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Alcohol Tremor

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1061. Octanol to Treat Essential Tremor

will evaluate the effectiveness of 1-octanol, a substance similar to alcohol but less intoxicating, for treating essential tremor. Essential tremor is an involuntary shaking, usually of the hands, for which there is no satisfactory treatment. It affects about 1.4 percent of the general U.S. population, with the figure climbing to nearly 4 percent among people over 40. Results of two previous NIH studies have shown 1-octanol to be promising as a potential new treatment. This study will test the effectiveness (...) treatment. Blood pressure and pulse are measured at 15, 30, and 60 minutes after the first dose of the day and then 3 times a day each day of hospitalization, EKG and blood draws are done every other day during hospitalization, and blood is drawn again 1 week after the end of the study. Patients evaluate their tremor daily according to a tremor scale and are also rated according to an alcohol intoxication scale. Condition or disease Intervention/treatment Phase Essential Tremor Drug: 1-Octanol Phase 2

2004 Clinical Trials

1062. Pregabalin in the Treatment of Essential Tremor

- Spermicide and barrier - Intrauterine device - Partner sterility Prior to participation in this study, each subject must sign an informed consent. Exclusion Criteria: Patients do not meet TRIG criteria for probable ET. Subjects who are not able to abstain from alcohol for 24 hours prior to each evaluation. Patients who can not maintain an identical dose of any medicine that may affect tremor during their entire study involvement. Subjects who have exhibited any psychotic symptomatology. Subjects who have (...) Pregabalin in the Treatment of Essential Tremor Pregabalin in the Treatment of Essential Tremor - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Pregabalin in the Treatment of Essential Tremor The safety

2007 Clinical Trials

1063. 123I-ALTROPANE® Reference Image Acquisition in Subjects With Diagnostically Uncertain Tremor

123I-ALTROPANE® Reference Image Acquisition in Subjects With Diagnostically Uncertain Tremor 123I-ALTROPANE® Reference Image Acquisition in Subjects With Diagnostically Uncertain Tremor - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. 123I-ALTROPANE® Reference Image Acquisition in Subjects With Diagnostically Uncertain Tremor (AIM) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00596908 Recruitment Status : Completed First Posted : January 17, 2008 Last Update Posted : May 29, 2009 Sponsor: Alseres

2008 Clinical Trials

1064. A Proof of Concept Study of the Effectiveness of Carisbamate in the Treatment of Essential Tremor

must have a negative blood alcohol test at screening and be willing to abstain from alcohol for at least 24 hours prior to each study visit. Exclusion Criteria: Abnormal neurologic signs or progressive neurological disorders, such as Parkinson's Disease, brain tumor, demyelinating disease, CNS trauma, active CNS infection, stroke, or any CNS disease, other than ET, that could interfere with the evaluation of tremor Patients with dystonia or dystonic tremors, enhanced physiologic tremor, task (...) A Proof of Concept Study of the Effectiveness of Carisbamate in the Treatment of Essential Tremor A Proof of Concept Study of the Effectiveness of Carisbamate in the Treatment of Essential Tremor - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove

2007 Clinical Trials

1065. Zonisamide in the Treatment of Essential Tremor

Inclusion Criteria: Diagnosis of Essential Tremor based on the Tremor Investigational Group criteria for definite or probable Essential Tremor. Age: 18 years or over. Willingness and ability to comply with the study requirements and give informed consent. Exclusion Criteria: Known history of psychiatric disorder, major depression, dementia, aplastic anemia, or Stevens-Johnson syndrome. Known alcohol or substance abuse in previous 12 months. Positive pregnancy test. Unwillingness to use adequate (...) Zonisamide in the Treatment of Essential Tremor Zonisamide in the Treatment of Essential Tremor - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Zonisamide in the Treatment of Essential Tremor The safety

2008 Clinical Trials

1066. A Pilot Clinical Trial Of Memantine for Essential Tremor

-tremor medication. Subject is able to comply with all testing and follow-up visit requirements. Subject is able to abstain from alcohol for at least 12 hours prior to each Study Visit and from caffeinated beverages on the day of the Visit. Subject has voluntarily signed an informed consent in accordance with institutional policies. Subject is either Not taking medication for Essential Tremor and has not done so for at least 28 days prior to Visit 1. Taking medication for Essential Tremor and has been (...) taking a stable dose so for at least 28 days prior to Visit 1. Exclusion Criteria: Subject has progressive neurological disease other than Essential Tremor. Subject has history of alcoholism or drug abuse within the past year. Subject has history of mania, bipolar depressive disorder, schizophrenia, or other major psychiatric disorder. Subject drinks more than 2 glasses of wine or equivalent per day in last 30 days. Subject has received botulinum injection of the upper extremities in the past 6

