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Alcoholic Hepatitis

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121. Correction: Survival from alcoholic hepatitis has not improved over time. Full Text available with Trip Pro

Correction: Survival from alcoholic hepatitis has not improved over time. [This corrects the article DOI: 10.1371/journal.pone.0192393.].

2018 PLoS ONE

122. Survival from alcoholic hepatitis has not improved over time. Full Text available with Trip Pro

Survival from alcoholic hepatitis has not improved over time. We aimed to describe changes in survival in alcoholic hepatitis (AH) over time by examining published data.A systematic literature search of Ovid Embase and PubMed was undertaken using the MESH terms 'hepatitis, alcoholic' to identify randomised controlled trials (RCT) and observational studies (OS) in alcoholic hepatitis. Data were extracted from included studies regarding 28-day, 90-day, 180-day mortality, as well as biochemical (...) for effective treatments for this alcoholic hepatitis.

2018 PLoS ONE

123. OTU-11 Non-severe alcoholic hepatitis is not a benign condition: systematic review and meta-analysis of mortality data Full Text available with Trip Pro

OTU-11 Non-severe alcoholic hepatitis is not a benign condition: systematic review and meta-analysis of mortality data OTU-11 Non-severe alcoholic hepatitis is not a benign condition: systematic review and meta-analysis of mortality data | Gut Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password (...) For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here OTU-11 Non-severe alcoholic hepatitis is not a benign condition: systematic review and meta-analysis of mortality data Article Text Liver Orals OTU-11 Non-severe alcoholic hepatitis is not a benign condition: systematic review and meta-analysis of mortality data Free Kris Bennett , , Doyo Enki , Mark Thursz , Matthew Cramp , , Ashwin Dhanda , Statistics from Altmetric.com Request

2019 Liver

124. Alcohol-related changes in the intestinal microbiome influence neutrophil infiltration, inflammation and steatosis in early alcoholic hepatitis in mice. Full Text available with Trip Pro

protein monocyte chemoattractant protein-1 (MCP-1) were also reduced in antibiotic-treated alcohol-fed mice. Alcohol-induced hepatic steatosis measured by Oil-Red O staining was significantly reduced in antibiotic treated mice. Genes regulating lipid production and storage were also altered by alcohol and antibiotic treatment. Interestingly, antibiotic treatment did not protect from alcohol-induced increases in serum aminotransferases (ALT/AST).Our data indicate that acute-on-chronic alcohol feeding (...) Alcohol-related changes in the intestinal microbiome influence neutrophil infiltration, inflammation and steatosis in early alcoholic hepatitis in mice. Alcohol-induced intestinal dysbiosis disrupts homeostatic gut-liver axis function and is essential in the development of alcoholic liver disease. Here, we investigate changes in enteric microbiome composition in a model of early alcoholic steatohepatitis and dissect the pathogenic role of intestinal microbes in alcohol-induced liver

2017 PLoS ONE

125. Correction: Alcohol-related changes in the intestinal microbiome influence neutrophil infiltration, inflammation and steatosis in early alcoholic hepatitis in mice. Full Text available with Trip Pro

Correction: Alcohol-related changes in the intestinal microbiome influence neutrophil infiltration, inflammation and steatosis in early alcoholic hepatitis in mice. [This corrects the article DOI: 10.1371/journal.pone.0174544.].

2017 PLoS ONE

126. In vivo imaging of hepatic neutrophil migration in severe alcoholic hepatitis with 111In-radiolabelled leucocytes Full Text available with Trip Pro

