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Alpha Adrenergic Antagonist

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101. Role of supraspinal and spinal {alpha}1-adrenergic receptor subtypes in micturition reflex in conscious rats. (PubMed)

Role of supraspinal and spinal {alpha}1-adrenergic receptor subtypes in micturition reflex in conscious rats. α(1)-Adrenergic receptor subtypes are widely distributed in the central nervous system and are involved in autonomic functions such as micturition. We investigated the presence and the role of supraspinal and/or spinal α(1)-adrenergic receptors in modulating the micturition reflex in conscious female Wistar rats. The expression of α(1)-adrenergic receptor subtypes in rat brain (...) and lumbosacral spinal cord was studied using RT-PCR. Continuous-infusion cystometrograms were obtained in conscious rats, and α(1)-adrenergic receptor antagonists were administered via intracerebroventricular or intrathecal routes. The mRNA expression of α(1A)-, α(1B)-, and α(1D)-adrenergic receptors was detected in rat brain (midbrain and pons) and lumbosacral spinal cord (dorsal and ventral parts of spinal cord). In addition, intracerebroventricular injection of the α(1)-adrenergic receptor antagonist

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2010 American Journal of Physiology. Renal physiology

102. Nimodipine Enhances {alpha}2 Adrenergic Modulation of NMDA Receptor Via A Mechanism Independent of Ca++ Channel Blocking. (PubMed)

Nimodipine Enhances {alpha}2 Adrenergic Modulation of NMDA Receptor Via A Mechanism Independent of Ca++ Channel Blocking. To further understand alpha2 receptor signaling in the retina and the mechanisms that mediate ocular beneficial effects of brimonidine (an alpha2 agonist) and nimodipine (an L-type Ca(2+) channel blocker).The authors used in situ retinal ganglion cells (RGCs) in the isolated rat retina to characterize alpha2 modulation of NMDA receptor function and a rabbit retinal NMDA (...) -elicited currents in RGCs. This suppressive effect of brimonidine was substantially enhanced by background addition of nimodipine or isradipine, but not by diltiazem, verapamil, or cadmium. This effect of nimodipine was blocked by either a selective alpha2 antagonist, a cyclic adenosine monophosphate (cAMP) analogue, or an adenylate cyclase activator, indicating that nimodipine acts through the alpha2 receptor-G(alphai)-coupled pathway. Brimonidine protects RGCs in the rabbit excitotoxicity model

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2010 Investigative Ophthalmology & Visual Science

103. Doxazosin an a1 Antagonist for Alcohol Dependence

Alcohol craving Additional relevant MeSH terms: Layout table for MeSH terms Alcoholism Alcohol-Related Disorders Substance-Related Disorders Chemically-Induced Disorders Mental Disorders Ethanol Doxazosin Anti-Infective Agents, Local Anti-Infective Agents Central Nervous System Depressants Physiological Effects of Drugs Antihypertensive Agents Adrenergic alpha-1 Receptor Antagonists Adrenergic alpha-Antagonists Adrenergic Antagonists Adrenergic Agents Neurotransmitter Agents Molecular Mechanisms (...) that the noradrenergic (NE) system is involved in the neurobiology of AD, thus representing an interesting new pharmacotherapy target and the theoretical rationale for this proposal. Consistent with the concept that the NE system may represent a new pharmacological target for AD, recent studies have shown that the prototype alpha-1 NE receptor antagonist prazosin reduces alcohol drinking in different animal models. Furthermore, clinical evidence has also confirmed that prazosin appears to be efficacious in reducing

2011 Clinical Trials

104. Advanced Benefits of Alpha-blocker Monotherapy on Lower Urinary Tracts Symptoms(LUTS) Patients

alpha reductase inhibitor Proscar Finasteride alpha blocker Tamsulosin Harnal D Additional relevant MeSH terms: Layout table for MeSH terms Hyperplasia Lower Urinary Tract Symptoms Prostatic Hyperplasia Pathologic Processes Urological Manifestations Signs and Symptoms Prostatic Diseases Genital Diseases, Male Tamsulosin Finasteride Adrenergic alpha-Antagonists Adrenergic alpha-1 Receptor Antagonists Adrenergic Antagonists Adrenergic Agents Neurotransmitter Agents Molecular Mechanisms (...) of Pharmacological Action Physiological Effects of Drugs Urological Agents 5-alpha Reductase Inhibitors Steroid Synthesis Inhibitors Enzyme Inhibitors Hormone Antagonists Hormones, Hormone Substitutes, and Hormone Antagonists