2007 Clinical Trials

1067. A Safety/Efficacy Trial of Zonisamide for Essential Tremor

(Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: age 18 or older diagnosis of essential tremor tremor present in both hands for at least one year tremor is bothersome in at least one hand, so that reduction of tremor would improve quality of life able to comply with study visits and procedures has voluntarily signed consent form able to abstain from alcohol for 12 hours prior to each visit, and from caffeine on day prior to visit taking (...) no medications or stable doses of anti-tremor medication for 4 weeks prior to the Baseline visit Exclusion Criteria: medical condition likely to cause hospitalization during the study progressive neurological disorder other than essential tremor history of serious psychiatric illness history of drug or alcohol abuse in past year consumes more than two glasses of wine or equivalent per day has received botulinum toxin injection in past 6 months currently using experimental device has taken experimental drug

2005 Clinical Trials

1068. Pilot trial of 1-octanol in essential tremor. (Abstract)

Pilot trial of 1-octanol in essential tremor. 1-Octanol (an 8-C alcohol currently used as a food-flavoring agent) is known to inhibit tremor in essential tremor (ET) animal models at a much lower dose than ethyl alcohol. The authors conducted a randomized, placebo-controlled pilot trial of a single oral dose of 1 mg/kg of 1-octanol in 12 patients with ET. No significant side effects or signs of intoxication were observed. 1-Octanol significantly decreased tremor amplitude for up to 90 minutes

2004 Neurology Controlled trial quality: uncertain

1069. Abnormal vibration induced illusion of movement in essential tremor: evidence for abnormal muscle spindle afferent function. Full Text available with Trip Pro

)). No difference was observed in patients with alcohol or non-alcohol responsive tremor.The VIIM decreased with increasing age in healthy control subjects. Abnormal VIIM implies abnormal sensorimotor processing in patients with essential tremor, similar to that found in idiopathic focal dystonia, and the change of the perception with age could explain the age related onset of the disorder. (...) Abnormal vibration induced illusion of movement in essential tremor: evidence for abnormal muscle spindle afferent function. Vibration induced illusion of movement (VIIM) is abnormal in patients with idiopathic focal dystonia, an abnormality which corrects with fatigue of the vibrated muscle. Since dystonia and essential tremor sometimes coexist in families, we investigated the perception of VIIM and the effect of fatigue on VIIM in patients with essential tremor.VIIM in 18 patients

2005 Neurosurgery and Psychiatry

1070. Alcoholism and Alcohol Abuse - Management

are used to reduce tremor and agitation - eg, diazepam or chlordiazepoxide. Some hospitals have alcohol withdrawal assessment charts to determine how much to give - eg, the Clinical Institute Withdrawal Assessment for Alcohol scale. [ ] Short-acting benzodiazepines are used for seizures - eg, lorazepam intravenously (IV). Be careful of possible dependence on benzodiazepines - advise short courses at the lowest necessary dose. Vitamin B complex This is given as IV Pabrinex® to inpatients for a couple (...) Alcoholism and Alcohol Abuse - Management Alcoholism and Alcohol Abuse - Management | Doctor | Patient TOPICS Try our Symptom Checker TREATMENT RESOURCES Try our Symptom Checker PROFESSIONAL Upgrade to Patient Pro / / Search Alcoholism and Alcohol Misuse - Management Authored by , Reviewed by | Last edited 8 Apr 2015 | Certified by This article is for Medical Professionals Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based

2008 Mentor

1071. Tremor

. Causes include Parkinson's disease, Parkinsonism, other extrapyramidal diseases and multiple sclerosis. Postural - occurs when a part of the body is held in a fixed position against gravity (it can also remain during movement). Types include physiological tremor, exaggerated physiological tremor (eg, thyrotoxicosis), anxiety states, alcohol abuse, drugs (see below), heavy metal poisoning, neurological diseases, Wilson's disease, neurosyphilis, peripheral neuropathies, essential (familial) tremor (...) and physiological state. Background tremor amplitude tends to progress over the course of years. Some degree of control over the tremor, exerted by concentration on a task or via execution of a skilled manual repertoire, is common. Tremor does not occur during sleep. Most report improvement of tremor following alcohol ingestion. It may be difficult to distinguish from exaggerated physiological tremor, that caused by hyperthyroidism/fever or tremor due to medications; these causes should always be borne in mind

2008 Mentor

1072. 1-Octanol to Treat Essential Tremor

Healthy Volunteers: No Criteria Patients with essential tremor affecting the upper limbs who are 21 years of age or older. Patients who are not taking medications for essential tremor or any other medical condition for at least 2 weeks. Patients who have not consumed alcohol or cold medications containing alcohol for at least 24 hours prior to the day of the study. Women must not be pregnant or lactating. Women of childbearing age must use birth control while participating in this study. Patients must (...) by National Institutes of Health Clinical Center (CC): Alcohol Octanol Treatment Tremor Additional relevant MeSH terms: Layout table for MeSH terms Tremor Essential Tremor Dyskinesias Neurologic Manifestations Nervous System Diseases Signs and Symptoms Movement Disorders Central Nervous System Diseases

2000 Clinical Trials

1073. 1-Octanol to Treat Essential Tremor

be off any medications used to treat essential tremor such as mysoline or propranalol for at least 2 weeks. Patients must withhold ethanol and caffeine from 24 hours prior to starting the study until study termination (10 days). EXCLUSION CRITERIA: Patients with abnormalities on neurologic exam other than tremor. Patients with a history of chronic alcohol dependence. Patients with chronic medical conditions such as renal failure, hepatic failure and chronic lung disease. Patients on other chronic (...) 1-Octanol to Treat Essential Tremor 1-Octanol to Treat Essential Tremor - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. 1-Octanol to Treat Essential Tremor The safety and scientific validity of this study

