How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

12,104 results for

Anaphylaxis

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

41. Midazolam anaphylaxis during general anesthesia: A case report. Full Text available with Trip Pro

Midazolam anaphylaxis during general anesthesia: A case report. Midazolam is known as a safe drug and is widely used as a sedative and an anesthetic adjuvant. Therefore, there is a lack of awareness that midazolam can cause anaphylaxis. Midazolam anaphylaxis is rare, and only a few cases have been reported, but such a risk is always present. In this study, we report a case of midazolam anaphylaxis by an intravenous injection, in the prone position, during general anesthesia.A 62-year-old woman (...) was intravenously administered 1 mg midazolam during general anesthesia, and sudden severe hypotension, bronchospasm, decreased oxygen saturation, erythema, and diarrhea occurred.Midazolam anaphylaxis was presumptively diagnosed by clinical symptoms and was confirmed by an intradermal test after 9 weeks.The patient was treated with 100% oxygen, large volume of fluid, epinephrine, phenylephrine, ephedrine, dexamethasone and prednisolone, ranitidine, and flumazenil.Severe hypotension and decreased oxygen

2019 Medicine

42. Intubation and intensive care after laminaria anaphylaxis in second-trimester abortion. (Abstract)

Intubation and intensive care after laminaria anaphylaxis in second-trimester abortion. Laminaria are cervical dilators inserted for several days preceding second-trimester abortions and other uterine procedures. Our patient was intubated after a life-threatening anaphylactic reaction to laminaria prior to her surgical abortion. Abortions with laminaria dilators are frequently performed outpatient across the United States. Due to stigma, increasing restrictions, and forced closure of family (...) planning clinics, these procedures are often obtained covertly and remotely. Patients may present obtunded, in shock, without records or proxy, and with no external evidence of the allergen's location or continued presence. Emergency and critical care physicians may consider this etiology in obtunded women with anaphylaxis who are responding poorly to standard care.Copyright © 2019. Published by Elsevier Inc.

2019 American Journal of Emergency Medicine

43. Wheat-dependent exercise-induced anaphylaxis in Chinese people: a clinical research on 33 cases with antigenic analysis of wheat proteins. (Abstract)

Wheat-dependent exercise-induced anaphylaxis in Chinese people: a clinical research on 33 cases with antigenic analysis of wheat proteins. Wheat-dependent exercise-induced anaphylaxis (WDEIA) is a severe allergic condition in which wheat ingestion together followed by physical exercise induces anaphylaxis. For patients with WDEIA, omega-5 gliadin is considered to be one of the major allergens.To analyse the clinical features and allergen spectrum of WDEIA and to investigate the relationship (...) in IL-9 or IL-33 between the two groups.WDEIA is a rare type of anaphylaxis. GAPDH and omega-5 gliadin may be the most common allergy-causing wheat proteins for Chinese people. PAF may be associated with the onset and development of WDEIA.© 2019 British Association of Dermatologists.

2019 Clinical & Experimental Dermatology

44. Paired acute-baseline serum tryptase levels in perioperative anaphylaxis: an observational study 97/100. (Abstract)

Paired acute-baseline serum tryptase levels in perioperative anaphylaxis: an observational study 97/100. Anaphylaxis is recognized mainly through clinical criteria, which may lack specificity or relevance in the perioperative setting. The transient increase in serum tryptase has been proposed since 1989 as a diagnostic tool. Sampling for well-defined acute and baseline determinations has been recommended. We assessed the performance of four proposed algorithms with tightly controlled time (...) frames for tryptase sampling, their robustness with inadequate sampling times, and the possible use of mature tryptase determination.A retrospective study was performed on 102 adult patients from the Aix-Marseille University Hospitals who had experienced a perioperative hypersensitivity reaction clinically suggesting anaphylaxis. EAACI and ICON criteria were used to diagnose anaphylaxis. Mature and total serum tryptase levels were measured.Based on EAACI guidelines, clinical diagnostic criteria

