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Alpha Adrenergic Antagonist

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81. Beta-Adrenergic Potentiation of the Increased In Vitro Accumulation of Cycloleucine by Rat Thymocytes Induced by Triiodothyronine Full Text available with Trip Pro

by the concomitant addition of epinephrine, norepinephrine, and possibly isoproterenol, whereas terbutaline and phenylephrine were without effect. Neither basal nor T(3)-enhanced CLE accumulation was affected by the addition alone of the adrenergic blocking agents, propranolol (0.1 mM), phentolamine (10 muM), or practolol (0.1 mM). Nevertheless, the beta(1)- and beta(2)-antagonist, propranol, and the beta(1)-antagonist, practolol, blocked the increment in CLE accumulation produced by epinephrine; the alpha (...) Beta-Adrenergic Potentiation of the Increased In Vitro Accumulation of Cycloleucine by Rat Thymocytes Induced by Triiodothyronine We have previously demonstrated that 3,5,3'-triiodothyronine (T(3)), whether administered in vivo or added to suspending media in vitro, promptly stimulates the in vitro accumulation of the nonmetabolized amino acids, alpha-aminoisobutyric acid, and cycloleucine (CLE) by thymocytes isolated from weanling rats. In these studies, we have examined the in vitro

1979 Journal of Clinical Investigation

82. Identification of α-Adrenergic Receptors in Human Platelets by [3H]Dihydroergocryptine Binding Full Text available with Trip Pro

potent than the (-)isomers. The potent alpha-adrenergic antagonists phentolamine, phenoxybenzamine, and yohimbine competed potently for the sites, whereas beta-antagonists such as propranolol and dichlorisoproterenol were quite weak. Dopamine and serotonin competed only at high concentrations (0.1 mM). The [(3)H]dihydroergocryptine binding sites could also be demonstrated in intact platelets where they displayed comparable specificity, stereospecificity, and saturability. Saturation binding studies (...) with the intact platelets indicated 220+/-45 receptors per platelet, in good agreement with the value derived from studies with platelet lysates. Ability of alpha-adrenergic agonists to inhibit adenylate cyclase and of alpha-adrenergic antagonists to antagonize this inhibitory effect directly paralleled ability to interact with the [(3)H]dihydroergocryptine binding sites. These data demonstrate the feasibility of directly studying alpha-adrenergic receptor binding sites in human platelets with [(3)H

1978 Journal of Clinical Investigation

83. Initial investigations into adrenaline accumulation and adrenergic responsiveness in cultured neonatal rat heart cells. Full Text available with Trip Pro

-concentration data were not linearly correlated with dose-response data. 4 Accumulation did not correlate well with beta-adrenoceptor responsiveness in a number of situations of varying responsiveness. 5 Accumulation was not blocked by a variety of uptake blocking agents or alpha- and beta-adrenoceptor antagonists. 6 A much smaller accumulation process was observed in fibroblasts which respond to adrenaline with reversible morphological changes. (...) Initial investigations into adrenaline accumulation and adrenergic responsiveness in cultured neonatal rat heart cells. 1 Accumulation of tritiated adrenaline (and/or its products) has been studied by a variety of techniques in viable, attached and free-floating myoblasts cultured from neonatal rat heart cells. 2 Accumulation increased with the number of cells used, the culture age of cells, incubation time and the concentration of adrenaline in the incubation mixture. 3 Accumulation

1978 British journal of pharmacology

84. Comparative Study of Use of Alpha-Blockers to Treat Symptoms in Prostate Cancer Patients Undergoing Radiation Therapy

Adrenergic alpha-Antagonists Silodosin Adrenergic Antagonists Adrenergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs Adrenergic alpha-1 Receptor Antagonists Urological Agents (...) Comparative Study of Use of Alpha-Blockers to Treat Symptoms in Prostate Cancer Patients Undergoing Radiation Therapy Comparative Study of Use of Alpha-Blockers to Treat Symptoms in Prostate Cancer Patients Undergoing Radiation Therapy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2014 Clinical Trials

