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Alpha Adrenergic Antagonist

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1. Treatment of Post-Traumatic Stress Disorders with the Alpha-1 Adrenergic Antagonist Prazosin: A Review of Outcome Studies (PubMed)

Treatment of Post-Traumatic Stress Disorders with the Alpha-1 Adrenergic Antagonist Prazosin: A Review of Outcome Studies The present review aims to assess the clinical efficacy and safety of the α-1-adrenergic antagonist prazosin as primary pharmacologic treatment for post-traumatic stress disorder (PTSD).A systematic review was performed using keywords (i.e., prazosin, α-1-adrenergic antagonist, α-1-blocker, post-traumatic stress disorder) in the databases PubMed/Medline (1966-May 2016

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2016 Canadian journal of psychiatry. Revue canadienne de psychiatrie

2. Acute Urinary Morbidity Following Stereotactic Body Radiation Therapy for Prostate Cancer with Prophylactic Alpha-Adrenergic Antagonist and Urethral Dose Reduction (PubMed)

Acute Urinary Morbidity Following Stereotactic Body Radiation Therapy for Prostate Cancer with Prophylactic Alpha-Adrenergic Antagonist and Urethral Dose Reduction Stereotactic body radiation therapy (SBRT) delivers high doses of radiation to the prostate while minimizing radiation to the adjacent critical organs. Large fraction sizes may increase urinary morbidity due to unavoidable treatment of the prostatic urethra. This study reports rates of acute urinary morbidity following SBRT (...) for localized prostate cancer with prophylactic alpha-adrenergic antagonist utilization and urethral dose reduction (UDR).From April 2013 to September 2014, 102 patients with clinically localized prostate cancer were treated with robotic SBRT to a total dose of 35-36.25 Gy in five fractions. UDR was employed to limit the maximum point dose of the prostatic urethra to 40 Gy. Prophylactic alpha-adrenergic antagonists were initiated 5 days prior to SBRT and continued until resolution of urinary symptoms

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2016 Frontiers in oncology

3. Pilot Results from a Randomized Trial in Men Comparing Alpha-Adrenergic Antagonist versus Behavior and Exercise for Nocturia and Sleep. (PubMed)

Pilot Results from a Randomized Trial in Men Comparing Alpha-Adrenergic Antagonist versus Behavior and Exercise for Nocturia and Sleep. Nocturia and sleep problems are common in older adults. We developed and tested a novel intervention, multicomponent behavioral treatment and exercise therapy (M-BET), that may reduce nocturia and improve sleep in men. We compared reductions in nocturia and improvement in sleep in men with M-BET versus an active drug comparator (α-blocker) used alone

2016 Clinical therapeutics

4. Alpha Adrenergic Antagonist

Alpha Adrenergic Antagonist Alpha Adrenergic Antagonist Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Alpha Adrenergic Antagonist (...) Alpha Adrenergic Antagonist Aka: Alpha Adrenergic Antagonist , Selective Alpha-1a Antagonist , Prazosin , Minipress , Terazosin , Hytrin , Doxazosin , Cardura , Tamsulosin , Flomax , Alfuzosin , Uroxatral , Silodosin , Rapaflo From Related Chapters II. Indications (not Tamsulosin) III. Mechanism: General See (Alpha-1 antagonist) IV. Mechanism: Benign Prostatic Hypertrophy Preparations used in Terazosin (Hytrin) Doxazosin (Cardura) Tamsulosin (Flomax) Prazosin (Minipress) Rapid relaxation of smooth

2018 FP Notebook

5. Effects of Combination Treatment of Alpha 1-Adrenergic Receptor Antagonists on Voiding Dysfunction: Study on Target Organs in Overactive Bladder Rats (PubMed)

Effects of Combination Treatment of Alpha 1-Adrenergic Receptor Antagonists on Voiding Dysfunction: Study on Target Organs in Overactive Bladder Rats Overactive bladder (OAB) causes urinary urgency, usually accompanied by frequency and nocturia. Alpha 1-adrenergic receptor (α1-AR) antagonists are known to improve lower urinary tract symptoms associated with OAB. The α1-AR antagonists constitute a variety of drugs according to the receptor subtype affinity. This study investigated the efficacy

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2016 International neurourology journal

6. The efficacy and safety of adrenergic alpha-antagonists in treatment of distal ureteral stones in pediatric patients: A systematic review and meta-analysis. (PubMed)

