How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

8,218 results for

Anaphylaxis

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

41. Anaphylaxis After Vaccination Reported To The Vaccine Adverse Event Reporting System, 1990-2016. (PubMed)

Anaphylaxis After Vaccination Reported To The Vaccine Adverse Event Reporting System, 1990-2016. Anaphylaxis, a rare and potentially life-threatening hypersensitivity reaction, can occur after vaccination.We sought to describe reports of anaphylaxis after vaccination made to the Vaccine Adverse Event Reporting System (VAERS) during 1990-2016.We identified domestic reports of anaphylaxis within VAERS using a combination of Medical Dictionary for Regulatory Activity queries and Preferred Terms (...) . We performed a descriptive analysis, including history of hypersensitivity (anaphylaxis, respiratory allergies, and drug allergies) and vaccines given. We reviewed all serious reports and all nonserious reports with available medical records to determine if they met the Brighton Collaboration case definition for anaphylaxis or received a physician's diagnosis.During the analytic period, VAERS received 467,960 total reports; 828 met the Brighton Collaboration case definition or received

2019 Journal of Allergy and Clinical Immunology

42. Anaphylaxis risk factors for hospitalization and intensive care: A comparison between adults and children in an upstate New York emergency department. (PubMed)

Anaphylaxis risk factors for hospitalization and intensive care: A comparison between adults and children in an upstate New York emergency department. Background: Anaphylaxis is an acute, systemic allergic reaction that can be life threatening, and with an increasing incidence and costs associated with hospitalization and intensive care. Objective: To assess the risk factors for hospitalization by comparing pediatric and adult patients. Methods: We performed a retrospective chart review (...) for patients with anaphylactic reactions who presented to the Albany Medical Center emergency department between 2005 and 2012. Results: We identified 267 anaphylactic reactions in 258 patients (143 adults). Of those, 128 (48%) were not coded as anaphylaxis despite fulfilling diagnostic criteria. Foods were the most common trigger both in adults and children. Factors associated with increased odds of hospitalization (intensive care unit [ICU] and hospital floor combined) included a severity score of 3

2019 Allergy and Asthma Proceedings

43. Integrating basophil activation tests into evaluation of perioperative anaphylaxis to neuromuscular blocking agents. (PubMed)

Integrating basophil activation tests into evaluation of perioperative anaphylaxis to neuromuscular blocking agents. Neuromuscular blocking agents (NMBAs) remain the leading cause of perioperative anaphylaxis in Australia. Standard evaluation comprises history, skin tests, and in vitro specific immunoglobulin E tests. Drug provocation tests to suspected NMBA culprits are associated with a significant risk. Basophil activation testing (BAT) is a potentially useful in vitro test (...) that is not commercially available in Australia or as part of standard evaluation.All patients attending the Anaesthetic Allergy Clinic in Sydney, Australia between May 2017 and July 2018 exposed to an NMBA before the onset of anaphylaxis during their anaesthetic qualified for the study. We recruited 120 patients sequentially who received standard evaluation plus BAT using CD63, CD203c, and CD300a as surface activation markers.BAT results were expressed as % upregulation above the negative control and stimulation

2019 British Journal of Anaesthesia

44. Assessing cross-reactivity to neuromuscular blocking agents by skin and basophil activation tests in patients with neuromuscular blocking agent anaphylaxis. (PubMed)

Assessing cross-reactivity to neuromuscular blocking agents by skin and basophil activation tests in patients with neuromuscular blocking agent anaphylaxis. Following diagnosis of neuromuscular blocking agent (NMBA) anaphylaxis, identifying safe alternatives for subsequent anaesthesia is critical. A patient with anaphylaxis to one NMBA can also have an allergic reaction to other NMBAs (cross-reactivity). Whilst drug provocation testing is standard for identifying or excluding allergy (...) , there is significant risk. In vitro, after an allergen activates basophils, basophils express surface activation markers that can be measured by basophil activation testing (BAT). We compared cross-reactivity between NMBAs assessed by BAT against that by skin testing.All patients attending an anaesthetic allergy clinic in Sydney, Australia between May 2017 and July 2018 diagnosed with NMBA anaphylaxis qualified for this study comparing intradermal skin tests and BAT with a panel of NMBAs (rocuronium, vecuronium

