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Anaphylaxis

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1. Anaphylaxis

Anaphylaxis Anaphylaxis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Anaphylaxis Last reviewed: February 2019 Last updated: March 2019 Summary Sudden onset of respiratory or cardiovascular compromise, usually with a history of allergen exposure in sensitised individuals. Skin rash, wheezing and inspiratory stridor, hypotension, anxiety, nausea, and vomiting are the cardinal signs and symptoms. The diagnosis (...) is clinical. Allergy testing is helpful only for secondary prophylaxis. Securing the airway and initiating prompt treatment with epinephrine (adrenaline) may save lives. Comorbidities (e.g., coronary artery disease and COPD) may pose a treatment challenge and warrant expert consultation Definition Anaphylaxis is an acute, severe, life-threatening allergic reaction in pre-sensitised individuals, leading to a systemic response caused by the release of immune and inflammatory mediators from basophils

2019 BMJ Best Practice

3. Anaphylaxis

Anaphylaxis Anaphylaxis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Anaphylaxis Last reviewed: February 2019 Last updated: March 2019 Summary Sudden onset of respiratory or cardiovascular compromise, usually with a history of allergen exposure in sensitised individuals. Skin rash, wheezing and inspiratory stridor, hypotension, anxiety, nausea, and vomiting are the cardinal signs and symptoms. The diagnosis (...) is clinical. Allergy testing is helpful only for secondary prophylaxis. Securing the airway and initiating prompt treatment with epinephrine (adrenaline) may save lives. Comorbidities (e.g., coronary artery disease and COPD) may pose a treatment challenge and warrant expert consultation Definition Anaphylaxis is an acute, severe, life-threatening allergic reaction in pre-sensitised individuals, leading to a systemic response caused by the release of immune and inflammatory mediators from basophils

2018 BMJ Best Practice

4. Perioperative Anaphylaxis Management Guidelines

Perioperative Anaphylaxis Management Guidelines Page 1 Guidelines Anaphylaxis 2016 Australian and New Zealand College of Anaesthetists (ANZCA) and Australian and New Zealand Anaesthetic Allergy Group (ANZAAG) Perioperative Anaphylaxis Management Guidelines INTRODUCTON Anaphylaxis is a life-threatening emergency that requires prompt recognition of signs and symptoms, early administration of adrenaline (epinephrine) in adequate dosage, and aggressive volume replacement. Due to the paucity (...) of randomised controlled trials of sufficient quality on the management of anaphylaxis 1-6 the recommendations in these guidelines are consensus statements developed by the Australian and New Zealand Anaesthetic Allergy Group (ANZAAG) and the Australian and New Zealand College of Anaesthetists (ANZCA) after a review of the literature 1-12 . Management of anaphylaxis consists of prompt diagnosis, immediate treatment, refractory management, and post crisis management. To facilitate the management of each

2019 Australian and New Zealand College of Anaesthetists

6. ASCIA Guidelines - Acute management of anaphylaxis

ASCIA Guidelines - Acute management of anaphylaxis 1 Acute Management of Anaphylaxis These guidelines are intended for medical practitioners and nurses providing first responder emergency care. The appendix includes additional information for emergency department staff, ambulance staff, rural or remote medical practitioners and nurses providing emergency care. Anaphylaxis definitions • Any acute onset illness with typical skin features (urticarial rash or erythema/flushing, and/or angioedema (...) ), PLUS involvement of respiratory and/or cardiovascular and/or persistent severe gastrointestinal symptoms; or • Any acute onset of hypotension or bronchospasm or upper airway obstruction where anaphylaxis is considered possible, even if typical skin features are not present. The most common triggers of anaphylaxis (severe allergic reaction) are foods, insect stings and drugs (medications). Signs and symptoms of allergic reactions Mild or moderate reactions • Swelling of lips, face, eyes • Hives

