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Alpha Adrenergic Antagonist

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41. Alpha-2 receptor antagonist add-on therapy in the treatment of schizophrenia; a meta-analysis. (Abstract)

Alpha-2 receptor antagonist add-on therapy in the treatment of schizophrenia; a meta-analysis. Reduced dopaminergic activity in the pre-frontal cortex may partially explain the negative symptoms of schizophrenia. Animal models have shown that adding an alpha-2 adrenergic receptor antagonist to a D2 antagonist can efflux dopamine into the frontal cortex increasing dopaminergic activity. Trials of alpha-2 antagonist add-on therapy in humans have been limited by small sample sizes. Therefore (...) , a meta-analysis was conducted to determine if adding an alpha-2 antagonist to a D2 antagonist improves schizophrenia treatment by reducing negative symptoms.Randomized, placebo-controlled trials of the addition of an alpha-2 antagonist to a D2 antagonist were identified through a PubMed search. Treatment effects were measured using schizophrenia rating scales and meta-analyzed as standardized mean differences using random effects models.Eight unique studies were identified, each including 18 to 41

2012 Schizophrenia research

42. Prazosin, a selective antagonist of post-synaptic alpha-adrenoceptors [proceedings]. Full Text available with Trip Pro

Prazosin, a selective antagonist of post-synaptic alpha-adrenoceptors [proceedings]. 14760 1977 05 20 2018 11 13 0007-1188 59 3 1977 Mar British journal of pharmacology Br. J. Pharmacol. Prazosin, a selective antagonist of post-synaptic alpha-adrenoceptors [proceedings]. 514P-515P Cambridge D D Davey M J MJ Massingham R R eng Journal Article England Br J Pharmacol 7502536 0007-1188 0 Adrenergic alpha-Antagonists 0 Quinazolines XM03YJ541D Prazosin IM Adrenergic alpha-Antagonists Animals In Vitro

1977 British journal of pharmacology

43. Profiles of alpha-adrenoceptor antagonists in the pitched rat [proceedings] Full Text available with Trip Pro

Profiles of alpha-adrenoceptor antagonists in the pitched rat [proceedings] 27278 1978 09 15 2018 11 13 0007-1188 63 2 1978 Jun British journal of pharmacology Br. J. Pharmacol. Profiles of alpha-adrenoceptor antagonists in the pitched rat [proceedings]. 401P-402P Doxey J C JC Easingwood R E RE eng Journal Article England Br J Pharmacol 7502536 0007-1188 0 Adrenergic alpha-Antagonists IM Adrenergic alpha-Antagonists pharmacology Animals Male Muscle Contraction drug effects Rats Spinal Cord

1978 British journal of pharmacology

44. Beta Adrenergic Receptor Blockade as a Novel Therapy for Patients With Adenocarcinoma of the Prostate

by Histologic Type Neoplasms Genital Neoplasms, Male Urogenital Neoplasms Neoplasms by Site Genital Diseases, Male Prostatic Diseases Carvedilol Adrenergic Agents Adrenergic beta-Antagonists Adrenergic Antagonists Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs Antihypertensive Agents Antioxidants Protective Agents Calcium Channel Blockers Membrane Transport Modulators Calcium-Regulating Hormones and Agents Vasodilator Agents Adrenergic alpha-1 Receptor (...) Antagonists Adrenergic alpha-Antagonists

