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Amniocentesis

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1. Amniocentesis and chorionic villus sampling for prenatal diagnosis. (PubMed)

Amniocentesis and chorionic villus sampling for prenatal diagnosis. During pregnancy, fetal cells suitable for genetic testing can be obtained from amniotic fluid by amniocentesis (AC), placental tissue by chorionic villus sampling (CVS), or fetal blood. A major disadvantage of second trimester amniocentesis is that the results are available relatively late in pregnancy (after 16 weeks' gestation). Earlier alternatives are chorionic villus sampling (CVS) and early amniocentesis, which can (...) , 95% CI 0.99 to 2.00; moderate-quality evidence). In the same study, spontaneous miscarriages were also higher (2.1% versus 1.3%; average RR 1.60, 95% CI 1.02 to 2.52; high-quality evidence). The number of congenital anomalies was similar in both groups (2.0% versus 2.2%, average RR 0.93, 95% CI 0.62 to 1.39; moderate-quality evidence).One study (women = 4334) found that early amniocentesis was not a safe early alternative compared to second trimester amniocentesis because of increased total

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2017 Cochrane

2. The Role of Amniocentesis in the Diagnosis of Congenital Zika Syndrome. (PubMed)

The Role of Amniocentesis in the Diagnosis of Congenital Zika Syndrome. There is limited data on amniocentesis as a diagnostic tool for congenital Zika syndrome. Here we report on a prospective cohort of 16 women with suspected Zika virus infection in a highly endemic area, and discusss the role of amniocentesis in the prenatal diagnosis of fetal Zika infection.

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2019 Clinical Infectious Diseases

3. Mother-to-child transmission of hepatitis B virus after amniocentesis: A retrospective matched cohort study. (PubMed)

Mother-to-child transmission of hepatitis B virus after amniocentesis: A retrospective matched cohort study. The objective of this study is to determine whether amniocentesis increases the risk of mother-to-child transmission (MTCT) of hepatitis B virus (HBV) and evaluate risk factors for MTCT.One hundred forty-three hepatitis B surface antigen (HBsAg)-positive women with amniocentesis were enrolled into the amniocentesis group. Six hundred five nonamniocentesis cases were matched (...) with amniocentesis cases based on maternal viral loads, antiviral therapy regimens, and delivery dates. MTCT of HBV was defined as HBsAg and/or DNA positivity in infants from birth to age 7 to 12 months.Mother-to-child transmission rate was significantly higher in HBsAg-positive women with amniocentesis than in those without amniocentesis (2.80% vs 0.50%; relative risk [RR], 5.64; 95% CI, 1.28-24.93). In the amniocentesis group, maternal HBV DNA more than or equal to 7.0 log10 IU/mL and hepatitis B e-antigen

2019 Prenatal diagnosis

4. Procedure related risk of miscarriage from chorionic villus sampling and amniocentesis. (PubMed)

Procedure related risk of miscarriage from chorionic villus sampling and amniocentesis. The objective of our study was to estimate the procedure-related risks of miscarriage following CVS and amniocentesis in a large unselected screened and to determine whether these risks are consistent with those reported in systematic reviews and meta-analysis.This was a retrospective cohort study undertaken at a large Fetal Medicine Unit in the United Kingdom during the period of January 2009 to May 2018 (...) . We included all singleton pregnancies that booked at our unit before 20 weeks after excluding those with multiple pregnancies, major fetal defects, terminations and lost to follow-up. We estimated the risk of miscarriage in those that had a CVS or amniocentesis as well as those that did not have any invasive procedure, to estimate the procedure-related risk as a risk-difference (95% confidence interval [CI]). Univariate and multivariate regression analysis was used to derive odds ratios (OR) (95

2019 Ultrasound in Obstetrics and Gynecology

5. The effect of diagnostic amniocentesis and its complications on early spontaneous abortion (PubMed)

The effect of diagnostic amniocentesis and its complications on early spontaneous abortion The occurrence of early abortion after amniocentesis is a serious problem in the fields of obstetrics and gynecology, and it is always important to discover the factors influencing this phenomenon. The incidence rate has been reported in different studies, even up to about 10%. So far, no studies have been conducted in Iran on the effect of amniocentesis and related complications on early abortion (...) . The aim of this study was to determine the effects of amniocentesis and relevant complications on the incidence of early abortion in pregnant women undergoing amniocentesis.This cohort study was conducted between March 2014 and March 2016 on pregnant candidates for amniocentesis referred to the perinatology clinic at Ommol-Banin Hospital, Mashhad, Iran. Amniocentesis was performed for all patients with about 20-30cc in the same manner by a perinatologist. Maternal blood group, causes of amniocentesis