85. Role of alpha-1 blocker in expulsion of stone fragments after extracorporeal shock wave lithotripsy for renal stones. (Abstract)

to improve spontaneous stone passage rates.This study was a randomized, controlled, prospective study to determine whether the administration of Alpha-1-adrenergic receptor antagonists as an adjunctive medical therapy, increases the efficacy of ESWL to treat renal stones. Sixty patients with renal stones of 0.5-1.5 Cm in size (average size 1.2 Cm) were included in this study underwent ESWL followed by administration of Alpha-1-adrenergic receptor antagonists at department of Urology Liaquat National (...) Role of alpha-1 blocker in expulsion of stone fragments after extracorporeal shock wave lithotripsy for renal stones. Renal stone disease is a significant and worldwide health problem. Recent advances in stone management have allowed kidney stones to be treated using extracorporeal shock wave lithotripsy (ESWL), uretero-renoscopy (URS), and percutaneous nephrostolithotomy (PCNL). Recently, medical expulsion therapy (MET) has been investigated as a supplement to observation in an effort

2014 Journal of Ayub Medical College, Abbottabad : JAMC Controlled trial quality: uncertain

86. Interaction of {alpha}1D-Adrenergic and P2X7 Receptors in the Rat Lacrimal Gland and the Effect on Intracellular [Ca2+] and Protein Secretion. Full Text available with Trip Pro

Interaction of {alpha}1D-Adrenergic and P2X7 Receptors in the Rat Lacrimal Gland and the Effect on Intracellular [Ca2+] and Protein Secretion. To determine whether α(1D)-adrenergic receptors (α(1D)-AR) and P2X(7) receptors interact by determining their effect on ATP release, intracellular [Ca(2+)] ([Ca(2+)](i)), and protein secretion in rat lacrimal gland acini.Exorbital lacrimal glands from male Sprague-Dawley rats were divided into pieces or digested with collagenase to form acini (...) . With the use of an imaging system, [Ca(2+)](i) was measured in acini loaded with fura-2. Adenosine triphosphate (ATP) release was determined using the luciferin-luciferase reaction. Peroxidase secretion, our index for protein secretion, was measured spectrophotometrically. Acini were stimulated with the P2X(7) receptor agonist, (benzoylbenzoyl)adenosine 5' triphosphate (BzATP) or the α(1D)-AR agonist phenylephrine with or without antagonist preincubation.Phenylephrine increased ATP release from pieces

2011 Investigative Ophthalmology & Visual Science

87. Working Mechanism Underlying the Reduction of the Behavioral and Accumbal Dopamine Response to Cocaine by α-1-Adrenoceptor Antagonists Full Text available with Trip Pro

Saigusa Tadashi T Koshikawa Noriaki N Cools Alexander R AR eng Letter Research Support, Non-U.S. Gov't Review England Neuropsychopharmacology 8904907 0893-133X 0 Adrenergic alpha-1 Receptor Antagonists I5Y540LHVR Cocaine VTD58H1Z2X Dopamine IM Adrenergic alpha-1 Receptor Antagonists pharmacology Animals Cocaine pharmacology Dopamine deficiency metabolism Humans Nucleus Accumbens drug effects metabolism 2013 1 17 6 0 2013 1 17 6 0 2013 10 18 6 0 ppublish 23322161 npp2012209 10.1038/npp.2012.209 (...) Working Mechanism Underlying the Reduction of the Behavioral and Accumbal Dopamine Response to Cocaine by α-1-Adrenoceptor Antagonists 23322161 2013 10 17 2018 11 13 1740-634X 38 3 2013 Feb Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Neuropsychopharmacology Working mechanism underlying the reduction of the behavioral and accumbal dopamine response to cocaine by α-1-adrenoceptor antagonists. 540-1 10.1038/npp.2012.209 Verheij Michel M M MM

2013 Neuropsychopharmacology

88. Hemodynamic Response of Neuropathic And Non-Neuropathic POTS Patients To Adrenoreceptor Agonist And Antagonist

: No Criteria Inclusion Criteria: CDC criteria for chronic fatigue syndrome Evidence of postural tachycardia syndrome with symptoms of orthostatic intolerance Exclusion Criteria: Pregnant or lactating females. The administration of droxidopa is harmful to the fetus Concomitant therapy with anticholinergic, alpha-, and beta-adrenergic antagonists or other medications that affect autonomic function Clinically significant coronary artery, cerebrovascular or peripheral vascular disease Cardiac arrhythmias (...) will have different responsiveness than patients with neuropathic POTS to direct alpha-1 adrenoreceptor agonist therapy (droxidopa) and to non-selective beta-adrenoreceptor antagonist therapy (atenolol). The specific goal of this protocol is to investigate the effect of atenolol and droxidopa on cardiovascular autonomic functions such as cardiovagal control, sympathetic nerve activity, and sympathetic vascular transduction, systemic hemodynamic response to orthostatic stress and on the quality of life

