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Alopecia

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1. Comprehensive Transcriptome Profiling of Balding and Non-Balding Scalps in Trichorhinophalangeal Syndrome Type I Patient Full Text available with Trip Pro

Comprehensive Transcriptome Profiling of Balding and Non-Balding Scalps in Trichorhinophalangeal Syndrome Type I Patient Trichorhinophalangeal syndrome (TRPS) patients tend to have alopecia that appears to be androgenetic, and this genetic model might give clues to the pathogenesis of hair loss or hair morphogenesis.This study was conducted to identify additional genetic evidence of TRPS and hair morphogenesis from a TRPS patient.From one TRPS type I patient, we extracted RNA and profiled whole (...) transcriptome in non-balding and balding scalp areas using high-throughput RNA sequencing.We found a total of 26,320 genes, which comprised 14,892 known genes with new isoforms and 4,883 novel genes from the non-balding and balding areas. Among these, a total of 1,242 genes showed different expression in the two scalp areas (p<0.05 and log2 fold-change >0). Several genes related to the skin and hair, alopecia, and the TRPS1 gene were validated by qRT-PCR. Twelve of 15 genes (KRT6C, KRTAP3-1, MKI67, GPRC5D

2017 Annals of dermatology

2. Bald thigh syndrome in sighthounds-Revisiting the cause of a well-known disease. Full Text available with Trip Pro

Bald thigh syndrome in sighthounds-Revisiting the cause of a well-known disease. Bald thigh syndrome is a common hair loss disorder in sighthounds. Numerous possible causes, including environmental conditions, trauma, stress, endocrinopathies and genetic components have been proposed, but only endocrinopathies have been ruled out scientifically. The overall goal of our study was to identify the cause of bald thigh syndrome and the pathological changes associated with it. We approached this aim (...) by comparing skin biopsies and hair shafts of affected and control dogs microscopically as well as by applying high-throughput technologies such as genomics, transcriptomics and proteomics. While the histology is rather unspecific in most cases, trichogram analysis and scanning electron microscopy revealed severe structural abnormalities in hair shafts of affected dogs. This finding is supported by the results of the transcriptomic and proteomic profiling where genes and proteins important

2019 PLoS ONE

3. Serum androgens and PSA levels in androgenetic alopecia - is there a difference between frontal and vertex baldness? (Abstract)

Serum androgens and PSA levels in androgenetic alopecia - is there a difference between frontal and vertex baldness? Androgenetic alopecia (AGA) seems to be a marker of increased risk of prostate cancer (PCa).We sought to investigate potential pathophysiological differences between frontal and vertex balding that might have the impact on the incidence of PCa.Serum concentrations of testosterone (T), dihydrotestosterone (DHT) and prostate-specific antigen (PSA) were measured in 88 subjects (...) with AGA.We have examined sixty patients with frontal baldness and 28 patients with vertex baldness. The subgroups did not differ significantly in age, BMI and as regards age of AGA onset, duration of AGA and comorbidities. The mean value of DHT in serum of the men with vertex baldness was higher than those in the men with frontal baldness with statistical significance (P < 0.05). The groups did not show significant differences in mean value of serum T and PSA levels, and DHT/T ratio. No correlation

2017 Journal of the European Academy of Dermatology and Venereology

4. Correction: The cultivable autochthonous microbiota of the critically endangered Northern bald ibis (Geronticus eremita). Full Text available with Trip Pro

Correction: The cultivable autochthonous microbiota of the critically endangered Northern bald ibis (Geronticus eremita). [This corrects the article DOI: 10.1371/journal.pone.0195255.].

