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Allergic Fungal Sinusitis

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1. Conversion to Chronic Invasive Fungal Sinusitis From Allergic Fungal Sinusitis in Immunocompetence. (PubMed)

Conversion to Chronic Invasive Fungal Sinusitis From Allergic Fungal Sinusitis in Immunocompetence. A review of the treatment of allergic and invasive fungal sinusitis, as well as a presentation of the first recorded case of a conversion from allergic fungal sinusitis (AFS) to chronic granulomatous invasive sinusitis and the fourth case of invasive fungal sinusitis associated with Curvularia. This immunocompetent patient suffering from chronic AFS converted after repeated high-dose steroid

2019 Laryngoscope

2. Allergic fungal sinusitis caused by Schizophyllum commune (PubMed)

Allergic fungal sinusitis caused by Schizophyllum commune A case of allergic fungal sinusitis (AFS) due to Schizophyllum commune was reported. The pathogen was identified using molecular bioanalysis. The patient underwent the functional endoscopic sinus surgery followed by the radical maxillary sinusotomy with canine fossa trephine. This case suggested that complete surgery allowed optimal disease clearance for AFS caused by Schizophyllum commune.

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2017 World journal of otorhinolaryngology - head and neck surgery

3. Image Diagnosis: Allergic Fungal Sinusitis (PubMed)

Image Diagnosis: Allergic Fungal Sinusitis 30005729 2018 12 11 2019 02 28 1552-5775 22 2018 The Permanente journal Perm J Image Diagnosis: Allergic Fungal Sinusitis. 17-230 10.7812/TPP/17-230 Bakshi Satvinder S SS Associate Professor in the Department of Ear, Nose, and Throat and Head and Neck Surgery at Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth, in Pillaiyarkuppam, Pondicherry, India. saty.bakshi@gmail.com. eng Case Reports Journal Article United States Perm (...) J 9800474 1552-5767 IM Adult Aspergillosis diagnosis Aspergillus niger isolation & purification Female Humans Rhinitis, Allergic microbiology Sinusitis microbiology 2018 7 15 6 0 2018 7 15 6 0 2018 12 12 6 0 ppublish 30005729 17-230 10.7812/TPP/17-230 PMC6045506 Aust N Z J Med. 1989 Aug;19(4):351-3 2783086 Otolaryngol Head Neck Surg. 1994 Nov;111(5):580-8 7970796 Am J Rhinol Allergy. 2015 Jul-Aug;29(4):243-5 26163244 Saudi Med J. 2014 Aug;35(8):791-5 25129175 Head Neck Pathol. 2015 Dec;9(4):488

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2018 The Permanente journal

4. New tools for preoperative diagnosis of allergic fungal sinusitis? A prospective study about 71 patients. (PubMed)

New tools for preoperative diagnosis of allergic fungal sinusitis? A prospective study about 71 patients. 30354031 2018 12 06 1749-4486 44 1 2019 Jan Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery Clin Otolaryngol New tools for preoperative diagnosis of allergic fungal sinusitis? A prospective study about 71 patients. 91-96 10.1111/coa.13243 Vatin Loraine L http://orcid.org/0000-0002-8678-7224

2018 Clinical Otolaryngology

5. Ethmoid malformation associated with pediatric nasal polyposis and allergic fungal sinusitis (PubMed)

Ethmoid malformation associated with pediatric nasal polyposis and allergic fungal sinusitis A 17-year-old female with allergic fungal sinusitis and nasal polyposis presented with epistaxis in the emergency room. On examination, right-sided proptosis and irregular nasal obstruction were observed in the right nasal cavity. CT imaging revealed massive right-sided polyposis and significant ipsilateral malformation with boney architecture preservation of the ethmoidal labyrinth and lamina papyracea (...) . The patient was treated surgically with symptomatic improvement. These findings indicate a unique malformation of the ethmoid while the patient was in development. To the authors' knowledge, this anatomical malformation has not been previously described in the literature. Physicians should implement diagnostic procedures early if nasal polyposis and allergic fungal sinusitis is suspected in pediatric patients, especially with periocular involvement, to mitigate the risk of boney malformations

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2017 Journal of surgical case reports

