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Alcohol Tremor

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121. Treating Opioid Use Disorder During Pregnancy: Guideline Supplement

patients.10 Summary of Clinical recommendations Table 1- Summary of recommendations Also refer to the Summary of Recommendations of the Guideline for contextualizing information. Prenatal screening and assessment 1. All individuals who are or may become pregnant should be offered regular screening for alcohol, tobacco, and non-medical drug use, and informed about relevant risks and available risk reduction strategies. Screenings should be accompanied by brief support. (See Screening and Assessment (...) .) 8. Breastfeeding should be encouraged in mothers who are stable on OAT. (See Rooming-in and Breastfeeding.)11 Introduction Obtaining accurate prevalence data on substance use during pregnancy is particularly difficult primarily due to the stigma and prejudice against pregnant women who use substances. While non-medical opioid use during pregnancy is less frequently self-reported than alcohol and tobacco use, it is recognized by the Public Health Agency of Canada as a significant concern across

2018 British Columbia Perinatal Health Program

122. AIM Clinical Appropriateness Guidelines for Interventional Pain Management

, motor dysfunction (eg, weakness, tremor, dystonia), or trophic changes (eg, hair, nail, skin) ? At least 1 sign at time of evaluation in at least two (2) of the following categories: o Sensory: Evidence of hyperalgesia (to pinprick), allodynia (to light touch, temperature sensation, deep somatic pressure, or joint movement) o Vasomotor: Evidence of temperature asymmetry (>1°C), skin color changes or asymmetry o Sudomotor/edema: Evidence of edema, sweating changes, or sweating asymmetry o Motor (...) /trophic: Evidence of decreased range of motion, motor dysfunction (eg, weakness, tremor, dystonia), or trophic changes (eg, hair, nail, skin) o No other diagnosis better explaining the signs and symptoms ? In addition, all of the following are required: o Level of pain and disability in the moderate to severe range o Failure of at least two (2) weeks of conservative management o Documentation of ongoing participation in a comprehensive pain management program The performance of an initial diagnostic

2019 AIM Specialty Health

123. Pregabalin

doses of pregabalin (150 mg per day to 600 mg per day; 34 participants) or matching placebo (30 2016 4. Randomised controlled trial: Pregabalin similar to lorazepam for alcohol withdrawal symptoms Pregabalin similar to lorazepam for alcohol withdrawal symptoms | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password (...) * your user name or password? Search for this keyword Search for this keyword Main menu Log (...) in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Pregabalin similar to lorazepam for alcohol withdrawal symptoms Article Text Therapeutics Randomised controlled trial Pregabalin similar to lorazepam for alcohol withdrawal symptoms Giovanni Addolorato 1 , Lorenzo Leggio 1 , 2 Statistics from

2018 Trip Latest and Greatest

124. NARCAN Nasal Spray

, Taylor D, Forbes B. Nalox- one without the needle — Systematic review of candidate routes for non- injectable naloxone for opioid overdose reversal. Drug & Alcohol Dependence. 2016;163:16–23. NARCAN® Nasal Spray efficacy for emergency treatment of opioid overdose Key Take-Home Messages • The administration of ready-to-use, needle-free concentrated NARCAN® Nasal Spray (containing 4mg of naloxone hydrochloride in low volume of 0.1 mL) results in pharmacokinetic parameters that either equal or exceed (...) development or regulatory approval. 18. Dowling J, Isbister GK, Kirkpatrick CM, Naidoo D, Graudins A. Popula- tion pharmacokinetics of intravenous, intramuscular, and intranasal naloxone in human volunteers. Therapeutic Drug Monitoring. 2008;30(4):490–6. 19. McDonald R, Danielsson Glende O, Dale O, Strang J. International patent applications for non-injectable naloxone for opioid overdose reversal: Explor- atory search and retrieve analysis of the PatentScope database. Drug & Alcohol Review. 2018;37(2

