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Alpha Adrenergic Antagonist

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61. Muscarinic receptor antagonist and an alpha-adrenergic agonist are required in combination to provide stable mydriasis following intravitreal injection in mice (PubMed)

Muscarinic receptor antagonist and an alpha-adrenergic agonist are required in combination to provide stable mydriasis following intravitreal injection in mice Tropicamide (muscarinic receptor antagonist) and phenylephrine (α-adrenergic receptor agonist) are commonly used to dilate the pupils by topical application. These two eye drops are often used, singly or in combination, to dilate the pupil and perform acute light-evoked physiological experiments (electroretinography, for example), before (...) full and stable pupillary dilation following intravitreal injections. Re-instillation of topical mydriatics after intravitreal injections was required for maximal pupillary dilation. A combination of a muscarinic receptor antagonist and an alpha-adrenergic agonist is required for stable mydriasis following intravitreal injection.

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2010 Biology and medicine (Aligarh)

62. The alpha(2) adrenergic antagonist fipamezole improves quality of levodopa action in Parkinsonian primates. (PubMed)

The alpha(2) adrenergic antagonist fipamezole improves quality of levodopa action in Parkinsonian primates. Reduction in the antiparkinsonian benefit of levodopa is a major complication of long-term levodopa treatment in advanced Parkinson's disease (PD). Such loss of benefit arises because of reduced duration of action and appearance of disabling dyskinesia. We assess the potential of the α(2) adrenergic antagonist fipamezole to reduce motor complications in parkinsonian macaques. MPTP (...) to that provided by the higher dose levodopa alone. However, with the combination, antiparkinsonian benefit was of much better quality. The proportion of on time without disabling dyskinesia (79%) was significantly greater than that with high dose levodopa alone (45%). Increased duration and quality of levodopa action may represent therapeutically valuable actions of α(2) adrenergic antagonists.

2010 Movement Disorders

63. Adrenergic and 'non-adrenergic' components in the contractile response of the vas deferens to a single indirect stimulus. (PubMed)

components were more rapid and briefer than the equivalent response of rat anococcygeus. 3. The second, slow component was abolished by alpha-adrenoceptor antagonist drugs, potentiated and prolonged by drugs which inhibit the neuronal uptake of noradrenaline and absent from tissues taken from rats pre-treated with reserpine, suggesting that the neurotransmitter for this component is noradrenaline. 4. These experiments were extended to the mouse or guinea-pig vas deferens. Both showed the same two (...) component mechanical response as the rat vas and in both the second, slow component was preferentially inhibited by alpha-adrenoceptor antagonists and potentiated by drugs blocking noradrenaline uptake. 5. Drugs known to reduce the response to repetitive nerve stimulation of the vas were examined for their effect on the response to a single stimulus. Lysergic acid diethylamide preferentially inhibited the second, slow phase of contraction whereas apomorphine preferentially inhibited the first rapid

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1978 The Journal of physiology

64. The maturation of neuromuscular function in a multiply innervated structure: development of the longitudinal smooth muscle of the foetal mammalian gut and its cholinergic excitatory, adrenergic inhibitory, and non-adrenergic inhibitory innervation (PubMed)

of gestation. Both were also present in the mouse by the 16th day of gestation. Responsiveness of rabbit tissue to exogenous acetylcholine appeared together with the advent of a functional cholinergic innervation. Since excitatory responses were potentiated by eserine, the tissue was probably able to inactivate acetylcholine through hydrolysis mediated by cholinesterase. Early relaxant responses resisted blockade by adrenergic neurone blocking agents and by antagonists active at alpha- and beta (...) The maturation of neuromuscular function in a multiply innervated structure: development of the longitudinal smooth muscle of the foetal mammalian gut and its cholinergic excitatory, adrenergic inhibitory, and non-adrenergic inhibitory innervation 1. The earliest components of the developing innervation of the rabbit intestine to be detected in this study were the cholinergic excitatory and the intrinsic inhibitory innervation. These developed simultaneously in the rabbit at 17 days