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2016 Electronic physician

6. Music Listening to Decrease Pain during Second Trimester Genetic Amniocentesis: A Randomized Trial. (PubMed)

Music Listening to Decrease Pain during Second Trimester Genetic Amniocentesis: A Randomized Trial. To evaluate whether music listening decreased pain perception during second trimester genetic amniocentesis.We conducted a prospective randomized study to compare the pain perception using a visual analogue scale (VAS), pain rating, future decision to repeat the procedure, and pain perception compared to a venipuncture before and after the second trimester genetic amniocentesis between groups (...) of pregnant women who underwent amniocentesis with and without music listening.Three hundred thirty two pregnant women were enrolled; 161 listened and 171 did not listen to the music. The pre-procedure anxiety, the anticipated pain, post-procedure pain/ anxiety median VAS scores, pain rating, future decision and level of pain compare to a venipuncture in the music-listening and non-music-listening groups did not show statistically significant difference. The pre-procedure anxiety median VAS scores were

2018 Journal of the Medical Association of Thailand = Chotmaihet thangphaet

7. Effect of Supportive Information on Anxiety Levels in Pregnant Women Awaiting Amniocentesis Results: A Randomized Controlled Trial. (PubMed)

Effect of Supportive Information on Anxiety Levels in Pregnant Women Awaiting Amniocentesis Results: A Randomized Controlled Trial. To evaluate the effect of supportive information on anxiety levels in women awaiting amniocentesis results.Women underwent amniocentesis were randomized into two groups according to whether they did (group A) or did not (group B) receive supportive information. Anxiety levels were measured using the Spielberger State-Trait Anxiety Inventory at four time points, (1 (...) ) after amniocentesis, (2) before phoning for test result appointment confirmation, (3) after phoning, during which supportive information was given to group A, and (4) before receiving the test results. Semistructured interviews were conducted after the last anxiety measurement.There were no significant differences in the state anxiety scores between the two groups after amniocentesis and before phoning to confirm that the amniocentesis results were available. The state anxiety scores after

2018 Journal of the Medical Association of Thailand = Chotmaihet thangphaet

8. Oral paracetamol premedication effect on maternal pain in amniocentesis: a randomised double blind placebo-controlled trial. (PubMed)

Oral paracetamol premedication effect on maternal pain in amniocentesis: a randomised double blind placebo-controlled trial. The objective of this study was to evaluate the effectiveness of oral paracetamol premedication in decreasing the maternal pain during amniocentesis. A randomised double blind placebo-controlled trial was conducted. Two hundred and forty participants were equally allocated into two groups (one paracetamol and one placebo). Seven patients were excluded due (...) to their incomplete information. The basic characteristics between the two groups were statistically similar. The pain score anticipated by both groups were not significantly different (VAS score = 5.41 ± 1.97 vs. 5.48 ± 1.83; p = .771). The differences were significant for the pain scores during and after the amniocentesis. Concerning the pain scores during the amniocentesis, they were 3.00 ± 1.90 and 3.79 ± 1.78 for the paracetamol group and the placebo group, respectively (p = .001). As for pain scores two

2018 Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology

9. Prospective chromosome analysis of 3429 amniocentesis samples in China using copy number variation sequencing. (PubMed)

Prospective chromosome analysis of 3429 amniocentesis samples in China using copy number variation sequencing. Next-generation sequencing is emerging as a viable alternative to chromosome microarray analysis for the diagnosis of chromosome disease syndromes. One next-generation sequencing methodology, copy number variation sequencing, has been shown to deliver high reliability, accuracy, and reproducibility for detection of fetal copy number variations in prenatal samples. However, its clinical (...) utility as a first-tier diagnostic method has yet to be demonstrated in a large cohort of pregnant women referred for fetal chromosome testing.We sought to evaluate copy number variation sequencing as a first-tier diagnostic method for detection of fetal chromosome anomalies in a general population of pregnant women with high-risk prenatal indications.This was a prospective analysis of 3429 pregnant women referred for amniocentesis and fetal chromosome testing for different risk indications, including

2018 American Journal of Obstetrics and Gynecology

10. The impact of late amniocentesis in the modern genomic technologies era. (PubMed)

The impact of late amniocentesis in the modern genomic technologies era. The traditional timing for amniocentesis is between 17-23 weeks of pregnancy. This timing enables pregnancy associated decisions to be made before viability. Less frequently, third trimester amniocentesis is performed. Advanced genomic technologies such as chromosomal microarray analysis (CMA) introduce far more detailed information about the fetus compared to traditional G-banded chromosomal analysis. Not much is known (...) about the indications, safety and CMA yield for late amniocentesis.To assess the indications for late amniocentesis, safety, genetic test results (especially in the context of CMA technology) and pregnancy outcomes.We retrospectively analyzed medical records of all women that performed amniocentesis at gestational age of 24+0 to 38+6 weeks, between June 2013 and March 2017. Parameters investigated included indications for late amniocentesis, complications, CMA results and pregnancy outcomes.291