2018 PLoS ONE

5. Seasonal differences of corticosterone metabolite concentrations and parasite burden in northern bald ibis (Geronticus eremita): The role of affiliative interactions. Full Text available with Trip Pro

Seasonal differences of corticosterone metabolite concentrations and parasite burden in northern bald ibis (Geronticus eremita): The role of affiliative interactions. The reproductive season is energetically costly as revealed by elevated glucocorticoid concentrations, constrained immune functions and an increased risk of infections. Social allies and affiliative interactions may buffer physiological stress responses and thereby alleviate associated effects. In the present study, we (...) investigated the seasonal differences of immune reactive corticosterone metabolite concentrations, endoparasite burden (nematode eggs and coccidian oocysts) and affiliative interactions in northern bald ibis (Geronticus eremita), a critically endangered bird. In total, 43 individually marked focal animals from a free-ranging colony were investigated. The analyses included a description of initiated and received affiliative interactions, pair bond status as well as seasonal patterns of hormone

2018 PLoS ONE

6. Characterization of the antibacterial activity of Bald's eyesalve against drug resistant Staphylococcus aureus and Pseudomonas aeruginosa. Full Text available with Trip Pro

Characterization of the antibacterial activity of Bald's eyesalve against drug resistant Staphylococcus aureus and Pseudomonas aeruginosa. Bald's eyesalve is an Anglo-Saxon medicinal remedy that has been used through ancient times to treat eye sty infections and may represent a source of ancientbiotics. This study assessed the efficacy of Bald's eyesalve against several strains of Staphylococcus aureus and Pseudomonas aeruginosa, including a multi-drug resistant phenotype, and identified (...) the principal compound conveying antibacterial activity. Bald's eyesalve formulations were produced by combining garlic, onion or leek, wine, bovine bile, and brass, with specific ingredient omissions in several formulations, followed by incubation at 4 °C for 9 days. Bald's eyesalve formulation ES-GBBr exhibited the greatest antibacterial activity against S. aureus and P. aeruginosa. Fractionation of ES-GBBr using molecular size exclusion and organic solvent partitioning isolated its antibacterial activity

2018 PLoS ONE

7. The cultivable autochthonous microbiota of the critically endangered Northern bald ibis (Geronticus eremita). Full Text available with Trip Pro

The cultivable autochthonous microbiota of the critically endangered Northern bald ibis (Geronticus eremita). The critically endangered Northern bald ibis (Geronticus eremita) is a migratory bird that became extinct in Europe centuries ago. Since 2014, the Northern bald ibis is subject to an intensive rehabilitation and conservation regime aiming to reintroduce the bird in its original distribution range in Central Europe and concurrently to maintain bird health and increase population size (...) . Hitherto, virtually nothing is known about the microbial communities associated with the ibis species; an information pivotal for the veterinary management of these birds. Hence, the present study was conducted to provide a baseline description of the cultivable microbiota residing in the Northern bald ibis. Samples derived from the choana, trachea, crop and cloaca were examined employing a culturomic approach in order to identify microbes at each sampling site and to compare their frequency among age

2018 PLoS ONE

8. Drugs for male- and female-pattern baldness: Just a hair bit more effective than doing nothing?

care research. www.acfp.ca October 11, 2016 Drugs for male- and female-pattern baldness: Just a hair bit more effective than doing nothing? Clinical Question: What is the effect of approved medications for androgenic alopecia in men and women? Bottom-line: For men using finasteride or minoxidil, one in 4-8 more than placebo will notice at least slight improvement in hair count over 6-12 months, with no clear evidence one is better. For every 84 men taking finasteride for hair loss, one extra (...) outcome. o Minoxidil 1-5% versus placebo: ? Patient-rated moderate improvement or better (26% versus 14%, NNT=8) ? Increase in hair count, +13 hairs/cm 2 , at 6-12 months. Context: • Prevalence of androgenic alopecia increases with age, with approximately ½ of men and ? of women balding after age 70. 10 • Numerous other interventions (like nutritional supplements or Handi-Dome Comb) have low quality evidence with inconsistent results. 9,11 • Only minoxidil for women or men, and finasteride for men