2019 Allergy

45. Evaluation of Antibody Properties and Clinically Relevant Immunogenicity, Anaphylaxis, and Hypersensitivity Reactions in Two Phase III Trials of Tralokinumab in Severe, Uncontrolled Asthma. Full Text available with Trip Pro

Evaluation of Antibody Properties and Clinically Relevant Immunogenicity, Anaphylaxis, and Hypersensitivity Reactions in Two Phase III Trials of Tralokinumab in Severe, Uncontrolled Asthma. Tralokinumab is a monoclonal antibody (mAb) that neutralizes interleukin (IL)-13, a cytokine involved in the pathogenesis of asthma.The objectives of this study were to characterize the potential immunogenic properties of tralokinumab and report data for anti-drug antibodies (ADAs) and hypersensitivity (...) %, placebo 25.5%; STRATOS 2-Q2 W 13.2%, placebo 9.0%. External evaluation for anaphylaxis by Sampson criteria found no tralokinumab-related severe hypersensitivity or anaphylaxis reactions.Preclinical assessments suggested a low likelihood of immunogenicity for tralokinumab. In STRATOS 1 and 2, ADA incidence was low, no differences were found between tralokinumab-treated and placebo groups in reporting of hypersensitivity reactions, and there were no Sampson criteria-evaluated anaphylaxis events

2019 Drug Safety Controlled trial quality: uncertain

46. Anaphylaxis to Carboxymethylcellulose: Add Food Additives to the List of Elicitors. Full Text available with Trip Pro

Anaphylaxis to Carboxymethylcellulose: Add Food Additives to the List of Elicitors. A 14-year-old girl developed 4 episodes of anaphylaxis of unknown etiology, which required intramuscular adrenaline administration each time. She had eaten pizza and a cheeseburger immediately before the first 2 episodes, respectively, but had not eaten anything for several hours before the last 2 episodes. It turned out that she had eaten the same ice lolly 4 hours before the first 3 episodes and a Café au lait (...) Swirkle (a half-frozen beverage) 4 hours before the last episode. We detected carboxymethylcellulose sodium as the only common ingredient in all anaphylactic episodes. Skin prick tests were positive for carboxymethylcellulose solution and carboxymethylcellulose-containing food products. We obtained a custom-made carboxymethylcellulose sodium-free ice lolly from the manufacturer and confirmed that it did not induce anaphylactic reactions by a challenge test. Carboxymethylcellulose, an anionic water

2019 Pediatrics

47. Anaphylaxis After Vaccination Reported To The Vaccine Adverse Event Reporting System, 1990-2016. Full Text available with Trip Pro

Anaphylaxis After Vaccination Reported To The Vaccine Adverse Event Reporting System, 1990-2016. Anaphylaxis, a rare and potentially life-threatening hypersensitivity reaction, can occur after vaccination.We sought to describe reports of anaphylaxis after vaccination made to the Vaccine Adverse Event Reporting System (VAERS) during 1990-2016.We identified domestic reports of anaphylaxis within VAERS using a combination of Medical Dictionary for Regulatory Activity queries and Preferred Terms (...) . We performed a descriptive analysis, including history of hypersensitivity (anaphylaxis, respiratory allergies, and drug allergies) and vaccines given. We reviewed all serious reports and all nonserious reports with available medical records to determine if they met the Brighton Collaboration case definition for anaphylaxis or received a physician's diagnosis.During the analytic period, VAERS received 467,960 total reports; 828 met the Brighton Collaboration case definition or received