2018 Ultrasound in Obstetrics and Gynecology

11. Why do patients decline amniocentesis? Analysis of factors influencing the decision to refuse invasive prenatal testing. (PubMed)

Why do patients decline amniocentesis? Analysis of factors influencing the decision to refuse invasive prenatal testing. In recent years, determination of personalized risk for fetal chromosomal anomalies emerged as an important component of prenatal genetic counseling. Women in whom fetal risk for chromosomal aberrations is elevated are offered further testing. The aim of this study was to identify factors that may influence the decision to refuse invasive prenatal testing aimed (...) at determination of fetal karyotype in a group of patients at increased risk of trisomy 21.The analysis included 177 patients with singleton pregnancy, whose personalized risk score for trisomy 21 calculated on the basis of the combined test exceeded 1:300. Diagnostic amniocentesis was performed in 125 patients from this subset, since the remaining 52 women declined invasive prenatal testing. The following factors were analyzed as potential determinants of the decision to refuse amniocentesis: maternal age

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2018 BMC Pregnancy and Childbirth

12. Analgesia for amniocentesis or chorionic villus sampling. (PubMed)

Analgesia for amniocentesis or chorionic villus sampling. Besides risks of miscarriage, pregnant women undergoing amniocentesis or chorionic villus sampling (CVS) are also concerned about pain associated with these procedures. Currently, approaches to analgesia can be categorised in two broad categories - non-pharmacological and pharmacological agents.To evaluate whether different methods of analgesia have any impact on pain reduction during amniocentesis or chorionic villus sampling (CVS).We (...) searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 August 2011).All randomised trials comparing different method of analgesia for amniocentesis or CVS. We also include trials with quasi-randomised designs, but analyse and report their results separately.Both review authors assessed eligibility and trial quality and performed data extraction.We included a total of five randomised studies (involving 805 women) evaluating different methods of analgesia for amniocentesis; there were

2011 Cochrane

13. Congenital Cytomegalovirus Infection: Prognostic Value of Maternal DNAemia at Amniocentesis. (PubMed)

Congenital Cytomegalovirus Infection: Prognostic Value of Maternal DNAemia at Amniocentesis. Human Cytomegalovirus (HCMV) is the most common cause of childhood hearing loss and can lead to neurodevelopmental delay. To date, few studies have examined the correlation between maternal viremia and congenital HCMV infection. The aim of our study was to ascertain if HCMV DNA in the peripheral blood of pregnant women with primary HCMV infection at the time of amniocentesis may have a prognostic value (...) in terms of congenital infection and neonatal symptomatic disease.We performed a prospective observational study of pregnant women referred to our maternal-fetal medicine division with suspected HCMV infection. Primary infection was diagnosed based on seroconversion for HCMV and/or HCMV immunoglobulin M-positive and low or moderate HCMV immunoglobulin G avidity. At the time of amniocentesis, maternal blood samples were collected and analyzed by means of real-time polymerase chain reaction to determine

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2017 Clinical Infectious Diseases

14. Risk of miscarriage following amniocentesis and chorionic villus sampling: a systematic review of the literature. (PubMed)

Risk of miscarriage following amniocentesis and chorionic villus sampling: a systematic review of the literature. The aim of this paper was to estimate the risk of miscarriage after amniocentesis or chorionic villus sampling (CVS) based on a systematic review of the literature.A search of Medline, Embase, and The Cochrane Library (2000-2017) was carried out to identify studies reporting complications following CVS or amniocentesis. The inclusion criteria for the systematic review were studies (...) from the summary statistics for cases and controls.The electronic search from the databases yielded 2465 potential citations of which 2431 were excluded, leaving 34 studies for full-text review. The final review included 10 studies for amniocentesis and 6 studies for CVS, which were used to estimate risk of miscarriage in pregnancies that had an invasive procedure and the control pregnancies that did not. The procedure-related risk of miscarriage following amniocentesis was 0.35% (95% confidence

2017 Minerva ginecologica

15. Management of suspected primary Toxoplasma gondii infection in pregnant women in Norway: twenty years of experience of amniocentesis in a low-prevalence population. (PubMed)