2018 Ontario HIV Treatment Network

127. Clearing the Smoke on Cannabis: Regular Use and Cognitive Functioning

psychoactive substance in Canada, led only by alcohol. According to the 2018 National Cannabis Survey (second quarter), 16% of Canadians aged 15 years and older reported using cannabis in the past three months. The use of cannabis is generally more prevalent among young people, with 33% of individuals between the age of 15 to 24 reporting use in the past three months compared to 13% of those aged 25 or older (Statistics Canada, 2018). Given the proportion of Canadians using cannabis and in light (...) , time distortion, deficits in attention span and memory, body tremors, increased heart rate and blood pressure, and impaired motor functioning. Over the past few decades, there has been an increase in the concentrations of THC (and decrease in CBD levels) in illicit cannabis, increasing from 4% in 1995 to 12% in 2014 (ElSohly et al., 2016). Canada legalized the use of cannabis for non- medical purposes for individuals over 18 years of age (19 in some provinces) on October 17, 2018. A review

2019 Canadian Centre on Substance Abuse

128. Hereditary Hemochromatosis

be elevated among patients with nonalcoholic fatty liver disease and in those with alcoholic liver disease. These diagnoses are more common than HH among patients with elevated serum ferritin who are not C282Y homozygotes or C282Y/H63D compound heterozygotes. A secondary cause for liver disease should be excluded among patients with suspected iron overload who are not C282Y homozygotes. Phlebotomy remains the mainstay of therapy, but emerging novel therapies such as new chelating agents may have a role (...) with either abnormally low levels of hepcidin ( ) or decreased binding of hepcidin to ferroportin (FPN), the transmembrane protein that exports iron outside the cell ( ). Secondary iron overload may be considered as any condition of acquired hepcidin deficiency from disorders of erythropoiesis or increased red blood cell (RBC) turnover or due to other chronic liver disease or excess alcohol intake ( ). Over time, iron deposition can lead to dysfunction and failure in multiple organs including the liver

2019 American College of Gastroenterology

130. Assessment and Management of Patients at Risk for Suicide

both drug and non-drug poisoning.[8] Other means include, but are not limited to, overdose of licit or illicit drugs, alcohol or combinations thereof, hanging, poisoning (with chemical compounds such as industrial cleaners or pesticides), carbon monoxide inhalation, suffocation (with plastic hoods or inert gasses), electric shock, immolation, drowning, exsanguination, and evisceration. Hanging deaths have increased in the past decade, with evidence of suicide contagion stemming from the deaths

2019 VA/DoD Clinical Practice Guidelines

131. Management of Atopic Eczema

) Methotrexate 2.5 - 5 mg/kg daily in two divided doses Hypertension, hepatoxicity, tremor, paraesthesia, hypertrichosis, oedema, acne, gingival hypertrophy, hyperkalaemia, increased susceptibility to infections, nephrotoxicity, seizures Limit use to two years to prevent increased risk of malignancy Avoid excessive sunlight exposure Pregnancy and breast feeding Screen for Hepatitis B, C and HIV before commencement Monitor FBC, RP and LFT two weeks after commencement and as needed subsequently 10 - 25 mg (...) weekly (0.2 - 0.5 mg/kg); not to exceed 30mg weekly (Off-label use) Gastrointestinal disturbances (e.g. diarrhoea, nausea, vomiting), bone marrow depression, aplastic anaemia, hepatotoxicity, renal failure, skin reactions (e.g. photosensitivity, toxic epidermal necrolysis) alopecia, dizziness, neurotoxicity, encephalopathy, seizure, infections Chronic liver disease, alcoholic liver disease, breast-feeding, hypersensitivity to methotrexate, evidence of immunodeficiency syndrome, pre-existing blood

2019 Ministry of Health, Malaysia

132. Clearing the Smoke on Cannabis: Regular Use and Cognitive Functioning

psychoactive substance in Canada, led only by alcohol. According to the 2018 National Cannabis Survey (second quarter), 16% of Canadians aged 15 years and older reported using cannabis in the past three months. The use of cannabis is generally more prevalent among young people, with 33% of individuals between the age of 15 to 24 reporting use in the past three months compared to 13% of those aged 25 or older (Statistics Canada, 2018). Given the proportion of Canadians using cannabis and in light (...) , time distortion, deficits in attention span and memory, body tremors, increased heart rate and blood pressure, and impaired motor functioning. Over the past few decades, there has been an increase in the concentrations of THC (and decrease in CBD levels) in illicit cannabis, increasing from 4% in 1995 to 12% in 2014 (ElSohly et al., 2016). Canada legalized the use of cannabis for non- medical purposes for individuals over 18 years of age (19 in some provinces) on October 17, 2018. A review