2019 Journal of Allergy and Clinical Immunology

48. Epidemiology and trends of anaphylaxis in the United States, 2004-2016. (Abstract)

Epidemiology and trends of anaphylaxis in the United States, 2004-2016. No national study has examined the epidemiology of anaphylaxis after introduction of the codes of the International Statistical Classification of Diseases and Health Related Problems, Tenth Revision, Clinical Modification (ICD-10 CM). Our objective was to examine the trends in incidence and hospitalization rates in the United States utilizing ICD-9 and ICD-10 CM codes.We used the Clinformatics database from 2004 to 2016 (...) . Our outcome measures included incidence of anaphylaxis and hospitalization trends. Multivariable logistic regression was used to assess the predictors of anaphylaxis and hospitalization.There were a total of 462,906 anaphylaxis cases. The incidence increased from 153 in 2004 to 218 in 2016 (per 100,000). Women were 1.19 (95% confidence interval, 1.18-1.20) times more likely to present with anaphylaxis. Medication-induced anaphylaxis increased 15-fold.This is the first population-based study

2019 International forum of allergy & rhinology

49. Anaphylaxis risk factors for hospitalization and intensive care: A comparison between adults and children in an upstate New York emergency department. Full Text available with Trip Pro

for patients with anaphylactic reactions who presented to the Albany Medical Center emergency department between 2005 and 2012. Results: We identified 267 anaphylactic reactions in 258 patients (143 adults). Of those, 128 (48%) were not coded as anaphylaxis despite fulfilling diagnostic criteria. Foods were the most common trigger both in adults and children. Factors associated with increased odds of hospitalization (intensive care unit [ICU] and hospital floor combined) included a severity score of 3 (...) Anaphylaxis risk factors for hospitalization and intensive care: A comparison between adults and children in an upstate New York emergency department. Background: Anaphylaxis is an acute, systemic allergic reaction that can be life threatening, and with an increasing incidence and costs associated with hospitalization and intensive care. Objective: To assess the risk factors for hospitalization by comparing pediatric and adult patients. Methods: We performed a retrospective chart review

2019 Allergy and Asthma Proceedings

50. The global incidence and prevalence of anaphylaxis in children in the general population: a systematic review. Full Text available with Trip Pro

The global incidence and prevalence of anaphylaxis in children in the general population: a systematic review. Despite an increasing number of publications from individual countries and regions, there is still no systematic review of the global epidemiology of anaphylaxis in the general paediatric population.We conducted a systematic review, using a protocol registered and published with the international prospective register of systematic reviews (PROSPERO). Results were reported following (...) and 17 reported prevalence data. The incidence of anaphylaxis in children worldwide varied widely, ranging from 1 to 761 per 100 000 person-years for total anaphylaxis and 1 to 77 per 100 000 person-years for food-induced anaphylaxis. The definition of anaphylaxis from NIAID/FAAN was the most commonly used. Gender and ethnicity were demographic risk factors associated with anaphylaxis in children. Increasing total or food-induced anaphylaxis incidence over time was reported by 19 studies.The reported

2019 Allergy

51. Diagnosis and management of drug-induced anaphylaxis in children: an EAACI position paper. Full Text available with Trip Pro

Diagnosis and management of drug-induced anaphylaxis in children: an EAACI position paper. Drug hypersensitivity reactions (DHR) constitute a major and common public health problem, particularly in children. One of the most severe manifestations of DHR is anaphylaxis, which might be associated with a life-threatening risk. During those past decades, anaphylaxis has received particularly a lot of attention and international consensus guidelines have been recently published. Whilst drug-induced (...) anaphylaxis is more commonly reported in adulthood, less is known about the role of drugs in pediatric anaphylaxis. Betalactam antibiotics and non-steroidal anti-inflammatory drugs are the most commonly involved drugs, probably related to high prescription rates. Diagnosis relies on the recognition of symptoms pattern and is based on complete allergic workup, particularly including skin tests and/or specific IgE. However, the real diagnostic value of those tests to diagnose immediate reactions in children

2019 Pediatric Allergy and Immunology

52. Molecular mechanisms and pathophysiology of perioperative hypersensitivity and anaphylaxis: a narrative review. Full Text available with Trip Pro

