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Anaphylaxis

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101. Anaphylaxis Full Text available with Trip Pro

Anaphylaxis Anaphylaxis is an acute, potentially fatal systemic allergic reaction with varied mechanisms and clinical presentations. Although prompt recognition and treatment of anaphylaxis are imperative, both patients and healthcare professionals often fail to recognize and diagnose early signs and symptoms of the condition. Clinical manifestations vary widely; however, the most common signs are cutaneous symptoms, including urticaria, angioedema, erythema and pruritus. Immediate (...) intramuscular administration of epinephrine into the anterolateral thigh is first-line therapy, even if the diagnosis is uncertain. The mainstays of long-term management include specialist assessment, avoidance measures, and the provision of an epinephrine auto-injector and an individualized anaphylaxis action plan. This article provides an overview of the causes, clinical features, diagnosis and acute and long-term management of this serious allergic reaction.

2018 Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology

102. Assessing severity of anaphylaxis: a data-driven comparison of 23 instruments Full Text available with Trip Pro

Assessing severity of anaphylaxis: a data-driven comparison of 23 instruments The severity of an allergic reaction can range from mild local symptoms to anaphylactic shock. To score this, a number of instruments have been developed, although heterogeneous in design and purpose. Severity scoring algorithms are therefore difficult to compare, but are frequently used beyond their initial purpose. Our objective was to compare the most used severity scoring instruments by a data-driven approach (...) on both milder reactions and anaphylaxis.All positive challenges to foods or drugs (n = 2828) including anaphylaxis (n = 616) at Odense University Hospital, Denmark from 1998 to 2016 were included and severity was scored according to Sampson5. Based on recommendations from an expert group, the symptoms and values from Sampson5 were for all reactions and anaphylaxis only translated and compared by kappa statistics with 22 instruments, ranging from 3 to 6 steps.For milder reactions

2018 Clinical and translational allergy

103. Spinacetin Suppresses the Mast Cell Activation and Passive Cutaneous Anaphylaxis in Mouse Model Full Text available with Trip Pro

Spinacetin Suppresses the Mast Cell Activation and Passive Cutaneous Anaphylaxis in Mouse Model We previously reported the anti-inflammatory and anti-asthmatic activities of the extract of the Inula japonica Thunb. Aiming for discovery of a novel anti-inflammatory compound, we isolated spinacetin from the extract and investigated its in vitro and in vivo anti-inflammatory effect and the related mechanism. Effect of spinacetin on the Syk signaling pathway was studied in bone marrow-derived mast (...) cells (BMMCs), and that on the nuclear factor-κB (NF-κB) and mitogen-activated protein kinases (MAPKs) was investigated in Rat basophilic leukemia (RBL)-2H3 cells and human mast cell line (HMC-1). The in vivo anti-inflammatory activity was assessed with passive cutaneous anaphylaxis (PCA) reaction assay. Spinacetin significantly inhibited the release of histamine, and production of inflammatory mediators such as leukotriene C4 (LTC4) and interlukin-6 (IL-6) in IgE/Ag stimulated BMMCs. Analysis

2018 Frontiers in pharmacology

104. Anaphylaxis management: a survey of school and day care nurses in Lebanon Full Text available with Trip Pro

Anaphylaxis management: a survey of school and day care nurses in Lebanon Children are at a high risk of developing allergic reactions. Since they spend lots of time at the school or day care, the odds of having an allergic event in this setting is high, hence placing the onus of properly managing their event on nurses. In Lebanon, little is known whether a standardised policy for managing allergic and anaphylactic reaction exists, leaving children unsafe and the school personnel liable. Thus (...) . Only 12 had witnessed an anaphylactic event. Of those, 10 reported administering an antihistamine medication orally instead of epinephrine intramuscular. Most respondents (56) believed that a standardised guideline for the management of anaphylaxis was essential, and 9 indicated being hesitant to give the epinephrine intramuscular even in the presence of a policy. Finally, 55 stated the need for training nurses in identifying and managing anaphylaxis as a must.Currently, the management

