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Alpha Adrenergic Antagonist

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41. Alpha blockers v calcium blockers to increase spontaneous passage of renal calculi

Therapy (MET) – but you don’t know whether to prescribe alpha-adrenergic antagonists or calcium channel blockers. Search Strategy Ovid MEDLINE 1946 to Nov week 2 2012 and Embase 1980 to 2012 Week 46 via OVIDSP interface. [adrenergic alpha antagonist.mp OR alpha blocker$.mp. OR tamsulosin.mp. OR flomax.mp. OR alfuzosin.mp. OR doxazosin.mp. OR terazosin.mp. OR silodosin.mp. OR calcium antagonist$.mp. calcium channel blocker.mp. OR nifedipine.mp. OR nimodipine.mp. OR amlodipine.mp. OR felodipine.mp (...) : 17th April 2013 Status: Green (complete) Three Part Question In [adult patients with urinary calculi] is [treatment with alpha receptor blockers superior to treatment with calcium channel antagonists] at [increasing the speed and success of spontaneous stone passage]? Clinical Scenario A 51 year old presents to A&E with loin pain and macroscopic haematuria and a diagnosis of renal calculi is made. The patient’s pain is adequately controlled and the decision is discharge with Medical Expulsive

2013 BestBETS

42. Interaction of {alpha}1D-Adrenergic and P2X7 Receptors in the Rat Lacrimal Gland and the Effect on Intracellular [Ca2+] and Protein Secretion. (Full text)

Interaction of {alpha}1D-Adrenergic and P2X7 Receptors in the Rat Lacrimal Gland and the Effect on Intracellular [Ca2+] and Protein Secretion. To determine whether α(1D)-adrenergic receptors (α(1D)-AR) and P2X(7) receptors interact by determining their effect on ATP release, intracellular [Ca(2+)] ([Ca(2+)](i)), and protein secretion in rat lacrimal gland acini.Exorbital lacrimal glands from male Sprague-Dawley rats were divided into pieces or digested with collagenase to form acini (...) . With the use of an imaging system, [Ca(2+)](i) was measured in acini loaded with fura-2. Adenosine triphosphate (ATP) release was determined using the luciferin-luciferase reaction. Peroxidase secretion, our index for protein secretion, was measured spectrophotometrically. Acini were stimulated with the P2X(7) receptor agonist, (benzoylbenzoyl)adenosine 5' triphosphate (BzATP) or the α(1D)-AR agonist phenylephrine with or without antagonist preincubation.Phenylephrine increased ATP release from pieces

2011 Investigative Ophthalmology & Visual Science PubMed

43. Repurposing alpha1 Noradrenergic Antagonists for Alcoholism Treatment

Norepinephrine Anxiety Fear Stress Additional relevant MeSH terms: Layout table for MeSH terms Alcoholism Alcohol-Related Disorders Substance-Related Disorders Chemically-Induced Disorders Mental Disorders Prazosin Antihypertensive Agents Adrenergic alpha-1 Receptor Antagonists Adrenergic alpha-Antagonists Adrenergic Antagonists Adrenergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs (...) Repurposing alpha1 Noradrenergic Antagonists for Alcoholism Treatment Repurposing alpha1 Noradrenergic Antagonists for Alcoholism Treatment - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Repurposing alpha1

2016 Clinical Trials

44. Alpha-2 receptor antagonist add-on therapy in the treatment of schizophrenia; a meta-analysis. (PubMed)

Alpha-2 receptor antagonist add-on therapy in the treatment of schizophrenia; a meta-analysis. Reduced dopaminergic activity in the pre-frontal cortex may partially explain the negative symptoms of schizophrenia. Animal models have shown that adding an alpha-2 adrenergic receptor antagonist to a D2 antagonist can efflux dopamine into the frontal cortex increasing dopaminergic activity. Trials of alpha-2 antagonist add-on therapy in humans have been limited by small sample sizes. Therefore (...) , a meta-analysis was conducted to determine if adding an alpha-2 antagonist to a D2 antagonist improves schizophrenia treatment by reducing negative symptoms.Randomized, placebo-controlled trials of the addition of an alpha-2 antagonist to a D2 antagonist were identified through a PubMed search. Treatment effects were measured using schizophrenia rating scales and meta-analyzed as standardized mean differences using random effects models.Eight unique studies were identified, each including 18 to 41

