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Alopecia Areata

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1. Alopecia areata

Alopecia areata Evidence Maps - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4

2018 Trip Evidence Maps

3. Alopecia areata

Alopecia areata Alopecia areata - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Alopecia areata Last reviewed: February 2019 Last updated: November 2017 Summary Autoimmune disease that targets the hair follicle. Characterised by sudden onset of patchy hair loss. Diagnosis is clinical. Characteristic physical findings are exclamation mark hairs (short, broken hairs) and a positive pull test. A scalp biopsy shows (...) perifollicular inflammation. Topical or intralesional corticosteroids are appropriate for patients with limited hair loss. Skin atrophy can be a temporary side effect. Definition Alopecia areata (AA) is an autoimmune disease that affects almost 2% of the population in the US. Safavi KH, Muller SA, Suman VJ, et al. Incidence of alopecia areata in Olmsted County, Minnesota, 1975 through 1989. Mayo Clin Proc. 1995;70:628-633. http://www.ncbi.nlm.nih.gov/pubmed/7791384?tool=bestpractice.com Inflammatory cells

2017 BMJ Best Practice

4. Alopecia areata multiplex following autologous dermal micro-graft injection for treatment of androgenetic alopecia. (PubMed)

Alopecia areata multiplex following autologous dermal micro-graft injection for treatment of androgenetic alopecia. Alopecia areata (AA) is an autoimmune disease of the hair follicle (HF). Human anagen HFs are protected by immune privilege, defined in part as the absence of MHC class I antigen expression. AA is postulated to occur when the immune-privileged state of the HF is compromised 1 ; however, the immunopathogenesis, including autoantigens, of AA remain incompletely defined. Recently (...) , through genome-wide association studies, gene expression analysis, and a C3H/HeJ mouse model of AA, the cytotoxic subset of CD8+NKG2D+ T cells was revealed to play a major role in AA development 2-4 . In contrast to AA, androgenetic alopecia (AGA) is believed to be caused by androgens on the hair cycles. Among other autologous transplantation procedures, autologous dermal micro-grafts have recently been used to treat AGA 5,6 . Herein, we report a case of AA that developed following an autologous

2019 Journal of the European Academy of Dermatology and Venereology

5. ATI-501 Oral Suspension Compared to Placebo in Subjects With Alopecia Areata, Alopecia Universalis or Alopecia Totalis

ATI-501 Oral Suspension Compared to Placebo in Subjects With Alopecia Areata, Alopecia Universalis or Alopecia Totalis ATI-501 Oral Suspension Compared to Placebo in Subjects With Alopecia Areata, Alopecia Universalis or Alopecia Totalis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. ATI-501 Oral Suspension Compared to Placebo in Subjects With Alopecia Areata, Alopecia Universalis or Alopecia Totalis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03594227 Recruitment Status : Active

2018 Clinical Trials

6. Risk of sun-induced skin cancers in patients with alopecia areata, alopecia totalis and alopecia universalis. (PubMed)

Risk of sun-induced skin cancers in patients with alopecia areata, alopecia totalis and alopecia universalis. 29679494 2018 10 27 1468-3083 32 11 2018 Nov Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Risk of sun-induced skin cancers in patients with alopecia areata, alopecia totalis and alopecia universalis. e409-e411 10.1111/jdv.15002 Conic R R Z RRZ Department of Dermatology, Cleveland Clinic Foundation, Cleveland, OH, USA. Department

2018 Journal of the European Academy of Dermatology and Venereology

7. ATI-502 Topical Solution for the Treatment of Alopecia Areata (AA), Alopecia Universalis (AU) and Alopecia Totalis (AT)

ATI-502 Topical Solution for the Treatment of Alopecia Areata (AA), Alopecia Universalis (AU) and Alopecia Totalis (AT) ATI-502 Topical Solution for the Treatment of Alopecia Areata (AA), Alopecia Universalis (AU) and Alopecia Totalis (AT) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. ATI-502 Topical Solution for the Treatment of Alopecia Areata (AA), Alopecia Universalis (AU) and Alopecia Totalis (AT) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details

2018 Clinical Trials

8. Scalp bacterial shift in Alopecia areata. (PubMed)

Scalp bacterial shift in Alopecia areata. The role of microbial dysbiosis in scalp disease has been recently hypothesized. However, little information is available with regards to the association between microbial population on the scalp and hair diseases related to hair growth. Here we investigated bacterial communities in healthy and Alopecia areata (AA) subjects. The analysis of bacterial distribution at the genus level highlighted an increase of Propionibacterium in AA subjects alongside

