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Alpha Adrenergic Central Agonist

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1. Alpha-2 adrenergic agonists for the prevention of cardiac complications among adults undergoing surgery. (PubMed)

Alpha-2 adrenergic agonists for the prevention of cardiac complications among adults undergoing surgery. The surgical stress response plays an important role on the pathogenesis of perioperative cardiac complications. Alpha-2 adrenergic agonists attenuate this response and may help prevent postoperative cardiac complications.To determine the efficacy and safety of α-2 adrenergic agonists for reducing mortality and cardiac complications in adults undergoing cardiac surgery and non-cardiac (...) surgery.We searched CENTRAL (2017, Issue 4), MEDLINE (1950 to April Week 4, 2017), Embase (1980 to May 2017), the Science Citation Index, clinical trial registries, and reference lists of included articles.We included randomized controlled trials that compared α-2 adrenergic agonists (i.e. clonidine, dexmedetomidine or mivazerol) against placebo or non-α-2 adrenergic agonists. Included trials had to evaluate the efficacy and safety of α-2 adrenergic agonists for preventing perioperative mortality

2018 Cochrane

2. Alpha₂-adrenergic agonists for the management of opioid withdrawal. (PubMed)

Alpha₂-adrenergic agonists for the management of opioid withdrawal. Withdrawal is a necessary step prior to drug-free treatment or as the endpoint of long-term substitution treatment.To assess the effectiveness of interventions involving the use of alpha2-adrenergic agonists compared with placebo, reducing doses of methadone, symptomatic medications, or an alpha2-adrenergic agonist regimen different to the experimental intervention, for the management of the acute phase of opioid withdrawal (...) . Outcomes included the withdrawal syndrome experienced, duration of treatment, occurrence of adverse effects, and completion of treatment.We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (1946 to November week 2, 2015), EMBASE (January 1985 to November week 2, 2015), PsycINFO (1806 to November week 2, 2015), Web of Science, and reference lists of articles.Randomised controlled trials comparing alpha2-adrenergic agonists (clonidine, lofexidine, guanfacine, tizanidine

Full Text available with Trip Pro

2016 Cochrane

3. Alpha-2 adrenergic agonists for the prevention of shivering following general anaesthesia. (PubMed)

Alpha-2 adrenergic agonists for the prevention of shivering following general anaesthesia. Shivering after general anaesthesia is common. It is unpleasant but can also have adverse physiological effects. Alpha-2 (α-2) adrenergic agonist receptors, which can lead to reduced sympathetic activity and central regulation of vasoconstrictor tone, are a group of drugs that have been used to try to prevent postoperative shivering.To assess the following: the effects of α-2 agonists on the prevention (...) of shivering and subsequent complications after general anaesthesia in people undergoing surgery; the effects of α-2 agonists on the risk of inadvertent perioperative hypothermia; and whether any adverse effects are associated with these interventions.We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, and EMBASE on 13 June 2014. Our search terms were relevant to the review question and limited to studies that assessed shivering or hypothermia. We also carried out searches

2015 Cochrane

4. Alpha Adrenergic Central Agonist

Alpha Adrenergic Central Agonist Alpha Adrenergic Central Agonist Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Alpha Adrenergic (...) Central Agonist Alpha Adrenergic Central Agonist Aka: Alpha Adrenergic Central Agonist , Central Adrenergic Agonist , Methyl-Dopa , Methyldopa , Aldomet , Guanabenz , Wytensin From Related Chapters II. Mechanism See Bind vasomotor receptors to inhibit sympathetic outflow Decreases peripheral vascular resistance (and ) Decreases III. Preparations ( ) Methyl-Dopa (Aldomet) Guanabenz (Wytensin) Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search

2018 FP Notebook

5. Do ?2-Adrenergic Agonists Decrease the Symptoms Associated With Opioid Withdrawal?

Commentator) Department of Emergency Medicine, Rush University Medical Center, Chicago, IL DOI: | Publication History Published online: November 04, 2016 Expand all Collapse all Article Outline Take-Home Message α 2 -Adrenergic agonists (eg, clonidine) are associated with lower rates of severe withdrawal symptoms and higher rates of adherence; however, this must be balanced with known adverse effects such as hypotension. Methods Data Sources Electronic searches were performed with the Cochrane Central (...) Do ?2-Adrenergic Agonists Decrease the Symptoms Associated With Opioid Withdrawal? Do α2-Adrenergic Agonists Decrease the Symptoms Associated With Opioid Withdrawal? - Annals of Emergency Medicine Email/Username: Password: Remember me Search Terms Search within Search Share this page Access provided by Volume 69, Issue 6, Pages 740–742 Do α 2 -Adrenergic Agonists Decrease the Symptoms Associated With Opioid Withdrawal? x Michael Gottlieb , MD (EBEM Commentator) , x Katarzyna Gore , MD (EBEM