2012 Schizophrenia research

45. Alpha and beta adrenergic blockade in hypertension. (PubMed)

Alpha and beta adrenergic blockade in hypertension. 4112366 1972 07 08 2017 09 20 0140-6736 1 7758 1972 May 06 Lancet (London, England) Lancet Alpha and beta adrenergic blockade in hypertension. 979-82 Beilin L J LJ Juel-Jensen B E BE eng Clinical Trial Journal Article Randomized Controlled Trial England Lancet 2985213R 0140-6736 0 Adrenergic alpha-Antagonists 0 Adrenergic beta-Antagonists 0 Drug Combinations 0 Placebos 0TTZ664R7Z Phenoxybenzamine 9Y8NXQ24VQ Propranolol AIM IM S Adrenergic (...) alpha-Antagonists administration & dosage Adrenergic beta-Antagonists administration & dosage Adult Blood Pressure Body Weight Clinical Trials as Topic Drug Antagonism Drug Combinations Female Humans Hypertension drug therapy Hypotension, Orthostatic etiology Male Middle Aged Phenoxybenzamine administration & dosage adverse effects Physical Exertion Placebos Posture Propranolol administration & dosage adverse effects Pulse 72175671 1972 5 6 1972 5 6 0 1 1972 5 6 0 0 ppublish 4112366 S0140-6736(72

1972 Lancet (London, England)

46. Regulation of rabbit myometrial alpha adrenergic receptors by estrogen and progesterone. (Full text)

Regulation of rabbit myometrial alpha adrenergic receptors by estrogen and progesterone. The effects of estrogen and progesterone on uterine alpha-adrenergic receptors were investigated by direct receptor-binding studies. Immature female rabbits were primed with estrogen by intramuscular injections for 4 days. Other rabbits were primed with progesterone by injections of estrogen for 4 days followed by injections of progesterone for 4 days. The alpha adrenergic antagonist, [3H (...) ]dihydroergocryptine, was used to directly assess the number and affinity of alpha adrenergic receptors in membranes derived from estrogen-and progesterone-primed uteri. Membranes from estrogen-primed uteri contained 257 +/- 52 fmol of [3H]dihydroergocryptine-binding sites per mg protein whereas membranes from progesterone-primed uteri contained 83 +/- 11 fmol of of binding sites per mg protein. This reduction of alpha adrenergic receptor-binding sites by progesterone was statistically significant (P less than

1977 Journal of Clinical Investigation PubMed

47. N-Aralkyl substitution increases the affinity of adrenergic drugs for the alpha-adrenoceptor in rat liver. (Full text)

N-Aralkyl substitution increases the affinity of adrenergic drugs for the alpha-adrenoceptor in rat liver. 1 The alpha-adrenoceptor of rat liver plasma membranes was studied by use of the specific alpha-antagonist [3H]-dihydroergocryptine ([3H]-DHEC). Catecholamines and adrenergic compounds displayed an order of affinity that is typical of an alpha-receptor. Nevertheless, protokylol, a potent beta-adrenoceptor agonist, exhibited a higher affinity than that of adrenaline for alpha-sites (...) . This result might be due to its bulky substituent on the amino group. 2 Further displacement experiments between [3H]-DHEC and four pairs of drugs differently substituted on the amino group (isoprenaline vs Cc-25, orciprenaline vs fenoterol, AH 3474 vs labetalol, pindolol vs hydroxybenzylpindolol) provided evidence that N-alkyl substitution decreased the affinity for alpha-sites (20 micromolar less than KD less than 200 micromolar), whereas an N-aralkyl one increased the affinity (0.17 micromloar less

1979 British journal of pharmacology PubMed

48. Alpha-blockers increase the chances of a successful trial without catheter

) for the past 10 hours. On closer questioning he reveals a history of preceding lower urinary tract symptoms. Following the uneventful passage of a urethral catheter, the production of a residual volume Search Strategy MEDLINE 1950 to September Week 2 2010 using the OVID interface. [(exp Adrenergic alpha-Antagonists/ OR adrenergic alpha-antagonists.mp OR alpha blocker$.mp OR tamsulosin.mp OR alfuzosin.mp OR exp Doxazosin/ OR doxazosin.mp OR exp Indoramin/ OR indoramin.mp OR exp Prazosin/ OR prazosin.mp (...) catheter after treatment with an alpha-adrenergic receptor blocker for acute urinary retention caused by benign prostatic hyperplasia. International Urology and Nephrology 2010; 42: 7-12.