2012 Clinical Trials

105. Protective effect of Chresta martii extract on ethanol-induced gastropathy depends on alpha-2 adrenoceptors pathways but not on nitric oxide, prostaglandins or opioids. (PubMed)

action mechanism. Animals were sacrificed 30 min after ethanol challenge to stomach analysis. Determination of non-protein sulfhydryl groups and tissue hemoglobin, besides histological assessment (H&E) were taken to fully characterize the HAE gastro protective effect.HAE (100 and 200 mg/kg) was able to protect mucosa against ethanol gastropathy in presence of three (naloxone, indomethacin and L-NAME) of four antagonist/inhibitor tools. The HAE effect was reversed only by yohimbine, showing the alpha (...) has antioxidant activity that is thought to either play a role in this biological activity or to be a byproduct of alpha-2 adrenergic complex activation.Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

2012 Journal of Ethnopharmacology

106. Effects of some sympathomimetic drugs and their antagonists on afterdischarges elicited in chronically isolated slabs of cerebral cortex (PubMed)

Effects of some sympathomimetic drugs and their antagonists on afterdischarges elicited in chronically isolated slabs of cerebral cortex 1. The role of sympathomimetic agents in the maintenance and termination of induced cortical epileptiform activity was studied in chronically neuronally isolated slabs of cerebral cortex in the suprasylvian gyrus of unanaesthetized, unrestrained cats.2. The administration of the sympathomimetic agents (+)-amphetamine, methamphetamine, tyramine, and ephedrine (...) resulted in a highly significant decrease in the duration of epileptiform afterdischarge (EADs).3. The alpha-adrenoceptor blocking drugs phenoxybenzamine, phentolamine and tolazoline did not significantly alter the duration of EADs but prevented the decrease in duration of EADs produced by the sympathomimetic drugs.4. The effect of atropine and arecoline on the duration of EADs, previously described, were not modified by the alpha-adrenoceptor blocking drugs, but atropine prevented and reversed

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1971 British journal of pharmacology

107. Proceedings: Release of 3-H-(--)-noradrenaline from guinea-pig hypothalamic slices: effects of adrenoceptor agonists and antagonists. (PubMed)

Proceedings: Release of 3-H-(--)-noradrenaline from guinea-pig hypothalamic slices: effects of adrenoceptor agonists and antagonists. 236800 1975 09 09 2014 11 20 0007-1188 53 3 1975 Mar British journal of pharmacology Br. J. Pharmacol. Release of 3-H-(--)-noradrenaline from guinea-pig hypothalamic slices: effects of adrenoceptor agonists and antagonists. 454P Bryant B J BJ McCulloch M W MW Rand M J MJ Story D F DF eng Journal Article England Br J Pharmacol 7502536 0007-1188 0 Adrenergic alpha (...) -Agonists 0 Adrenergic alpha-Antagonists X4W3ENH1CV Norepinephrine IM Adrenergic alpha-Agonists pharmacology Adrenergic alpha-Antagonists pharmacology Animals Electric Stimulation Guinea Pigs Hypothalamus drug effects metabolism physiology In Vitro Techniques Norepinephrine metabolism 1975 3 1 1975 3 1 0 1 1975 3 1 0 0 ppublish 236800 PMC1666453

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1975 British journal of pharmacology

108. An Observational Study of Dutasteride and Alpha-blocker Combination Therapy in Men With Symptomatic Benign Prostatic Hyperplasia and PSA Level Over 4 ng/mL

Adrenergic alpha-Antagonists 5-alpha Reductase Inhibitors Steroid Synthesis Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Hormone Antagonists Hormones, Hormone Substitutes, and Hormone Antagonists Physiological Effects of Drugs Adrenergic Antagonists Adrenergic Agents Neurotransmitter Agents (...) An Observational Study of Dutasteride and Alpha-blocker Combination Therapy in Men With Symptomatic Benign Prostatic Hyperplasia and PSA Level Over 4 ng/mL An Observational Study of Dutasteride and Alpha-blocker Combination Therapy in Men With Symptomatic Benign Prostatic Hyperplasia and PSA Level Over 4 ng/mL - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record

