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Amrinone

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1. Amrinone

Amrinone Amrinone Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Amrinone Amrinone Aka: Amrinone From Related Chapters II. Class (...) Preparation Dilute Amrinone Lactate in NS or 1/2NS Do not dilute directly in dextrose solutions May be infused in a line with dextrose solution Final Concentration: 1-3 mg/ml Load: 0.75 mg/kg (max: 1 mg/kg) bolus over 10-15 min Maintenance Infusion Start: 2-5 ug/kg/min Titrate to: 10-15 ug/kg/min VIII. Monitoring Central hemodynamics IX. Adverse Effects (2-3%) Occurs within 48-72 hours Resolves after discontinuing Amrinone Dose dependent effect and Myalgia Hepatic dysfunction Arrhythmia Ventricular

2018 FP Notebook

2. Amrinone

Amrinone Amrinone Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Amrinone Amrinone Aka: Amrinone From Related Chapters II. Class (...) Preparation Dilute Amrinone Lactate in NS or 1/2NS Do not dilute directly in dextrose solutions May be infused in a line with dextrose solution Final Concentration: 1-3 mg/ml Load: 0.75 mg/kg (max: 1 mg/kg) bolus over 10-15 min Maintenance Infusion Start: 2-5 ug/kg/min Titrate to: 10-15 ug/kg/min VIII. Monitoring Central hemodynamics IX. Adverse Effects (2-3%) Occurs within 48-72 hours Resolves after discontinuing Amrinone Dose dependent effect and Myalgia Hepatic dysfunction Arrhythmia Ventricular

2015 FP Notebook

3. Retraction note to: Amrinone improves contractility of fatigued diaphragm in dogs. Can J Anaesth 1995; 42: 80-6,DOI 10.1007/BF03010577. (PubMed)

Retraction note to: Amrinone improves contractility of fatigued diaphragm in dogs. Can J Anaesth 1995; 42: 80-6,DOI 10.1007/BF03010577. Further to the Expression of Concern posted online on March 13th, 2012, it is with considerable regret that the Canadian Journal of Anesthesia hereby retracts the above-cited article by Dr. Yoshitaka Fujii as a result of:(1) overwhelming evidence of fabrication relating to the fact that the distributions of many variables reported by Dr. Fujii in these studies

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2012 Canadian Journal Of Anaesthesia

4. Inotropic agents and vasodilator strategies for the treatment of cardiogenic shock or low cardiac output syndrome. (PubMed)

ongoing studies. We categorised studies into eight comparisons, all against cardiac care and additional other active drugs or placebo. These comparisons investigated the efficacy of levosimendan versus dobutamine, enoximone or placebo, epinephrine versus norepinephrine-dobutamine, amrinone versus dobutamine, dopexamine versus dopamine, enoximone versus dopamine and nitric oxide versus placebo.All trials were published in peer-reviewed journals, and analysis was done by the intention-to-treat (ITT (...) ), amrinone with dobutamine (RR 0.33, 95% CI 0.04 to 2.85; 30 participants), dopexamine with dopamine (no in-hospital deaths from 70 participants), enoximone with dobutamine (two deaths from 40 participants) and nitric oxide with placebo (one death from three participants).Apart from low quality of evidence data suggesting a short-term mortality benefit of levosimendan compared with dobutamine, at present there are no robust and convincing data to support a distinct inotropic or vasodilator drug-based

2018 Cochrane

5. CRACKCast E171 – Pediatric Cardiac Disorders

for the 2 bigs and 2 fasts as well as wheezes or cough) If decompensated cardiogenic shock: 1st line pressor: norepinephrine 2nd line inotrope: dobutamine or epinephrine NOTE: What is absent? Don’t give venodilators like nitroglycerin as first line agents! Children are much more sensitive to the drug’s potent vasodilatory effects than adults, and they can experience profound and rapid hypotension with its administration. Amrinone and milrinone, most commonly used in the ICU setting, [8] List 12

2018 CandiEM

7. Extracorporeal Membrane Oxygenation (ECMO)

and the blood flow was either by-level shunt or completely shunt from right side to left side. 2. Non-ECMO group: Oxygenation Index > 16 and reach the Montreux definition of severe respiratory distress syndrome Vasoactive-inotropic score (VIS) ≥ 40 [VIS=dopamine dose (μg/kg/min)×1 + dobutamine dose (μg/kg/min)×1 + milrinone dose (μg/kg/min)×10 + amrinone dose (μg/kg/min)×10 + epinephrine dose (μg/kg/min)×100 + isoprenaline dose (μg/kg/min)×100] Exclusion Criteria: Gestational age < 36 weeks, birth weight