2011 BestBETS

49. A Phase 4 Study to Evaluate the Efficacy, Safety, and Tolerability of Mirabegron in Male Subjects With Overactive Bladder (OAB) Symptoms, While Taking the Alpha Blocker for Benign Prostatic Hypertrophy (BPH)

Bladder, Overactive Hypertrophy Prostatic Hyperplasia Urinary Bladder Diseases Urologic Diseases Lower Urinary Tract Symptoms Urological Manifestations Signs and Symptoms Pathological Conditions, Anatomical Prostatic Diseases Genital Diseases, Male Tamsulosin Mirabegron Adrenergic alpha-Antagonists Adrenergic alpha-1 Receptor Antagonists Adrenergic Antagonists Adrenergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs Urological Agents (...) A Phase 4 Study to Evaluate the Efficacy, Safety, and Tolerability of Mirabegron in Male Subjects With Overactive Bladder (OAB) Symptoms, While Taking the Alpha Blocker for Benign Prostatic Hypertrophy (BPH) A Phase 4 Study to Evaluate the Efficacy, Safety, and Tolerability of Mirabegron in Male Subjects With Overactive Bladder (OAB) Symptoms, While Taking the Alpha Blocker for Benign Prostatic Hypertrophy (BPH) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers

2016 Clinical Trials

50. Evaluation of Tumour Necrosis Factor Alpha (TNFα) Blockers in Early Rheumatoid Arthritis in France

Diseases Adrenergic alpha-Antagonists Adrenergic Antagonists Adrenergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs (...) Evaluation of Tumour Necrosis Factor Alpha (TNFα) Blockers in Early Rheumatoid Arthritis in France Evaluation of Tumour Necrosis Factor Alpha (TNFα) Blockers in Early Rheumatoid Arthritis in France - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove

2016 Clinical Trials

51. Re: Giuseppe Magistro, Florian M.E. Wagenlehner, Magnus Grabe, Wolfgang Weidner, Christian G. Stief, J. Curtis Nickel. Contemporary Management of Chronic Prostatitis/Chronic Pelvic Pain Syndrome. Eur Urol 2016;69:286-97: Determining the effect of alpha-bl (PubMed)

07 Switzerland Eur Urol 7512719 0302-2838 0 Adrenergic alpha-Antagonists IM Eur Urol. 2016 Feb;69(2):286-97 26411805 Eur Urol. 2016 Dec;70(6):e166-e167 27210460 Adrenergic alpha-Antagonists Chronic Disease Humans Male Pain Management Pelvic Pain Prostatitis 2016 04 15 2016 05 10 2016 6 11 6 0 2018 2 1 6 0 2016 6 11 6 0 ppublish 27283214 S0302-2838(16)30183-X 10.1016/j.eururo.2016.05.019 (...) Re: Giuseppe Magistro, Florian M.E. Wagenlehner, Magnus Grabe, Wolfgang Weidner, Christian G. Stief, J. Curtis Nickel. Contemporary Management of Chronic Prostatitis/Chronic Pelvic Pain Syndrome. Eur Urol 2016;69:286-97: Determining the effect of alpha-bl 27283214 2018 01 31 2018 02 01 1873-7560 70 6 2016 12 European urology Eur. Urol. Re: Giuseppe Magistro, Florian M.E. Wagenlehner, Magnus Grabe, Wolfgang Weidner, Christian G. Stief, J. Curtis Nickel. Contemporary Management of Chronic

2016 European Urology

52. Brief report: low dose alpha-2 antagonist paradoxically enhances rat norepinephrine and clonidine analgesia. (Full text)

Brief report: low dose alpha-2 antagonist paradoxically enhances rat norepinephrine and clonidine analgesia. Ultralow-dose opioid antagonists prolong opioid antinociception and block tolerance. In this study we determined whether low doses of the α-2 adrenergic receptor (A2-R) antagonist, atipamezole, similarly influenced A2-R-induced antinociception and tolerance. In rats, intrathecal norepinephrine (NE) or clonidine in combination with atipamezole was tested using tail-flick and paw pressure (...) tests. Acute tolerance to NE was induced by serial injections. Low-dose atipamezole significantly prolonged NE and clonidine-induced antinociception. Coadministration of atipamezole with A2-R agonists also prevented loss of agonist potency in the acute tolerance model. This study demonstrates paradoxical effects of low-dose A2-R antagonists augmenting A2-R agonist-induced analgesia.

