesthesia agents and alternative endotracheal intubation tools in a patient with a recent history of an intra-operative anaphylaxis to an unknown anaesthetic agent.A (...) in this setting. The airway was managed using flexible endoscopic intubation in a spontaneously ventilating awake patient. Continuous remifentanil infusion was maintained throughout the case. Anaesthesia was maintained with sevoflurane at less than one MAC, with an uneventful completion of the biopsy of corpus callosum. All of the anaesthetic agents used during the prior care episode, with the exception of remifentanil, were avoided.In cases of an anaphylaxis to an unknown anaesthetic allergen, anaesthetic

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2018 BMC Anesthesiology

160. Management of anaphylaxis and allergies in patients with long QT syndrome: A review of the current evidence. (PubMed)

Management of anaphylaxis and allergies in patients with long QT syndrome: A review of the current evidence. To develop a treatment algorithm for patients with long QT syndrome (LQTS) in case they need antiallergic medications for allergic reactions, including asthma and anaphylaxis.A literature review was performed to assess safety and to develop antiallergic treatment strategies for patients with LQTS.LQTS is a heterogeneous group of myocardial repolarization disorders characterized (...) by prolongation of the QT interval that potentially results in life-threatening torsades de pointes tachycardia. Data on pharmacologic treatment in case of anaphylaxis in LQTS are sparse. For this narrative review, all currently available articles on the use of antiallergic drugs for allergic reactions, anaphylaxis, and asthma in patients with LQTS were used.Local allergic symptoms can be safely treated primarily with fexofenadine, levocetirizine, desloratadine, or cetirizine and, if needed, a short course

2018 Asthma & Immunology

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