In vivo imaging of hepatic neutrophil migration in severe alcoholic hepatitis with 111In-radiolabelled leucocytes The study's aim was to image severe alcoholic hepatitis (SAH) using 111In-labelled leucocytes with two objectives in mind: firstly for non-invasive diagnosis and secondly to provide a platform for experimental therapies aiming to inhibit intrahepatic neutrophil migration. 111In-leucocyte scintigraphy was performed 30 min and 24 h post-injection in 19 patients with SAH, 14 abstinent (...) patients with alcohol-related cirrhosis and 11 normal controls. Eleven with SAH and seven with cirrhosis also had 99mTc-nanocolloid scintigraphy. Change in hepatic 111In radioactivity was expressed as decay-corrected 24 h:30 min count ratio and, in SAH, compared with histological grading of steatohepatitis and expression of granulocyte marker, CD15. Hepatic microautoradiography on biopsy specimens obtained 24 h post-injection of 111In-leucocytes was performed in one patient. Median 24 h:30 min hepatic

2018 Bioscience reports

127. Microvesicles in hepatic and peripheral vein can predict nonresponse to corticosteroid therapy in severe alcoholic hepatitis. Full Text available with Trip Pro

Microvesicles in hepatic and peripheral vein can predict nonresponse to corticosteroid therapy in severe alcoholic hepatitis. Severe alcoholic hepatitis patients have high mortality and limited response to corticosteroids. Microvesicles reflect cellular stress and disease conditions.To investigate whether microvesicles are associated with severity, response to steroid therapy and inflammation in severe alcoholic hepatitis.Microvesicles originating from different cells were studied pre-therapy (...) regeneration. Also, microvesicles of 0.2-0.4 μm size were higher in nonresponders (P < 0.03) at baseline. Microvesicles from patients trigger more (P = 0.04) ROS generation, TNF-α production (P = 0.04) and up-regulate pro-inflammatory cytokine related genes in neutrophils in vitro.Pre-therapy peripheral plasma levels of CD34+ and ASGPR+ microvesicles are reliable non-invasive markers of steroid nonresponse and mortality in patients with severe alcoholic hepatitis.© 2018 John Wiley & Sons Ltd.

2018 Alimentary Pharmacology & Therapeutics

128. The effect of dietary patterns on non-alcoholic fatty liver disease (NAFLD) and its related hepatic and extra-hepatic complications

The effect of dietary patterns on non-alcoholic fatty liver disease (NAFLD) and its related hepatic and extra-hepatic complications Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record

2020 PROSPERO

129. Adverse Drug Reactions to Disulfiram Treatment with or without Alcohol Challenge in the Indian Setting: Systematic Review Full Text available with Trip Pro

ExanthematousPustulosis during 15 days of DSF therapy. DSF stopped Topical and systemic steroids Rash subsided with topical and systemic steroids. 9 Ghosh et al. (2015) Case report/ Assam 28 250 mg/od for 3 weeks Alcohol dependence syndrome, No prior significant medical history such as HTN,DM etc. Catatonia ( mutism, waxy flexibility, and posturing) after 5 days of drinking 60 ml IMFL Inj. Lorazepam Recovery of presented symptoms after seven days of stopping DSF. 6 Babu et al. (2014) Case report/ Karnataka 35 250mg (...) /od for 3 months Alcohol dependence syndrome No prior significant medical history such as HTN,DM etc. Ischemic stroke episode (Left sided hemiplegia) within 10-15 minutes of drinking 150 ml of whisky. Patient was treated with mannitol, glycerol, antiplatelet drugs, statins, fo lic acid and vitamin B complex supplements Patient recovered from hemiplegia at 1 month follow-up (power 4/5 in affected limb) 6 Manjunatha et al. (2011) Case report/ Karnataka 32 250mg/od for 20 days and 250 mg /od for 25

2019 Journal of Postgraduate Medicine, Education and Research

130. What influences treatment response in animal models of non-alcoholic fatty liver disease? A meta-analysis with meta-regression Full Text available with Trip Pro