2016 Tools for Practice

9. Differential expression between human dermal papilla cells from balding and non-balding scalps reveals new candidate genes for androgenetic alopecia. Full Text available with Trip Pro

Differential expression between human dermal papilla cells from balding and non-balding scalps reveals new candidate genes for androgenetic alopecia. Androgenetic alopecia (AGA) is a common heritable and androgen-dependent hair loss condition in men. Twelve genetic risk loci are known to date, but it is unclear which genes at these loci are relevant for AGA. Dermal papilla cells (DPCs) located in the hair bulb are the main site of androgen activity in the hair follicle. Widely used monolayer (...) -cultured primary DPCs in hair-related studies often lack dermal papilla characteristics. In contrast, immortalized DPCs have high resemblance to intact dermal papilla. We derived immortalized human DPC lines from balding (BAB) and non-balding (BAN) scalp. Both BAB and BAN retained high proportions of dermal papilla signature gene and versican protein expression. We performed expression analysis of BAB and BAN and annotated AGA risk loci with differentially expressed genes. We found evidence for AR

2016 Journal of Investigative Dermatology

10. Efficacy and safety of ingenol mebutate gel in field treatment of actinic keratosis on full face, balding scalp or approximately 250 cm<sup>2</sup> on the chest: a Phase III randomized controlled trial. (Abstract)

Efficacy and safety of ingenol mebutate gel in field treatment of actinic keratosis on full face, balding scalp or approximately 250 cm2 on the chest: a Phase III randomized controlled trial. Ingenol mebutate (IngMeb) 0.015% or 0.05% is approved for actinic keratosis (AK) areas ≤25 cm2; some patients require treatment of larger fields.Determine efficacy and safety of IngMeb 0.027% in areas of AK ≤250 cm2 during an eight-week initial assessment period and extended 12-month follow (...) -up.This Phase III, randomized, double-blind, vehicle-controlled trial (NCT02361216) enrolled adult patients with 5-20 AK lesions on the face/scalp (25-250cm2) or chest (∼250cm2). Patients received once-daily IngMeb or vehicle for three consecutive days on the full face, full balding scalp or ∼250cm2 on the chest. Primary endpoint: complete AK clearance (AKCLEAR 100; Week 8). Additional endpoints included: partial AK clearance (AKCLEAR 75), recurrence, patient satisfaction, cosmetic outcome

2019 Journal of American Academy of Dermatology Controlled trial quality: predicted high

11. Safety and Efficacy of Escalating Doses of Ingenol Mebutate for Field Treatment of Actinic Keratosis on the Full Face, Full Balding Scalp, or Chest. (Abstract)

Safety and Efficacy of Escalating Doses of Ingenol Mebutate for Field Treatment of Actinic Keratosis on the Full Face, Full Balding Scalp, or Chest.

Background: Actinic keratosis (AK) can affect large skin areas. Ingenol mebutate (IngMeb) gel (0.015% and 0.05%) is approved for topical treatment of AK in a single contiguous area of ~25 cm2.

Objective: The study sought to determine the maximum tolerated dose (MTD), efficacy, and tolerability of IngMeb applied to AK on a contiguous area

2018 Journal of drugs in dermatology : JDD Controlled trial quality: uncertain

12. Obstructive sleep apnea, low transferrin saturation levels, and male-pattern baldness. Full Text available with Trip Pro

Obstructive sleep apnea, low transferrin saturation levels, and male-pattern baldness. There are limited data on the association between obstructive sleep apnea (OSA), which is characterized by intermittent hypoxia, and male-pattern baldness (MPB). Low blood iron levels are reportedly associated with hypoxia and hair loss. This study explored a possible link among OSA, iron status, and MPB.Polysomnography (PSG) and hair assessments were conducted in a cross-sectional study including 932 men (...) aged 46-76 years. OSA was defined as an apnea-hypopnea index ≥5 by PSG evaluation and MPB as scales from IV to VII according to the Norwood-Hamilton scale classification. Serum transferrin saturation (TSA) levels were assessed.A total of 224 men (24%) were identified as MPB cases and 495 men (53%) as having OSA. After considering potential risk factors, OSA and other sleep-related variables were not associated with MPB. In joint analysis of OSA and family history of hair loss, men with these two