2018 BMJ Paediatrics Open

105. The Rare Anaphylaxis-Associated FcγRIIa3 Exhibits Distinct Characteristics From the Canonical FcγRIIa1 Full Text available with Trip Pro

The Rare Anaphylaxis-Associated FcγRIIa3 Exhibits Distinct Characteristics From the Canonical FcγRIIa1 FcγRIIa is an activating FcγR, unique to humans and non-human primates. It induces antibody-dependent proinflammatory responses and exists predominantly as FcγRIIa1. A unique splice variant, we designated FcγRIIa3, has been reported to be associated with anaphylactic reactions to intravenous immunoglobulins (IVIg) therapy. We aim to define the functional consequences of this FcγRIIa variant (...) acid cytoplasmic insertion and these two FcγRIIa forms responded distinctly to antibody ligation. Whereas FcγRIIa1 was rapidly internalized, FcγRIIa3 was retained longer at the membrane, inducing greater calcium mobilization and cell degranulation. Four FCGR2A SNPs were identified including the previously reported intronic SNP associated with anaphylaxis, but in only 1 of 224 individuals. The unique cytoplasmic element of FcγRIIa3 delays internalization and is associated with enhanced cellular

2018 Frontiers in immunology

106. Anaphylactic shock to vaginal misoprostol: a rare adverse reaction to a frequently used drug Full Text available with Trip Pro

Anaphylactic shock to vaginal misoprostol: a rare adverse reaction to a frequently used drug Misoprostol is widely used in daily practice for induction of labor and cervical dilatation prior to intrauterine procedures, including dilatation and curettage or hysteroscopy. Anaphylactic shock to intravaginal misoprostol can occur not only in pregnant women, as reported in 2 previous cases, but also in a non-pregnant, perimenopausal woman, as in the case described herein. A 49-year-old woman (...) received vaginal misoprostol for cervical ripening prior to hysteroscopic myomectomy and experienced anaphylactic shock. Two 400 μg doses of misoprostol 6 hours apart caused uncontrolled shaking and high fever followed by shock. In conclusion, the possibility of anaphylactic shock should be considered in patients with sudden hypotension following misoprostol administration. Prompt identification and management are crucial to prevent morbidity and mortality following an anaphylactic shock to misoprostol.

2018 Obstetrics & gynecology science

107. Acute Myocardial Infarction Induced by Anaphylaxis in China: The Kounis Syndrome Full Text available with Trip Pro

Acute Myocardial Infarction Induced by Anaphylaxis in China: The Kounis Syndrome 30246738 2018 11 14 2542-5641 131 19 2018 Oct 05 Chinese medical journal Chin. Med. J. Acute Myocardial Infarction Induced by Anaphylaxis in China: The Kounis Syndrome. 2392-2393 10.4103/0366-6999.241810 Kounis Nicholas G NG Department of Cardiology, Patras University General Hospital, Rion, Patras, Achaia 26504, Greece. Koniari Ioanna I Department of Electrophysiology, Queen Elizabeth Hospital, Birmingham B15 2TH

2018 Chinese medical journal

108. Reply to “Acute Myocardial Infarction Induced by Anaphylaxis in China: The Kounis Syndrome” Full Text available with Trip Pro

Reply to “Acute Myocardial Infarction Induced by Anaphylaxis in China: The Kounis Syndrome” 30246739 2018 11 14 2542-5641 131 19 2018 Oct 05 Chinese medical journal Chin. Med. J. Reply to "Acute Myocardial Infarction Induced by Anaphylaxis in China: The Kounis Syndrome". 2394 10.4103/0366-6999.241811 Tang Rui R Department of Allergy, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China. Sun Jin-Lu JL Department

2018 Chinese medical journal

109. A qualitative study exploring parents’ experiences with epinephrine use for their child’s anaphylactic reaction Full Text available with Trip Pro