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1973 The Journal of physiology

65. The Influence of Hyperbaric Oxygen in Patients With Perianal Crohn's Disease Already Treated With TNF Alpha Blockers Treated With TNF Alpha Blockers

TNF alpha blockers hyperbaric oxygen therapy Additional relevant MeSH terms: Layout table for MeSH terms Crohn Disease Fistula Rectal Fistula Inflammatory Bowel Diseases Gastroenteritis Gastrointestinal Diseases Digestive System Diseases Intestinal Diseases Pathological Conditions, Anatomical Intestinal Fistula Digestive System Fistula Rectal Diseases Adrenergic alpha-Antagonists Adrenergic Antagonists Adrenergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action (...) The Influence of Hyperbaric Oxygen in Patients With Perianal Crohn's Disease Already Treated With TNF Alpha Blockers Treated With TNF Alpha Blockers The Influence of Hyperbaric Oxygen in Patients With Perianal Crohn's Disease Already Treated With TNF Alpha Blockers Treated With TNF Alpha Blockers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved

2013 Clinical Trials

66. Study to Assess the Influence of Three Different α-antagonists and Placebo on the Extent of Weekly Phenylephrine-induced Mydriasis at Three Different Concentrations of Phenylephrine in Healthy Male Volunteers

Agents Adrenergic alpha-1 Receptor Antagonists Adrenergic alpha-Antagonists Adrenergic Antagonists Urological Agents Antihypertensive Agents (...) table for MeSH terms Mydriasis Pupil Disorders Eye Diseases Phenylephrine Oxymetazoline Tamsulosin Doxazosin Alfuzosin Cardiotonic Agents Mydriatics Autonomic Agents Peripheral Nervous System Agents Physiological Effects of Drugs Sympathomimetics Vasoconstrictor Agents Nasal Decongestants Respiratory System Agents Adrenergic alpha-1 Receptor Agonists Adrenergic alpha-Agonists Adrenergic Agonists Adrenergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Protective

2014 Clinical Trials

67. Treatment of Schizophrenia With L-tetrahydropalmatine (l-THP): a Novel Dopamine Antagonist With Anti-inflammatory and Antiprotozoal Activity

Treatment of Schizophrenia With L-tetrahydropalmatine (l-THP): a Novel Dopamine Antagonist With Anti-inflammatory and Antiprotozoal Activity Treatment of Schizophrenia With L-tetrahydropalmatine (l-THP): a Novel Dopamine Antagonist With Anti-inflammatory and Antiprotozoal Activity - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save (...) this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Treatment of Schizophrenia With L-tetrahydropalmatine (l-THP): a Novel Dopamine Antagonist With Anti-inflammatory and Antiprotozoal Activity The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your

2014 Clinical Trials

68. Combining benefits of an adrenergic and a muscarinic blocker in a single formulation - a pharmacokinetic evaluation. (PubMed)

Combining benefits of an adrenergic and a muscarinic blocker in a single formulation - a pharmacokinetic evaluation. A pharmacokinetic bioequivalence study was conducted in Asian subjects, to compare a fixed dose combination capsule single oral dose of alpha adrenoceptor blocker-Alfuzosin hydrochloride 10mg extended release and muscarinic antagonists-Solifenacin succinate 5mg against individually administered Xatral XL 10mg tablets (Alfuzosin) of Sanofi Synthelabo Limited, United Kingdom (UK