6. Hyperprolactinemia Secondary to Allergic Fungal Sinusitis Compressing the Pituitary Gland (PubMed)

Hyperprolactinemia Secondary to Allergic Fungal Sinusitis Compressing the Pituitary Gland Objective. We aim to describe the first case in the literature of allergic fungal sinusitis (AFS) presenting with hyperprolactinemia due to compression of the pituitary gland. Case Presentation. A 37-year-old female presented with bilateral galactorrhea and occipital headaches of several weeks. Workup revealed elevated prolactin of 94.4, negative pregnancy test, and normal thyroid function. MRI and CT (...) demonstrated a 5.0 × 2.7 × 2.5 cm heterogeneous expansile mass in the right sphenoid sinus with no pituitary adenoma as originally suspected. Patient was placed on cabergoline for symptomatic control until definitive treatment. Results. The patient underwent right endoscopic sphenoidotomy, which revealed nasal polyps and fungal debris in the sphenoid sinus, consistent with AFS. There was bony erosion of the sella and clivus. Pathology and microbiology were consistent with allergic fungal sinusitis caused

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2016 Case reports in otolaryngology

7. Allergic Fungal Sinusitis

Allergic Fungal Sinusitis Allergic Fungal Sinusitis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Allergic Fungal Sinusitis Allergic (...) Fungal Sinusitis Aka: Allergic Fungal Sinusitis From Related Chapters II. Epidemiology Affects immunocompetent children and young adults Higher in warm, humid environments Accounts for 7% of requiring surgery III. Associated Conditions (33%) sensitivity is not related IV. Signs s Chronic pansinusitis refractory to standard therapy V. Labs: Sinus mucus examination Charcot Leyden crystals Non-invasive hyphae Numerous s VI. Radiology: Sinus XRay Findings Complete opacification of multiple sinuses

2018 FP Notebook

8. An investigation on non-invasive fungal sinusitis; Molecular identification of etiologic agents (PubMed)

An investigation on non-invasive fungal sinusitis; Molecular identification of etiologic agents Fungal sinusitis is increasing worldwide in the past two decades. It is divided into two types including invasive and noninvasive. Noninvasive types contain allergic fungal sinusitis (AFS) and fungus ball. AFS is a hypersensitivity reaction to fungal allergens in the mucosa of the sinonasal tract in atopic individuals. The fungus ball is a different type of noninvasive fungal rhinosinusitis which (...) is delineated as an accumulation of debris and fungal elements inside a paranasal sinus. Fungal sinusitis caused by various fungi such as Aspergillus species, Penicillium, Mucor, Rhizopus, and phaeohyphomycetes. The aim of the present study is to identify fungal species isolated from noninvasive fungal sinusitis by molecular methods.During 2015-2016, a total of 100 suspected patients were examined for fungal sinusitis. Functional endoscopic sinus surgery was performed using the Messerklinger technique

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2017 Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

9. Analysis of differential expression of protease-activated receptors in patients with allergic fungal rhinosinusitis (PubMed)

Analysis of differential expression of protease-activated receptors in patients with allergic fungal rhinosinusitis Ever since its characterization in the 1970s, allergic fungal rhinosinusitis (AFRS) has been the subject of much controversy, especially regarding its pathogenesis. In this study, we analyzed the differential expression of genes that encode protease-activated receptors (PAR) in patients with AFRS and patients with chronic rhinosinusitis, and tried to understand the pathogenic (...) basis of this disease.To analyze the differential expression of PAR genes in patients with AFRS and in patients with chronic rhinosinusitis.Mucosa from ethmoid sinuses of 51 patients (tests and controls) was biopsied and evaluated for messenger RNA expression of PAR genes by using reverse transcriptase-polymerase chain reaction. Each of the four PAR genes, i.e., par1, par2, par3 and par4 was amplified, the final gene products were run on 1.8% agarose gel and analyzed by densitometry to calculate

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2018 Allergy & Rhinology

10. Allergic fungal rhinosinusitis. (PubMed)

Allergic fungal rhinosinusitis. Allergic fungal rhinosinusitis (AFRS) is a subset of chronic rhinosinusitis with nasal polyps (CRSwNP) characterized by antifungal IgE sensitivity, eosinophil-rich mucus (ie, allergic mucin), and characteristic computed tomographic and magnetic resonance imaging findings in paranasal sinuses. AFRS develops in immunocompetent patients, with occurrence influenced by climate, geography, and several identified host factors. Molecular pathways and immune responses (...) driving AFRS are still being delineated, but prominent adaptive and more recently recognized innate type 2 immune responses are important, many similar to those established in patients with other forms of CRSwNP. It is unclear whether AFRS represents merely a more extreme expression of pathways important in patients with CRSwNP or whether there are other disordered immune responses that would define a distinct endotype or endotypes. Although AFRS and allergic bronchopulmonary aspergillosis share some

