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Alpha-Hydroxy acid

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1. Dual Effects of Alpha-Hydroxy Acids on the Skin Full Text available with Trip Pro

Dual Effects of Alpha-Hydroxy Acids on the Skin AHAs are organic acids with one hydroxyl group attached to the alpha position of the acid. AHAs including glycolic acid, lactic acid, malic acid, tartaric acid, and citric acid are often used extensively in cosmetic formulations. AHAs have been used as superficial peeling agents as well as to ameliorate the appearance of keratoses and acne in dermatology. However, caution should be exercised in relation to certain adverse reactions among patients

2018 Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

2. Effects of Alpha-hydroxy-isocaproic acid upon Body Composition in a Type I Diabetic Patient with Muscle Atrophy – A Case Study Full Text available with Trip Pro

Effects of Alpha-hydroxy-isocaproic acid upon Body Composition in a Type I Diabetic Patient with Muscle Atrophy – A Case Study Research involving dietary supplement interventions for sarcopenia and osteopenia in type 1 diabetes patients is scarce. Here we present a case study of a type 1 diabetic patient that was treated with supplemental alpha-hydroxy-isocaproic acid (α-HICA) for 120 days. Several measures of body composition by dual x-ray absorptiometry, blood markers, and maximum voluntary

2018 The Yale journal of biology and medicine

3. Alpha-Hydroxy acid

Alpha-Hydroxy acid Alpha-Hydroxy acid Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Alpha-Hydroxy acid Alpha-Hydroxy acid Aka: Alpha (...) -Hydroxy acid , Lac-Hydrin , Glycolic Acid From Related Chapters II. Indications III. Preparations Alpha-Hydroxy acid preparations Glycolic Acid (8%) or Lac-Hydrin (8-12%) Urea (3-6%) Combination agents with Eucerin plus Lubriderm moisture recovery cream IV. Mechanism Forces epidermal cells to produce keratin Keratin is softer and more flexible Keratin is less likely to crack and fissure V. Adverse Effects May burn for few minutes with first applications Do not replace or add to oil barrier VI. Dosing

2018 FP Notebook

4. Bile acid malabsorption assessed by 7 alpha-hydroxy-4-cholesten-3-one in pediatric inflammatory bowel disease: correlation to clinical and laboratory findings. Full Text available with Trip Pro

Bile acid malabsorption assessed by 7 alpha-hydroxy-4-cholesten-3-one in pediatric inflammatory bowel disease: correlation to clinical and laboratory findings. Measurement of 7 alpha-hydroxy-4-cholesten-3-one (C4) in serum is a semiquantitative test for bile acid malabsorption (BAM). We have previously established pediatric normal values for C4 with an upper limit of normal of 66.5 ng/mL, independent of age and sex. Here we performed the C4 test in 58 pediatric patients with Crohn's disease (CD (...) -bloody diarrhea in the absence of active disease or elevated inflammatory markers. The C4-test identifies a subgroup of CD patients with persistent diarrhea in spite of clinical remission which may benefit from bile acid binding therapy.Copyright © 2014 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.

2014 Journal of Crohn's & colitis

5. Serum 7-Alpha-Hydroxy-4-Cholesten-3-One as a Marker for Bile Acid Loss in Children. (Abstract)

Serum 7-Alpha-Hydroxy-4-Cholesten-3-One as a Marker for Bile Acid Loss in Children. To establish age-related reference values for 7-alpha-hydroxy-4-cholesten-3-one (C4) in a pediatric population and to investigate bile acid malabsorption in children with short bowel syndrome (SBS).Serum was obtained between 8:00 a.m. and 11:00 a.m. from 100 healthy children (52% males, 9 months to 18 years of age) after 10 hours of fasting. Pediatric patients with SBS served as disease controls (n = 12 (...) patients with SBS had C4 concentrations above 100 ng/mL (mean 299.6 ± 167.8 ng/mL; range 105.7-562.1 ng/mL, P < .0001 compared with controls).The determined upper limit of normal for C4 concentration in healthy children corresponds to previously published levels in healthy adults and is independent of age and sex. The consistently elevated C4 concentrations in our patients with SBS confirm the reliability of this noninvasive, nonisotopic method to assess bile acid malabsorption in children.Copyright ©