Molecular mechanisms and pathophysiology of perioperative hypersensitivity and anaphylaxis: a narrative review. Perioperative hypersensitivity reactions (POH) constitute a clinical and diagnostic challenge, a consequence of heterogeneous clinical presentations, and multiple underlying pathomechanisms. POH do not necessarily involve an allergen-specific immune response with cross-linking of specific immunoglobulin E (sIgE) antibodies on mast cells and basophils. POH can also result from (...) alternative specific and non-specific effector cell activation/degranulation such as complement-derived anaphylatoxins and off-target occupancy of mast cell, basophil, or both surface receptors. Moreover, POH and anaphylaxis can occur independent from mast cell and basophil degranulation. The manifestations of POH primarily affect the cardiovascular, respiratory, and integumentary systems. POH present within the context of surgical or procedural pathology and the effects of surgical and anaesthetic

2019 British Journal of Anaesthesia

53. Use of simulation to improve management of perioperative anaphylaxis: a narrative review. Full Text available with Trip Pro

Use of simulation to improve management of perioperative anaphylaxis: a narrative review. Simulation-based education is often highlighted as a method to prepare health personnel to handle clinical emergencies through repeated training and the design of supports. As one of the most common clinical emergencies in anaesthesia, anaphylaxis is often included in simulation scenarios at both graduate and postgraduate levels. Case reviews of anaphylaxis management continue to identify deficiencies (...) in clinical responses. We evaluated the evidence to support the use of simulation to address these deficiencies. We undertook a comprehensive review of the MEDLINE and Embase databases with MESH terms 'Anaphylaxis', 'Anaesthesia', 'Simulation training', and variations of these terms. Articles were also searched from reference lists in the identified papers. A total of 39 articles on perioperative anaphylaxis simulation were identified, with most focusing on the clinical skills of individuals. However

2019 British Journal of Anaesthesia

54. Integrating basophil activation tests into evaluation of perioperative anaphylaxis to neuromuscular blocking agents. (Abstract)

Integrating basophil activation tests into evaluation of perioperative anaphylaxis to neuromuscular blocking agents. Neuromuscular blocking agents (NMBAs) remain the leading cause of perioperative anaphylaxis in Australia. Standard evaluation comprises history, skin tests, and in vitro specific immunoglobulin E tests. Drug provocation tests to suspected NMBA culprits are associated with a significant risk. Basophil activation testing (BAT) is a potentially useful in vitro test (...) that is not commercially available in Australia or as part of standard evaluation.All patients attending the Anaesthetic Allergy Clinic in Sydney, Australia between May 2017 and July 2018 exposed to an NMBA before the onset of anaphylaxis during their anaesthetic qualified for the study. We recruited 120 patients sequentially who received standard evaluation plus BAT using CD63, CD203c, and CD300a as surface activation markers.BAT results were expressed as % upregulation above the negative control and stimulation

2019 British Journal of Anaesthesia

55. Assessing cross-reactivity to neuromuscular blocking agents by skin and basophil activation tests in patients with neuromuscular blocking agent anaphylaxis. (Abstract)

Assessing cross-reactivity to neuromuscular blocking agents by skin and basophil activation tests in patients with neuromuscular blocking agent anaphylaxis. Following diagnosis of neuromuscular blocking agent (NMBA) anaphylaxis, identifying safe alternatives for subsequent anaesthesia is critical. A patient with anaphylaxis to one NMBA can also have an allergic reaction to other NMBAs (cross-reactivity). Whilst drug provocation testing is standard for identifying or excluding allergy (...) , there is significant risk. In vitro, after an allergen activates basophils, basophils express surface activation markers that can be measured by basophil activation testing (BAT). We compared cross-reactivity between NMBAs assessed by BAT against that by skin testing.All patients attending an anaesthetic allergy clinic in Sydney, Australia between May 2017 and July 2018 diagnosed with NMBA anaphylaxis qualified for this study comparing intradermal skin tests and BAT with a panel of NMBAs (rocuronium, vecuronium