2017 Annals of Emergency Medicine Systematic Review Snapshots

6. Alpha 2 Agonists for Sedation to Produce Better Outcomes From Critical Illness (A2B Trial)

table for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Product Manufactured in and Exported from the U.S.: No Keywords provided by University of Edinburgh: Sedation Ventilation Additional relevant MeSH terms: Layout table for MeSH terms Critical Illness Disease Attributes Pathologic Processes Propofol Dexmedetomidine Clonidine Adrenergic alpha-2 Receptor Agonists Hypnotics and Sedatives Central Nervous System Depressants (...) Physiological Effects of Drugs Anesthetics, Intravenous Anesthetics, General Anesthetics Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents Adrenergic alpha-Agonists Adrenergic Agonists Adrenergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Antihypertensive Agents Sympatholytics Autonomic Agents

2018 Clinical Trials

7. Alpha Adrenergic Central Agonist

Alpha Adrenergic Central Agonist Alpha Adrenergic Central Agonist Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Alpha Adrenergic (...) Central Agonist Alpha Adrenergic Central Agonist Aka: Alpha Adrenergic Central Agonist , Central Adrenergic Agonist , Methyl-Dopa , Methyldopa , Aldomet , Guanabenz , Wytensin From Related Chapters II. Mechanism See Bind vasomotor receptors to inhibit sympathetic outflow Decreases peripheral vascular resistance (and ) Decreases III. Preparations ( ) Methyl-Dopa (Aldomet) Guanabenz (Wytensin) Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search

2015 FP Notebook

8. Alpha Adrenergic Receptor

muscle postsynaptic s striction Positive Inotrope Negative Chronotrope Eye Radial muscle contraction Gastrointestinal and Genitourinary Sphincter (e.g. anus) contraction IV. Effects: Alpha 2 Receptors Peripheral Alpha 2 Receptors Vascular Smooth Muscle (mixed effect) Modulates large vessel tone Arteriolar and venous striction Opposes alpha 1 receptor striction Inhibits release Decreases adrenergic activity Gastrointestinal Smooth muscle wall relaxation Metabolic Fat Cell Lipolysis Central Alpha 2 (...) Receptors (CNS) Inhibits Locus Ceruleus reflex arc Peripheral vasodilatation V. Medications: Alpha Adrenergics Alpha Adrenergic Agonist (Alpha Adrenergic Receptor) Alpha Non-Specific Alpha 1 Selective Methoxamine Alpha 2 Selective (See ) Alpha-methylnorepinephrine Alpha Receptor Antagonist Alpha Non-Specific Phentolamine Alpha 1 Selective (See ) Phenoxybenzamine Alpha 2 Selective Tolazoline Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search

2018 FP Notebook

9. Treatment of OSA Associated Hypertension With Alpha 2 Agonist or Diuretic

Apnea, Obstructive Vascular Diseases Cardiovascular Diseases Apnea Respiration Disorders Respiratory Tract Diseases Sleep Disorders, Intrinsic Dyssomnias Sleep Wake Disorders Nervous System Diseases Hydrochlorothiazide Guanfacine Antihypertensive Agents Diuretics Natriuretic Agents Physiological Effects of Drugs Sodium Chloride Symporter Inhibitors Membrane Transport Modulators Molecular Mechanisms of Pharmacological Action Adrenergic alpha-2 Receptor Agonists Adrenergic alpha-Agonists Adrenergic (...) Treatment of OSA Associated Hypertension With Alpha 2 Agonist or Diuretic Treatment of OSA Associated Hypertension With Alpha 2 Agonist or Diuretic - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Treatment

2016 Clinical Trials

10. Alpha-2 agonists for sedation of mechanically ventilated adults in intensive care units: a systematic review. (PubMed)

sedatives are propofol (Diprivan(®), AstraZeneca), benzodiazepines [e.g. midazolam (Hypnovel(®), Roche) and lorazepam (Ativan(®), Pfizer)] and alpha-2 adrenergic receptor agonists [e.g. dexmedetomidine (Dexdor(®), Orion Corporation) and clonidine (Catapres(®), Boehringer Ingelheim)]. Sedative agents vary in onset/duration of effects and in their side effects. The pattern of sedation of alpha-2 agonists is quite different from that of other sedatives in that patients can be aroused readily (...) Alpha-2 agonists for sedation of mechanically ventilated adults in intensive care units: a systematic review. Care of critically ill patients in intensive care units (ICUs) often requires potentially invasive or uncomfortable procedures, such as mechanical ventilation (MV). Sedation can alleviate pain and discomfort, provide protection from stressful or harmful events, prevent anxiety and promote sleep. Various sedative agents are available for use in ICUs. In the UK, the most commonly used

