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Amiodarone

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1. Amiodarone: Wonder Drug or Wonder Why?

Amiodarone: Wonder Drug or Wonder Why? Emergency Medicine > Journal Club > Archive > January 2018 Toggle navigation January 2018 Amiodarone: Wonder Drug or Wonder Why? Vignette Working in TCC can be draining, and on one particularly busy afternoon, you begin to suspect your own sanity. After back-to-back cardiac arrest patients, you wonder if perhaps you should have done something less stressful with your life, like maybe become a lobster boat captain or an ice road trucker. Your first code (...) is a middle-aged female who suffered cardiac arrest while watching Alabama beat Clemson during the Sugar Bowl (yeah...that's right!!!). She was initially noted to be in ventricular fibrillation (VF), and remained so after three rounds of defibrillation. As she arrives in the trauma room, you immediately continue CPR and set up to shock her again. Your attending orders amiodarone, and even though you remember hearing that this may not be very effective, you realize it's not the time to argue. The patient

2018 Washington University Emergency Medicine Journal Club

2. Amiodarone

Amiodarone Top results for amiodarone - Trip Database or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4 (...) ) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for amiodarone The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you

2018 Trip Latest and Greatest

3. In Patients With Cardiac Arrest, Does Amiodarone or Lidocaine Increase Meaningful Survival?

In Patients With Cardiac Arrest, Does Amiodarone or Lidocaine Increase Meaningful Survival? TAKE-HOME MESSAGE Among out-of-hospital cardiac arrest patients with shock-refractory ventricular tachycardia or ventricular ?brillation, neither amiodarone nor lidocaine increases survival to hospital discharge or good neurologic outcome. In Patients With Cardiac Arrest, Does Amiodarone or Lidocaine Increase Meaningful Survival? EBEM Commentators Benton R. Hunter, MD Paul I. Musey, MD Department (...) of Emergency Medicine Indiana University School of Medicine Indianapolis, IN Results Threerandomizedcontrolledtrials (n¼3,677) and 4 observational studies (n¼704) were included for meta-analysis out of 528 articles identi?edontheinitialsearch.The results were driven by a single large (n¼3,026) randomized controlled trial at low risk of bias. The 2 smaller randomized con- trolled trials had moderate risk of bias, and the observational studies were generally at low risk of bias. Both lidocaine and amiodarone

2017 Annals of Emergency Medicine Systematic Review Snapshots

4. Amiodarone versus Lidocaine for Arrhythmias: Comparative Clinical Effectiveness

Amiodarone versus Lidocaine for Arrhythmias: Comparative Clinical Effectiveness Amiodarone versus Lidocaine for Arrhythmias: Comparative Clinical Effectiveness | CADTH.ca Find the information you need Amiodarone versus Lidocaine for Arrhythmias: Comparative Clinical Effectiveness Amiodarone versus Lidocaine for Arrhythmias: Comparative Clinical Effectiveness Published on: January 8, 2016 Project Number: RB0949-000 Product Line: Research Type: Drug Report Type: Summary of Abstracts Result type (...) : Report Question What is the comparative clinical effectiveness of intravenous amiodarone versus intravenous lidocaine for patients in cardiac arrest or with life-threatening arrhythmias? Key Message One systematic review, two randomized controlled trials, and one non-randomized study were identified regarding intravenous amiodarone versus intravenous lidocaine for arrhythmias. Tags amiodarone, death, heart arrest, lidocaine, heart attack, Arrhythmias, Cardiac, Cardiac, Sudden Files Rapid Response

2016 Canadian Agency for Drugs and Technologies in Health - Rapid Review

5. Efficacy of Wenxin Keli Plus Amiodarone versus Amiodarone Monotherapy in Treating Recent-Onset Atrial Fibrillation. (PubMed)

Efficacy of Wenxin Keli Plus Amiodarone versus Amiodarone Monotherapy in Treating Recent-Onset Atrial Fibrillation. Use of amiodarone (AMIO) in atrial fibrillation (AF) has significant side effects over prolonged periods. Wenxin Keli (WXKL), a Chinese herb extract, has been shown to be effective in atrial-selective inhibiting peak INa and hence beneficial in treating atrial arrhythmias, including atrial fibrillation. The aim of this randomized controlled trial was to evaluate potential effects (...) of AMIO plus WXKL on conversion rate and time in patients with recent-onset AF.A total of 41 patients (71 ± 12 years, 44% male) with recent-onset (<48 h) AF eligible for conversion were randomized to receive either intravenous amiodarone (loading dose 5 mg/kg in 1 hour followed by 50 mg/h; n=21) or amiodarone with same dosage plus oral WXKL 18 g thrice daily (n=20) for 24 hours.Conversion rate at 24 hours was of no difference between the two groups (75.0% vs. 81.0%, P=0.72); however, conversion time