The efficacy and safety of adrenergic alpha-antagonists in treatment of distal ureteral stones in pediatric patients: A systematic review and meta-analysis. We carried out a systematic review and meta-analysis to evaluate the efficacy and safety of adrenergic alpha-antagonists as a medical expulsive therapy for ureteral stones in pediatric patients.The PubMed, EMBASE and Cochrane Controlled Trials Register databases were searched up to January 2016. All randomized controlled trials and all (...) cohort studies in which patients were randomized to receive either adrenergic alpha-antagonists or placebo for ureteral stones were identified. The outcome measures assessed were overall stone expulsion rate (primary), expulsion time (secondary), and treatment-emergent adverse events.Five trials with a total of 406 pediatric patients met the inclusion criteria. According to the doses of adrenergic alpha-antagonists, the pooling effects of adrenergic alpha-antagonists were analyzed, with a higher

2016 Journal of Pediatric Surgery

7. Coupling to Gq Signaling Is Required for Cardioprotection by an Alpha-1A-Adrenergic Receptor Agonist. (PubMed)

Coupling to Gq Signaling Is Required for Cardioprotection by an Alpha-1A-Adrenergic Receptor Agonist. Gq signaling in cardiac myocytes is classically considered toxic. Targeting Gq directly to test this is problematic, because cardiac myocytes have many Gq-coupled receptors.Test whether Gq coupling is required for the cardioprotective effects of an alpha-1A-AR (adrenergic receptor) agonist.In recombinant cells, a mouse alpha-1A-AR with a 6-residue substitution in the third intracellular loop (...) does not couple to Gq signaling. Here we studied a knockin mouse with this alpha-1A-AR mutation. Heart alpha-1A receptor levels and antagonist affinity in the knockin were identical to wild-type. In wild-type cardiac myocytes, the selective alpha-1A agonist A61603-stimulated phosphoinositide-phospholipase C and myocyte contraction. In myocytes with the alpha-1A knockin, both A61603 effects were absent, indicating that Gq coupling was absent. Surprisingly, A61603 activation of cardioprotective ERK

2019 Circulation Research

8. The Effects of α-adrenergic Receptor Antagonists on Choroid and Pupil

Adrenergic alpha-1 Receptor Antagonists Adrenergic alpha-Antagonists Adrenergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs Urological Agents (...) The Effects of α-adrenergic Receptor Antagonists on Choroid and Pupil The Effects of α-adrenergic Receptor Antagonists on Choroid and Pupil - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Effects of α

2017 Clinical Trials

9. Effects of Alfuzosin, an Alpha-1 Αdrenergic Antagonist on Anal Pressures and Bowel Habits, in Women With and Without Defecatory Disorders. (PubMed)

Effects of Alfuzosin, an Alpha-1 Αdrenergic Antagonist on Anal Pressures and Bowel Habits, in Women With and Without Defecatory Disorders. Some patients with defecatory disorders (DD) have high anal pressures that may impede rectal evacuation. Alpha-1 adrenoreceptors mediate as much as 50% of anal resting pressure in humans. We performed a randomized, placebo-controlled study of the effects of alfuzosin, an alpha1-adrenergic receptor antagonist, on anal pressures alone in healthy women and also

2018 Clinical Gastroenterology and Hepatology

10. A pilot trial of prazosin, an alpha-1 adrenergic antagonist, for comorbid alcohol dependence and posttraumatic stress disorder. (PubMed)

A pilot trial of prazosin, an alpha-1 adrenergic antagonist, for comorbid alcohol dependence and posttraumatic stress disorder. Posttraumatic stress disorder (PTSD) and alcohol dependence (AD) commonly co-occur and are associated with greater symptom severity and costs than either disorder alone. No pharmacologic interventions have been found to decrease both alcohol use and PTSD symptom severity relative to matched placebo. Prazosin, an alpha-1 adrenoreceptor antagonist, has demonstrated

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2015 Alcoholism, clinical and experimental research

11. SELECTIVE ALPHA ADRENERGIC ANTAGONIST REDUCES SEVERITY OF TRANSIENT HYPERTENSION DURING SEXUAL STIMULATION AFTER SPINAL CORD INJURY. (PubMed)