2011 Clinical Trials

109. Comparison Between Alpha Blocker Monotherapy and 5ARI Monotherapy Following Combination Therapy in Benign Prostatic Hyperplasia (BPH)

relevant MeSH terms: Layout table for MeSH terms Hyperplasia Prostatic Hyperplasia Pathologic Processes Prostatic Diseases Genital Diseases, Male Adrenergic alpha-Antagonists 5-alpha Reductase Inhibitors Adrenergic Antagonists Adrenergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs Steroid Synthesis Inhibitors Enzyme Inhibitors Hormone Antagonists Hormones, Hormone Substitutes, and Hormone Antagonists (...) Comparison Between Alpha Blocker Monotherapy and 5ARI Monotherapy Following Combination Therapy in Benign Prostatic Hyperplasia (BPH) Comparison Between Alpha Blocker Monotherapy and 5ARI Monotherapy Following Combination Therapy in Benign Prostatic Hyperplasia (BPH) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You

2011 Clinical Trials

110. Letter: Alpha-receptor-blocking drugs in bronchial asthma. (PubMed)

Letter: Alpha-receptor-blocking drugs in bronchial asthma. 46503 1975 05 09 2015 06 16 0140-6736 1 7902 1975 Feb 08 Lancet (London, England) Lancet Letter: Alpha-receptor-blocking drugs in bronchial asthma. 348-9 Patel K R KR Kerr J W JW eng Clinical Trial Journal Article Randomized Controlled Trial England Lancet 2985213R 0140-6736 0 Adrenergic alpha-Antagonists 0 Adrenergic beta-Agonists 0 Drug Combinations L628TT009W Isoproterenol PW8QYA7KI0 Moxisylyte QF8SVZ843E Albuterol Z468598HBV (...) Phentolamine AIM IM Adrenergic alpha-Antagonists administration & dosage therapeutic use Adrenergic beta-Agonists administration & dosage therapeutic use Airway Obstruction drug therapy Airway Resistance drug effects Albuterol therapeutic use Asthma drug therapy Drug Combinations Humans Isoproterenol therapeutic use Moxisylyte therapeutic use Phentolamine therapeutic use Respiratory Therapy 1975 2 8 1975 2 8 0 1 1975 2 8 0 0 ppublish 46503 S0140-6736(75)91271-4

1975 Lancet (London, England)

111. Some complementary data on AH 5158, an inhibitor of both alpha-and beta-adrenoceptors [proceedings]. (PubMed)

Some complementary data on AH 5158, an inhibitor of both alpha-and beta-adrenoceptors [proceedings]. 11020 1977 01 29 2018 11 13 0007-1188 58 3 1976 Nov British journal of pharmacology Br. J. Pharmacol. Some complementary data on AH 5158, an inhibitor of both alpha-and beta-adrenoceptors [proceedings]. 412P Harichaux P P Hary L L eng Journal Article England Br J Pharmacol 7502536 0007-1188 0 Adrenergic alpha-Antagonists 0 Adrenergic beta-Antagonists 0 Ethanolamines R5H8897N95 Labetalol IM (...) Adrenergic alpha-Antagonists Adrenergic beta-Antagonists Animals Ethanolamines pharmacology Guinea Pigs In Vitro Techniques Labetalol pharmacology Rabbits Rats 1976 11 1 1976 11 1 0 1 1976 11 1 0 0 ppublish 11020 PMC1667557 Br J Pharmacol. 1972 Aug;45(4):660-75 4404413 Br J Pharmacol. 1975 Apr;53(4):585-92 238705

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1976 British journal of pharmacology

112. Discrimination between nicotinic receptors in vertebrate ganglia and skeletal muscle by alpha-bungarotoxin and cobra venoms. (PubMed)

Discrimination between nicotinic receptors in vertebrate ganglia and skeletal muscle by alpha-bungarotoxin and cobra venoms. 1. We have used snake neurotoxins, alpha-bungarotoxin and venoms from Naja naja siamensis and Naja nivea, to distinguish the nicotinic receptors of ganglia from those of skeletal neuromuscular junctions. 2. These neurotoxins failed to block responses of isolated guinea-pig longitudinal muscle with adherent myenteric plexus to the nicotinic agonists, nicotine (...) or dimethylphenylpiperazinium, to acetylcholine (ACh), or to electrical field stimulation. 3. The toxins failed to affect responses of the isolated guinea-pig stomach to pregnaglionic stimulation by way of the vagus nerves or of the vas deferens to preganglionic stimulation via the hypogastric nerves. 4. Snake neurotoxins did not block non-adrenergic inhibitory responses of the rabbit small intestine to nicotine or electrical field stimulation. 5. Neurotoxins were ineffective blockers against nicotinic agonists in new-born