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2019 PLoS ONE

9. Quality of Life with Alopecia Areata versus Androgenetic Alopecia Assessed Using Hair Specific Skindex-29 (PubMed)

Quality of Life with Alopecia Areata versus Androgenetic Alopecia Assessed Using Hair Specific Skindex-29 29853767 2018 11 14 1013-9087 30 3 2018 Jun Annals of dermatology Ann Dermatol Quality of Life with Alopecia Areata versus Androgenetic Alopecia Assessed Using Hair Specific Skindex-29. 388-391 10.5021/ad.2018.30.3.388 Jun Myungsoo M Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea. Keum Dong In DI Department

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2018 Annals of dermatology

10. HrQoL in hair loss affected patients with Alopecia Areata, Androgenetic Alopecia and Telogen Effluvium: The role of personality traits and psychosocial anxiety. (PubMed)

HrQoL in hair loss affected patients with Alopecia Areata, Androgenetic Alopecia and Telogen Effluvium: The role of personality traits and psychosocial anxiety. Illness impact on HrQoL has been widely studied in hair loss-affected patients, yet no study has addressed whether individual differences modulate HrQoL in patients with alopecia areata (AA), androgenetic alopecia (AGA) and telogen effluvium (TE).To identify the personality dimensions most predictive of the impact of disease on HrQoL.A (...) single-site cross-sectional study was carried out in the Dermatology Unit of Sant'Orsola-Malpighi Hospital, Bologna between September 2016 and September 2017. The study included 143 patients (105 females, ages 18-60 years) diagnosed with AA (n = 27), AGA (n = 80) and TE (n = 36). Illness severity, alopecia type, age, gender, education and civil status were documented. Health-related quality of life (HrQoL), personality traits, trait anxiety, emotional intelligence, social anxiety and social phobia

2018 Journal of the European Academy of Dermatology and Venereology

11. Utility of Horizontal Sections of Scalp Biopsies in Differentiating between Androgenetic Alopecia and Alopecia Areata. (PubMed)

Utility of Horizontal Sections of Scalp Biopsies in Differentiating between Androgenetic Alopecia and Alopecia Areata. Androgenetic alopecia (AGA) and alopecia areata (AA) are common causes of alopecia which can sometimes be difficult to differentiate clinically. Horizontal sections of scalp biopsies are used to study non-cicatricial alopecias due to the ability to perform both quantitative and morphometric analysis of hair follicles on them.It was a prospective, cross-sectional study conducted (...) to assess the utility of horizontal sections to differentiate between the alopecias. Fifty-two cases were included: 20 cases of male AGA, 11 of female AGA and 21 cases of AA. After clinical examination and dermoscopy, a skin biopsy was taken and subjected to transverse sectioning. Histopathological assessment was done by two dermatopathologists blinded to clinical details.Among the quantitative parameters, terminal:vellus hair ratio (3.08 in AGA and 1.83 in AA, p = 0.0091) and anagen:non-anagen hair

2018 Dermatology

12. The value of dermoscopy in diagnosing eyebrow loss in patients alopecia areata and frontal fibrosing alopecia. (PubMed)

The value of dermoscopy in diagnosing eyebrow loss in patients alopecia areata and frontal fibrosing alopecia. Alopecia areata and frontal fibrosing alopecia are common causes of eyebrow loss (madarosis).Assessment of trichoscopic markers of eyebrow loss in alopecia areata and frontal fibrosing alopecia.The analysis included 50 patients with scalp alopecia areata with madarosis, 50 patients with scalp frontal fibrosing alopecia with madarosis and 50 healthy controls. In every case, trichoscopy (...) of the eyebrow area was performed.Empty follicular and eccrine duct openings were observed in all patients and presented predominantly as yellow dots. Exclamation mark hairs were only detected in patients with alopecia areata (30%). Tapered hairs, broken hair, black dots and Pohl-Pinkus constrictions were observed in 14%, 36%, 26% and 4% of patients with alopecia areata, respectively, 4%, 16%, 2% and 0% of patients with frontal fibrosing alopecia, respectively, and they were not present in healthy controls

2018 Journal of the European Academy of Dermatology and Venereology

13. Quality of life in mild and severe alopecia areata patients (PubMed)

Quality of life in mild and severe alopecia areata patients Alopecia areata is a relapsing hair disorder characterized by a sudden hairloss and has a considerable impact on patient's quality of life. The goal of this study was to determine quality of life among patients with mild and severe forms of alopecia areata and compare the two groups.During one year, 176 patients (96 mild, 80 severe) were selected and asked to complete Dermatology Life Quality Index (DLQI) questionnaires.Our study (...) confirms that alopecia areata considerably impacts quality of life and this is more pronounced in patients with severe disease and those who had acute stress recently.