A qualitative study exploring parents’ experiences with epinephrine use for their child’s anaphylactic reaction Children with life threatening food allergies live with the constant threat of a fatal reaction, and caregivers must always be prepared to treat with an epinephrine auto-injector (EAI). This interpretive phenomenological study explored parents' perceptions and lived experiences with prescribed EAI use for their child.The purposive sample included ten parents of five children under (...) 12 years of age, diagnosed with a food allergy and prescribed with an EAI who recently experienced anaphylaxis. Data sources included digitally-recorded semi-structured interviews and a reflexive journal.Eight main themes emerged: perception of anaphylaxis, life challenges, isolation, anxiety, hesitation, guilt, influence of health care professionals, and lessons learned. Parents uniformly described multiple life challenges and feelings of isolation, anxiety and hesitation during a reaction

2018 Clinical and translational allergy

110. Evaluation of the left venticular systolic function with the measurement of global longitudinal strain by Speckle tracking echocardiography in anaphylaxis Full Text available with Trip Pro

in the study. Tryptase levels were measured on the third hour of the reaction and 6 weeks later. Left ventricular systolic functions were evaluated with global strain measurement using echocardiography, approximately 4 hours and 6-week post reaction.Twelve patients were included in the anaphylaxis group (83.3% female; mean age, 43.25 ± 9.9 years). The causes of anaphylaxis were drug ingestion (n = 11) and venom immunotherapy. Eight of the anaphylactic reactions (66.7%) were severe and in 9 reactions (75 (...) Evaluation of the left venticular systolic function with the measurement of global longitudinal strain by Speckle tracking echocardiography in anaphylaxis It is not known how cardiac functions are affected during anaphylaxis.Our aim was to measure the cardiac functions shortly after an anaphylaxis attack using a new technique that detects subclinical left ventricular dysfunction.Patients in our hospital who experienced anaphylaxis and urticaria (control group) due to any cause were included

2018 Asia Pacific allergy

111. A pediatric case of anaphylactic shock induced by tipepidine hibenzate (Asverin) Full Text available with Trip Pro

A pediatric case of anaphylactic shock induced by tipepidine hibenzate (Asverin) Tipepidine hibenzate (Asverin) is commonly used as an antitussive drug for acute and chronic cough in various age groups and is generally safe and well-tolerated. However, we experienced a case of tipepidine hibenzate-induced anaphylactic shock in a 1-year-old boy. After ingesting cold medication including tipepidine hibenzate, the patient presented with generalized erythema and urticaria, swollen face, coughing (...) , wheezing and vomiting, together with hypotension and a decreased level of consciousness. To identify the culprit drug, we performed skin prick tests (SPTs) and oral drug provocation tests (DPTs). SPTs revealed a negative reaction for all drugs, but DPTs caused a positive reaction only for a full therapeutic dose of tipepidine hibenzate. Physicians need to consider tipepidine hibezate as a culprit drug when anaphylaxis occurs after taking anticough or common cold medication.

2018 Asia Pacific allergy

112. Anaphylaxis to diphenylcyclopropenone during sensitization for wart treatment—A case report Full Text available with Trip Pro

Anaphylaxis to diphenylcyclopropenone during sensitization for wart treatment—A case report 30306114 2019 02 26 2352-5126 4 9 2018 Oct JAAD case reports JAAD Case Rep Anaphylaxis to diphenylcyclopropenone during sensitization for wart treatment-A case report. 872-873 10.1016/j.jdcr.2018.07.003 Venkatesh Kavya K St. Vincent's Hospital, Sydney, Australia. Yun James J Department of Allergy and Immunology, Royal North Shore Hospital, Sydney, Australia. The University of Sydney, Sydney, Australia (...) . Bakis-Petsoglou Sophie S Hills Dermatology (Private Practice), Sydney, Australia. eng Case Reports 2018 10 03 United States JAAD Case Rep 101665210 2352-5126 DPCP, diphenylcyclopropenone SPT, skin prick testing anaphylaxis diphencyprone diphenylcyclopropenone hypersensitivity verruca verrucae warts 2018 10 12 6 0 2018 10 12 6 0 2018 10 12 6 1 epublish 30306114 10.1016/j.jdcr.2018.07.003 S2352-5126(18)30183-8 PMC6172440 Australas J Dermatol. 1988 Apr;29(1):33-6 2977943 Allergy. 2001 Sep;56(9):850-6