2019 Australasian Society of Clinical Immunology and Allergy

7. Secondary prevention measures in anaphylaxis patients: Data from the Anaphylaxis Registry. (PubMed)

Secondary prevention measures in anaphylaxis patients: Data from the Anaphylaxis Registry. Patients with a history of anaphylaxis are at risk of future anaphylactic reactions. Thus, secondary prevention measures are recommended for these patients to prevent or attenuate the next reaction.Data from the Anaphylaxis Registry were analyzed to identify secondary prevention measures offered to patients who experienced anaphylaxis. Our analysis included 7788 cases from 10 European countries

2019 Allergy

8. Should patients, with a history of anaphylaxis, avoid ACE Inhibitors?

Should patients, with a history of anaphylaxis, avoid ACE Inhibitors? Q&A - Should patients, with a history of anaphylaxis, avoid ACE Inhibitors? - Trip Database NEW! or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers (...) in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Asked 25 Oct 2019 · , Doctor/physician - primary care/family practice, UK Should patients, with a history of anaphylaxis, avoid ACE Inhibitors? A colleague has been to a recent update and was advised by acute care physicians that patients with a history of anaphylaxis (any cause) should avoid

2019 Trip Community Q&A

9. CRACKCast E119 – Allergy, Hypersensitivity, Angioedema, and Anaphylaxis

CRACKCast E119 – Allergy, Hypersensitivity, Angioedema, and Anaphylaxis CRACKCast E119 – Allergy, Hypersensitivity, Angioedema, and Anaphylaxis - CanadiEM CRACKCast E119 – Allergy, Hypersensitivity, Angioedema, and Anaphylaxis In , by Chris Lipp October 19, 2017 This episode of CRACKCast covers Rosen’s Chapter 119 (109 in 9th), Allergy, Hypersensitivity, Angioedema, and Anaphylaxis. Patients suffering from acute allergic reactions, anaphylaxis, and angioedema are amongst the most unstable (...) , raised, and pruritic rash . Angioedema Another important syndrome, mediated by either an allergic (histaminergic) mechanism in response to exposure to foods, drugs, physical stimuli, or a non-allergic (non-histaminergic) mechanism (e.g., hereditary angioedema [HAE], or angiotensin-converting enzyme [ACE] inhibitor). Angioedema is characterized by edema of the subcutaneous or submucosal tissues, which can cause airway compromise if the tongue or larynx is involved. Anaphylaxis A life-threatening

2017 CandiEM

10. ASCIA Checklist - Travel for people with allergy, asthma and anaphylaxis

ASCIA Checklist - Travel for people with allergy, asthma and anaphylaxis ASCIA Travel Plan: Anaphylaxis - Australasian Society of Clinical Immunology and Allergy (ASCIA) | | ASCIA Travel Plan: Anaphylaxis Other travel information for people at risk of anaphylaxis is available from Allergy & Anaphylaxis Australia: Page updated January 2019 Site last updated: 6 Nov 2019 Member Login Remember Me Log in ASCIA Update Information for the community about allergic diseases, immunodeficiencies and other

2017 Australasian Society of Clinical Immunology and Allergy

11. Factors increasing the risk for a severe reaction in anaphylaxis: An analysis of Data from The European Anaphylaxis Registry. (PubMed)

Factors increasing the risk for a severe reaction in anaphylaxis: An analysis of Data from The European Anaphylaxis Registry. Preventive measures to decrease the frequency and intensity of anaphylactic events are essential to provide optimal care for allergic patients. Aggravating factors may trigger or increase the severity of anaphylaxis and therefore need to be recognized and avoided.To identify and prioritize factors associated with an increased risk of developing severe anaphylaxis.Data (...) from the Anaphylaxis Registry (122 centers in 11 European countries) were used in logistic regression models considering existing severity grading systems, elicitors, and symptoms to identify the relative risk of factors on the severity of anaphylaxis.We identified higher age and concomitant mastocytosis (OR: 3.1, CI: 2.6-3.7) as the most important predictors for an increased risk of severe anaphylaxis. Vigorous physical exercise (OR: 1.5, CI: 1.3-1.7), male sex (OR: 1.2, CI: 1.1-1.3