2018 International Journal of Dermatology

13. Author Correction: GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk Full Text available with Trip Pro

Author Correction: GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk We have been alerted that in our recent Article the calculations used to transform the heritability from the observed scale to the liability scale did not take into account the individuals in category 2 of the baldness scale, who were removed in our original analysis. This led to an overestimation of the heritability on the liability scale, which should have been 0.62 instead of 0.94 (...) . Moreover, in the Title and in the Abstract, we report that we can explain 38% of the risk, while in fact that is the proportion of heritability explained by the loci we discovered. These errors do not substantially change the paper or its conclusions apart from the statement MBP is therefore probably one of the most heritable complex traits. Genome-wide significant associations and pathway analyses are not affected in any way and male-pattern baldness remains less genetically complex than other complex

2018 Nature communications

14. Misestimation of heritability and prediction accuracy of male-pattern baldness Full Text available with Trip Pro

Misestimation of heritability and prediction accuracy of male-pattern baldness 29959328 2018 12 14 2019 03 06 2041-1723 9 1 2018 06 29 Nature communications Nat Commun Misestimation of heritability and prediction accuracy of male-pattern baldness. 2537 10.1038/s41467-018-04807-3 Yap Chloe X CX 0000-0002-1788-2842 Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, Australia. Sidorenko Julia J Institute for Molecular Bioscience, The University of Queensland (...) Council United Kingdom MR/K026992/1 Medical Research Council United Kingdom 1113400 Department of Health | National Health and Medical Research Council (NHMRC) International Letter Research Support, Non-U.S. Gov't 2018 06 29 England Nat Commun 101528555 2041-1723 IM Nat Commun. 2018 Nov 20;9(1):4953 30459399 Nat Commun. 2018 Jun 29;9(1):2538 29959316 Adult Alleles Alopecia diagnosis genetics Gene Frequency Humans Male Middle Aged Models, Genetic Polymorphism, Single Nucleotide Predictive Value

2018 Nature communications

15. A Bald Statement - Current Approaches to Manipulate Miniaturisation Focus only on Promoting Hair Growth. Full Text available with Trip Pro

an estimated $87 Billion, with hair loss estimated at $2.8 Billion. Considering that no current hair loss-related products can completely reverse hair loss, it is reasonable to believe this market could expand significantly with the discovery of a comprehensive therapy. As such, a great deal of research focuses on overcoming hair loss, and in particular, a common form of hair loss known as androgenetic alopecia (AGA) or male pattern baldness. In AGA, hair follicles miniaturise in a large step change from (...) A Bald Statement - Current Approaches to Manipulate Miniaturisation Focus only on Promoting Hair Growth. Hair plays a large part in communication and society with its role changing through time and across cultures. Most people do not leave the house before combing their hair or shaving their beard and for many hair loss or irregular hair growth can have a significant impact on their psychological health. Somewhat unsurprisingly, according to GMR Data, today's global hair care industry is worth

2018 Experimental Dermatology

16. Shaved hair style scalp medical tattooing technique for treatment of advanced male pattern baldness patients. Full Text available with Trip Pro

Shaved hair style scalp medical tattooing technique for treatment of advanced male pattern baldness patients. The most infallible approach to male pattern baldness (MPB) is hair transplantation in the thinning area in parallel to medical treatment to prevent further alopecia progression. For an individual with advanced stage hair loss, a megasession surgery is recommended to meet the high donor hair requirement. Yet a most effective therapeutic regimen for alopecia, hair transplantation (...) inevitably has its advantages and disadvantages for it is done with the expense of donor hair sacrifice, intraoperative and postoperative pain, and unavoidable scars. Also, with poor donor condition, surgery may not even be an option. Nowadays, more patients with such limitations are undergoing shaved style scalp medical tattoo (SMT).To assess the effectiveness of SMT technique for shaved hair style.A total of 80 patients who were included in the study underwent SMT for shaved hair style between June