Institute for Data Analytics, University of Leeds , Leeds, UK Jake P. Mann 3 Institute of Metabolic Science, University of Cambridge , Cambridge, UK For correspondence: Abstract The classical drug development pipeline necessitates studies using animal models of human disease to gauge future efficacy in humans, however, there is a comparatively low conversion rate from success in animals to in humans. Non-alcoholic fatty liver disease (NAFLD) is a complex chronic disease without any licensed therapies (...) What influences treatment response in animal models of non-alcoholic fatty liver disease? A meta-analysis with meta-regression What influences treatment response in animal models of non-alcoholic fatty liver disease? A meta-analysis with meta-regression | bioRxiv Search for this keyword New Results What influences treatment response in animal models of non-alcoholic fatty liver disease? A meta-analysis with meta-regression Harriet Hunter , Dana de Gracia Hahn , Amedine Duret , Yu Ri Im

2019 Cold Spring Harbor Laboratory

131. Physical activity intervention for non-alcoholic fatty liver disease: a meta-analysis of randomized controlled trials Full Text available with Trip Pro

the most common cause of chronic liver disease. Diet and lifestyle changes have dramatically increased its prevalence worldwide. This meta-analysis was performed to investigate the efficacy of physical activity intervention on liver-specific endpoints in the NAFLD population, namely hepatic enzyme levels, serum lipid levels, and glucose metabolism. Methods: PubMed and China National Knowledge Infrastructure (CNKI) databases were searched for randomized clinical trials of physical activity intervention (...) First submitted On 20 Nov, 2019 Metrics Metrics Comments : 0 PDF Downloads : ... HTML Views : ... Subject Areas Subject Areas DOI & PDF DOI: License License: This work is licensed under a CC BY 4.0 License. Declarations The most recent version of this article is available . Abstract Background: Non-alcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease. Diet and lifestyle changes have dramatically increased its prevalence worldwide. This meta-analysis

2019 Research Square

132. A Systematic Review of Korean Medicine for Non-Alcoholic Fatty Liver Disease Full Text available with Trip Pro

of laparoscopic gastric bypass in patients with cirrhosis. Obesity Surgery 2004:14(1):47–53. 9. Jeongughanuigwadaehag gangyenaegwahaggyosil. Gangyenaegwahag 2013. Seoul: Nado: p. 321–8. 10. Chen L, Jiang YK, Cai YB. Effects of resolving phlegm method on fibrinolytic status in non-alcoholic steatohepatitis patients of phlegm and blood-stasis syndrome. Chinese Journal of Integrated Traditional and Western Medicine 2006:26(12):1090–3. 11. Gu CL, Zhang YK, Fu YX, Yang SF, Li XQ. Effect of Tiaozhi Yanggan (...) with non-alcoholic Fatty Liver of damp-heat Syndrome Type:A Multicenter Randomized Controlled Trial. Journal of Chinese Integrative Medicine 2008:6(2):128–34. 14. Li L, Zhang XJ, Lan Y, Xu L, Zhang XZ, Wang HH. Treatment of non-alcoholic fatty liver disease by Qianggan Capsule(强肝胶囊). Chinese Association of Traditional and Western Medicine 2010:16(1):23–7. 15. Lou SY, Wang WJ. Effects of Yiqi Sanju Formula on non-alcoholic fatty liver disease:a randomized controlled trial. Journal of Chinese Integrative

2019 The Journal of Internal Korean Medicine

133. rs641738C>T near MBOAT7 promotes steatosis, NASH, fibrosis and hepatocellular carcinoma in non-alcoholic fatty liver disease: a meta-analysis Full Text available with Trip Pro

previously associated with hepatic fat and advanced histology in non-alcoholic fatty liver disease (NAFLD), however, these findings have not been consistently replicated in the literature. We aimed to establish whether rs641738C>T is a risk factor across the spectrum of NAFLD and characterize its role in the regulation of related metabolic phenotypes through meta-analysis. Methods We performed meta-analysis of studies with data on the association between rs641738C>T genotype and: liver fat, NAFLD (...) rs641738C>T near MBOAT7 promotes steatosis, NASH, fibrosis and hepatocellular carcinoma in non-alcoholic fatty liver disease: a meta-analysis rs641738C>T near MBOAT7 is positively associated with liver fat, ALT, and histological severity of NAFLD: a meta-analysis | medRxiv Search for this keyword rs641738C>T near MBOAT7 is positively associated with liver fat, ALT, and histological severity of NAFLD: a meta-analysis Kevin Teo , Kushala W. M. Abeysekera , Leon Adams , Elmar Aigner , Jesus M