2012 Clinical Trials

89. Alpha-Blockers in Allergic Rhinitis (MAN 01)

Infections Otorhinolaryngologic Diseases Respiratory Hypersensitivity Hypersensitivity, Immediate Hypersensitivity Immune System Diseases Doxazosin Antihypertensive Agents Adrenergic alpha-1 Receptor Antagonists Adrenergic alpha-Antagonists Adrenergic Antagonists Adrenergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs (...) or decreased lumen diameter of the gastrointestinal tract. Concomitant use of PDE5 inhibitors (sildenafil etc.) Alpha antagonists - this is the medication under investigation. Other cardiovascular medications including but not limited to: ACE inhibitors, Angiotensin II antagonists, Beta blockers, calcium channel blockers, diuretics, nitrates, phosphodiesterase type-5 inhibitors or other vasodilating medications - these in combination with doxazosin carry an increased risk of symptomatic hypotension

2013 Clinical Trials

90. Brief report: low dose alpha-2 antagonist paradoxically enhances rat norepinephrine and clonidine analgesia. Full Text available with Trip Pro

Brief report: low dose alpha-2 antagonist paradoxically enhances rat norepinephrine and clonidine analgesia. Ultralow-dose opioid antagonists prolong opioid antinociception and block tolerance. In this study we determined whether low doses of the α-2 adrenergic receptor (A2-R) antagonist, atipamezole, similarly influenced A2-R-induced antinociception and tolerance. In rats, intrathecal norepinephrine (NE) or clonidine in combination with atipamezole was tested using tail-flick and paw pressure (...) tests. Acute tolerance to NE was induced by serial injections. Low-dose atipamezole significantly prolonged NE and clonidine-induced antinociception. Coadministration of atipamezole with A2-R agonists also prevented loss of agonist potency in the acute tolerance model. This study demonstrates paradoxical effects of low-dose A2-R antagonists augmenting A2-R agonist-induced analgesia.

2011 Anesthesia and Analgesia

91. Effects of some sympathomimetic drugs and their antagonists on afterdischarges elicited in chronically isolated slabs of cerebral cortex Full Text available with Trip Pro

Effects of some sympathomimetic drugs and their antagonists on afterdischarges elicited in chronically isolated slabs of cerebral cortex 1. The role of sympathomimetic agents in the maintenance and termination of induced cortical epileptiform activity was studied in chronically neuronally isolated slabs of cerebral cortex in the suprasylvian gyrus of unanaesthetized, unrestrained cats.2. The administration of the sympathomimetic agents (+)-amphetamine, methamphetamine, tyramine, and ephedrine (...) resulted in a highly significant decrease in the duration of epileptiform afterdischarge (EADs).3. The alpha-adrenoceptor blocking drugs phenoxybenzamine, phentolamine and tolazoline did not significantly alter the duration of EADs but prevented the decrease in duration of EADs produced by the sympathomimetic drugs.4. The effect of atropine and arecoline on the duration of EADs, previously described, were not modified by the alpha-adrenoceptor blocking drugs, but atropine prevented and reversed

1971 British journal of pharmacology

92. Proceedings: Release of 3-H-(--)-noradrenaline from guinea-pig hypothalamic slices: effects of adrenoceptor agonists and antagonists. Full Text available with Trip Pro

Proceedings: Release of 3-H-(--)-noradrenaline from guinea-pig hypothalamic slices: effects of adrenoceptor agonists and antagonists. 236800 1975 09 09 2014 11 20 0007-1188 53 3 1975 Mar British journal of pharmacology Br. J. Pharmacol. Release of 3-H-(--)-noradrenaline from guinea-pig hypothalamic slices: effects of adrenoceptor agonists and antagonists. 454P Bryant B J BJ McCulloch M W MW Rand M J MJ Story D F DF eng Journal Article England Br J Pharmacol 7502536 0007-1188 0 Adrenergic alpha (...) -Agonists 0 Adrenergic alpha-Antagonists X4W3ENH1CV Norepinephrine IM Adrenergic alpha-Agonists pharmacology Adrenergic alpha-Antagonists pharmacology Animals Electric Stimulation Guinea Pigs Hypothalamus drug effects metabolism physiology In Vitro Techniques Norepinephrine metabolism 1975 3 1 1975 3 1 0 1 1975 3 1 0 0 ppublish 236800 PMC1666453