2019 British Journal of Anaesthesia

45. Molecular mechanisms and pathophysiology of perioperative hypersensitivity and anaphylaxis: a narrative review. (PubMed)

Molecular mechanisms and pathophysiology of perioperative hypersensitivity and anaphylaxis: a narrative review. Perioperative hypersensitivity reactions (POH) constitute a clinical and diagnostic challenge, a consequence of heterogeneous clinical presentations, and multiple underlying pathomechanisms. POH do not necessarily involve an allergen-specific immune response with cross-linking of specific immunoglobulin E (sIgE) antibodies on mast cells and basophils. POH can also result from (...) alternative specific and non-specific effector cell activation/degranulation such as complement-derived anaphylatoxins and off-target occupancy of mast cell, basophil, or both surface receptors. Moreover, POH and anaphylaxis can occur independent from mast cell and basophil degranulation. The manifestations of POH primarily affect the cardiovascular, respiratory, and integumentary systems. POH present within the context of surgical or procedural pathology and the effects of surgical and anaesthetic

2019 British Journal of Anaesthesia

46. Use of simulation to improve management of perioperative anaphylaxis: a narrative review. (PubMed)

Use of simulation to improve management of perioperative anaphylaxis: a narrative review. Simulation-based education is often highlighted as a method to prepare health personnel to handle clinical emergencies through repeated training and the design of supports. As one of the most common clinical emergencies in anaesthesia, anaphylaxis is often included in simulation scenarios at both graduate and postgraduate levels. Case reviews of anaphylaxis management continue to identify deficiencies (...) in clinical responses. We evaluated the evidence to support the use of simulation to address these deficiencies. We undertook a comprehensive review of the MEDLINE and Embase databases with MESH terms 'Anaphylaxis', 'Anaesthesia', 'Simulation training', and variations of these terms. Articles were also searched from reference lists in the identified papers. A total of 39 articles on perioperative anaphylaxis simulation were identified, with most focusing on the clinical skills of individuals. However

2019 British Journal of Anaesthesia

47. Trends in hospitalizations related to anaphylaxis, angioedema, and urticaria in the United States. (PubMed)

Trends in hospitalizations related to anaphylaxis, angioedema, and urticaria in the United States. Data on the prevalence of allergic disorders over time are limited. Recent studies have noted marked increase in the prevalence of allergic conditions in different parts of the world.To examine time trends in the prevalence of anaphylaxis, angioedema, and urticaria in the United States.Using the largest inpatient National Inpatient Sample data in the United States from 2001 to 2014, adults (...) admitted with a primary diagnosis of anaphylaxis, angioedema, or urticaria were identified based on International Classification of Diseases, Ninth Revision codes. Yearly distribution of hospital admissions was stratified per different age groups, and yearly trends of hospitalizations related to anaphylaxis, angioedema, and urticaria were calculated.Although an increasing trend in the rate of hospitalizations was seen for angioedema (annual percentage change [APC], 4.48), a decreasing trend (APC, -2.19

2019 Asthma & Immunology

48. Factors predicting anaphylaxis in children with tree nut allergies. (PubMed)

Factors predicting anaphylaxis in children with tree nut allergies. Background: Tree nut (TN) allergies are the most common cause of fatal anaphylaxis and generally are ongoing food allergies throughout life. Objective: To investigate the predicting factors for TN anaphylaxis in children. Methods: Children with TN allergy were divided into anaphylactic and nonanaphylactic groups, those who had an anaphylactic reaction with at least one type of TN and those with any type of reaction other than (...) anaphylaxis with TNs, respectively. Children with TN allergies were evaluated for the predictors of anaphylaxis by using multivariate logistic regression analysis. Results: A total of 184 children (ages 4.9 years; 3.2-6.9 years) with TN allergy were included in the study. Of these, 90 experienced an anaphylactic type of reaction on exposure to at least one type of TNs. Comparisons of the two groups showed that concomitant asthma, skin-prick test, specific immunoglobulin E, total immunoglobulin E