2016 Clinical Trials

45. Letter: Adrenergic-blocking drugs in hyperthyroidism. (Abstract)

Letter: Adrenergic-blocking drugs in hyperthyroidism. 4148614 1974 02 11 2013 11 21 0003-4819 79 6 1973 Dec Annals of internal medicine Ann. Intern. Med. Letter: Adrenergic-blocking drugs in hyperthyroidism. 899-900 Distiller L A LA Joffe B I BI Seftel H C HC eng Clinical Trial Journal Article Randomized Controlled Trial United States Ann Intern Med 0372351 0003-4819 0 Adrenergic alpha-Antagonists 0 Adrenergic beta-Antagonists 0 Benzyl Compounds 0 Guanidines 9Y8NXQ24VQ Propranolol SUG9176GRW (...) Practolol AIM IM Adrenergic alpha-Antagonists therapeutic use Adrenergic beta-Antagonists therapeutic use Benzyl Compounds administration & dosage adverse effects therapeutic use Drug Evaluation Guanidines administration & dosage adverse effects therapeutic use Heart Rate drug effects Humans Hyperthyroidism drug therapy Practolol administration & dosage therapeutic use Propranolol administration & dosage therapeutic use 1973 12 1 1973 12 1 0 1 1973 12 1 0 0 ppublish 4148614

1974 Annals of Internal Medicine Controlled trial quality: uncertain

46. The effects of increasing doses of MK-467, a peripheral alpha(2)-adrenergic receptor antagonist, on the cardiopulmonary effects of intravenous dexmedetomidine in conscious dogs. (Abstract)

The effects of increasing doses of MK-467, a peripheral alpha(2)-adrenergic receptor antagonist, on the cardiopulmonary effects of intravenous dexmedetomidine in conscious dogs. Different doses of MK-467, a peripheral alpha(2)-adrenergic receptor antagonist, with or without dexmedetomidine were compared in conscious dogs. Eight animals received either dexmedetomidine (10 μg/kg [D]), MK-467 (250 μg/kg [M250] or dexmedetomidine (10 μg/kg) with increasing doses of MK-467 (250 μg/kg [DM250], 500 μg

2011 Journal of veterinary pharmacology and therapeutics Controlled trial quality: uncertain

47. The maturation of neuromuscular function in a multiply innervated structure: development of the longitudinal smooth muscle of the foetal mammalian gut and its cholinergic excitatory, adrenergic inhibitory, and non-adrenergic inhibitory innervation Full Text available with Trip Pro

of gestation. Both were also present in the mouse by the 16th day of gestation. Responsiveness of rabbit tissue to exogenous acetylcholine appeared together with the advent of a functional cholinergic innervation. Since excitatory responses were potentiated by eserine, the tissue was probably able to inactivate acetylcholine through hydrolysis mediated by cholinesterase. Early relaxant responses resisted blockade by adrenergic neurone blocking agents and by antagonists active at alpha- and beta (...) The maturation of neuromuscular function in a multiply innervated structure: development of the longitudinal smooth muscle of the foetal mammalian gut and its cholinergic excitatory, adrenergic inhibitory, and non-adrenergic inhibitory innervation 1. The earliest components of the developing innervation of the rabbit intestine to be detected in this study were the cholinergic excitatory and the intrinsic inhibitory innervation. These developed simultaneously in the rabbit at 17 days

1973 The Journal of physiology

48. Adrenergic and 'non-adrenergic' components in the contractile response of the vas deferens to a single indirect stimulus. Full Text available with Trip Pro

components were more rapid and briefer than the equivalent response of rat anococcygeus. 3. The second, slow component was abolished by alpha-adrenoceptor antagonist drugs, potentiated and prolonged by drugs which inhibit the neuronal uptake of noradrenaline and absent from tissues taken from rats pre-treated with reserpine, suggesting that the neurotransmitter for this component is noradrenaline. 4. These experiments were extended to the mouse or guinea-pig vas deferens. Both showed the same two (...) component mechanical response as the rat vas and in both the second, slow component was preferentially inhibited by alpha-adrenoceptor antagonists and potentiated by drugs blocking noradrenaline uptake. 5. Drugs known to reduce the response to repetitive nerve stimulation of the vas were examined for their effect on the response to a single stimulus. Lysergic acid diethylamide preferentially inhibited the second, slow phase of contraction whereas apomorphine preferentially inhibited the first rapid