2013 Journal of Pediatrics

6. Alpha-Hydroxy acid

Alpha-Hydroxy acid Alpha-Hydroxy acid Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Alpha-Hydroxy acid Alpha-Hydroxy acid Aka: Alpha (...) -Hydroxy acid , Lac-Hydrin , Glycolic Acid From Related Chapters II. Indications III. Preparations Alpha-Hydroxy acid preparations Glycolic Acid (8%) or Lac-Hydrin (8-12%) Urea (3-6%) Combination agents with Eucerin plus Lubriderm moisture recovery cream IV. Mechanism Forces epidermal cells to produce keratin Keratin is softer and more flexible Keratin is less likely to crack and fissure V. Adverse Effects May burn for few minutes with first applications Do not replace or add to oil barrier VI. Dosing

2015 FP Notebook

7. Canadian Association of Gastroenterology Clinical Practice Guideline on the Management of Bile Acid Diarrhea

Canadian Association of Gastroenterology Clinical Practice Guideline on the Management of Bile Acid Diarrhea e10 © 2019 by the Canadian Association of Gastroenterology and the AGA Institute This article is being published jointly in Journal of the Canadian Association of Gastroenterology and Clinical Gastroenterology and Hepatology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc (...) /4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com Original Article Canadian Association of Gastroenterology Clinical Practice Guideline on the Management of Bile Acid Diarrhea Daniel C. Sadowski 1 , Michael Camilleri 2 , William D. Chey 3 , Grigorios I. Leontiadis 4 , John K. Marshall 4 , Eldon A. Shaffer 5 , Frances T se 4 , Julian R. F. Walters

2020 Canadian Association of Gastroenterology

8. Modified Jessner's Solution With Trichloroacetic Acid Versus Glycolic Acid With Trichloroacetic Acid

, and the disruption and removal of melanin granules .Many depigmenting agents and other therapies such as chemical peeling are used for treating melasma, in the form of monotherapy or combined therapy .The most commonly used peeling agents are alpha-hydroxy-acids, glycolic acid , Jessner solution, salicylic acid resorcinol,trichloroacetic acid , pyruvic acid and phenol Several hypopigmenting agents such as topical hydroquinone (2 to 4%) alone or in combination with tretinoin (0.05 to 0.1%) have been used (...) Modified Jessner's Solution With Trichloroacetic Acid Versus Glycolic Acid With Trichloroacetic Acid Modified Jessner's Solution With Trichloroacetic Acid Versus Glycolic Acid With Trichloroacetic Acid - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2017 Clinical Trials

9. The specificity of a 7 alpha-hydroxy steroid dehydrogenase from Escherichia coli. Full Text available with Trip Pro

The specificity of a 7 alpha-hydroxy steroid dehydrogenase from Escherichia coli. 1. Thirty-eight steroids were tested as substrates for a 7 alpha-hydroxy steroid dehydrogenase preparation from a strain of Escherichia coli; an improved method of making the crude enzyme is described. 2. Steroids having a 7 alpha-hydroxyl group in the molecule were substrates except (a) when the 5 beta-cholan-24-oic acid side chain was shortened to less than four carbon atoms and (b) in certain cases when (...) sulphate ester groups were present in the molecule. 3. For testing with the enzyme, a new specimen of 7 alpha-hydroxy-3,12-dioxo-5 beta-cholan-24-oic acid was made, which had properties different from those previously described.

1976 Biochemical Journal

10. Effect of ileal bile acid transporter inhibitor GSK2330672 on pruritus in primary biliary cholangitis: a double-blind, randomised, placebo-controlled, crossover, phase 2a study. Full Text available with Trip Pro

in serum total bile acids and 7 alpha hydroxy-4-cholesten-3-one (C4), and changes in the pharmacokinetic parameters of ursodeoxycholic acid and its conjugates. The trial was registered with ClinicalTrials.gov, number NCT01899703.Between March 10, 2014, and Oct 7, 2015, we enrolled 22 patients. 11 patients were assigned to receive intervention followed by placebo (sequence 1), and 11 patients were assigned to receive placebo followed by intervention (sequence 2). One patient assigned to sequence 2 (...) Effect of ileal bile acid transporter inhibitor GSK2330672 on pruritus in primary biliary cholangitis: a double-blind, randomised, placebo-controlled, crossover, phase 2a study. Up to 70% of patients with primary biliary cholangitis develop pruritus (itch) during the course of their disease. Treatment of pruritus in primary biliary cholangitis is challenging and novel therapies are needed. Ursodeoxycholic acid, the standard first-line treatment for primary biliary cholangitis, is largely