2018 Clinical Trials

8. Evaluate the Efficacy and Safety of Short-term Administration of SIMDAX

in patients with ADHF who will be hospitalized with ADHF and continue to have symptom of dyspnea at rest(NYHA Class III or IV) despite with treatment of SOCs(include intravenous diuretics, vasodilators and/or positive inotropic drugs but except amrinone and milrinone) within 48hrs Efficacy is measured by Clinical composite classification(Improved, No change, Worse), bio-marker(change of BNP and ST-2), Patient's Global Assessment, NYHA functional Classification, hospitalization period and renal function (...) 120 bpm or greater, persistent for at least 5 minutes at screening or baseline. Serum potassium less than 3.5mmol/l or greater than 5.4 mmol/l. Angina pectoris during the 6 hours before baseline. Administration of amrinone or milrinone within 24 hours before start of study drug infusion. Hypersensitivity to levosimendan or any of the excipients: Povidone, Citric acid, Ethanol A history of Torsades de Pointes. Severe renal insufficiency (serum creatinine > 450mol/l (5.0 mg/dl)) or on dialysis

2018 Clinical Trials

9. Resuscitation in Special Circumstances

discharge in the setting of severe cardiovascular toxicity associated with beta-blocker toxicity. Case reports described the use of phosphodiesterase inhibitors calcium salts, extracorporeal support, intraaortic balloon pumps, and ECMO. Animal studies supported the use of calcium salts and the phosphodiesterase inhibitor amrinone. Animal studies suggested that dopamine, a combination of dopamine and isoprenaline, and milrinone may decrease the effectiveness of glucagon as an antidote for beta-blocker

2011 Australian Resuscitation Council

10. Understanding the Pathophysiology of Migraine Pain

for both angiography and for participation in this study, and must be willing to undergo angiography for the evaluation of their symptoms Exclusion Criteria: Subjects taking vasoactive drugs including epinephrine, norepinephrine, dopamine, dobutamine, isoprenaline, dopexamine, milrinone, amrinon, levosimendan, glucagon, phenylephrine, metaraminol, ephedrine, vasopressin, digoxin, and levothyroxine Subjects with underlying cardiac pathology including but not limited to coronary artery disease, heart

2016 Clinical Trials

11. Investigation of Calcium Channel Blockers as Antiprotozoal Agents and Their Interference in the Metabolism of Leishmania (L.) infantum. (PubMed)

to investigate whether the in vitro anti-Leishmania infantum and anti-Trypanosoma cruzi activities of this therapeutic class would be shared by other non-dihydropyridine-CCBs. Except for amrinone, our results demonstrated antiprotozoal activity for fendiline, mibefradil, and lidoflazine, with IC50 values in a range between 2 and 16 μM and Selectivity Index between 4 and 10. Fendiline demonstrated depolarization of mitochondrial membrane potential, with increased reactive oxygen species production

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2016 Evidence-based Complementary and Alternative Medicine (eCAM)

12. Balanced Salt Solution Versus 0.9% Saline Infusion for Prevention of Contrast-induced Acute Kidney Injury (BASIC Trial)

or IV) Decompensated heart failure patients who use dobutamine, dopamine, milrinone, amrinone, nesiritide or patients who have acute pulmonary edema History of hyperkalemia (serum K > 5.5 mEq/L) or hypernatremia ( serum Na > 145 mEq/L) in screening period Recent exposure to radiocontrast within 7 days of the study History of hypersensitivity to radiocontrast Multiple myeloma Pregnant/lactation Expected survival < 6 months Enrolled in other clinical trials Contacts and Locations Go to Information

2016 Clinical Trials

13. Pharmacological interventions for ischaemia reperfusion injury in liver resection surgery performed under vascular control. (PubMed)

or available case analysis. However, all outcomes were only reported on by single trials, and meta-analysis could not be performed. Therefore, we performed Fisher's exact test on dichotomous outcomes.We identified a total of five randomised trials evaluating nine different pharmacological interventions (amrinone, prostaglandin E1, pentoxifylline, dopexamine, dopamine, ulinastatin, gantaile, sevoflurane, and propofol). All trials had high risk of bias. There was no significant difference between the groups