SELECTIVE ALPHA ADRENERGIC ANTAGONIST REDUCES SEVERITY OF TRANSIENT HYPERTENSION DURING SEXUAL STIMULATION AFTER SPINAL CORD INJURY. On a daily basis, the majority of those with high-level spinal cord injury have autonomic dysreflexia, which describes a life-threatening episode of transient extreme hypertension (i.e., as high as 300 mm Hg) as many as 90% of people living with this condition. Unfortunately, ejaculation is a major initiating factor for autonomic dysreflexia, which discourages (...) -acting selective α1 antagonist (prazosin) on autonomic dysreflexia severity using a randomized placebo trial during medically supervised penile vibrostimulation in six males with cervical spinal cord injury. Beat-by-beat blood pressure and heart rate were recorded throughout penile vibrostimulation during placebo and prazosin-treated days. The increase in systolic blood pressure was mitigated during vibrostimulation in subjects administered prazosin as compared with those administered placebo (+140

2014 Journal of neurotrauma

12. Alpha Adrenergic Receptor

Receptors (CNS) Inhibits Locus Ceruleus reflex arc Peripheral vasodilatation V. Medications: Alpha Adrenergics Alpha Adrenergic Agonist (Alpha Adrenergic Receptor) Alpha Non-Specific Alpha 1 Selective Methoxamine Alpha 2 Selective (See ) Alpha-methylnorepinephrine Alpha Receptor Antagonist Alpha Non-Specific Phentolamine Alpha 1 Selective (See ) Phenoxybenzamine Alpha 2 Selective Tolazoline Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search (...) Alpha Adrenergic Receptor Alpha Adrenergic Receptor Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Alpha Adrenergic Receptor Alpha

2018 FP Notebook

13. The Alpha-1A Adrenergic Receptor in the Rabbit Heart (PubMed)

The Alpha-1A Adrenergic Receptor in the Rabbit Heart The alpha-1A-adrenergic receptor (AR) subtype is associated with cardioprotective signaling in the mouse and human heart. The rabbit is useful for cardiac disease modeling, but data on the alpha-1A in the rabbit heart are limited. Our objective was to test for expression and function of the alpha-1A in rabbit heart. By quantitative real-time reverse transcription PCR (qPCR) on mRNA from ventricular myocardium of adult male New Zealand White (...) rabbits, the alpha-1B was 99% of total alpha-1-AR mRNA, with <1% alpha-1A and alpha-1D, whereas alpha-1A mRNA was over 50% of total in brain and liver. Saturation radioligand binding identified ~4 fmol total alpha-1-ARs per mg myocardial protein, with 17% alpha-1A by competition with the selective antagonist 5-methylurapidil. The alpha-1D was not detected by competition with BMY-7378, indicating that 83% of alpha-1-ARs were alpha-1B. In isolated left ventricle and right ventricle, the selective alpha

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2016 PloS one

14. The alpha-1 adrenergic antagonist doxazosin for treatment of cocaine dependence: A pilot study. (PubMed)

The alpha-1 adrenergic antagonist doxazosin for treatment of cocaine dependence: A pilot study. Medications decreasing central noradrenergic activity have been associated with attenuation of cocaine effects.This pilot study examined the efficacy of doxazosin versus placebo for reducing cocaine use in treatment-seeking cocaine dependent persons.We screened 108 cocaine dependent subjects and assigned 35 participants to receive either doxazosin (8mg/day) or placebo for 13 weeks. Participants were

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2013 Drug and alcohol dependence

15. Alpha Adrenergic Antagonist

Alpha Adrenergic Antagonist Alpha Adrenergic Antagonist Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Alpha Adrenergic Antagonist (...) Alpha Adrenergic Antagonist Aka: Alpha Adrenergic Antagonist , Selective Alpha-1a Antagonist , Prazosin , Minipress , Terazosin , Hytrin , Doxazosin , Cardura , Tamsulosin , Flomax , Alfuzosin , Uroxatral , Silodosin , Rapaflo From Related Chapters II. Indications (not Tamsulosin) III. Mechanism: General See (Alpha-1 antagonist) IV. Mechanism: Benign Prostatic Hypertrophy Preparations used in Terazosin (Hytrin) Doxazosin (Cardura) Tamsulosin (Flomax) Prazosin (Minipress) Rapid relaxation of smooth

2015 FP Notebook

16. The use of alpha-1 adrenergic blockers in children with distal ureterolithiasis: a systematic review and meta-analysis. (PubMed)

was resolved by consensus.Alpha-1 adrenergic antagonists increased the probability of calculus expulsion by 27% (NNT=4). Calculi smaller than 5mm, increased by 33% (NNT=3). Larger than 5mm, increased by 34% (NNT=3).Alpha-1 adrenergic blocker use is related with a greater incidence of expulsion of ureteral calculi, smaller or greater than 5mm, and fewer episodes of pain when compared to ibuprofen. However it is necessary larger samples to enhance the power analysis of the expulsion of ureteral calculi (...) larger than 5mm and the episodes of pain.This review analyzed the outcome of alpha adrenergic antagonist in children with ureteral calculi. We conclude that it is the best medicine for use, since it helps the expulsion of the stone.