2017 Lancet Controlled trial quality: predicted high

11. Lactic and lactobionic acids as typically moisturizing compounds. (Abstract)

Lactic and lactobionic acids as typically moisturizing compounds. Recently more attention has been drawn to alpha hydroxy and polyhydroxy acids (AHA and PHA) due to their excellent moisturizing and antioxidant properties. These compounds are very beneficial in terms of both cosmetic and dermatological treatments.The aim of this study was an assessment of moisturizing properties of lactobionic and lactic acids based on available literature.Literature review using scientific databases: PubMed (...) , Medline (EBSCO), Medline Complete, Karger, Springer/ICM, SpringerLink/online, Wiley Online Library.Through their construction, alpha AHA and PHA are able to bind large amounts of water and act as potent antioxidant agents through inhibition of matrix metalloproteinases and strong chelating properties. Another important characteristic is the maintenance of the epidermal barrier integrity during application of lactic acid (LAC) and lactobionic acid (LA) and thus the opportunity to use them on sensitive

2018 International Journal of Dermatology

12. Treatment of Melasma With Glycolic Acid-Salicylic Acid Peel Versus Glycolic Acid Peel

, alpha-hydroxy acids, such as glycolic acid, are known to be hydrophilic, whereas salicylic acid is lipophilic and anti-inflammatory. As each peeling agent has unique properties, it can be hypothesized that the combined use of these agents may result in better clinical outcomes than the use of an agent alone. Prior studies have demonstrated that the combined use of these peels are safe and effective in improving a variety of skin conditions including acne scars, hyperpigmentation, and infraorbital (...) Treatment of Melasma With Glycolic Acid-Salicylic Acid Peel Versus Glycolic Acid Peel Treatment of Melasma With Glycolic Acid-Salicylic Acid Peel Versus Glycolic Acid Peel - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before

2015 Clinical Trials

13. A Trial Comparing the Efficacy of Subcutaneous Injections of Brodalumab to Oral Administrations of Fumaric Acid Esters in Adults With Moderate to Severe Plaque Psoriasis

emollients without urea or beta or alpha hydroxy acids) Have received any biologic immune modulating treatments used for indication other than psoriasis within 4 weeks of baseline or within a period of 5 half-lives of the IMP, whichever is longer Have received any other systemic immune modulating treatment (including but not limited to oral retinoids, methotrexate, calcineurin inhibitors, oral or parenteral corticosteroids etc. used for indications other than psoriasis) within 4 weeks of baseline (...) A Trial Comparing the Efficacy of Subcutaneous Injections of Brodalumab to Oral Administrations of Fumaric Acid Esters in Adults With Moderate to Severe Plaque Psoriasis A Trial Comparing the Efficacy of Subcutaneous Injections of Brodalumab to Oral Administrations of Fumaric Acid Esters in Adults With Moderate to Severe Plaque Psoriasis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search

2017 Clinical Trials

14. Changes in Bile Acid Homeostasis and Stool Habits After Cholecystectomy

by (Responsible Party): Zealand University Hospital Study Details Study Description Go to Brief Summary: Investigate serial plasma samples of fibroblast growth factor 19 (FGF19) after oral stimulation with chenodeoxycholic acid in the same subjects before and after elective cholecystectomy Condition or disease Intervention/treatment Phase Bile Acid Malabsorption Cholelithiasis Drug: chenodeoxycholic acid Phase 4 Detailed Description: Lack of FGF19 and elevated 7-alpha-hydroxy-colestenone (C4) is associated (...) Changes in Bile Acid Homeostasis and Stool Habits After Cholecystectomy Changes in Bile Acid Homeostasis and Stool Habits After Cholecystectomy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Changes