2013 Regulatory toxicology and pharmacology : RTP

69. Sympathectomy and sympathetic blockade reduce pain behavior via alpha-2 adrenoceptor of the dorsal root ganglion neurons in a lumbar radiculopathy model. (PubMed)

pain. There are several reports that sympathectomy and pharmacological sympathetic blockades are often effective to treat neuropathic pain. However, its pathophysiological mechanisms remain obscure.We used 91 male Sprague-Dawley rats. Just after root constriction (RC), the rats underwent sympathectomy or received 3 local injections of subtype-specific α-adrenergic receptor antagonists around the DRG. We evaluated the analgesic effects of sympathectomy and sympathetic blockade using behaviors (...) Sympathectomy and sympathetic blockade reduce pain behavior via alpha-2 adrenoceptor of the dorsal root ganglion neurons in a lumbar radiculopathy model. Animal experimental study with intervention.We investigated whether sympathectomy and pharmacological sympathetic blockade reduced pain behavior and reversed adrenoceptor mRNA expression of the dorsal root ganglion (DRG) in a lumbar radiculopathy model.The abnormal sympathetic-somatosensory interaction may underlie some forms of neuropathic

2015 Spine

70. Meta-analysis of the efficacy and safety of alpha2-adrenergic agonists, beta-adrenergic antagonists, and topical carbonic anhydrase inhibitors with prostaglandin analogs. (PubMed)

Meta-analysis of the efficacy and safety of alpha2-adrenergic agonists, beta-adrenergic antagonists, and topical carbonic anhydrase inhibitors with prostaglandin analogs. To perform a meta-analysis to estimate the intraocular pressure (IOP)-lowering efficacy and safety of alpha(2)-adrenergic agonists (AAs), beta-adrenergic antagonists (BBs), and topical carbonic anhydrase inhibitors (TCAIs) when used in combination with a prostaglandin analog (PGA).MEDLINE, Embase, and the Cochrane Controlled

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2010 Archives of ophthalmology

71. Role of alpha-1 blocker in expulsion of stone fragments after extracorporeal shock wave lithotripsy for renal stones. (PubMed)

to improve spontaneous stone passage rates.This study was a randomized, controlled, prospective study to determine whether the administration of Alpha-1-adrenergic receptor antagonists as an adjunctive medical therapy, increases the efficacy of ESWL to treat renal stones. Sixty patients with renal stones of 0.5-1.5 Cm in size (average size 1.2 Cm) were included in this study underwent ESWL followed by administration of Alpha-1-adrenergic receptor antagonists at department of Urology Liaquat National (...) Role of alpha-1 blocker in expulsion of stone fragments after extracorporeal shock wave lithotripsy for renal stones. Renal stone disease is a significant and worldwide health problem. Recent advances in stone management have allowed kidney stones to be treated using extracorporeal shock wave lithotripsy (ESWL), uretero-renoscopy (URS), and percutaneous nephrostolithotomy (PCNL). Recently, medical expulsion therapy (MET) has been investigated as a supplement to observation in an effort

2014 Journal of Ayub Medical College, Abbottabad : JAMC

72. Comparative Study of Use of Alpha-Blockers to Treat Symptoms in Prostate Cancer Patients Undergoing Radiation Therapy

Adrenergic alpha-Antagonists Silodosin Adrenergic Antagonists Adrenergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs Adrenergic alpha-1 Receptor Antagonists Urological Agents (...) Comparative Study of Use of Alpha-Blockers to Treat Symptoms in Prostate Cancer Patients Undergoing Radiation Therapy Comparative Study of Use of Alpha-Blockers to Treat Symptoms in Prostate Cancer Patients Undergoing Radiation Therapy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2014 Clinical Trials

73. Beta Adrenergic Receptor

. Related Studies (from Trip Database) Ontology: Receptors, Adrenergic, beta-1 (C0001642) Definition (MSH) A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The adrenergic beta-1 receptors are equally sensitive to EPINEPHRINE and NOREPINEPHRINE and bind the agonist DOBUTAMINE and the antagonist METOPROLOL with high affinity. They are found in the HEART, juxtaglomerular cells, and in the central and peripheral nervous systems. Definition (NCI) Beta 1 adrenergic receptor protein (477 (...) adrenergic fibers, Beta Adrenergic Receptors are one of two major classes of adrenergic receptors (alpha and beta) based on their reactions to norepinephrine and epinephrine, on cellular effects of receptor activation, and on relative affinities and reactions to synthetic blocking or stimulating agents. Beta-adrenergic receptors respond to blocking agents such as propranolol and to activating agents such as isoproterenol. Beta-1 type receptors mediate lipolysis and increase cardiac rate and force