2019 Cold Spring Harbor Laboratory

134. Frequent Emergency Department Visits are More Prevalent in Psychiatric, Alcohol Abuse, and Dual Diagnosis Conditions than in Chronic Viral Illnesses Such as Hepatitis and Human Immunodeficiency Virus. (Abstract)

Frequent Emergency Department Visits are More Prevalent in Psychiatric, Alcohol Abuse, and Dual Diagnosis Conditions than in Chronic Viral Illnesses Such as Hepatitis and Human Immunodeficiency Virus. Repeat users of Emergency Departments (ED), so-called "frequent visitors," place a substantial burden on limited ED resources. The illness features of frequent visitors have not been well defined, though chronic medical and psychiatric illness and substance abuse are implicated.This study assessed (...) whether chronic conditions such as hepatitis C (HCV) and human immunodeficiency virus (HIV) are more prevalent in frequent ED users compared to a viral condition with relatively less disability, hepatitis B (HBV). As a comparison, psychiatric complaints and alcohol abuse were also compared in frequent and non-frequent visitors.All visits to a university ED in a particular calendar year were retrospectively reviewed. Frequent visitors were defined as those who made four or more visits. Presenting

2013 Journal of Emergency Medicine

135. FGF21, a liver hormone that inhibits alcohol intake in mice, increases in human circulation after acute alcohol ingestion and sustained binge drinking at Oktoberfest Full Text available with Trip Pro

responses, and problems. Finally, we characterized the effect of recombinant human FGF21 injection on ad libitum alcohol intake in mice.We show that alcohol ingestion (25.3 g or ∼2.5 standard drinks) acutely increases plasma levels of FGF21 (1-181) 3.4-fold in fasting humans. We also find that binge drinking for three days at Oktoberfest is associated with a 2.1-fold increase in baseline FGF21 (1-181) levels, in contrast to minor deteriorations in metabolic and hepatic biomarkers. However, basal FGF21 (...) (1-181) levels were not correlated with differences in alcohol-related behaviors, emotional responses, or problems in our non-alcoholic subjects. Finally, we show that once-daily injection of recombinant human FGF21 reduces ad libitum alcohol intake by 21% in mice.FGF21 (1-181) is markedly increased in circulation by both acute and sub-chronic alcohol intake in humans, and reduces alcohol intake in mice. These observations are consistent with a role for FGF21 as an endocrine inhibitor of alcohol

2018 Molecular metabolism

136. Effects of DA-5513 on alcohol metabolism and alcoholic fatty liver in rats Full Text available with Trip Pro

Effects of DA-5513 on alcohol metabolism and alcoholic fatty liver in rats Hangover is characterized by a number of unpleasant physical and mental symptoms that occur after heavy alcohol drinking. In addition, consistently excessive alcohol intake is considered as a major reason causes liver disease. The present study investigated the in vivo effects of DA-5513 (Morning care® Kang Hwang) on biological parameters relevant to hangover relief and alcoholic fatty liver. Blood alcohol (...) in the groups treated with DA-5513 or Yeomyung®, as compared with control rats. However, Ukon® did not produce any significant effects on these parameters. Treatment with DA-5513 significantly reduced serum aspartate and alanine aminotransferase activities and markedly reduced serum cholesterol and triglyceride levels, as compared with control rats. Histological observations using Oil Red O staining found that DA-5513 delayed the development of alcoholic fatty liver by reversing hepatic fat accumulation

2018 Laboratory animal research

137. Parental non-alcoholic fatty liver disease increases risk of non-alcoholic fatty liver disease in offspring. Full Text available with Trip Pro