2017 Clinical Trials

15. Bile Acids and Dysbiosis in Non-Alcoholic Fatty Liver Disease Full Text available with Trip Pro

, cross-sectional study of adults with biopsy-confirmed NAFLD (non-alcoholic fatty liver: NAFL or non-alcoholic steatohepatitis: NASH) and healthy controls (HC). Clinical and laboratory data, stool samples and 7-day food records were collected. Fecal BA profiles, serum markers of BA synthesis 7-alpha-hydroxy-4-cholesten-3-one (C4) and intestinal BA signalling, as well as IM composition were assessed.53 subjects were included: 25 HC, 12 NAFL and 16 NASH. Levels of total fecal BA, cholic acid (CA (...) Bile Acids and Dysbiosis in Non-Alcoholic Fatty Liver Disease Non-alcoholic fatty liver disease (NAFLD) is characterized by dysbiosis. The bidirectional effects between intestinal microbiota (IM) and bile acids (BA) suggest that dysbiosis may be accompanied by an altered bile acid (BA) homeostasis, which in turn can contribute to the metabolic dysregulation seen in NAFLD. This study sought to examine BA homeostasis in patients with NAFLD and to relate that with IM data.This was a prospective

2016 PloS one

16. A Multicenter Prospective Study to Investigate the Diagnostic Accuracy of the SeHCAT Test in Measuring Bile Acid Malabsorption: Research Protocol Full Text available with Trip Pro

, but response to treatment with a bile acid sequestrant (BAS) is often accepted as confirmation. The SeHCAT (tauroselcholic [selenium-75] acid) test uses a radiolabeled synthetic bile acid and provides a diagnostic test for BAM, but its performance against "trial of treatment" is unknown. Fibroblast growth factor 19 (FGF-19) and 7-alpha-hydroxy-4-cholesten-3-one (C4) also offer potential new biomarkers of BAM.This protocol describes a multicenter prospective study to evaluate the diagnostic accuracy (...) A Multicenter Prospective Study to Investigate the Diagnostic Accuracy of the SeHCAT Test in Measuring Bile Acid Malabsorption: Research Protocol Bile acid malabsorption (BAM) is one possible explanation for chronic diarrhea. BAM may be idiopathic, or result from ileal resection or inflammation including Crohn's disease, or may be secondary to other conditions, including cholecystectomy, peptic ulcer surgery, and chronic pancreatitis. No "gold standard" exists for clinical diagnosis of BAM

2016 JMIR Research Protocols

17. Study to Assess the Relative Potency of Multiple Oral Doses of LUM001 and SHP626 in Overweight and Obese Adults as Assessed by Fecal Bile Acid Excretion

in subjects receiving SHP626 or SHP626 (Placebo) [ Time Frame: Day -2/-1 to Day 7 ] Serum 7- alpha-hydroxy-4-cholesten-3-one in subjects receiving LUM001 or LUM001 (Placebo) [ Time Frame: Day -2/-1 to Day 7 ] Serum 7- alpha-hydroxy-4-cholesten-3-one in subjects receiving SHP626 or SHP626 (Placebo) [ Time Frame: Day -2/-1 to Day 7 ] Bristol Stool Chart in subjects receiving LUM001 or LUM001 (Placebo) [ Time Frame: Day -2/-1 to Day 7 ] Bristol Stool Chart in subjects receiving SHP626 or SHP626 (Placebo (...) Study to Assess the Relative Potency of Multiple Oral Doses of LUM001 and SHP626 in Overweight and Obese Adults as Assessed by Fecal Bile Acid Excretion Study to Assess the Relative Potency of Multiple Oral Doses of LUM001 and SHP626 in Overweight and Obese Adults as Assessed by Fecal Bile Acid Excretion - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail