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2017 International journal of women's dermatology

14. A new therapy for alopecia areata using fire needles: a systematic review and meta-analysis of randomised controlled trials

A new therapy for alopecia areata using fire needles: a systematic review and meta-analysis of randomised controlled trials Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

15. Establishing and Prioritising Research Questions for the Treatment of Alopecia Areata: The Alopecia Areata Priority Setting Partnership. (PubMed)

Establishing and Prioritising Research Questions for the Treatment of Alopecia Areata: The Alopecia Areata Priority Setting Partnership. Alopecia areata (AA) is a common hair loss disorder that results in patchy to complete hair loss. Many uncertainties exist around the most effective treatments for this condition.To identify uncertainties in AA management and treatment that are important to both service users (people with hair loss, carers and relatives) and healthcare professionals.An AA

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2016 British Journal of Dermatology

16. Alopecia Areata Progression Index, a Scoring System for Evaluating Overall Hair Loss Activity in Alopecia Areata Patients with Pigmented Hair: A Development and Reliability Assessment. (PubMed)

Alopecia Areata Progression Index, a Scoring System for Evaluating Overall Hair Loss Activity in Alopecia Areata Patients with Pigmented Hair: A Development and Reliability Assessment. No scoring systems to evaluate overall hair loss activity in alopecia areata (AA) have been established.We sought to develop a measurement tool (Alopecia Areata Progression Index, AAPI) for the evaluation of overall hair loss activity in AA patients with pigmented hair.The scalp surface area was divided into 4

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2016 Dermatology

17. JAK inhibitors for alopecia areata: a systematic review and meta-analysis. (PubMed)

JAK inhibitors for alopecia areata: a systematic review and meta-analysis. There have been a number of case reports and small clinical trials reporting promising outcomes of JAK inhibitors tofacitinib, ruxolitinib, and baracitinib for alopecia areata (AA). The majority of the literature to date is based on small volume data, with a lack of definitive evidence or guidelines.To determine the expected response of AA to JAK inhibitor therapy, and factors which influence response and recurrence

2019 Journal of the European Academy of Dermatology and Venereology

18. Alopecia areata in Tunisia: epidemio-clinical aspects and comorbid conditions. A prospective study of 204 cases. (PubMed)

Alopecia areata in Tunisia: epidemio-clinical aspects and comorbid conditions. A prospective study of 204 cases. Alopecia areata (AA) is an autoimmune condition that usually presents as patchy, nonscarring hair loss. Autoimmune disorders and atopy are reported as comorbid conditions. We aimed to investigate the demographics, clinical characteristics, and associations of AA in Tunisian patients.Demographic data, pattern of alopecia, age of onset, and associations were evaluated in 204 patients (...) ), lichen sclerosus atrophicus (one case), and pemphigus vulgaris (one case). Patchy AA was the most common manifestation (49.5%) followed by alopecia universalis (27.5%), alopecia ophiasis (12.7%), and alopecia totalis (10.3%). Nail changes consisting of pitting, trachyonychia, and longitudinal ridging were reported in 24.8%. AA patterns were more severe in females (P = 0.049). Severe forms showed more persistent disease duration (P = 0.005), earlier onset (P = 0.001), and more recurring episodes (P

2019 International Journal of Dermatology

19. Assessment of a Bidirectional Association Between Major Depressive Disorder and Alopecia Areata. (PubMed)

Assessment of a Bidirectional Association Between Major Depressive Disorder and Alopecia Areata. Alopecia areata (AA) is an autoimmune disease characterized by hair loss that can impose a substantial psychological burden on patients, including major depressive disorder (MDD), yet many patients report mental health symptoms prior to the onset of AA. As such, there may be an association between MDD and AA that acts in both directions.To assess the bidirectional association between MDD and AA.This

2019 JAMA dermatology (Chicago, Ill.)

20. White hair in alopecia areata: Clinical forms and proposed physiopathological mechanisms. (PubMed)

White hair in alopecia areata: Clinical forms and proposed physiopathological mechanisms. Alopecia areata is a common form of non-scaring type of hair loss. It is believed to be a consequence of an immune-mediated stimulus, probably involving autoreactive T-cells against antigens present in the hair follicle. The exact antigen is still unknown; however, some authors have proposed that melanogenesis-associated molecules might trigger autoimmunity. Although transient white hair regrowth (...) is a common and well-known situation in alopecia areata, there are other different types of white hair phenomena in this context; including permanent white hair regrowth, spearing of white hair in a patchy pattern or spearing in a diffuse form giving the appearance of the so-called "overnight graying phenomena" or Canitis subita. In this review we aim to describe the different clinical aspects of white hair in alopecia areata as well as the proposed pathophysiological mechanisms involved

2019 Journal of American Academy of Dermatology

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