1978 The Journal of physiology

49. Repurposing alpha1 Noradrenergic Antagonists for Alcoholism Treatment

Norepinephrine Anxiety Fear Stress Additional relevant MeSH terms: Layout table for MeSH terms Alcoholism Alcohol-Related Disorders Substance-Related Disorders Chemically-Induced Disorders Mental Disorders Prazosin Antihypertensive Agents Adrenergic alpha-1 Receptor Antagonists Adrenergic alpha-Antagonists Adrenergic Antagonists Adrenergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs (...) Repurposing alpha1 Noradrenergic Antagonists for Alcoholism Treatment Repurposing alpha1 Noradrenergic Antagonists for Alcoholism Treatment - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Repurposing alpha1

2016 Clinical Trials

50. Alpha-blockers increase the chances of a successful trial without catheter

) for the past 10 hours. On closer questioning he reveals a history of preceding lower urinary tract symptoms. Following the uneventful passage of a urethral catheter, the production of a residual volume Search Strategy MEDLINE 1950 to September Week 2 2010 using the OVID interface. [(exp Adrenergic alpha-Antagonists/ OR adrenergic alpha-antagonists.mp OR alpha blocker$.mp OR tamsulosin.mp OR alfuzosin.mp OR exp Doxazosin/ OR doxazosin.mp OR exp Indoramin/ OR indoramin.mp OR exp Prazosin/ OR prazosin.mp (...) catheter after treatment with an alpha-adrenergic receptor blocker for acute urinary retention caused by benign prostatic hyperplasia. International Urology and Nephrology 2010; 42: 7-12.

2011 BestBETS

51. Response of the Adrenergic System After Provoked Bronchoconstriction in Patients with Bronchial Asthma Full Text available with Trip Pro

Response of the Adrenergic System After Provoked Bronchoconstriction in Patients with Bronchial Asthma In this paper, effect of the Tolazoline as antagonist of the alpha-2 adrenergic receptors in patients with bronchial asthma and chronic obstructive bronchitis was studied, and also the effect of stimulation with Hexoprenaline of beta-2 adrenergic receptor after bronchi-constriction caused with Propranolol, and Acetylcholine.Lung function parameters are determined with Body plethysmography (...) . In patients with bronchial asthma and chronic obstructive bronchitis was registered resistance (Raw), was determined the amount of intrathoracic gas volume (ITGV), and specific resistance was calculated as well (SRaw). Aerosolization was done with standard aerosolizing machine-Asema.The study included a total of 21 patients. Two hours after the inhalation of Propranolol, in experimental group, it was applied the blocker of alpha-2 adrenergic receptors (Tolazoline 20 mg / ml with inhalator ways), which did

2014 Acta Informatica Medica

52. Activation of β-adrenergic receptors during sexual arousal facilitates vaginal lubrication by regulating vaginal epithelial Cl(-) secretion. (Abstract)

Activation of β-adrenergic receptors during sexual arousal facilitates vaginal lubrication by regulating vaginal epithelial Cl(-) secretion. Vaginal lubrication, an indicator of sexual arousal and tissue health, increases significantly during genital sexual arousal. Adrenergic alpha-receptors (AR) are an important regulator of genital physiological responses involved in mediating vascular and nonvascular smooth muscle contractility; the role of β-AR in sexual arousal, however, has not yet been (...) , respectively. The expressions of β-AR in vaginal epithelium were analyzed by reverse transcription-polymerase chain reaction, western blot, and immunofluorescence.Changes of ISC responses; mRNA, protein expressions and localization of β-AR; [cAMP]i ; vaginal lubrication.Serosal application of adrenaline induced an increase of ISC across rat vaginal epithelium that blocked by propranolol, a β-AR antagonist, rather than phentolamine, an α-AR antagonist. β1/2-AR were both present in rat and human vaginal