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2015 International braz j urol : official journal of the Brazilian Society of Urology

17. The effects of increasing doses of MK-467, a peripheral alpha(2)-adrenergic receptor antagonist, on the cardiopulmonary effects of intravenous dexmedetomidine in conscious dogs. (PubMed)

The effects of increasing doses of MK-467, a peripheral alpha(2)-adrenergic receptor antagonist, on the cardiopulmonary effects of intravenous dexmedetomidine in conscious dogs. Different doses of MK-467, a peripheral alpha(2)-adrenergic receptor antagonist, with or without dexmedetomidine were compared in conscious dogs. Eight animals received either dexmedetomidine (10 μg/kg [D]), MK-467 (250 μg/kg [M250] or dexmedetomidine (10 μg/kg) with increasing doses of MK-467 (250 μg/kg [DM250], 500 μg

2011 Journal of veterinary pharmacology and therapeutics

18. Observational Study in Patients Suffering From Benign Prostatic Hyperplasia Treated With Alpha-adrenergic Blockade

: Boehringer Ingelheim ClinicalTrials.gov Identifier: Other Study ID Numbers: 527.28 First Posted: September 19, 2014 Last Update Posted: September 19, 2014 Last Verified: September 2014 Additional relevant MeSH terms: Layout table for MeSH terms Hyperplasia Prostatic Hyperplasia Pathologic Processes Prostatic Diseases Genital Diseases, Male Adrenergic Agents Adrenergic Antagonists Adrenergic alpha-Antagonists Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Physiological Effects (...) Observational Study in Patients Suffering From Benign Prostatic Hyperplasia Treated With Alpha-adrenergic Blockade Observational Study in Patients Suffering From Benign Prostatic Hyperplasia Treated With Alpha-adrenergic Blockade - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2014 Clinical Trials

19. Importance of Alpha-adrenergic Receptor Subtypes in Regulating of Airways Tonus at Patients with Bronchial Asthma (PubMed)

Importance of Alpha-adrenergic Receptor Subtypes in Regulating of Airways Tonus at Patients with Bronchial Asthma In this work, effect of Tamsulosin hydrochloride as antagonist of alpha1A and alpha1B- adrenergic receptor and effect of Salbutamol as agonist of beta2- adrenergic receptor in patients with bronchial asthma and increased bronchial reactibility was studied.Parameters of the lung function are determined by Body plethysmography. Raw and ITGV were registered and specific resistance (...) (SRaw) was also calculated. Tamsulosin was administered in per os way as a preparation in the form of the capsules with a brand name of "Prolosin", producer: Niche Generics Limited, Hitchin, Herts.Results gained from this research show that blockage of alpha1A and alpha1B- adrenergic receptor with Tamsulosin hydrochloride (0.4 mg and 0.8 mg in per os way) has not changed significantly (p > 0.1) the bronchomotor tonus of tracheobronchial tree in comparison to the inhalation of Salbutamol as agonist

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2014 Acta Informatica Medica

20. Neuropeptide Y1 and alpha‐1 adrenergic receptor‐mediated decreases in functional vasodilation in gluteus maximus microvascular networks of prediabetic mice (PubMed)

(Y1R) and alpha-1 adrenergic receptor (α1R) activation. Using intravital video microscopy, second-, third-, and fourth-order (2A, 3A, and 4A) arteriolar diameters were measured before and following electrical field stimulation of the gluteus maximus muscle (GM) in prediabetic (PD, Pound Mouse) and control (CTRL, c57bl6, CTRL) mice. Baseline diameter was similar between groups; however, single tetanic contraction (100 Hz; 400 and 800 msec) and sustained rhythmic contraction (2 and 8 Hz, 30 sec (...) Neuropeptide Y1 and alpha‐1 adrenergic receptor‐mediated decreases in functional vasodilation in gluteus maximus microvascular networks of prediabetic mice Prediabetes is associated with impaired contraction-evoked dilation of skeletal muscle arterioles, which may be due to increased sympathetic activity accompanying this early stage of diabetes disease. Herein, we sought to determine whether blunted contraction-evoked vasodilation resulted from enhanced sympathetic neuropeptide Y1 receptor

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2018 Physiological reports

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