2019 British Journal of Anaesthesia

56. Gaps in the management of food-induced anaphylaxis reactions at school. (Abstract)

Gaps in the management of food-induced anaphylaxis reactions at school. 31172595 2019 07 18 1399-3038 2019 Jun 06 Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology Pediatr Allergy Immunol Gaps in the management of food-induced anaphylaxis reactions at school. 10.1111/pai.13091 Pouessel Guillaume G https://orcid.org/0000-0003-0900-588X Department of Pediatrics, Children's Hospital, Roubaix, France. Pediatric Pulmonology

2019 Pediatric Allergy and Immunology

57. Red-meat desensitization in a child with delayed anaphylaxis due to alpha-Gal allergy. (Abstract)

Red-meat desensitization in a child with delayed anaphylaxis due to alpha-Gal allergy. 31188497 2019 07 09 1399-3038 2019 Jun 12 Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology Pediatr Allergy Immunol Red meat desensitization in a child with delayed anaphylaxis due to alpha-Gal allergy. 10.1111/pai.13092 Yucel Esra E https://orcid.org/0000-0003-3712-2522 Division of Pediatric Allergy and Immunology, Department of Pediatrics

2019 Pediatric Allergy and Immunology

58. Anaphylaxis - lessons learnt when East meets West. (Abstract)

Anaphylaxis - lessons learnt when East meets West. The rapidly increasing prevalence of allergic disorders over the past 2 decades highlights the need to understand the epidemiology of anaphylaxis. In Europe, the United States and Australia, the incidence of anaphylaxis is estimated to be between 60 and 950 cases per 100,000 population, with a lifetime prevalence of anaphylaxis of 0.05% -2%. The incidence appears to be increasing over time. Although the existing Asian literature (...) is heterogeneous and limited by underreporting, it also suggests a similar increasing trend in anaphylaxis incidence in Asia. Anaphylaxis triggers in Asia, such as the predominance of shellfish and wheat in older children and adolescents differ from those seen in Western populations. Triggers unique to Asia such as traditional Chinese medications, galacto-oligosaccharides and food delicacies have also been reported. Low usage of adrenaline as first-line treatment of anaphylaxis is evident across all countries

2019 Pediatric Allergy and Immunology

59. IL-13-induced Intestinal secretory epithelial cell antigen passages are required for IgE-mediated food-induced anaphylaxis. Full Text available with Trip Pro

IL-13-induced Intestinal secretory epithelial cell antigen passages are required for IgE-mediated food-induced anaphylaxis. Food-induced anaphylaxis is an IgE-dependent immune response that may affect multi-organs and lead to life threatening complications. The processes by which food allergens cross the mucosal surface and are delivered to the sub-epithelial immune compartment to promote the clinical manifestations associated with food-triggered anaphylaxis are largely unexplored.To define (...) the processes involved in the translocation of food allergens across the mucosal epithelial surface to the subepithelial immune compartment in food-induced anaphylaxis (FIA).2 photon (2P) confocal and immunofluorescence microscopy was employed to visualize and trace food allergen passage in a murine model of FIA. Human colon cancer cell line, RNA silencing and pharmacological approaches were used to identify the molecular regulation of intestinal epithelial allergen uptake and translocation. Human

2019 Journal of Allergy and Clinical Immunology

60. Changing the history of anaphylaxis mortality statistics through the World Health Organization's International Classification of Diseases-11. (Abstract)

Changing the history of anaphylaxis mortality statistics through the World Health Organization's International Classification of Diseases-11. We review the history of the classification and coding changes for anaphylaxis and provide current and perspective information in the field. In 2012, an analysis of Brazilian data demonstrated undernotification of anaphylaxis-related deaths because of the difficulties of coding using the International Classification of Diseases, 10th Revision. This work (...) -11 perspective. Coding accuracy was much improved, reaching 95% for definite anaphylaxis. As the results were provided to the WHO Mortality Reference Group, coding rules have been changed, allowing anaphylaxis to be recorded as an underlying cause of death in official mortality statistics. The mandatory use of ICD-11 from January 2022 for documenting cause of death could have 2 immediate consequences: (1) the reported number of anaphylaxis-related deaths might increase because of more appropriate

2019 Journal of Allergy and Clinical Immunology

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>