Parental non-alcoholic fatty liver disease increases risk of non-alcoholic fatty liver disease in offspring. Little is known regarding the risk of hepatic steatosis (HS) among adult children of affected parents. We examined the association between parental and offspring HS in the multigenerational Framingham Heart Study, which characterized HS using computed tomography.We performed multivariable logistic regression models adjusted for age, sex, alcohol use, and body mass index to generate (...) the odds of HS according to parental HS. We determined the proportion of participants with HS according to parental HS and the presence or absence of hypertension, diabetes, or obesity (BMI ≥30 kg/m2 ). After excluding heavy alcohol use (n = 126) and missing covariates (n = 1), 785 offspring with at least one parent were included.Approximately 23% (183/785) had at least one parent with HS and 1.1% had two affected parents (9/785). In adjusted models, participants with at least one parent with HS had

2018 Liver International

138. Effect of alcohol consumption on survival in non-alcoholic fatty liver disease: a national prospective cohort study. Full Text available with Trip Pro

of their survival. We diagnosed NAFLD based on a previously validated biochemical model (Hepatic Steatosis Index). We built multivariate Cox proportional hazards models to evaluate the effect of alcohol consumption on survival of patients with NAFLD. After excluding participants with significant alcohol use, viral hepatitis, or increased transferrin saturation, 4,568 participants with NAFLD were included in the analysis. In a Cox model adjusted for age, sex, and smoking history, drinking 0.5-1.5 drinks per day (...) Effect of alcohol consumption on survival in non-alcoholic fatty liver disease: a national prospective cohort study. Nonalcoholic fatty liver disease (NAFLD) comprises more than two thirds of patients with chronic liver disease in the United States. The effect of alcohol consumption on survival in patients with NAFLD is not clear. We gathered data on National Health and Nutrition Examination Survey participants from 1988 to 2010, and linked them to the National Death Index for follow-up

2018 Hepatology

139. Alcohol Consumption in Patients with Non-alcoholic Fatty Liver Disease: Convenient vs. Inconvenient Truths. (Abstract)

Alcohol Consumption in Patients with Non-alcoholic Fatty Liver Disease: Convenient vs. Inconvenient Truths. Understanding the role of modest alcohol consumption in patients with non-alcohol induced fatty liver disease (NAFLD) remains a significant challenge, with no clear guidance on counselling regarding alcohol use. Conventionally, the strong association of alcohol excess and development of complications related to chronic liver disease, including hepatocellular carcinoma, has led (...) practitioners to advocate complete abstinence to those with NAFLD. New evidence published in this issue of the Red Journal challenges the historic paradigm by showing that modest, non-binge wine consumption (<70 g/week) associates with significantly lower risk of advanced hepatic fibrosis on biopsy compared with complete abstinence across a well-characterised single centre cohort of nearly 200 patients with NAFLD.

2018 American Journal of Gastroenterology

140. Non-alcoholic steatofibrosis (NASF) can independently predict mortality in patients with non-alcoholic fatty liver disease (NAFLD) Full Text available with Trip Pro

causes of chronic liver disease (alcohol consumption <20 gr/day, hepatitis B surface-antigen negative, anti-hepatitis C virus antibody negative, transferrin saturation <50%). Significant hepatic fibrosis was estimated by high NFS (>0.676) and calculated with previously published formula. Subjects with NAFLD and high NFS have significant NASF.NHANES III included 20 050 adult participants. 2515 participants complete data and NAFLD with 5.1% (n=129) meeting criteria for significant SF. Subjects (...) Non-alcoholic steatofibrosis (NASF) can independently predict mortality in patients with non-alcoholic fatty liver disease (NAFLD) Hepatic fibrosis in patients with non-alcoholic fatty liver disease (NAFLD) independently predicts mortality. Given liver biopsy's invasive nature, non-invasive method to assess hepatic steatosis and fibrosis provides NAFLD risk stratification algorithm in clinical practice. NAFLD fibrosis score (NFS) is simple and non-invasive predictive model recommended

2018 BMJ open gastroenterology

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