2015 FP Notebook

74. Working Mechanism Underlying the Reduction of the Behavioral and Accumbal Dopamine Response to Cocaine by α-1-Adrenoceptor Antagonists (PubMed)

Saigusa Tadashi T Koshikawa Noriaki N Cools Alexander R AR eng Letter Research Support, Non-U.S. Gov't Review England Neuropsychopharmacology 8904907 0893-133X 0 Adrenergic alpha-1 Receptor Antagonists I5Y540LHVR Cocaine VTD58H1Z2X Dopamine IM Adrenergic alpha-1 Receptor Antagonists pharmacology Animals Cocaine pharmacology Dopamine deficiency metabolism Humans Nucleus Accumbens drug effects metabolism 2013 1 17 6 0 2013 1 17 6 0 2013 10 18 6 0 ppublish 23322161 npp2012209 10.1038/npp.2012.209 (...) Working Mechanism Underlying the Reduction of the Behavioral and Accumbal Dopamine Response to Cocaine by α-1-Adrenoceptor Antagonists 23322161 2013 10 17 2018 11 13 1740-634X 38 3 2013 Feb Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Neuropsychopharmacology Working mechanism underlying the reduction of the behavioral and accumbal dopamine response to cocaine by α-1-adrenoceptor antagonists. 540-1 10.1038/npp.2012.209 Verheij Michel M M MM

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2013 Neuropsychopharmacology

75. Blockade of intra-articular adrenergic receptors increases analgesic demands for pain relief after knee surgery. (PubMed)

examined the expression of opioid peptides and adrenergic receptors in cells infiltrating inflamed synovial tissue and we hypothesized that intra-articular (i.a.) administration of the adrenergic receptor antagonist labetalol will increase postoperative analgesic consumption and/or pain intensity in these patients. In a double-blind, randomized manner, 75 patients undergoing therapeutic knee arthroscopy received i.a. placebo (20 ml saline) or labetalol (2.5 or 5 mg in 20 ml saline) at the end (...) of surgery. Postoperative pain intensity was assessed by visual analog and verbal rating scales at rest and on exertion, and by the consumption of morphine via patient-controlled analgesia. Synovial biopsies were taken during the operation for double-immunofluorescence confocal microscopy studies. Alpha(1)- and beta(2)-adrenergic receptors were co-expressed in opioid peptide-containing cells. No significant difference was seen in pain scores, but patients receiving 2.5 mg labetalol requested

2011 Rheumatology international

76. DASH After TBI Study: Decreasing Adrenergic or Sympathetic Hyperactivity After Traumatic Brain Injury

Severe TBI TBI Catecholamines Heart rate variability Adrenergic alpha-Agonists Adrenergic beta-Antagonists Cognitive Impairment Additional relevant MeSH terms: Layout table for MeSH terms Wounds and Injuries Brain Injuries Brain Injuries, Traumatic Hyperkinesis Craniocerebral Trauma Trauma, Nervous System Brain Diseases Central Nervous System Diseases Nervous System Diseases Dyskinesias Neurologic Manifestations Signs and Symptoms Propranolol Clonidine Adrenergic Agents Adrenergic beta-Antagonists (...) Adrenergic Antagonists Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs Anti-Arrhythmia Agents Antihypertensive Agents Vasodilator Agents Analgesics Sensory System Agents Peripheral Nervous System Agents Sympatholytics Autonomic Agents Adrenergic alpha-2 Receptor Agonists Adrenergic alpha-Agonists