1975 British journal of pharmacology

93. Protective effect of Chresta martii extract on ethanol-induced gastropathy depends on alpha-2 adrenoceptors pathways but not on nitric oxide, prostaglandins or opioids. (Abstract)

action mechanism. Animals were sacrificed 30 min after ethanol challenge to stomach analysis. Determination of non-protein sulfhydryl groups and tissue hemoglobin, besides histological assessment (H&E) were taken to fully characterize the HAE gastro protective effect.HAE (100 and 200 mg/kg) was able to protect mucosa against ethanol gastropathy in presence of three (naloxone, indomethacin and L-NAME) of four antagonist/inhibitor tools. The HAE effect was reversed only by yohimbine, showing the alpha (...) has antioxidant activity that is thought to either play a role in this biological activity or to be a byproduct of alpha-2 adrenergic complex activation.Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

2012 Journal of Ethnopharmacology

94. Advanced Benefits of Alpha-blocker Monotherapy on Lower Urinary Tracts Symptoms(LUTS) Patients

alpha reductase inhibitor Proscar Finasteride alpha blocker Tamsulosin Harnal D Additional relevant MeSH terms: Layout table for MeSH terms Hyperplasia Lower Urinary Tract Symptoms Prostatic Hyperplasia Pathologic Processes Urological Manifestations Signs and Symptoms Prostatic Diseases Genital Diseases, Male Tamsulosin Finasteride Adrenergic alpha-Antagonists Adrenergic alpha-1 Receptor Antagonists Adrenergic Antagonists Adrenergic Agents Neurotransmitter Agents Molecular Mechanisms (...) of Pharmacological Action Physiological Effects of Drugs Urological Agents 5-alpha Reductase Inhibitors Steroid Synthesis Inhibitors Enzyme Inhibitors Hormone Antagonists Hormones, Hormone Substitutes, and Hormone Antagonists

2012 Clinical Trials

95. Letter: Alpha-receptor-blocking drugs in bronchial asthma. (Abstract)

Letter: Alpha-receptor-blocking drugs in bronchial asthma. 46503 1975 05 09 2015 06 16 0140-6736 1 7902 1975 Feb 08 Lancet (London, England) Lancet Letter: Alpha-receptor-blocking drugs in bronchial asthma. 348-9 Patel K R KR Kerr J W JW eng Clinical Trial Journal Article Randomized Controlled Trial England Lancet 2985213R 0140-6736 0 Adrenergic alpha-Antagonists 0 Adrenergic beta-Agonists 0 Drug Combinations L628TT009W Isoproterenol PW8QYA7KI0 Moxisylyte QF8SVZ843E Albuterol Z468598HBV (...) Phentolamine AIM IM Adrenergic alpha-Antagonists administration & dosage therapeutic use Adrenergic beta-Agonists administration & dosage therapeutic use Airway Obstruction drug therapy Airway Resistance drug effects Albuterol therapeutic use Asthma drug therapy Drug Combinations Humans Isoproterenol therapeutic use Moxisylyte therapeutic use Phentolamine therapeutic use Respiratory Therapy 1975 2 8 1975 2 8 0 1 1975 2 8 0 0 ppublish 46503 S0140-6736(75)91271-4

1975 Lancet (London, England)

96. Letter: Alpha-adrenoceptor-blocking drugs in asthma. Full Text available with Trip Pro

Letter: Alpha-adrenoceptor-blocking drugs in asthma. 4154123 1975 01 28 2018 11 13 0007-1447 4 5941 1974 Nov 16 British medical journal Br Med J Letter: Alpha-adrenoceptor-blocking drugs in asthma. 409 Palmer K N KN Gaddie J J Skinner C C eng Clinical Trial Controlled Clinical Trial Journal Article England Br Med J 0372673 0007-1447 0 Adrenergic beta-Antagonists 0 Receptors, Adrenergic QF8SVZ843E Albuterol AIM IM Adrenergic beta-Antagonists therapeutic use Albuterol therapeutic use Asthma drug (...) therapy Drug Synergism Humans Receptors, Adrenergic 1974 11 16 1974 11 16 0 1 1974 11 16 0 0 ppublish 4154123 PMC1612497 Br J Dis Chest. 1972 Apr;66(2):141-6 4402506 Lancet. 1972 Sep 23;2(7778):657 4116809