2014 Journal Of Sexual Medicine

53. Expression and Function of Sulfonylurea, Adrenergic, and Glucagon- Like Peptide 1 Receptors in Isolated Porcine Islets Full Text available with Trip Pro

in isolated porcine islets. Quantitative (q)PCR revealed that porcine islets express mRNA transcripts for sulfonylurea receptor 1 (Sur1), inward rectifying potassium channel (Kir6.2, associated with Sur1), glucagon-like peptide 1 receptor (GLP1R), and adrenergic receptor alpha 2A (ADRα2A). Receptor function was assessed in static incubations with stimulatory glucose concentrations, and in the presence of receptor agonists. Glibenclamide, an anti-diabetic sulfonylurea, and exendin-4, a GLP-1 mimetic (...) Expression and Function of Sulfonylurea, Adrenergic, and Glucagon- Like Peptide 1 Receptors in Isolated Porcine Islets The scarcity of human cadaveric pancreata limits large-scale application of islet transplantation for patients with diabetes. Islets isolated from pathogen-free pigs provide an economical and abundant alternative source assuming immunologic barriers are appropriate. Membrane receptors involved in insulin secretion that also have potential as imaging targets were investigated

2014 Xenotransplantation

54. Adrenergic and glucocorticoid modulation of the sterile inflammatory response. (Abstract)

) responses; and (2) to test the role of alpha-1 (α1), beta-1 (β1), beta-2 (β2), and beta-3 (β3) ADRs, as well as GCRs in signaling the sterile inflammatory response. The data presented indicate plasma and SQ adipose are significantly more stress responsive than the liver and spleen. Further, administration of ADR and GCR-specific antagonists revealed both similarities and differences in the signaling mechanisms of the sterile inflammatory response in the tissues studied. Finally, given the selective (...) Adrenergic and glucocorticoid modulation of the sterile inflammatory response. Exposure to an intense, acute stressor, in the absence of a pathogen, alters immune function. Exposure to a single bout of inescapable tail shock increases plasma and tissue concentrations of cytokines, chemokines, and the danger associated molecular pattern (DAMP) Hsp72. Although previous studies have demonstrated that adrenergic receptor (ADR) and glucocorticoid receptor (GCR)-mediated pathways alter pathogen

2014 Brain, behavior, and immunity

55. Effect of Beta-adrenergic Blockers on Cardiac Function, Systemic and Splanchnic Haemodynamic and Kidney Function in Cirrhotic Patiets With Refractory Ascites

Adrenergic Antagonists Adrenergic beta-Antagonists Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs (...) Effect of Beta-adrenergic Blockers on Cardiac Function, Systemic and Splanchnic Haemodynamic and Kidney Function in Cirrhotic Patiets With Refractory Ascites Effect of Beta-adrenergic Blockers on Cardiac Function, Systemic and Splanchnic Haemodynamic and Kidney Function in Cirrhotic Patiets With Refractory Ascites - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record

2014 Clinical Trials

56. Re: Giuseppe Magistro, Florian M.E. Wagenlehner, Magnus Grabe, Wolfgang Weidner, Christian G. Stief, J. Curtis Nickel. Contemporary Management of Chronic Prostatitis/Chronic Pelvic Pain Syndrome. Eur Urol 2016;69:286-97: Determining the effect of alpha-bl (Abstract)

07 Switzerland Eur Urol 7512719 0302-2838 0 Adrenergic alpha-Antagonists IM Eur Urol. 2016 Feb;69(2):286-97 26411805 Eur Urol. 2016 Dec;70(6):e166-e167 27210460 Adrenergic alpha-Antagonists Chronic Disease Humans Male Pain Management Pelvic Pain Prostatitis 2016 04 15 2016 05 10 2016 6 11 6 0 2018 2 1 6 0 2016 6 11 6 0 ppublish 27283214 S0302-2838(16)30183-X 10.1016/j.eururo.2016.05.019 (...) Re: Giuseppe Magistro, Florian M.E. Wagenlehner, Magnus Grabe, Wolfgang Weidner, Christian G. Stief, J. Curtis Nickel. Contemporary Management of Chronic Prostatitis/Chronic Pelvic Pain Syndrome. Eur Urol 2016;69:286-97: Determining the effect of alpha-bl 27283214 2018 01 31 2018 02 01 1873-7560 70 6 2016 12 European urology Eur. Urol. Re: Giuseppe Magistro, Florian M.E. Wagenlehner, Magnus Grabe, Wolfgang Weidner, Christian G. Stief, J. Curtis Nickel. Contemporary Management of Chronic