2015 Clinical Trials

18. The effect of physically applied alpha hydroxyl acids on the skin pore and comedone. (Abstract)

The effect of physically applied alpha hydroxyl acids on the skin pore and comedone. Alpha hydroxy acids (AHA) have been recognized as commonly used therapy for acne. Our studies examined whether an additional effect of physical treatment using chemical peeling combined with negative pressure and compared with AHA treatment only occurs in acne-prone subjects.The chemical peeling agent used 4% of an AHA solution (mixture of 1000 mL of carbonated water, 20 mL of glycolic acid and 20 mL of lactic (...) acid). All subjects' faces were randomly divided into test and control groups. The test group was treated with chemical peeling combined with a physical effect, and the control group applied chemical peeling alone. For the 23 healthy females (average age: 30.17 ± 5.06 year), we measured sebum output level by light transmission, pore area and number by optical image analyser, and comedone counting before treatment and at 1, 2 and 4 weeks after a single treatment.Compared to the before treatment

2015 International journal of cosmetic science Controlled trial quality: uncertain

19. An Inborn Error of Metabolism with the Urinary Excretion of α-Hydroxy-Butyric Acid and Phenylpyruvic Acid Full Text available with Trip Pro

An Inborn Error of Metabolism with the Urinary Excretion of α-Hydroxy-Butyric Acid and Phenylpyruvic Acid 13534741 2000 07 01 2018 12 01 0003-9888 33 168 1958 Apr Archives of disease in childhood Arch. Dis. Child. An inborn error of metabolism with the urinary excretion of alpha-hydroxy-butyric acid and phenylpyruvic acid. 109-13 SMITH A J AJ STRANG L B LB eng Journal Article England Arch Dis Child 0372434 0003-9888 0 Butyrates 0 Ketone Bodies 0 Phenylpyruvic Acids X7CO62M413 phenylpyruvic (...) acid OM Butyrates Humans Ketone Bodies urine Phenylketonurias urine Phenylpyruvic Acids 5834:27276:321:459 KETONE BODIES/in urine PHENYLPYRUVIC OLIGOPHRENIA/urine in 1958 4 1 1958 4 1 0 1 1958 4 1 0 0 ppublish 13534741 PMC2012215 Biochem J. 1951 Jun;49(1):1-5 14848019 Biochem J. 1950 Mar;46(3):271-5 16748674 J Biol Chem. 1953 Jan;200(1):367-71 13034794 Nature. 1952 Feb 2;169(4292):202-3 14910729 Biochem J. 1951 Apr;48(4):467-77 14838868 Biochem J. 1947;41(2):240-53 16748150 Res Publ Assoc Res Nerv

1958 Archives of Disease in Childhood

20. Microbiological degradation of bile acids. Metabolites formed from 3-(3a alpha-hexahydro-7a beta-methyl-1,5-dioxoindan-4 alpha-yl) propionic acid by Streptomyces rubescens. Full Text available with Trip Pro

-hydroxy-6a beta-methylcyclopenta[f][1]benzopyran-3,7-dione (IVb), (E)-3-(3aalpha-hexahydro-5 alpha-hydroxy-7a beta-methyl-l-oxo-indan-4 alpha-yl)prop-2-enoic acid (V), (+)-(5R)-5-methyl-4-oxo-octane-1,8-dioic acid (VI), 3-(4-hydroxy-5-methyl-2-oxo-2H-pyran-6-yl)propionic acid (VII) and 3-(3a alpha-hexahydro-1 beta-hydroxy-7a beta-methyl-5-oxoindan-4 alpha-yl)propionic acid (VIII). The metabolites (IVb), (V), (VI) and (VII) were new compounds, and their structures were established by chemical synthesis (...) Microbiological degradation of bile acids. Metabolites formed from 3-(3a alpha-hexahydro-7a beta-methyl-1,5-dioxoindan-4 alpha-yl) propionic acid by Streptomyces rubescens. 1. The metabolism of 3-(3a alpha-hexahydro-7a beta-methyl-1,5-dioxoindan-4 alpha-yl)propionic acid (III), which is a possible precursor of 2,3,4,6,6a beta, 7,8,9,9a alpha,9b beta-decahydro-6a beta-methyl-1H-cyclopenta[f]quinoline-3,7-dione (II) formed from cholic acid (I) by streptomyces rubescens, was investigated by using

1977 Biochemical Journal

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