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2016 Health technology assessment (Winchester, England)

11. Blood pressure lowering efficacy of dual alpha and beta blockers for primary hypertension. (PubMed)

Blood pressure lowering efficacy of dual alpha and beta blockers for primary hypertension. Drugs with combined alpha and beta blocking activity are commonly prescribed to treat hypertension. However, the blood pressure (BP) lowering efficacy of this class of beta blockers has not been systematically reviewed and quantified.To quantify the dose-related effects of various types of dual alpha and beta adrenergic receptor blockers (dual receptor blockers) on systolic and diastolic blood pressure (...) estimate from combining carvedilol once and twice the starting doses is -4/-3 mm Hg. Doses higher than the recommended starting dose did not provide additional BP reduction. Higher doses of dual receptor blockers caused more bradycardia than lower doses. Based on indirect comparison with other classes of drugs, the blood pressure lowering effect of dual alpha- and beta-receptor blockers is less than non-selective, beta1 selective and partial agonist beta blockers, as well as thiazides and drugs

2015 Cochrane

12. Beta Adrenergic Receptor

. Related Studies (from Trip Database) Ontology: Receptors, Adrenergic, beta-1 (C0001642) Definition (MSH) A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The adrenergic beta-1 receptors are equally sensitive to EPINEPHRINE and NOREPINEPHRINE and bind the agonist DOBUTAMINE and the antagonist METOPROLOL with high affinity. They are found in the HEART, juxtaglomerular cells, and in the central and peripheral nervous systems. Definition (NCI) Beta 1 adrenergic receptor protein (477 (...) . Medications: Beta Adrenergics Beta Adrenergic Agonist (Beta Adrenergic Receptor) Beta Non-Specific Beta 1 Selective Prenalterol Beta 2 Selective (See ) Fenoterol Metaproterenol Beta Non-specific Pindolol Beta 1 Selective Acebutolol Alprenolol Beta 2 Selective Butoxamine Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Beta Adrenergic Receptor." Click on the image (or right click) to open the source website in a new browser window

2018 FP Notebook

13. Alpha Adrenergic Receptor

muscle postsynaptic s striction Positive Inotrope Negative Chronotrope Eye Radial muscle contraction Gastrointestinal and Genitourinary Sphincter (e.g. anus) contraction IV. Effects: Alpha 2 Receptors Peripheral Alpha 2 Receptors Vascular Smooth Muscle (mixed effect) Modulates large vessel tone Arteriolar and venous striction Opposes alpha 1 receptor striction Inhibits release Decreases adrenergic activity Gastrointestinal Smooth muscle wall relaxation Metabolic Fat Cell Lipolysis Central Alpha 2 (...) Receptors (CNS) Inhibits Locus Ceruleus reflex arc Peripheral vasodilatation V. Medications: Alpha Adrenergics Alpha Adrenergic Agonist (Alpha Adrenergic Receptor) Alpha Non-Specific Alpha 1 Selective Methoxamine Alpha 2 Selective (See ) Alpha-methylnorepinephrine Alpha Receptor Antagonist Alpha Non-Specific Phentolamine Alpha 1 Selective (See ) Phenoxybenzamine Alpha 2 Selective Tolazoline Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search

2015 FP Notebook

14. Evaluation of Bromocriptine, Metoprolol and Tamsulosin in Eyes With Non-Central DME

System Agents Physiological Effects of Drugs Adrenergic beta-1 Receptor Antagonists Adrenergic beta-Antagonists Adrenergic Antagonists Adrenergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Adrenergic alpha-1 Receptor Antagonists Adrenergic alpha-Antagonists Urological Agents Antiparkinson Agents Anti-Dyskinesia Agents Hormone Antagonists Hormones, Hormone Substitutes, and Hormone Antagonists Dopamine Agonists Dopamine Agents (...) Evaluation of Bromocriptine, Metoprolol and Tamsulosin in Eyes With Non-Central DME Evaluation of Bromocriptine, Metoprolol and Tamsulosin in Eyes With Non-Central DME - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before

2017 Clinical Trials

15. Central and Cerebral Circulation in Early Stages After LVAD Implantation

for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Keywords provided by Bjorn Reinsfelt, Sahlgrenska University Hospital, Sweden: Left Ventricular Assist Device Hemodynamic monitoring Additional relevant MeSH terms: Layout table for MeSH terms Heart Failure Heart Diseases Cardiovascular Diseases Norepinephrine Adrenergic alpha-Agonists Adrenergic Agonists Adrenergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological (...) Central and Cerebral Circulation in Early Stages After LVAD Implantation Central and Cerebral Circulation in Early Stages After LVAD Implantation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Central