2018 Journal of Allergy and Clinical Immunology

11. Understanding paediatric allergic fungal sinusitis: Is it more aggressive? (PubMed)

Understanding paediatric allergic fungal sinusitis: Is it more aggressive? To study and characterize the features of AFRS in children as compared to adults.50 consecutive patients of AFRS attending our outpatient department were included in the study from July 2011 to December 2013. They were divided into two groups (A and B) according to age being ≤14 years and >14 years. Clinical history and examination included anterior rhinoscopy, SNOT 20 scores, CT of Nose and PNS (para nasal sinuses (...) in children with increased fungal load when compared with adults. Typically, AFRS in children was less responsive to treatment with increased recurrence rates.Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

2015 International Journal of Pediatric Otorhinolaryngology

12. Evaluation of vitamin D levels in allergic fungal sinusitis, chronic rhinosinusitis, and chronic rhinosinusitis with polyposis. (PubMed)

Evaluation of vitamin D levels in allergic fungal sinusitis, chronic rhinosinusitis, and chronic rhinosinusitis with polyposis. Vitamin D3 (VD3 ) levels have been recently found to be responsible for a number of immunological, anti-inflammatory and anti-infectious roles. Some studies reported that some forms of allergic fungal rhinosinusitis (AFRS), occurs more commonly in patients who are more susceptible to VD3 deficiency. The aim of this work was to measure VD3 levels in patients with AFRS

2015 International forum of allergy & rhinology

13. Sublingual Immunotherapy for Allergic Fungal Sinusitis. (PubMed)

Sublingual Immunotherapy for Allergic Fungal Sinusitis. Allergic fungal sinusitis (AFS) is a condition that has an allergic basis caused by exposure to fungi in the sinonasal tract leading to chronic inflammation. Despite standard treatment modalities, which typically include surgery and medical management of allergies, patients still have a high rate of recurrence. Subcutaneous immunotherapy (SCIT) has been used as adjuvant treatment for AFS. Evidence exists to support the use of sublingual (...) immunotherapy (SLIT) as a safe and efficacious method of treating allergies, but no studies have assessed the utility of SLIT in the management of allergic fungal sinusitis. A record review of cases of AFS that are currently or previously treated with sublingual immunotherapy from 2007 to 2011 was performed. Parameters of interest included serum IgE levels, changes in symptoms, Lund-McKay scores, decreased sensitization to fungal allergens associated with AFS, and serum IgE levels. Ten patients

2015 Rhinology and Laryngology

14. Bony erosion patterns in patients with allergic fungal sinusitis. (PubMed)

Bony erosion patterns in patients with allergic fungal sinusitis. To investigate bony erosion patterns in allergic fungal sinusitis (AFS) and to determine whether the extent of erosion correlates with demographics and preoperative clinical parameters.Retrospective review of prospectively collected data.Seventy-four patients with a histopathologic diagnosis of AFS were identified. Preoperative computed tomographies (CT) were reviewed to determine sites with bony erosion. The 20-item Sinonasal

2015 American journal of rhinology & allergy

15. Sinus penetration of saline solution irrigation and atomizer in a cadaveric polyp and allergic fungal sinusitis model (PubMed)

Sinus penetration of saline solution irrigation and atomizer in a cadaveric polyp and allergic fungal sinusitis model Allergic fungal sinusitis (AFS) is a stubborn disease requiring surgical and medical management. Delivery of topical medication is paramount in these patients, but the most difficult to accomplish. We investigated heavy irrigation (nasal douche) and atomized medication delivery potential in a cadaveric sinus model of polypoid AFS disease. Three disease models were created (...) : a control that involved unoperated sinuses and no simulated disease; an unoperated AFS with type II polyposis mode; and an operated model with recurrent allergic fungal sinusitis with type II polyposis. The maxillary sinus showed the best irrigation and overall the heavy irrigator was more efficient than the atomizer.