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2018 Cardiology research and practice

6. Amiodarone method of administration for treatment of post-operative atrial fibrillation

Amiodarone method of administration for treatment of post-operative atrial fibrillation Amiodarone method of administration for treatment of post-operative atrial fibrillation Amiodarone method of administration for treatment of post-operative atrial fibrillation Mitchell MD, Strauss R, Mull N. Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database (...) . Citation Mitchell MD, Strauss R, Mull N.. Amiodarone method of administration for treatment of post-operative atrial fibrillation. Philadelphia: Center for Evidence-based Practice (CEP). 2016 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Humans; Postoperative Period Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence

2016 Health Technology Assessment (HTA) Database.

7. Amiodarone for prevention of atrial fibrillation in cardiac surgery patients

Amiodarone for prevention of atrial fibrillation in cardiac surgery patients Amiodarone for prevention of atrial fibrillation in cardiac surgery patients Amiodarone for prevention of atrial fibrillation in cardiac surgery patients Mitchell MD, Reynolds CR, Mull N Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Mitchell MD, Reynolds CR (...) , Mull N. Amiodarone for prevention of atrial fibrillation in cardiac surgery patients. Philadelphia: Center for Evidence-based Practice (CEP). 2016 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Amiodarone; Atrial Fibrillation; Cardiac Surgical Procedures; Humans Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence Center for Evidence-based Practice, University

2016 Health Technology Assessment (HTA) Database.

8. Ranolazine Added to Amiodarone Facilitates Earlier Conversion of Atrial Fibrillation Compared to Amiodarone-Only Therapy. (PubMed)

Ranolazine Added to Amiodarone Facilitates Earlier Conversion of Atrial Fibrillation Compared to Amiodarone-Only Therapy. Amiodarone (AMIO) is for many years effectively used to control ventricular rate during atrial fibrillation (AF) and to convert it into sinus rhythm. However, due to its delayed onset of action, ranolazine (RAN), a new antianginal agent with atrial-selective electrophysiologic properties, has recently been attempted as add-on therapy with AMIO to facilitate AF conversion.To

2017 Pacing and clinical electrophysiology : PACE

9. Topical amiodarone during cardiac surgery: Does epicardial application of amiodarone prevent postoperative atrial fibrillation? (PubMed)

Topical amiodarone during cardiac surgery: Does epicardial application of amiodarone prevent postoperative atrial fibrillation? Atrial fibrillation (AF) is a common complication after cardiac surgery. Topical amiodarone on the epicardium may help prevent postoperative AF while avoiding the side effects of its systemic administration. The purpose of this study was to evaluate the all-comer strategy of epicardial amiodarone application for the prevention of postoperative AF.A retrospective (...) observational study was performed that evaluated the incidence of new-onset AF in a consecutive series of cardiac surgery patients who were treated with either no amiodarone (historical control, n = 100), epicardial application of amiodarone mixed in a topical hydrogel (n = 50), or epicardial application of an amiodarone-soaked sealant patch (n = 50). Perioperative data were compared between the 3 groups, with all patients receiving continuous postoperative telemetry to monitor for new-onset AF.The cohort

2017 Journal of Thoracic and Cardiovascular Surgery

10. Thyroidectomy for Amiodarone-Induced Thyrotoxicosis: Mayo Clinic Experience (PubMed)

Thyroidectomy for Amiodarone-Induced Thyrotoxicosis: Mayo Clinic Experience Amiodarone-induced thyrotoxicosis (AIT) is a difficult diagnostic and management challenge, especially during severe thyrotoxicosis accompanied by cardiovascular compromise.To evaluate thyroidectomy for the management of AIT.Retrospective cohort study of adults with noncongenital heart disease with AIT after >3 months of amiodarone who underwent thyroidectomy from 1 November 2002 to 31 December 2016.Referral center.The

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2018 Journal of the Endocrine Society

11. Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death. (PubMed)

Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death. Sudden cardiac death (SCD) is one of the main causes of cardiac death. There are two main strategies to prevent it: managing cardiovascular risk factors and reducing the risk of ventricular arrhythmias. Implantable cardiac defibrillators (ICDs) constitute the standard therapy for both primary and secondary prevention; however, they are not widely available in settings with limited resources (...) . The antiarrhythmic amiodarone has been proposed as an alternative to ICD.To evaluate the effectiveness of amiodarone for primary or secondary prevention in SCD compared with placebo or no intervention or any other antiarrhythmic drugs in participants at high risk (primary prevention) or who have recovered from a cardiac arrest or a syncope due to Ventricular Tachycardia/Ventricular Fibrillation, or VT/VF (secondary prevention).We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE

2015 Cochrane

12. Amiodarone, lidocaine, magnesium or placebo in shock refractory ventricular arrhythmia: A Bayesian network meta-analysis. (PubMed)

Amiodarone, lidocaine, magnesium or placebo in shock refractory ventricular arrhythmia: A Bayesian network meta-analysis. Recent evidence challenges, the superiority of amiodarone, compared to other anti-arrhythmic medications, as the agent of choice in pulseless ventricular tachycardia (VT) or ventricular fibrillation (VF). We conducted Bayesian network and traditional meta-analyses to investigate the relative efficacies of amiodarone, lidocaine, magnesium (MgSO4) and placebo as treatments (...) ranking curve (SUCRA). Bayesian analysis demonstrated that lidocaine had superior effects on survival to hospital discharge, compared to amiodarone (OR, 2.18, 95% Cr.I 1.26-3.13), MgSO4 (OR, 2.03, 95% Cr.I 0.74-4.82) and placebo (OR, 2.42, 95% Cr.I 1.39-3.54). There were no statistical differences among treatment groups regarding survival to hospital admission/24 h (hrs) and return of spontaneous circulation (ROSC). Probability analysis revealed that lidocaine was the most effective therapy

2017 Heart & lung : the journal of critical care

13. Amiodarone and N-Acetylcysteine or Amiodarone Alone for Preventing Atrial Fibrillation After Thoracic Surgery

Amiodarone and N-Acetylcysteine or Amiodarone Alone for Preventing Atrial Fibrillation After Thoracic Surgery Amiodarone and N-Acetylcysteine or Amiodarone Alone for Preventing Atrial Fibrillation After Thoracic Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. Amiodarone and N-Acetylcysteine or Amiodarone Alone for Preventing Atrial Fibrillation After Thoracic Surgery The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier

2016 Clinical Trials

14. Amiodarone-Induced Thyrotoxicosis Recurrence After Amiodarone Reintroduction. (PubMed)

Amiodarone-Induced Thyrotoxicosis Recurrence After Amiodarone Reintroduction. Reintroduction of amiodarone in patients with a history of amiodarone-induced thyrotoxicosis (AIT) is rarely used. To date, the risk of AIT recurrence after amiodarone reintroduction is unpredicted. The aim of the study was to evaluate the risk of AIT recurrence. Retrospectively, from 2000 to 2011, all euthyroid patients with a history of AIT with amiodarone reintroduction were included. Type and severity of the first (...) AIT, amiodarone chronology, and thyroid function evolution after reintroduction of amiodarone were investigated: 46 of 172 patients with AIT history needed amiodarone reintroduction. At first AIT episode, the mean age was 62.2 ± 16 years with male gender predominance; 65% of patients were classified as type 1 AIT. AIT recurred in 14 patients (30%), 12 patients developed hypothyroidism (26%), and 20 patients remained euthyroid (44%). Characteristics of type 1 AIT during the first episode, namely

2016 American Journal of Cardiology

15. Environmental Iodine Content, Female Sex and Age Are Associated with New-Onset Amiodarone-Induced Hypothyroidism: A Systematic Review and Meta-Analysis of Adverse Reactions of Amiodarone on the Thyroid. (PubMed)

Environmental Iodine Content, Female Sex and Age Are Associated with New-Onset Amiodarone-Induced Hypothyroidism: A Systematic Review and Meta-Analysis of Adverse Reactions of Amiodarone on the Thyroid. To investigate the incidence of new-onset amiodarone-induced hypothyroidism (AIH) and the associated risk factors.We performed a systematic search in MEDLINE, Embase, the Cochrane Library and the Chinese database from 1995 to 2015. Studies that investigated amiodarone-related adverse reactions (...) %) of women and 13.3% (95% CI 7.9-21.7%) of men (p < 0.001). Meta-regression analysis indicated a positive correlation with the mean age and percentage of women.The occurrence of AIH is a relatively frequent complication of amiodarone, and older women are more likely to develop AIH, especially in areas with a high iodine content in the environment, and restriction of total exposure to iodine might decrease the incidence of AIH.© 2016 S. Karger AG, Basel.