2018 JAAD Case Reports

113. Food-dependent, exercise-induced anaphylaxis in a patient allergic to peach Full Text available with Trip Pro

Food-dependent, exercise-induced anaphylaxis in a patient allergic to peach Determining the single factor that triggered anaphylactic shock can be challenging. We present an interesting case of a 25-year-old female patient with recurrent anaphylactic reactions developing after eating various foods, particularly in presence of co-factors of allergic reactions. Symptoms occurred after consumption of various kinds of foods - peach, pancakes with cottage cheese and fruit, a meal from a Chinese (...) . ImmunoCAP ISAC test indicated increased levels of IgE specific for the lipid transfer protein (LTP) for walnut (nJug r 3), peach (Pru p 3), wheat (rTri a 14) and plane tree (rPla a 3). The patient was diagnosed with food-dependent, exercise-induced anaphylaxis associated with an allergy to lipid transport proteins (LTPs).

2018 International journal of immunopathology and pharmacology

114. A rapid caliber change in the inferior vena cava during multiphasic contrast-enhanced computed tomography may signal an acute anaphylactic reaction to nonionic contrast medium Full Text available with Trip Pro

A rapid caliber change in the inferior vena cava during multiphasic contrast-enhanced computed tomography may signal an acute anaphylactic reaction to nonionic contrast medium Severe anaphylactic reactions to an intravenous nonionic iodine contrast medium (NICM) are uncommon but can result in permanent morbidity or death if not managed appropriately. An anaphylactic reaction to an NICM typically manifests as clinical symptoms that include an itchy nose, sneezing, and skin redness. To our (...) knowledge, a rapid change in the caliber of the inferior vena cava (IVC) during multiphasic contrast-enhanced computed tomography (CT) has not been reported. Here, we report the computed tomographic findings in three cases of hypovolemic shock caused by an anaphylactic reaction to an NICM. We suspect that a decrease in caliber of the IVC during multiphasic contrast-enhanced CT may be a predictor of an allergic-like reaction to an NICM. Patients in whom physicians and radiographers detect a rapid caliber

2018 Radiology Case Reports

115. A case series: Association of anaphylaxis with a significant decrease in platelet levels and possible secondary risk of thrombosis Full Text available with Trip Pro

of thrombosis.A retrospective investigation into medical records including medication administrations times, laboratory, and radiology results. Platelet levels pre- and post- anaphylaxis were statistically analyzed.Case 1, a 44 year old man had an anaphylactic reaction shortly after envenomation and subsequently suffered an acute infarction with thrombus in a cerebral artery. Case 2 is a 49 year old man with idiopathic anaphylaxis who developed a deep vein thrombosis after a protracted anaphylaxis event. Case (...) 3 involved an 18 year old female with acute myeloid leukemia was found to have a thrombus in the celiac trunk following anaphylaxis. A paired two-tailed Wilcoxon test on the subjects pre and post anaphylactic platelet levels resulted in a overall P < 0.0001.These three cases illustrate the potential role platelets may have in anaphylaxis and possible increased secondary risk for the development of thrombosis. Larger studies are required to determine incidence and risk factors for blood clots

2018 Immunity, Inflammation and Disease

116. Anaphylactic Reaction to Cyanocobalamin: A Case Report Full Text available with Trip Pro

Anaphylactic Reaction to Cyanocobalamin: A Case Report Vitamin B12 is essential for the development of healthy nerves and red blood cells. Vitamin B12 deficiency is becoming widespread and most commonly affects elderly, pregnant women, vegetarians, and patients with renal or intestinal diseases. Either parenteral vitamin B12 treatment or high-dose oral vitamin B12 treatment is an effective therapy regardless of etiology. Parenteral therapy using the intramuscular route is considered the most (...) familiar treatment for vitamin B12 deficiency. Anaphylactic reaction after intramuscular injection is an uncommon and potentially serious side effect. In this study, we are documenting a case of anaphylactic reaction in a 55-year-old woman after her second dose of intramuscular injection of cyanocobalamin. The purpose of this case report is to highlight the need to understand the rare life-threatening side effect of intramuscular cyanocobalamin. Health care providers should be vigilant while