1974 British medical journal

97. Effect of alpha-blocking drugs in asthma. Full Text available with Trip Pro

Effect of alpha-blocking drugs in asthma. 4150269 1974 05 17 2018 11 13 0007-1447 1 5905 1974 Mar 09 British medical journal Br Med J Effect of alpha-blocking drugs in asthma. 457 Assem E S ES Paterson S S eng Journal Article England Br Med J 0372673 0007-1447 0 Adrenergic beta-Antagonists 0 Receptors, Adrenergic EC 4.6.1.1 Adenylyl Cyclases AIM IM Adenylyl Cyclases metabolism Adrenergic beta-Antagonists therapeutic use Asthma drug therapy Humans Leukocytes drug effects Male Receptors (...) , Adrenergic 1974 3 9 1974 3 9 0 1 1974 3 9 0 0 ppublish 4150269 PMC1633208 Br Med J. 1970 May 30;2(5708):504-7 4193661 Int Arch Allergy Appl Immunol. 1971;40(4-5):576-89 4102844 Clin Allergy. 1973 Jun;3(2):161-75 4131251

1974 British medical journal

98. Letter: Alpha-adrenoceptor-blocking drugs in asthma. Full Text available with Trip Pro

Letter: Alpha-adrenoceptor-blocking drugs in asthma. 234771 1975 06 09 2014 11 20 0007-1447 1 5954 1975 Feb 15 British medical journal Br Med J Letter: Alpha-adrenoceptor-blocking drugs in asthma. 394-5 Airaksinen M M MM Arnala I I Nousiainen T T Kokkola K K eng Journal Article England Br Med J 0372673 0007-1447 0 Adrenergic alpha-Antagonists 0 Adrenergic beta-Agonists AIM IM Adrenergic alpha-Antagonists pharmacology therapeutic use Adrenergic beta-Agonists pharmacology Animals Asthma drug

1975 British medical journal

99. Some complementary data on AH 5158, an inhibitor of both alpha-and beta-adrenoceptors [proceedings]. Full Text available with Trip Pro

Some complementary data on AH 5158, an inhibitor of both alpha-and beta-adrenoceptors [proceedings]. 11020 1977 01 29 2018 11 13 0007-1188 58 3 1976 Nov British journal of pharmacology Br. J. Pharmacol. Some complementary data on AH 5158, an inhibitor of both alpha-and beta-adrenoceptors [proceedings]. 412P Harichaux P P Hary L L eng Journal Article England Br J Pharmacol 7502536 0007-1188 0 Adrenergic alpha-Antagonists 0 Adrenergic beta-Antagonists 0 Ethanolamines R5H8897N95 Labetalol IM (...) Adrenergic alpha-Antagonists Adrenergic beta-Antagonists Animals Ethanolamines pharmacology Guinea Pigs In Vitro Techniques Labetalol pharmacology Rabbits Rats 1976 11 1 1976 11 1 0 1 1976 11 1 0 0 ppublish 11020 PMC1667557 Br J Pharmacol. 1972 Aug;45(4):660-75 4404413 Br J Pharmacol. 1975 Apr;53(4):585-92 238705

1976 British journal of pharmacology

100. Proceedings: Alpha-adrenoceptor inhibition from indoramin in man. Full Text available with Trip Pro

Proceedings: Alpha-adrenoceptor inhibition from indoramin in man. 4148923 1974 02 27 2018 11 13 0007-1188 44 2 1972 Feb British journal of pharmacology Br. J. Pharmacol. Proceedings: Alpha-adrenoceptor inhibition from indoramin in man. 378P-379P Boakes A J AJ Prichard B N BN Teoh P C PC eng Journal Article England Br J Pharmacol 7502536 0007-1188 0 Adrenergic alpha-Antagonists 0 Indoles 0 Piperidines 1WS297W6MV Phenylephrine IM Administration, Oral Adrenergic alpha-Antagonists administration

1972 British journal of pharmacology

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