2009 Cochrane

14. Metabolic effects of newly synthesized phosphodiesterase-3 inhibitor 6-[4-(4-methylpiperidin-1-yl)-4-oxobutoxy]-4-methylquinolin-2(1H)-one on rat adipocytes (PubMed)

chronotropic effect. This work was done to evaluate the effects of MC2 on adipocytes and compare its effects with those of amrinone and cilostamide.Preadipocytes were isolated from rat adipose tissue and differentiated to adipocyte in the presence of cilostamide, amrinone or MC2. Lipolysis and adipogenesis was evaluated by measuring glycerol level and Oil Red O staining, respectively. Adipocyte proliferation and apoptosis were determined with MTT assay and Annexin V/PI staining (...) , respectively.Differentiation to adipocyte was induced by amrinone but not by cilostamide or MC2. Basal and isoproterenol-stimulated lipolysis significantly increased by cilostamide (p<0.05). Similarly, amrinone enhanced the stimulated lipolysis (p<0.01). On the other hand, MC2 significantly decreased both adipogenesis (p<0.05) and stimulated lipolysis (p<0.001). Also, incubation of differentiated adipocytes with MC2 caused the loss of cell viability, which was associated with the elevation in apoptotic rate (p<0.05).Our

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2015 DARU Journal of Pharmaceutical Sciences

15. A Therapeutic Confirmatory Study to Evaluate the Efficacy and Safety of Cilostazol in Subjects With Vasospastic Angina

, or PDE3 inhibitors of the same class as Cilostazol, such as Amrinone, Milrinone and Enoximone, after the initiation of the amlodipine run-in period Subjects who used oral anticoagulants, such as warfarin, within 1 months prior to the screening visit Subjects who used any of the following drugs within 1 week prior to the screening visit CCBs apart from amlodipine Beta-blockers or alpha-blockers Oral nitrate, excluding nitroglycerin sublingual tablet, Nicorandil Vitamin E preparations Estrogens History

2014 Clinical Trials

16. Serial Daily Diaphragm Ultrasounds in Ventilated Patients

institution ] This will include any dose of steroids administered to the patient each day during their intubation. vasopressors given [ Time Frame: Will be recorded daily until they are extubated or the 3 month study period has ended, the expected average duration of mechanical ventilation is 4.4 days at our institution ] This will include any dose of medications to support the blood pressure (norepinephrine, epinephrine, dopamine, dobutamine, amrinone) administered to the patient each day during

2014 Clinical Trials

17. A Dose Ranging Phase IIa Study of 6 Hour Intravenous Dosages of CXL-1427 in Patients Hospitalized With Heart Failure

for PAL placement.] Have a primary HF etiology attributable to either restrictive/obstructive cardiomyopathy, idiopathic hypertrophic cardiomyopathy (as defined by any wall thickness > 1.8cm) or uncorrected severe valvular disease as defined by AHA/ACC/ESC criteria; Have been treated with dopamine, dobutamine, enoximone, nesiritide, nitroglycerine or nitroprusside within 4 hours, or with levosimendan, amrinone or milrinone within 8 hours, prior to performing baseline hemodynamic assessments, or have

2014 Clinical Trials

18. Cardiogenic Shock (Diagnosis)

be administered, as follows: Norepinephrine is started at a dose of 0.5 mcg/kg/min and titrated to maintain an MAP of 60 mm Hg The dose of norepinephrine may vary from 0.2-1.5 mcg/kg/min Doses as high as 3.3 mcg/kg/min have been used Phosphodiesterase inhibitors (eg, inamrinone [formerly amrinone], milrinone) are inotropic agents with vasodilating properties and long half-lives that are beneficial in patients with cardiac pump failure, but they may require concomitant vasopressor administration PCI and CABG

2014 eMedicine.com

19. Cardiogenic Shock (Treatment)

(PDIs), which include inamrinone (formerly amrinone) and milrinone, are inotropic agents with vasodilating properties and long half-lives. Milrinone is used in a dosage range of 0.3 to 0.75 mcg/kg/min and has a long half-life of 1.5 to 3 hours, with the longer half-life in patients with renal impairment. The mechanism of action of PDIs is distinct from dobutamine in that they prevent breakdown of cAMP, thereby increasing intracellular cAMP levels. The hemodynamic properties of PDIs are (1

2014 eMedicine.com

20. Cardiogenic Shock (Overview)

be administered, as follows: Norepinephrine is started at a dose of 0.5 mcg/kg/min and titrated to maintain an MAP of 60 mm Hg The dose of norepinephrine may vary from 0.2-1.5 mcg/kg/min Doses as high as 3.3 mcg/kg/min have been used Phosphodiesterase inhibitors (eg, inamrinone [formerly amrinone], milrinone) are inotropic agents with vasodilating properties and long half-lives that are beneficial in patients with cardiac pump failure, but they may require concomitant vasopressor administration PCI and CABG

2014 eMedicine.com

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