2011 Anesthesia and Analgesia PubMed

53. Prazosin, a selective antagonist of post-synaptic alpha-adrenoceptors [proceedings]. (Full text)

Prazosin, a selective antagonist of post-synaptic alpha-adrenoceptors [proceedings]. 14760 1977 05 20 2018 11 13 0007-1188 59 3 1977 Mar British journal of pharmacology Br. J. Pharmacol. Prazosin, a selective antagonist of post-synaptic alpha-adrenoceptors [proceedings]. 514P-515P Cambridge D D Davey M J MJ Massingham R R eng Journal Article England Br J Pharmacol 7502536 0007-1188 0 Adrenergic alpha-Antagonists 0 Quinazolines XM03YJ541D Prazosin IM Adrenergic alpha-Antagonists Animals In Vitro

1977 British journal of pharmacology PubMed

54. Profiles of alpha-adrenoceptor antagonists in the pitched rat [proceedings] (Full text)

Profiles of alpha-adrenoceptor antagonists in the pitched rat [proceedings] 27278 1978 09 15 2018 11 13 0007-1188 63 2 1978 Jun British journal of pharmacology Br. J. Pharmacol. Profiles of alpha-adrenoceptor antagonists in the pitched rat [proceedings]. 401P-402P Doxey J C JC Easingwood R E RE eng Journal Article England Br J Pharmacol 7502536 0007-1188 0 Adrenergic alpha-Antagonists IM Adrenergic alpha-Antagonists pharmacology Animals Male Muscle Contraction drug effects Rats Spinal Cord

1978 British journal of pharmacology PubMed

55. Effect of Beta-adrenergic Blockers on Cardiac Function, Systemic and Splanchnic Haemodynamic and Kidney Function in Cirrhotic Patiets With Refractory Ascites

Adrenergic Antagonists Adrenergic beta-Antagonists Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs (...) Effect of Beta-adrenergic Blockers on Cardiac Function, Systemic and Splanchnic Haemodynamic and Kidney Function in Cirrhotic Patiets With Refractory Ascites Effect of Beta-adrenergic Blockers on Cardiac Function, Systemic and Splanchnic Haemodynamic and Kidney Function in Cirrhotic Patiets With Refractory Ascites - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record

2014 Clinical Trials

56. Expression and Function of Sulfonylurea, Adrenergic, and Glucagon- Like Peptide 1 Receptors in Isolated Porcine Islets (Full text)

in isolated porcine islets. Quantitative (q)PCR revealed that porcine islets express mRNA transcripts for sulfonylurea receptor 1 (Sur1), inward rectifying potassium channel (Kir6.2, associated with Sur1), glucagon-like peptide 1 receptor (GLP1R), and adrenergic receptor alpha 2A (ADRα2A). Receptor function was assessed in static incubations with stimulatory glucose concentrations, and in the presence of receptor agonists. Glibenclamide, an anti-diabetic sulfonylurea, and exendin-4, a GLP-1 mimetic (...) Expression and Function of Sulfonylurea, Adrenergic, and Glucagon- Like Peptide 1 Receptors in Isolated Porcine Islets The scarcity of human cadaveric pancreata limits large-scale application of islet transplantation for patients with diabetes. Islets isolated from pathogen-free pigs provide an economical and abundant alternative source assuming immunologic barriers are appropriate. Membrane receptors involved in insulin secretion that also have potential as imaging targets were investigated

2014 Xenotransplantation PubMed

57. Activation of β-adrenergic receptors during sexual arousal facilitates vaginal lubrication by regulating vaginal epithelial Cl(-) secretion. (PubMed)