2017 Clinical Trials

16. Hypothalamic Alpha- and Beta-Adrenergic Systems Regulate Both Thirst and Hunger in the Rat (PubMed)

Hypothalamic Alpha- and Beta-Adrenergic Systems Regulate Both Thirst and Hunger in the Rat Adrenergic and adrenolytic drugs were injected directly into the hypothalamus of the rat brain through permanently implanted cannulas and were found to have reliable effects on water consumption in water-satiated and water-deprived subjects. The beta-adrenergic agonist stimulated thirst, and the beta-adrenergic blocker suppressed thirst. Conversely, the alpha-adrenergic agonist suppressed thirst (...) a neurochemical explanation for the ability of organisms to maintain food and water consumption at a constant ratio. In the regulation of both hunger and thirst, the central cholinergic system mimics the hypothalamic beta-adrenergic system and opposes the hypothalamic alpha-adrenergic system.

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1971 Proceedings of the National Academy of Sciences of the United States of America

17. Central cholinergic and adrenergic mechanisms in the release of antidiuretic hormone (PubMed)

Central cholinergic and adrenergic mechanisms in the release of antidiuretic hormone 1. Studies on the urine outflow, blood ADH concentration and electrolyte excretion were carried out in alpha-chloralose anaesthetized hydrated dogs; the agonists and antagonists of specific cholinoceptors and adrenoceptors were injected by the intracerebroventricular technique, to delineate the role of the C.N.S. receptors in the control of ADH secretion.2. Central injection of acetylcholine elicited a dose (...) -dependent antidiuretic response which was associated with an increase in the blood ADH titre. Central atropinization partially blocked the antidiuretic response. The remaining antidiuretic response was reversed to a diuretic one by further pretreatment with phenoxybenzamine. The diuretic response thus obtained could be blocked by propranolol.3. The alpha-adrenoceptor agonists, phenylephrine and noradrenaline, induced dose-dependent antidiuretic responses with a concomitant rise in blood ADH

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1972 British journal of pharmacology

18. A comparison of methadone, buprenorphine and alpha(2) adrenergic agonists for opioid detoxification: a mixed treatment comparison meta-analysis. (PubMed)

A comparison of methadone, buprenorphine and alpha(2) adrenergic agonists for opioid detoxification: a mixed treatment comparison meta-analysis. The aim of this systematic review was to compare the efficacy of methadone, buprenorphine, clonidine and lofexidine for opioid detoxification. Mixed treatment comparison meta-analyses were used to synthesise the data as it is designed for data-sets where limitations in standard pairwise meta-analyses make comparisons difficult to interpret.A systematic (...) search was conducted using the following databases: CENTRAL, CINAHL, Embase, HMIC, Medline and PsycINFO.RCTs that included opioid dependent participants over a mean age of 16 receiving opioid detoxification using buprenorphine, methadone, clonidine or lofexidine were included in the systematic review. Included studies were quality assessed and the completion of treatment data was extracted by the author and a research assistant independently. Mixed treatment comparison methods were used to synthesise

2010 Drug and alcohol dependence

19. Diagnosis of Central Adrenal Insufficiency in Patients With Prader-Willi Syndrome

Nervous System Diseases Abnormalities, Multiple Congenital Abnormalities Chromosome Disorders Genetic Diseases, Inborn Obesity Overnutrition Nutrition Disorders Adrenal Gland Diseases Endocrine System Diseases Epinephrine Racepinephrine Epinephryl borate Metyrapone Adrenergic alpha-Agonists Adrenergic Agonists Adrenergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs Adrenergic beta-Agonists Bronchodilator Agents (...) Diagnosis of Central Adrenal Insufficiency in Patients With Prader-Willi Syndrome Diagnosis of Central Adrenal Insufficiency in Patients With Prader-Willi Syndrome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding

2015 Clinical Trials

20. Beta Adrenergic Receptor

. Related Studies (from Trip Database) Ontology: Receptors, Adrenergic, beta-1 (C0001642) Definition (MSH) A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The adrenergic beta-1 receptors are equally sensitive to EPINEPHRINE and NOREPINEPHRINE and bind the agonist DOBUTAMINE and the antagonist METOPROLOL with high affinity. They are found in the HEART, juxtaglomerular cells, and in the central and peripheral nervous systems. Definition (NCI) Beta 1 adrenergic receptor protein (477 (...) . Medications: Beta Adrenergics Beta Adrenergic Agonist (Beta Adrenergic Receptor) Beta Non-Specific Beta 1 Selective Prenalterol Beta 2 Selective (See ) Fenoterol Metaproterenol Beta Non-specific Pindolol Beta 1 Selective Acebutolol Alprenolol Beta 2 Selective Butoxamine Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Beta Adrenergic Receptor." Click on the image (or right click) to open the source website in a new browser window

2015 FP Notebook

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