2019 Allergy and Asthma Proceedings

49. Pre-hospital management of pediatric anaphylaxis by French Emergency Medicine physicians: still to be improved. (PubMed)

Pre-hospital management of pediatric anaphylaxis by French Emergency Medicine physicians: still to be improved. Food allergy (FA), is the main cause of anaphylaxis in children (1). Early recognition and treatment are crucial to avoid a rapid progression into a life-threatening condition. Several anaphylaxis guidelines have been published, including those issued by the Resuscitation Council (2008), the World Health Organization (2011), the European Academy of Allergy and Clinical Immunology

2019 Clinical and Experimental Allergy

50. 'It's not an illness, it's just bad luck': The impact of anaphylaxis on quality of life in adults. (PubMed)

'It's not an illness, it's just bad luck': The impact of anaphylaxis on quality of life in adults. An increasing number of adults are being diagnosed with anaphylaxis, but its impact on health-related quality of life (HRQol) is not known.The aim of this study was to explore the impact of anaphylaxis on HRQoL of newly diagnosed adults.Interviews were conducted with 13 adults (aged 40-71; 5 males) with anaphylaxis (meeting WAO diagnostic criteria) to drugs, food, venom or spontaneous anaphylaxis (...) , recruited using purposive sampling from allergy clinics in Birmingham, UK. Data was transcribed verbatim and analysed using thematic analysis.Four themes were generated from the analysis: the journey from fear to frustration; the need to maintain a healthy identity; control over uncertainty; and the supportive role of others. Participants described their first experiences of anaphylaxis as frightening. Managing the condition was associated with frustration and anxiety, in part due to uncertainty

2019 Clinical and Experimental Allergy

51. Idiopathic anaphylaxis. (PubMed)

Idiopathic anaphylaxis. Idiopathic anaphylaxis (IA) or spontaneous anaphylaxis is a diagnosis of exclusion when no cause can be identified. The exact incidence and prevalence of IA is not known. The clinical manifestations of IA are similar to other known causes of anaphylaxis. A typical attack is usually acute in onset and can worsen over minutes to a few hours. The pathophysiology of IA has not yet been fully elucidated, although an IgE-mediated pathway by hitherto unidentified trigger/s (...) , pigeon tick bite (Argax reflexus), pine processionary caterpillar allergy, wheat-dependent exercise-induced anaphylaxis, Anisakis simplex allergy and mast cell disorders. Other differential diagnoses include 'allergy-mimics' such as asthma masquerading as anaphylaxis, undifferentiated somatoform disorder, panic attacks, globus hystericus, vocal cord dysfunction, scombroid poisoning, vasoactive amine intolerance, carcinoid syndrome and phaeochromocytoma. Acute treatment of IA is the same as for other

2019 Clinical and Experimental Allergy

52. Ingestion of Casein Hydrolysate Induces Oral Tolerance and Suppresses Subsequent Epicutaneous Sensitization and Development of Anaphylaxis Reaction to Casein in Mice. (PubMed)

Ingestion of Casein Hydrolysate Induces Oral Tolerance and Suppresses Subsequent Epicutaneous Sensitization and Development of Anaphylaxis Reaction to Casein in Mice. Casein is the most dominant causal allergen in cow's milk allergy (CMA). Casein hydrolysates are frequently applied in infant formulas for children with a risk or history of CMA. However, there is limited information on the oral tolerance-inducing ability of casein hydrolysates.The aim of this study was to investigate whether (...) the ingestion of casein hydrolysate induces tolerance to casein, ultimately preventing subsequent epicutaneous sensitization and development of an anaphylaxis reaction.BALB/c mice were orally administered casein or a casein hydrolysate (CNH) via the drinking water and were then epicutaneously sensitized by repeated exposure of casein on tape-stripped skin. Sensitization was assessed by basophil activation tests, the serum levels of casein-specific antibodies, and cytokine production from casein-stimulated