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2015 Allergy & Rhinology

16. Novel treatment of allergic fungal sinusitis using omalizumab (PubMed)

Novel treatment of allergic fungal sinusitis using omalizumab A case report of recalcitrant allergic fungal sinusitis (AFS) refractory to systemic corticosteroids and multiple functional endoscopic sinus surgeries (FESSs) treated with anti-IgE antibody omalizumab is reported. AFS is often classified with chronic rhinosinusitis (CRS). Although similar symptoms are among the two diseases, AFS has a unique pathophysiology. Patients with AFS demonstrate type 1 hypersensitivity to fungal allergens

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2014 Allergy & Rhinology

17. Allergic Fungal Sinusitis

Allergic Fungal Sinusitis Allergic Fungal Sinusitis: Practice Essentials, History of the Procedure, Problem Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvODM0NDAxLW92ZXJ2aWV3 processing > Allergic Fungal (...) Sinusitis Updated: Mar 16, 2018 Author: John E McClay, MD; Chief Editor: Arlen D Meyers, MD, MBA Share Email Print Feedback Close Sections Sections Allergic Fungal Sinusitis Overview Practice Essentials Over the past few decades, allergic fungal sinusitis (AFS) has become increasingly defined. [ ] Historically mistaken for a paranasal sinus tumor, allergic fungal sinusitis (AFS) now is believed to be an allergic reaction to aerosolized environmental fungi, usually of the dematiaceous species

2014 eMedicine Surgery

18. Sinusitis - Child

sinusitis; noninvasive subtypes include allergic fungal sinusitis and fungus ball (fungal mycetoma). The treatment strategies for the subtypes are different, as are their prognoses [35]. Acute invasive fungal sinusitis is the most lethal subtype with mortality rates reaching 50% to 80%; therefore, a high level of clinical suspicion is critical [36]. It is typically seen in immunocompromised children, often times with hematological malignancies with low neutrophil counts. Painless nasal septal necrosis (...) is the classical clinical presentation [34,35,37]. Allergic fungal sinusitis occurs in atopic children with refractory sinus disease, which requires a high index of suspicion for evaluation and aggressive treatment [38]. Allergic fungal sinusitis is more aggressive in children with increased fungal load and higher incidence of proptosis when compared with adults [39]. Allergic fungal sinusitis in children is also less responsive to treatment with increased recurrence rates [40]. Discussion of Procedures

2018 American College of Radiology

19. Predicting revision sinus surgery in allergic fungal and eosinophilic mucin chronic rhinosinusitis. (PubMed)

Predicting revision sinus surgery in allergic fungal and eosinophilic mucin chronic rhinosinusitis. Chronic rhinosinusitis consists of several disease processes. Eosinophilic mucin is found in the subtypes of allergic fungal sinusitis (AFS) and eosinophilic mucin chronic rhinosinusitis (EMCRS). These entities frequently require surgical intervention and have high recurrence rates.We aimed to determine factors in patients with AFS and EMCRS that may be associated with a higher rate of revision

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2016 Laryngoscope

20. Allergic fungal sinusitis and eosinophilic mucin rhinosinusitis: diagnostic criteria. (PubMed)

Allergic fungal sinusitis and eosinophilic mucin rhinosinusitis: diagnostic criteria. Chronic sinusitis is one of the most common otolaryngological diagnoses. Allergic fungal sinusitis and eosinophilic mucin rhinosinusitis can easily be misdiagnosed and treated as chronic sinusitis, causing continuing harm.To better identify and characterise these two subgroups of patients, who may suffer from a systemic disease requiring multidisciplinary treatment and prolonged follow up.A retrospective (...) , longitudinal study of all patients diagnosed with allergic fungal sinusitis or eosinophilic mucin rhinosinusitis within one otolaryngology department over a 15-year period.Thirty-four patients were identified, 26 with eosinophilic mucin rhinosinusitis and 8 with allergic fungal sinusitis. Orbital involvement at diagnosis was commoner in allergic fungal sinusitis patients (50 per cent) than eosinophilic mucin rhinosinusitis patients (7.7 per cent; p < 0.05). Asthma was diagnosed in 73 per cent

2013 Journal of Laryngology & Otology

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