Management of suspected primary Toxoplasma gondii infection in pregnant women in Norway: twenty years of experience of amniocentesis in a low-prevalence population. Primary infection with Toxoplasma gondii during pregnancy may pose a threat to the fetus. Women infected prior to conception are unlikely to transmit the parasite to the fetus. If maternal serology indicates a possible primary infection, amniocentesis for toxoplasma PCR analysis is performed and antiparasitic treatment given (...) . However, discriminating between primary and latent infection is challenging and unnecessary amniocenteses may occur. Procedure-related fetal loss after amniocentesis is of concern. The aim of the present study was to determine whether amniocentesis is performed on the correct patients and whether the procedure is safe for this indication.Retrospective study analysing data from all singleton pregnancies (n = 346) at Oslo University Hospital undergoing amniocentesis due to suspected maternal primary

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2017 BMC Pregnancy and Childbirth

16. Maternal anxiety and its correlation with pain experience during chorion villus sampling and amniocentesis (PubMed)

Maternal anxiety and its correlation with pain experience during chorion villus sampling and amniocentesis Invasive prenatal diagnostic procedures, such as chorion villus sampling (CVS) and amniocentesis (AC), are routinely performed to exclude or diagnose fetal chromosomal abnormalities. The aim of this study was to investigate anxiety-dependent pain experience during CVS and AC and the potential factors that increase anxiety and pain levels.During a 2-year period, women undergoing invasive

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2017 Journal of pain research

17. Effects of Vaginal Lactoferrin Administration Prior to Genetic Amniocentesis on Inflammatory Mediators

Effects of Vaginal Lactoferrin Administration Prior to Genetic Amniocentesis on Inflammatory Mediators Effects of Vaginal Lactoferrin Administration Prior to Genetic Amniocentesis on Inflammatory Mediators - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Effects of Vaginal Lactoferrin Administration Prior to Genetic Amniocentesis on Inflammatory Mediators The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02695563 Recruitment Status : Completed First Posted : March 1, 2016 Last Update Posted : March 4, 2016

2016 Clinical Trials

18. Oral Paracetamol Premedication Effect on Maternal Pain in Amniocentesis

Oral Paracetamol Premedication Effect on Maternal Pain in Amniocentesis Oral Paracetamol Premedication Effect on Maternal Pain in Amniocentesis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Oral (...) Paracetamol Premedication Effect on Maternal Pain in Amniocentesis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03035045 Recruitment Status : Unknown Verified November 2016 by Rajavithi Hospital. Recruitment status was: Active, not recruiting First Posted : January 27, 2017 Last Update Posted : January

2016 Clinical Trials

19. Clinical Implications for Children Born with Congenital Cytomegalovirus Infection Following a Negative Amniocentesis. (PubMed)

Clinical Implications for Children Born with Congenital Cytomegalovirus Infection Following a Negative Amniocentesis. Recently, congenital cytomegalovirus (cCMV) infection was reported irrespective of a negative amniotic fluid prenatal analysis for cytomegalovirus (CMV). The question of whether this phenomenon represents low sensitivity of the test or late development of fetal infection (after amniocentesis) was discussed, but not answered. However, if late transmission is the rule (...) , then infants born with cCMV after negative amniocentesis would be expected to carry better prognosis than those who tested positive.Data of all infants with cCMV infection, followed in 2 pediatric centers from 2006 to 2015, were reviewed. Infant outcome after birth of symptomatic vs asymptomatic disease was compared with infants born after a negative amniocentesis (study group) and those with a positive amniocentesis (control group).Amniocentesis was performed in 301 pregnancies of our cohort of infants

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2016 Clinical Infectious Diseases

20. Amniocentesis and chorionic villus sampling in HIV-infected pregnant women: a multicentre case series. (PubMed)

Amniocentesis and chorionic villus sampling in HIV-infected pregnant women: a multicentre case series. To assess in pregnant women with HIV the rates of amniocentesis and chorionic villus sampling (CVS), and the outcomes associated with such procedures.Observational study. Data from the Italian National Program on Surveillance on Antiretroviral Treatment in Pregnancy were used.University and hospital clinics.Pregnant women with HIV.Temporal trends were analysed by analysis of variance (...) performed under highly active antiretroviral therapy (HAART) (100% in 2011-2015). Three intrauterine deaths were observed (2.6%), and 14 pregnancies were terminated because of fetal anomalies. Among 96 live newborns, eight had no information available on HIV status. Among the remaining 88 cases with either amniocentesis (n = 75), CVS (n = 12), or both (n = 1), two HIV transmissions occurred (2.3%). No HIV transmission occurred among the women who were on HAART at the time of invasive testing, and none

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2016 BJOG

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