2016 Cardiology

16. Aggravation of atrial arrhythmia by amiodarone during the perinatal period: A case report. (PubMed)

Aggravation of atrial arrhythmia by amiodarone during the perinatal period: A case report. Amiodarone, a broad-spectrum antiarrhythmic drug, is widely used for the clinical treatment of tachyarrhythmias because of its safety and efficacy.A 30-year-old woman presented with known paroxysmal atrial tachycardia and severe preeclampsia. Two days before admission, she had given birth to twins. She described her symptoms as a sudden palpitation at 10:20 accompanied by chest tightness and shortness (...) of breath.Cardiac arrhythmia and acute left heart failure.Furosemide and sodium nitroprusside were administered to control the heart failure. At 16:20, 150 mg amiodarone (15 mg/min) was injected intravenously and continued at 1 mg/min. At 16:50, her electrocardiogram showed possible atrial tachycardia or atrial flutter with a ventricular rate of 206 beats/min. Administration of amiodarone was stopped at 17:23, and the medication was changed to esmolol.After 3 minutes, the palpitations stopped, the heart rate

2019 Medicine

17. Amiodarone and acupuncture for cardiac arrhythmia: Study protocol for a systematic review. (PubMed)

Amiodarone and acupuncture for cardiac arrhythmia: Study protocol for a systematic review. Amiodarone and acupuncture (AA) are commonly used to treat cardiac arrhythmia (CA). The objective of this systematic review is to assess the efficacy and safety of AA for patients with CA.Randomized controlled trials (RCTs) of AA for CC will be searched from 9 databases including PubMed, EMBASE, Cochrane Library, Web of Science, Scopus, Chinese Biomedical Literature Database, China National Knowledge

2019 Medicine

18. Safety of Rapid-Switching from Amiodarone to Dofetilide in Atrial Fibrillation Patients with Implantable Cardioverter Defibrillators. (PubMed)

Safety of Rapid-Switching from Amiodarone to Dofetilide in Atrial Fibrillation Patients with Implantable Cardioverter Defibrillators. Dofetilide is a class III antiarrhythmic drug commonly used for treatment of atrial fibrillation. Drug guidelines mandate a 3-month waiting period before initiating dofetilide after amiodarone use. Whether patients with an implantable cardioverter-defibrillator (ICD) can be rapidly switched from amiodarone to dofetilide is not known.The purpose of this study (...) was to evaluate whether rapid switching from amiodarone to dofetilide is safe in atrial fibrillation patients with an ICD.In this retrospective observational study, we assessed the feasibility and the short- and long-term safety of rapid switching from amiodarone to dofetilide in hospitalized atrial fibrillation with an ICD.The study included a total of 179 patients who were followed for 12.6 ± 2.2 months. All patients had drug initiation during hospitalization. Dofetilide resulted in successful cardioversion

2019 Heart Rhythm

19. Increased Risk of Antithyroid Drugs Agranulocytosis Associated with Amiodarone-induced Thyrotoxicosis: a Population-based Cohort Study. (PubMed)

Increased Risk of Antithyroid Drugs Agranulocytosis Associated with Amiodarone-induced Thyrotoxicosis: a Population-based Cohort Study. Agranulocytosis occurs in 0.2-0.5% of patients treated with the antithyroid drugs (ATDs) methimazole and propylthiouracil. The objectives of this study were to evaluate the risk of ATD-related agranulocytosis in patients with amiodarone-induced thyrotoxicosis (AIT), and to compare it with the agranulocytosis risk in patients with thyrotoxicosis due to other (...) agranulocytosis associated with AIT was 9.71 (4.28-22.05) compared to the risk in non-AIT thyrotoxicosis. In a multivariable model, adjusting for age, sex, body mass index, smoking history, year of cohort entry, diabetes mellitus, hypertension, renal failure, beta blockers, calcium channel blockers, anti-aggregants, and dose of ATDs, the risk associated with AIT was 5.70 (2.14-15.21). In a model adjusted for a propensity score to receive amiodarone, risk for ATD agranulocytosis associated with AIT was 6.32

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2019 Thyroid

20. Amiodarone for prevention of atrial fibrillation following esophagectomy. (PubMed)

Amiodarone for prevention of atrial fibrillation following esophagectomy. Atrial fibrillation (AF) is a common complication after esophagectomy and is associated with symptoms, hemodynamic instability, prolonged hospital stay, and an increased incidence of mortality. Our objective was to determine the efficacy and safety of intravenous amiodarone for prophylaxis of postesophagectomy AF.In this retrospective cohort study, 309 patients who underwent esophagectomy formed the initial cohort (...) . Following propensity score-matching, 110 patients who received prophylactic amiodarone 43.75 mg/hour via continuous intravenous infusion over 96 hours (total dose, 4200 mg) were matched to a control group of patients who did not undergo amiodarone prophylaxis (n = 110). The propensity score was obtained using a multivariate logistic regression model with amiodarone as the variable and the following covariates: age, sex, surgical approach, history of neoadjuvant chemotherapy and/or radiation, chronic

2019 Journal of Thoracic and Cardiovascular Surgery

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