2018 Allergy

12. Increasing trends of anaphylaxis-related events: an analysis of anaphylaxis using nationwide data in Taiwan, 2001–2013 (PubMed)

Increasing trends of anaphylaxis-related events: an analysis of anaphylaxis using nationwide data in Taiwan, 2001–2013 Anaphylaxis is a severe, potentially fatal, and systemic allergic reaction. Previous studies document increasing trends in incidence rates of anaphylaxis-related events in Western countries, yet little is known about the incidence and trend of anaphylaxis in Asia. In this study, we aimed to determine time trends in incidence rates of anaphylaxis-related events in Taiwan from (...) 2001 through 2013.We utilized medical claims data from the National Health Insurance Research Databases in Taiwan. We identified anaphylaxis-related events (ICD-9-CM-codes: 995.0, 995.60-995.69, 999.41-999.42, and 999.49) and calculated incidence rates. Poisson regression models were applied to examine trends and incidence rates.A total of 2496 patients (mean age, 45.11 years; 56% male) with first-time anaphylaxis were identified during 34,430,000 person-years of observation time. The overall

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2018 The World Allergy Organization journal

13. Anaphylaxis ? First Aid Management

Anaphylaxis ? First Aid Management ANZCOR Guideline 9.2.7 August 2016 Page 1 of 3 ANZCOR Guideline 9.2.7 – First Aid Management of Anaphylaxis Guideline Who does this guideline apply to? This guideline applies to adults, children and infant victims. Who is the audience for this guideline? This guideline is for use by bystanders, first aiders and first aid providers. 1 Introduction Anaphylaxis is the most severe form of allergic reaction and is potentially life threatening. It must be treated (...) as a medical emergency, requiring immediate treatment and urgent medical attention. Anaphylaxis is a generalised allergic reaction, which often involves more than one body system. A severe allergic reaction usually occurs within 20 minutes of exposure to the trigger. 1 Severe allergic reactions may occur without prior exposure to a trigger. It is characterised by rapidly developing airway and/or breathing and/or circulation problems usually associated with swelling, redness or itching of the skin, eyes

2016 Australian Resuscitation Council

14. Association Between Intravenous Thrombolysis and Anaphylaxis Among Medicare Beneficiaries With Acute Ischemic Stroke

Association Between Intravenous Thrombolysis and Anaphylaxis Among Medicare Beneficiaries With Acute Ischemic Stroke Background and Purpose- Allergic reactions, including anaphylaxis, can sometimes occur after intravenous thrombolysis in patients with acute ischemic stroke. However, it remains unclear whether patients with stroke who receive thrombolytic agents face a higher risk of anaphylaxis than those who do not receive thrombolytics. Methods- We performed a retrospective cohort study using (...) code 99.10). Our primary outcome was anaphylaxis, defined using an accepted International Classification of Diseases, Ninth Revision, Clinical Modification code algorithm (989.5, 995.0-4, 995.6x, E905, E905.3, E905.5, or E905.8-9). A secondary outcome was anaphylactic shock (995.0 or 995.6x). Multiple logistic regression was used to evaluate the association between intravenous thrombolysis and anaphylaxis after adjustment for demographics, vascular risk factors, the Charlson comorbidity index

2019 EvidenceUpdates

15. Patterns of anaphylaxis after diagnostic work-up: a follow-up study of 226 patients with suspected anaphylaxis. (PubMed)

Patterns of anaphylaxis after diagnostic work-up: a follow-up study of 226 patients with suspected anaphylaxis. Most published studies on anaphylaxis are retrospective or register based. Data on subsequent diagnostic workup are sparse. We aimed to characterize patients seen with suspected anaphylaxis at the emergency care setting (ECS), after subsequent diagnostic workup at our Allergy Center (AC).Prospective study including patients from the ECS, Odense University Hospital, during May 2013 (...) -April 2014. Possible anaphylaxis cases were daily identified based on a broad search profile including history and symptoms in patient records, diagnostic codes and pharmacological treatments. At the AC, all patients were evaluated according to international guidelines.Among 226 patients with suspected anaphylaxis, the diagnosis was confirmed in 124 (54.9%) after diagnostic workup; 118 of the 124 fulfilled WAO/EAACI criteria of anaphylaxis at the ECS, while six were found among 46 patients