2016 European Urology

57. A Phase 4 Study to Evaluate the Efficacy, Safety, and Tolerability of Mirabegron in Male Subjects With Overactive Bladder (OAB) Symptoms, While Taking the Alpha Blocker for Benign Prostatic Hypertrophy (BPH)

Bladder, Overactive Hypertrophy Prostatic Hyperplasia Urinary Bladder Diseases Urologic Diseases Lower Urinary Tract Symptoms Urological Manifestations Signs and Symptoms Pathological Conditions, Anatomical Prostatic Diseases Genital Diseases, Male Tamsulosin Mirabegron Adrenergic alpha-Antagonists Adrenergic alpha-1 Receptor Antagonists Adrenergic Antagonists Adrenergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs Urological Agents (...) A Phase 4 Study to Evaluate the Efficacy, Safety, and Tolerability of Mirabegron in Male Subjects With Overactive Bladder (OAB) Symptoms, While Taking the Alpha Blocker for Benign Prostatic Hypertrophy (BPH) A Phase 4 Study to Evaluate the Efficacy, Safety, and Tolerability of Mirabegron in Male Subjects With Overactive Bladder (OAB) Symptoms, While Taking the Alpha Blocker for Benign Prostatic Hypertrophy (BPH) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers

2016 Clinical Trials

58. Evaluation of Tumour Necrosis Factor Alpha (TNFα) Blockers in Early Rheumatoid Arthritis in France

Diseases Adrenergic alpha-Antagonists Adrenergic Antagonists Adrenergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs (...) Evaluation of Tumour Necrosis Factor Alpha (TNFα) Blockers in Early Rheumatoid Arthritis in France Evaluation of Tumour Necrosis Factor Alpha (TNFα) Blockers in Early Rheumatoid Arthritis in France - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove

2016 Clinical Trials

59. Sympathectomy and sympathetic blockade reduce pain behavior via alpha-2 adrenoceptor of the dorsal root ganglion neurons in a lumbar radiculopathy model. (Abstract)

pain. There are several reports that sympathectomy and pharmacological sympathetic blockades are often effective to treat neuropathic pain. However, its pathophysiological mechanisms remain obscure.We used 91 male Sprague-Dawley rats. Just after root constriction (RC), the rats underwent sympathectomy or received 3 local injections of subtype-specific α-adrenergic receptor antagonists around the DRG. We evaluated the analgesic effects of sympathectomy and sympathetic blockade using behaviors (...) Sympathectomy and sympathetic blockade reduce pain behavior via alpha-2 adrenoceptor of the dorsal root ganglion neurons in a lumbar radiculopathy model. Animal experimental study with intervention.We investigated whether sympathectomy and pharmacological sympathetic blockade reduced pain behavior and reversed adrenoceptor mRNA expression of the dorsal root ganglion (DRG) in a lumbar radiculopathy model.The abnormal sympathetic-somatosensory interaction may underlie some forms of neuropathic

2015 Spine

60. The Influence of Hyperbaric Oxygen in Patients With Perianal Crohn's Disease Already Treated With TNF Alpha Blockers Treated With TNF Alpha Blockers

TNF alpha blockers hyperbaric oxygen therapy Additional relevant MeSH terms: Layout table for MeSH terms Crohn Disease Fistula Rectal Fistula Inflammatory Bowel Diseases Gastroenteritis Gastrointestinal Diseases Digestive System Diseases Intestinal Diseases Pathological Conditions, Anatomical Intestinal Fistula Digestive System Fistula Rectal Diseases Adrenergic alpha-Antagonists Adrenergic Antagonists Adrenergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action (...) The Influence of Hyperbaric Oxygen in Patients With Perianal Crohn's Disease Already Treated With TNF Alpha Blockers Treated With TNF Alpha Blockers The Influence of Hyperbaric Oxygen in Patients With Perianal Crohn's Disease Already Treated With TNF Alpha Blockers Treated With TNF Alpha Blockers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved

2013 Clinical Trials

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