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1977 The Journal of physiology

113. Blockade of pre-synaptic alpha-adrenoceptors by metiamide [proceedings] (PubMed)

Blockade of pre-synaptic alpha-adrenoceptors by metiamide [proceedings] 31220 1979 02 12 2018 11 13 0007-1188 64 3 1978 Nov British journal of pharmacology Br. J. Pharmacol. Blockade of pre-synaptic alpha-adrenoceptors by metiamide [proceedings]. 416P Griffith O R OR Marshall I I Nasmyth P A PA eng Journal Article England Br J Pharmacol 7502536 0007-1188 0 Adrenergic alpha-Antagonists 3K7670861M Metiamide GYV9AM2QAG Thiourea IM Adrenergic alpha-Antagonists Animals In Vitro Techniques Male

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1978 British journal of pharmacology

114. Antagonism by (+)-amphetamine of the inhibition of [3H]-noradrenaline overflow obtained by alpha-adrenoceptor agonists or bretylium in the perfused cat spleen [proceedings] (PubMed)

C eng Journal Article England Br J Pharmacol 7502536 0007-1188 0 Adrenergic alpha-Agonists 0 Bretylium Compounds TZ47U051FI Dextroamphetamine X4W3ENH1CV Norepinephrine IM Adrenergic alpha-Agonists antagonists & inhibitors Animals Bretylium Compounds antagonists & inhibitors Cats Dextroamphetamine pharmacology In Vitro Techniques Norepinephrine metabolism Spleen drug effects metabolism 1979 7 1 1979 7 1 0 1 1979 7 1 0 0 ppublish 43177 PMC2043685 Rev Physiol Biochem Pharmacol. 1977;77:1-124 14389 (...) Antagonism by (+)-amphetamine of the inhibition of [3H]-noradrenaline overflow obtained by alpha-adrenoceptor agonists or bretylium in the perfused cat spleen [proceedings] 43177 1980 04 25 2018 11 13 0007-1188 66 3 1979 Jul British journal of pharmacology Br. J. Pharmacol. Antagonism by (+)-amphetamine of the inhibition of [3H]-noradrenaline overflow obtained by alpha-adrenoceptor agonists or bretylium in the perfused cat spleen [proceedings]. 460P-461P Dubocovich M L ML Langer S Z SZ Moret C

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1979 British journal of pharmacology

115. Relative affinities of some alpha-adrenoceptor blocking drugs in isolated human smooth muscle. (PubMed)

Relative affinities of some alpha-adrenoceptor blocking drugs in isolated human smooth muscle. 4395086 1971 02 04 2018 11 13 0007-1188 40 1 1970 Sep British journal of pharmacology Br. J. Pharmacol. Relative affinities of some alpha-adrenoceptor blocking drugs in isolated human smooth muscle. 155P-157P Coupar I M IM Turner P P eng Journal Article England Br J Pharmacol 7502536 0007-1188 0 Adrenergic alpha-Antagonists 0 Aniline Compounds 0 Dibenzazepines 0 Hydroquinones 0 Imidazoles 0 (...) Sympatholytics CHH9H12AQ3 Tolazoline Z468598HBV Phentolamine IM Adrenergic alpha-Antagonists pharmacology Aniline Compounds pharmacology Dibenzazepines pharmacology Humans Hydroquinones pharmacology Ileum drug effects Imidazoles pharmacology In Vitro Techniques Muscle, Smooth drug effects Phentolamine pharmacology Saphenous Vein drug effects Sympatholytics pharmacology Tolazoline pharmacology 1970 9 1 1970 9 1 0 1 1970 9 1 0 0 ppublish 4395086 PMC1702676 J Pharm Pharmacol. 1965 Jul;17(7):449-58 4379268 Br J

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1970 British journal of pharmacology

116. Proceedings: Alpha-adrenoceptor inhibition from indoramin in man. (PubMed)

Proceedings: Alpha-adrenoceptor inhibition from indoramin in man. 4148923 1974 02 27 2018 11 13 0007-1188 44 2 1972 Feb British journal of pharmacology Br. J. Pharmacol. Proceedings: Alpha-adrenoceptor inhibition from indoramin in man. 378P-379P Boakes A J AJ Prichard B N BN Teoh P C PC eng Journal Article England Br J Pharmacol 7502536 0007-1188 0 Adrenergic alpha-Antagonists 0 Indoles 0 Piperidines 1WS297W6MV Phenylephrine IM Administration, Oral Adrenergic alpha-Antagonists administration