2019 International Archives of Allergy and Immunology

53. Medical malpractice related to drug-induced anaphylaxis: An analysis of lawsuit judgments in South Korea. (PubMed)

Medical malpractice related to drug-induced anaphylaxis: An analysis of lawsuit judgments in South Korea. Drug-induced anaphylaxis (DIA) is a highly paradoxical disorder involving a fatal response to medicines prescribed for therapeutic purposes. This study aimed to improve the awareness on DIA and to prevent errors through an analysis of lawsuit judgments.Sentenced judgments involving DIA from 1998 to 2017 using the database of the Korean Supreme Court Judgment System were collected. General (...) ), respectively, suggesting insufficient time to cope with anaphylaxis. Consequently, either death (n = 18, 66.7%) or ischemic brain injury (n = 9, 33.3%) occurred in all cases. Violation of duty of care was recognized in 19 cases (70.4%) with median awarded amount of $106,060 (IQR = $70,296-$168,363). The recognized negligence included inadequate observation after drug administration (n = 6), delayed or missed epinephrine administration (n = 6), ignoring a history of allergy or drug hypersensitivity (n = 6

2019 Medicine

54. An interview with Tim Dribin about anaphylaxis and hospital admissions

An interview with Tim Dribin about anaphylaxis and hospital admissions An interview with Tim Dribin about anaphylaxis and hospital admissions – PEMBlog Search for: Search for: An interview with Tim Dribin about anaphylaxis and hospital admissions By | 2019-02-18T15:03:04-04:00 February 20th, 2019 | | You will no doubt see a child with anaphylaxis in the Emergency Department. Recognition, management and disposition are all key questions that feel incredibly fluid at this juncture. I had (...) the pleasure of interviewing Tim Dribin, an Emergency Medicine Attending from Cincinnati Children’s who recently published a paper in PLUS ONE focusing on admissions for children with anaphylaxis. Should we move the observation time from four to two hours? Who is most at risk for biphasic reaction? And how can we use data form kids that were admitted, and received no interventions, to inform practice in the ED? Listen Subscribe References Share this post About the Author: Brad Sobolewski, MD, MEd

2019 PEM Blog

55. Contact urticaria (CU): frequency, elicitors and cofactors in three cohorts (Information Network of Departments of Dermatology (IVDK); Network of Anaphylaxis and Dept. of Dermatology University Hospital Erlangen, Germany). (PubMed)

Contact urticaria (CU): frequency, elicitors and cofactors in three cohorts (Information Network of Departments of Dermatology (IVDK); Network of Anaphylaxis and Dept. of Dermatology University Hospital Erlangen, Germany). Contact urticaria (CU) is an infrequent, mostly occupational disease that may be life-threatening (CU syndrome stage 4).To identify the current frequency, elicitors and cofactors of CU.Three cohorts were retrospectively analysed for CU: (a) patients from the Information (...) Network of Departments of Dermatology (IVDK) database (2000-2014; n = 159 947); (b) patients from an allergy unit (Department of Dermatology, University Hospital Erlangen, 2000-2015; n = 4741); and (c) patients from the Anaphylaxis Registry (2007-2015: 6365 reported cases, including 2473 patients with Ring and Messmer grade III-IV reactions) for severe cases with skin/mucosal manifestations occurring at the workplace vs cases not occurring at the workplace (n = 68 vs n = 1821).Four hundred and forty

2019 Contact Dermatitis

56. Red-meat desensitization in a child with delayed anaphylaxis due to alpha-Gal allergy. (PubMed)

Red-meat desensitization in a child with delayed anaphylaxis due to alpha-Gal allergy. 31188497 2019 07 09 1399-3038 2019 Jun 12 Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology Pediatr Allergy Immunol Red meat desensitization in a child with delayed anaphylaxis due to alpha-Gal allergy. 10.1111/pai.13092 Yucel Esra E https://orcid.org/0000-0003-3712-2522 Division of Pediatric Allergy and Immunology, Department of Pediatrics