2011 Clinical Trials

77. Effects of Adrenergic Drugs on the Fluid Balance During Surgery

System Diseases Pharmaceutical Solutions Phenylephrine Oxymetazoline Adrenergic Agents Esmolol Adrenergic Agonists Cardiotonic Agents Mydriatics Autonomic Agents Peripheral Nervous System Agents Physiological Effects of Drugs Sympathomimetics Vasoconstrictor Agents Nasal Decongestants Respiratory System Agents Adrenergic alpha-1 Receptor Agonists Adrenergic alpha-Agonists Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Protective Agents Adrenergic beta-1 Receptor Antagonists (...) infusion 0.01 µg/kg/min of the alpha-1-adrenergic receptor agonist phenylephrine Other Name: Drug by Hefeng Pharmaceutical Co, Shanghai, China. Placebo Comparator: Lactated Ringer´s solution 10 ml/h lactated Ringer's solution without active drug was infused intravenously over 3 hours. Drug: Lactated Ringer´s solution Intravenous Infusion of 10 ml/h lactated Ringer's solution that contained no drug Outcome Measures Go to Primary Outcome Measures : Urinary excretion [ Time Frame: 3 hours ] Urine

2011 Clinical Trials

78. Identification of cardiac beta-adrenergic receptors by (minus) [3H]alprenolol binding. (PubMed)

[ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1]. The beta-adrenergic antagonist (minus) propranolol also had high affinity for the binding sites (KD equals 12 nM). The physiologically inactive catechol-containing compounds pyrocatechol and (plus or minus) dihydroxymandelic acid, as well as the metabolite (plus or minus) normetanephrine, and the alpha-adrenergic antagonist phentolamine did not compete for the binding sites at a concentration of 160 muM. Binding was rapid (t1/2 less than 30 sec (...) Identification of cardiac beta-adrenergic receptors by (minus) [3H]alprenolol binding. (Minus) [3-H] alprenolol, a potent beta-adrenergic antagonist, was used to identify binding sites in a fraction of canine cyocardium. Beta adrenergic agonists and antagonists compete for these binding sites in a manner which directly parallels their known affinity for the cardiac beta-adrenergic receptor. Thus, binding was highly stereo-specific, with the (minus) isomers of beta-adrenergic agonists

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1975 Proceedings of the National Academy of Sciences of the United States of America

79. Proceedings: Adrenergic blockade and the pulmonary pressor response to lactic acid. (PubMed)

Proceedings: Adrenergic blockade and the pulmonary pressor response to lactic acid. 238708 1975 10 30 2018 11 13 0007-1188 54 2 1975 Jun British journal of pharmacology Br. J. Pharmacol. Proceedings: Adrenergic blockade and the pulmonary pressor response to lactic acid. 262P James W R WR Thomas A J AJ eng Journal Article England Br J Pharmacol 7502536 0007-1188 0 Adrenergic alpha-Antagonists 0 Adrenergic beta-Antagonists 0 Lactates IM Adrenergic alpha-Antagonists pharmacology Adrenergic beta (...) -Antagonists pharmacology Animals Blood Pressure drug effects Drug Interactions Lactates antagonists & inhibitors pharmacology Pulmonary Circulation drug effects Sheep 1975 6 1 1975 6 1 0 1 1975 6 1 0 0 ppublish 238708 PMC1666597 Q J Exp Physiol Cogn Med Sci. 1969 Apr;54(2):156-72 5193730 J Clin Invest. 1971 May;50(5):1028-43 5552405

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1975 British journal of pharmacology

80. Immunological release of histamine from bovine leucocytes. Unusual adrenergic modulation. (PubMed)

Immunological release of histamine from bovine leucocytes. Unusual adrenergic modulation. Sensitized bovine granulocytes release histamine when exposed to specific antigen. In comparison with in vitro systems in several other species, the modulation of this release by adrenergic agents is unique. Beta-Adrenoceptor stimulation potentiates (rather than inhibits), whereas alpha-adrenoceptor stimulation inhibits (rather than potentiates) histamine release. Adrenaline, which is generally considered (...) to be a physiological antagonist of the anaphylactic reaction, potentiated histamine release in this study. Dopamine, which is present in high concentration in bovine mast cells, was without effect. The results are discussed in terms of the possible role of granulocytes in bovine hypersensitivity.

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1976 Immunology

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