2017 Allergy

16. Fatal anaphylaxis in France: analysis of national anaphylaxis data, 1979-2011. (PubMed)

Fatal anaphylaxis in France: analysis of national anaphylaxis data, 1979-2011. 28283420 2017 08 07 1097-6825 140 2 2017 Aug The Journal of allergy and clinical immunology J. Allergy Clin. Immunol. Fatal anaphylaxis in France: Analysis of national anaphylaxis data, 1979-2011. 610-612.e2 S0091-6749(17)30342-1 10.1016/j.jaci.2017.02.014 Pouessel Guillaume G Department of Pediatrics, Children's Hospital, Roubaix, France; Pediatric Pulmonology and Allergy Department, Pôle enfant, Hôpital Jeanne de

2017 Journal of Allergy and Clinical Immunology

17. Food-induced anaphylaxis and cofactors – data from the anaphylaxis registry (PubMed)

Food-induced anaphylaxis and cofactors – data from the anaphylaxis registry Food allergens are frequent causes of anaphylaxis. In particular in children and adolescents they are the most frequent elicitors of severe allergic reactions, and in adults food allergens rank third behind insect venom and drugs. Since July 2006 severe allergic reactions from Germany, Austria, and Switzerland are collected in the anaphylaxis registry. Currently 78 hospitals and private practises are connected. From (...) the most frequent elicitor. In adults fruits (13.4%) most often induced severe food-dependent anaphylaxis, but also animal products (12.2%); among these most frequently crustaceans and molluscs. Cofactors were often suspected in food-dependent anaphylaxis, namely in 39% of the adult group and in 14% of the pediatric group. In adults drugs (22%) and physical activity (10%) were reported to be the most frequent cofactors, in children physical activity was suspected in 8.7% and drugs in 2.6%. Concomitant

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2017 Allergologie Select

18. Fatal anaphylaxis registries data support changes in the who anaphylaxis mortality coding rules (PubMed)

Fatal anaphylaxis registries data support changes in the who anaphylaxis mortality coding rules Anaphylaxis is defined as a severe life-threatening generalized or systemic hypersensitivity reaction. The difficulty of coding anaphylaxis fatalities under the World Health Organization (WHO) International Classification of Diseases (ICD) system is recognized as an important reason for under-notification of anaphylaxis deaths. On current death certificates, a limited number of ICD codes are valid (...) as underlying causes of death, and death certificates do not include the word anaphylaxis per se. In this review, we provide evidences supporting the need for changes in WHO mortality coding rules and call for addition of anaphylaxis as an underlying cause of death on international death certificates. This publication will be included in support of a formal request to the WHO as a formal request for this move taking the 11th ICD revision.

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2017 Orphanet journal of rare diseases

19. ASCIA Clinical Update - Anaphylaxis

ASCIA Clinical Update - Anaphylaxis Disclaimer: ASCIA information is reviewed by ASCIA members and represents the available published literature at the time of review. The content of this document is not intended to replace professional medical advice and any questions regarding a medical diagnosis or treatment should be directed to a medical practitioner. © ASCIA 2016 Anaphylaxis Clinical Update This Clinical Update complements the latest version of ASCIA anaphylaxis e-training for health (...) professionals, which was first available in 2011. The main purpose of this document is to provide an evidence-based, ‘quick reference guide’ to assist primary health care physicians including general practitioners, paediatricians and nurses in the management of patients with allergy who are at risk of anaphylaxis. Contents Page 1. What is allergy and anaphylaxis? 2 1.1. Allergen sensitisation 1.2. Mechanisms of an allergic reaction 1.3. Definition of anaphylaxis 1.4. Signs and symptoms of allergy

2016 Australasian Society of Clinical Immunology and Allergy

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