Activation of β-adrenergic receptors during sexual arousal facilitates vaginal lubrication by regulating vaginal epithelial Cl(-) secretion. Vaginal lubrication, an indicator of sexual arousal and tissue health, increases significantly during genital sexual arousal. Adrenergic alpha-receptors (AR) are an important regulator of genital physiological responses involved in mediating vascular and nonvascular smooth muscle contractility; the role of β-AR in sexual arousal, however, has not yet been (...) , respectively. The expressions of β-AR in vaginal epithelium were analyzed by reverse transcription-polymerase chain reaction, western blot, and immunofluorescence.Changes of ISC responses; mRNA, protein expressions and localization of β-AR; [cAMP]i ; vaginal lubrication.Serosal application of adrenaline induced an increase of ISC across rat vaginal epithelium that blocked by propranolol, a β-AR antagonist, rather than phentolamine, an α-AR antagonist. β1/2-AR were both present in rat and human vaginal

2014 Journal Of Sexual Medicine

58. Response of the Adrenergic System After Provoked Bronchoconstriction in Patients with Bronchial Asthma (Full text)

Response of the Adrenergic System After Provoked Bronchoconstriction in Patients with Bronchial Asthma In this paper, effect of the Tolazoline as antagonist of the alpha-2 adrenergic receptors in patients with bronchial asthma and chronic obstructive bronchitis was studied, and also the effect of stimulation with Hexoprenaline of beta-2 adrenergic receptor after bronchi-constriction caused with Propranolol, and Acetylcholine.Lung function parameters are determined with Body plethysmography (...) . In patients with bronchial asthma and chronic obstructive bronchitis was registered resistance (Raw), was determined the amount of intrathoracic gas volume (ITGV), and specific resistance was calculated as well (SRaw). Aerosolization was done with standard aerosolizing machine-Asema.The study included a total of 21 patients. Two hours after the inhalation of Propranolol, in experimental group, it was applied the blocker of alpha-2 adrenergic receptors (Tolazoline 20 mg / ml with inhalator ways), which did

2014 Acta Informatica Medica PubMed

59. Adrenergic and glucocorticoid modulation of the sterile inflammatory response. (PubMed)

) responses; and (2) to test the role of alpha-1 (α1), beta-1 (β1), beta-2 (β2), and beta-3 (β3) ADRs, as well as GCRs in signaling the sterile inflammatory response. The data presented indicate plasma and SQ adipose are significantly more stress responsive than the liver and spleen. Further, administration of ADR and GCR-specific antagonists revealed both similarities and differences in the signaling mechanisms of the sterile inflammatory response in the tissues studied. Finally, given the selective (...) Adrenergic and glucocorticoid modulation of the sterile inflammatory response. Exposure to an intense, acute stressor, in the absence of a pathogen, alters immune function. Exposure to a single bout of inescapable tail shock increases plasma and tissue concentrations of cytokines, chemokines, and the danger associated molecular pattern (DAMP) Hsp72. Although previous studies have demonstrated that adrenergic receptor (ADR) and glucocorticoid receptor (GCR)-mediated pathways alter pathogen

2014 Brain, behavior, and immunity

60. Letter: Adrenergic-blocking drugs in hyperthyroidism. (PubMed)

Letter: Adrenergic-blocking drugs in hyperthyroidism. 4148614 1974 02 11 2013 11 21 0003-4819 79 6 1973 Dec Annals of internal medicine Ann. Intern. Med. Letter: Adrenergic-blocking drugs in hyperthyroidism. 899-900 Distiller L A LA Joffe B I BI Seftel H C HC eng Clinical Trial Journal Article Randomized Controlled Trial United States Ann Intern Med 0372351 0003-4819 0 Adrenergic alpha-Antagonists 0 Adrenergic beta-Antagonists 0 Benzyl Compounds 0 Guanidines 9Y8NXQ24VQ Propranolol SUG9176GRW (...) Practolol AIM IM Adrenergic alpha-Antagonists therapeutic use Adrenergic beta-Antagonists therapeutic use Benzyl Compounds administration & dosage adverse effects therapeutic use Drug Evaluation Guanidines administration & dosage adverse effects therapeutic use Heart Rate drug effects Humans Hyperthyroidism drug therapy Practolol administration & dosage therapeutic use Propranolol administration & dosage therapeutic use 1973 12 1 1973 12 1 0 1 1973 12 1 0 0 ppublish 4148614

1974 Annals of Internal Medicine

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