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1972 British journal of pharmacology

117. Proceedings: Is thymoxamine a specific alpha-adrenoceptor blocking agent? (PubMed)

Proceedings: Is thymoxamine a specific alpha-adrenoceptor blocking agent? 4148921 1974 02 27 2018 11 13 0007-1188 44 2 1972 Feb British journal of pharmacology Br. J. Pharmacol. Proceedings: Is thymoxamine a specific alpha-adrenoceptor blocking agent? 362P-362P Fawke L L eng Journal Article England Br J Pharmacol 7502536 0007-1188 0 Adrenergic alpha-Antagonists 0 Receptors, Adrenergic 1WS297W6MV Phenylephrine PW8QYA7KI0 Moxisylyte Z468598HBV Phentolamine IM Adrenergic alpha-Antagonists Animals (...) Electric Stimulation Guinea Pigs Hypogastric Plexus drug effects In Vitro Techniques Male Moxisylyte pharmacology Muscle Contraction drug effects Phentolamine pharmacology Phenylephrine pharmacology Receptors, Adrenergic drug effects Vas Deferens drug effects physiology 1972 2 1 1972 2 1 0 1 1972 2 1 0 0 ppublish 4148921 PMC1666072 Br J Pharmacol Chemother. 1963 Dec;21:569-80 14110756 J Pharm Pharmacol. 1965 Jul;17(7):449-58 4379268 J Physiol. 1956 Mar 28;131(3):678-89 13320365

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1972 British journal of pharmacology

118. Effect of alpha-blocking drugs in asthma. (PubMed)

Effect of alpha-blocking drugs in asthma. 4150269 1974 05 17 2018 11 13 0007-1447 1 5905 1974 Mar 09 British medical journal Br Med J Effect of alpha-blocking drugs in asthma. 457 Assem E S ES Paterson S S eng Journal Article England Br Med J 0372673 0007-1447 0 Adrenergic beta-Antagonists 0 Receptors, Adrenergic EC 4.6.1.1 Adenylyl Cyclases AIM IM Adenylyl Cyclases metabolism Adrenergic beta-Antagonists therapeutic use Asthma drug therapy Humans Leukocytes drug effects Male Receptors (...) , Adrenergic 1974 3 9 1974 3 9 0 1 1974 3 9 0 0 ppublish 4150269 PMC1633208 Br Med J. 1970 May 30;2(5708):504-7 4193661 Int Arch Allergy Appl Immunol. 1971;40(4-5):576-89 4102844 Clin Allergy. 1973 Jun;3(2):161-75 4131251

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1974 British medical journal

119. Letter: Alpha-adrenoceptor-blocking drugs in asthma. (PubMed)

Letter: Alpha-adrenoceptor-blocking drugs in asthma. 4154123 1975 01 28 2018 11 13 0007-1447 4 5941 1974 Nov 16 British medical journal Br Med J Letter: Alpha-adrenoceptor-blocking drugs in asthma. 409 Palmer K N KN Gaddie J J Skinner C C eng Clinical Trial Controlled Clinical Trial Journal Article England Br Med J 0372673 0007-1447 0 Adrenergic beta-Antagonists 0 Receptors, Adrenergic QF8SVZ843E Albuterol AIM IM Adrenergic beta-Antagonists therapeutic use Albuterol therapeutic use Asthma drug (...) therapy Drug Synergism Humans Receptors, Adrenergic 1974 11 16 1974 11 16 0 1 1974 11 16 0 0 ppublish 4154123 PMC1612497 Br J Dis Chest. 1972 Apr;66(2):141-6 4402506 Lancet. 1972 Sep 23;2(7778):657 4116809

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1974 British medical journal

120. Letter: Alpha-adrenoceptor-blocking drugs in asthma. (PubMed)

Letter: Alpha-adrenoceptor-blocking drugs in asthma. 234771 1975 06 09 2014 11 20 0007-1447 1 5954 1975 Feb 15 British medical journal Br Med J Letter: Alpha-adrenoceptor-blocking drugs in asthma. 394-5 Airaksinen M M MM Arnala I I Nousiainen T T Kokkola K K eng Journal Article England Br Med J 0372673 0007-1447 0 Adrenergic alpha-Antagonists 0 Adrenergic beta-Agonists AIM IM Adrenergic alpha-Antagonists pharmacology therapeutic use Adrenergic beta-Agonists pharmacology Animals Asthma drug

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1975 British medical journal

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