2019 Canadian Centre on Substance Abuse

135. Plitidepsin (Aplidin) - Multiple Myeloma

. Solubility studies were undertaken, where it was found that an alcoholic solvent/water mixture combined with a surfactant offers the required properties. A mixture of water for injections (WFI), ethanol and macrogolglycerol ricinoleate was found to afford suitable dissolution characteristics and the relative amounts of each component were optimised. It was found that this solution can be terminally sterilised although re-homogenisation is required afterwards as it become biphasic at high temperature

2018 European Medicines Agency - EPARs

137. Cognitive Impairment - Part 1: Symptoms To Diagnosis

there were any precipitating factors (e.g., vascular event). Background health information (e.g., medical problems, medications, alcohol and other recreational drug use, social history including years of education and presence of potential caregivers, family history) should be ascertained. 12 FAMILY/CAREGIVER INTERVIEW A separate history should be obtained from someone who knows the patient well to determine whether the cognitive and non-cognitive complaints represent a change from prior performance (...) disease - chorea, Creutzfeldt-Jakob disease - myoclonus, amyotrophic lateral sclerosis - fasciculations). In the early stages of dementia an abnormal gait (which can be observed as they walk into your office) suggests non-Alzheimer causes. Focal or lateralizing signs (e.g., hemiplegia, hyperreflexia, Babinski response, pseudobulbar palsy [dysarthria, dysphagia, emotional lability]) are suggestive of cerebrovascular disease. Finding parkinsonism (i.e., rest tremor, bradykinesia, rigidity, postural

2017 Toward Optimized Practice

139. A Guideline for the Clinical Management of Opioid Use Disorder

elimination half-life), and potential for interactions with alcohol and other drugs does increase the relative risk of toxicity and adverse events. For example, in the United States, after controlling for the total number of prescriptions dispensed, methadone-re- lated emergency room visits occur at a rate that is approximately 6 and 23 times higher than the prescription opioids oxycodone and hydrocodone, respectively. 58 Moreover, although methadone accounts for fewer than 5% of all opioid prescriptions (...) been consistently associated with risk of methadone-involved overdose are non-prescribed, diverted and illicit use (including illicit use when prescribed methadone dose is insufficient to control withdrawal symptoms); unsupervised or non-witnessed doses; combined use with alcohol and benzodiazepines; and when methadone is prescribed for pain management, as opposed to treatment of opioid use disorder where doses are witnessed and titration schedules are strictly enforced. 60-64 Witnessed dosing

2017 Clinical Practice Guidelines and Protocols in British Columbia

140. Dental Management of Pediatric Patients Receiving Chemotherapy, Hematopoietic Cell Transplantation, and/or Radiation Therapy

be gently flossed daily. If pain or exces - sive bleeding occurs, the patient should avoid the affected area, but floss the other teeth. 1 Patients with poor oral hygiene and/or periodontal disease may use chlorhexidine rinses daily until the tissue health improves or mucositis develops. 13 The high alcohol content of commercially-available chlorhexidine mouthwash may cause discomfort and dehydrate the tissues in patients with mucositis; thus, an alcohol-free chlorhexidine solution is indicated (...) in this situation. Diet: Dental practitioners should discuss the importance of a healthy diet to maintain nutritional status with an empha- sis on foods that do not promote caries. Patients and parents should be advised about the high cariogenic potential of di- etary supplements rich in carbohydrates and oral pediatric medications rich in sucrose. 6 They should also be instructed that sharp, crunchy, spicy, and highly acidic foods and alcohol should be avoided during chemotherapy, radiation, and HCT. 1

2018 American Academy of Pediatric Dentistry

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