2019 Pediatric Allergy and Immunology

57. Gaps in the management of food-induced anaphylaxis reactions at school. (PubMed)

Gaps in the management of food-induced anaphylaxis reactions at school. 31172595 2019 07 18 1399-3038 2019 Jun 06 Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology Pediatr Allergy Immunol Gaps in the management of food-induced anaphylaxis reactions at school. 10.1111/pai.13091 Pouessel Guillaume G https://orcid.org/0000-0003-0900-588X Department of Pediatrics, Children's Hospital, Roubaix, France. Pediatric Pulmonology

2019 Pediatric Allergy and Immunology

58. Anaphylaxis - lessons learnt when East meets West. (PubMed)

Anaphylaxis - lessons learnt when East meets West. The rapidly increasing prevalence of allergic disorders over the past 2 decades highlights the need to understand the epidemiology of anaphylaxis. In Europe, the United States and Australia, the incidence of anaphylaxis is estimated to be between 60 and 950 cases per 100,000 population, with a lifetime prevalence of anaphylaxis of 0.05% -2%. The incidence appears to be increasing over time. Although the existing Asian literature (...) is heterogeneous and limited by underreporting, it also suggests a similar increasing trend in anaphylaxis incidence in Asia. Anaphylaxis triggers in Asia, such as the predominance of shellfish and wheat in older children and adolescents differ from those seen in Western populations. Triggers unique to Asia such as traditional Chinese medications, galacto-oligosaccharides and food delicacies have also been reported. Low usage of adrenaline as first-line treatment of anaphylaxis is evident across all countries

2019 Pediatric Allergy and Immunology

59. Food allergy endotype with high risk of severe anaphylaxis in children-Monosensitization to cashew 2S albumin Ana o 3. (PubMed)

Food allergy endotype with high risk of severe anaphylaxis in children-Monosensitization to cashew 2S albumin Ana o 3. Food allergy in children can be life-threatening. Component-resolved diagnostics approach to food anaphylaxis is rarely assessed in children. The aim of the study was to identify the food allergen components as the triggers responsible for severe anaphylaxis, with regard to characteristics and associated risks, among children in a large, population-based setting.Two hundred (...) and seventy-one children who were hospitalized due to systemic allergic reaction (SAR) and food anaphylaxis were recruited. Medical history was assessed, and culprit allergen source and anaphylaxis severity grade were established. Specific IgE to 112 allergen components using multiplex ImmunoCAP ISAC immunoassay and specific IgE to hazelnut, Cor a 14, and cashew, Ana o 3, using singleplex ImmunoCAP immunoassay were determined.We analyzed data from 237 SAR/anaphylaxis in 237 children. Trigger at allergen

2019 Allergy

60. IL-13-induced Intestinal secretory epithelial cell antigen passages are required for IgE-mediated food-induced anaphylaxis. (PubMed)

IL-13-induced Intestinal secretory epithelial cell antigen passages are required for IgE-mediated food-induced anaphylaxis. Food-induced anaphylaxis is an IgE-dependent immune response that may affect multi-organs and lead to life threatening complications. The processes by which food allergens cross the mucosal surface and are delivered to the sub-epithelial immune compartment to promote the clinical manifestations associated with food-triggered anaphylaxis are largely unexplored.To define (...) the processes involved in the translocation of food allergens across the mucosal epithelial surface to the subepithelial immune compartment in food-induced anaphylaxis (FIA).2 photon (2P) confocal and immunofluorescence microscopy was employed to visualize and trace food allergen passage in a murine model of FIA. Human colon cancer cell line, RNA silencing and pharmacological approaches were used to identify the molecular regulation of intestinal epithelial allergen uptake and translocation. Human

2019 Journal of Allergy and Clinical Immunology

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>