2018 International Journal of Dermatology

17. Single-Center Study Evaluating Systemic Exposure and Safety of KX2-391 Ointment 1% on the Face or Balding Scalp in Subjects With Actinic Keratosis

Single-Center Study Evaluating Systemic Exposure and Safety of KX2-391 Ointment 1% on the Face or Balding Scalp in Subjects With Actinic Keratosis Single-Center Study Evaluating Systemic Exposure and Safety of KX2-391 Ointment 1% on the Face or Balding Scalp in Subjects With Actinic Keratosis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies (...) Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Single-Center Study Evaluating Systemic Exposure and Safety of KX2-391 Ointment 1% on the Face or Balding Scalp in Subjects With Actinic Keratosis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies

2018 Clinical Trials

18. Nest use dynamics of an undisturbed population of bald eagles Full Text available with Trip Pro

Nest use dynamics of an undisturbed population of bald eagles Management or conservation targets based on demographic rates should be evaluated within the context of expected population dynamics of the species of interest. Wild populations can experience stable, cyclical, or complex dynamics, therefore undisturbed populations can provide background needed to evaluate programmatic success. Many raptor species have recovered from large declines caused by environmental contaminants, making them (...) strong candidates for ongoing efforts to understand population dynamics and ecosystem processes in response to human-caused stressors. Dynamic multistate occupancy models are a useful tool for analyzing species dynamics because they leverage the autocorrelation inherent in long-term monitoring datasets to obtain useful information about the dynamic properties of population or reproductive states. We analyzed a 23-year bald eagle monitoring dataset in a dynamic multistate occupancy modeling framework

2018 Ecology and evolution

19. Investigating individual and social behaviour of the Northern bald ibis (Geronticus eremita): behavioural variety and welfare Full Text available with Trip Pro

Investigating individual and social behaviour of the Northern bald ibis (Geronticus eremita): behavioural variety and welfare The Northern bald ibis (Geronticus eremita) (NBI) is one of the most threatened birds in the world. Intense conservation efforts have been undertaken and several research projects on the species are being done in Morocco and in Europe. Observing animal behaviour has been proved to be an efficient and non-invasive technique to assess the animal welfare (...) was reported. Moreover, the BVI highlighted a good behavioural variety as each bird performed approximately 78% of the natural behaviours described in the Northern bald ibis and in close relative species. Our findings seem to suggest the presence of qualitative and quantitative similarities between the behavioural repertoires of the study ibises and those described in wild conspecifics, suggesting a good welfare of the colony. Finally, the BVI proposed in the current study seems to be a useful

2018 PeerJ

20. Circulating and intraprostatic sex steroid hormonal profiles in relation to male pattern baldness and chest hair density among men diagnosed with localized prostate cancers. Full Text available with Trip Pro

Circulating and intraprostatic sex steroid hormonal profiles in relation to male pattern baldness and chest hair density among men diagnosed with localized prostate cancers. Prospective cohort studies of circulating sex steroid hormones and prostate cancer risk have not provided a consistent association, despite evidence from animal and clinical studies. However, studies using male pattern baldness as a proxy of early-life or cumulative androgen exposure have reported significant associations (...) with aggressive and fatal prostate cancer risk. Given that androgens underlie the development of patterned hair loss and chest hair, we assessed whether these two dermatological characteristics were associated with circulating and intraprostatic concentrations of sex steroid hormones among men diagnosed with localized prostate cancer.We included 248 prostate cancer patients from the NCI Prostate Tissue Study, who answered surveys and provided a pre-treatment blood sample as well as fresh frozen adjacent

2017 Prostate

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