2018 Cureus

117. Data on various allergen specific IgEs and prospective treatments on food-dependent exercise-induced anaphylaxis Full Text available with Trip Pro

Data on various allergen specific IgEs and prospective treatments on food-dependent exercise-induced anaphylaxis Food-dependent exercise-induced anaphylaxis (FDEIAn) is an anaphylactic reaction induced by physical exercise after ingestion of certain meals. FDEIAn is not very frequent, but recent case reports associated with various meals indicate an upward trend. Here, we report the data of various food specific IgEs and the clinical course of an experience with a patient who exhibited a unique

2018 Data in brief

118. S1P4 Regulates Passive Systemic Anaphylaxis in Mice but Is Dispensable for Canonical IgE-Mediated Responses in Mast Cells Full Text available with Trip Pro

S1P4 Regulates Passive Systemic Anaphylaxis in Mice but Is Dispensable for Canonical IgE-Mediated Responses in Mast Cells Mast cells are key players in the development of inflammatory allergic reactions. Cross-linking of the high-affinity receptor for IgE (FcεRI) on mast cells leads to the generation and secretion of the sphingolipid mediator, sphingosine-1-phosphate (S1P) which is able, in turn, to transactivate its receptors on mast cells. Previous reports have identified (...) and peritoneal mouse mast cells indicated that this receptor is dispensable for mast cell degranulation, cytokine/chemokine production and FcεRI-mediated chemotaxis in vitro. However, interleukin-33 (IL-33)-mediated enhancement of IgE-induced degranulation was reduced in S1P₄-deficient peritoneal mast cells, revealing a potential negative regulatory role for S1P₄ in an IL-33-rich environment. Surprisingly, genetic deletion of S1pr4 resulted in exacerbation of passive systemic anaphylaxis to IgE/anti

2018 International journal of molecular sciences

119. Anaphylaxis as a Rare Side Effect of Pantoprazole; a Case Report Full Text available with Trip Pro

Anaphylaxis as a Rare Side Effect of Pantoprazole; a Case Report Anaphylaxis is a serious life-threatening allergic reaction. Any medication may potentially trigger anaphylaxis, but reaction to pantoprazole is rare. Our case is a 21 year-old girl with anaphylactic reaction to pantoprazole a short time after prescription.

2018 Emergency

120. Acute Myocardial Infarction Induced by Anaphylaxis Full Text available with Trip Pro

Acute Myocardial Infarction Induced by Anaphylaxis 29722347 2018 12 11 2018 12 11 2542-5641 131 10 2018 05 20 Chinese medical journal Chin. Med. J. Acute Myocardial Infarction Induced by Anaphylaxis. 1251-1252 10.4103/0366-6999.231518 Tang Rui R Department of Allergy, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China. Sun Jin-Lu JL Department of Allergy, Peking Union Medical College Hospital, Peking Union Medical (...) College, Chinese Academy of Medical Sciences, Beijing 100730, China. eng Letter China Chin Med J (Engl) 7513795 0366-6999 IM Anaphylaxis complications Electrocardiography Humans Myocardial Infarction etiology There are no conflicts of interest 2018 5 4 6 0 2018 5 4 6 0 2018 12 12 6 0 ppublish 29722347 ChinMedJ_2018_131_10_1251_231518 10.4103/0366-6999.231518 PMC5956781 Chin Med J (Engl). 2015 Oct 5;128(19):2692-3 26415813 Int J Cardiol. 2015 Nov 1;198:83-4 26156319 Allergy Asthma Immunol Res. 2016 Jul

2018 Chinese medical journal

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