2001 Clinical Trials

1074. Pharmacologic trials in the treatment of cerebellar tremor. (Abstract)

Pharmacologic trials in the treatment of cerebellar tremor. We studied the effect of long-term administration of propranolol hydrochloride and isoniazid and the acute action of ethyl alcohol on cerebellar tremor in patients with multiple sclerosis and primary cerebellar degeneration in a placebo-controlled double-blind crossover test. None of the drugs decreased the severity of either static or kinetic cerebellar tremors.

1984 Archives of neurology

1075. Tremor disorders. Diagnosis and management. Full Text available with Trip Pro

to the use of anticholinergics and a combination of carbidopa and levodopa. Tremor can also be a manifestation of Wilson's disease, lesions of the cerebellum and midbrain, peripheral neuropathy, trauma, alcohol, and conversion disorders. Treatment should be directed to the underlying condition. Stereotactic thalamotomy of thalamic stimulation is a last resort. (...) Tremor disorders. Diagnosis and management. Tremor is commonly encountered in medical practice, but can be difficult to diagnose and manage. It is an involuntary rhythmic oscillation of a body part produced by reciprocally innervated antagonist muscles. Tremors vary in frequency and amplitude and are influenced by physiologic and psychological factors and drugs. Categorization is based on position, posture, and the movement necessary to elicit the tremor. A resting tremor occurs when the body

1995 Western Journal of Medicine

1076. Regional and racial differences in the prevalence of physician-diagnosed essential tremor in the United States. (Abstract)

Regional and racial differences in the prevalence of physician-diagnosed essential tremor in the United States. For reasons that are unclear, prevalence estimates of essential tremor (ET) differ considerably across the United States. Separate communities have never been sampled within the framework of the same study to substantiate these differences. We estimated the prevalence of physician-diagnosed ET in the elderly in four communities in the United States in whom the same screening questions (...) were used, and examined whether this prevalence differed between Caucasians and African Americans. The Cardiovascular Health Study recruited a sample of Medicare beneficiaries >/=65 years of age from four communities in different regions of the United States. In 1998 to 1999, 3,494 participants (mean age, 80.0 years; range, 70-103 years) answered a 12-question screen for ET, including the question, "has a doctor diagnosed you as having familial tremor or benign essential tremor?" Fifty-four

2003 Movement Disorders

1077. Long duration asymmetrical postural tremor is likely to predict development of Parkinson's disease and not essential tremor: clinical follow up study of 13 cases. Full Text available with Trip Pro

with asymmetrical postural tremor, initially thought to have ET based on tremor characteristics, alcohol responsiveness, and family history but who subsequently met the criteria of Parkinson's disease (PD).The patients were observed and followed up clinically with ancillary imaging using dopamine transporter SPECT scan or levodopa challenge tests in some cases. The diagnosis at original presentation with postural tremor was made with retrospective case note review.After a variable and long latent period all (...) patients developed additional signs suggesting a clinical diagnosis of PD although picking up an initial label of ET.We suggest exercising caution regarding a diagnosis of ET in patients presenting with late onset asymmetrical postural tremor even if there is no rest tremor. Alcohol sensitivity of tremor, family history of tremor, or responsiveness to beta blockers may not be helpful in diagnosing ET in these cases and some may develop PD in the long term.

2005 Neurosurgery and Psychiatry

1078. Sway patterns in a case of orthostatic tremor responsive to alcohol. (Abstract)

Sway patterns in a case of orthostatic tremor responsive to alcohol. We describe changes in the extent of sway in a man with orthostatic tremor (OT) who reported increased stability after alcohol. He was tested at baseline and again after 40 g (0.5 g/kg) of alcohol. These results were compared to those of 3 age-matched controls (no alcohol). The patient's baseline sway was greater than controls, larger in the lateral than the anteroposterior plane, but retained normal responsiveness to the use (...) of external support, increasing stance width, and vision. Tremor frequency significantly decreased after alcohol, as did low- and high-frequency tremor amplitude and the extent of body sway. Despite these findings, sway remained greater than controls. OT thus may show functionally important alcohol responsiveness.2004 Movement Disorder Society.

2004 Movement Disorders

1079. Influence of alcohol on gait in patients with essential tremor. Full Text available with Trip Pro

Influence of alcohol on gait in patients with essential tremor. To study the effect of ethanol on gait in patients with essential tremor (ET).Using a three-dimensional opto-electronic gait analysis system, the authors analyzed gait at free-speed walking, at a given velocity, and during tandem gait. Patients with ET with advanced disease were examined before and after a small oral dose of ethanol. The results of the patients with ET were compared with those from age-matched healthy controls (HCs (...) gait ataxia in patients with essential tremor (ET). This may reflect a reversible effect of ethanol on receptors being involved in the pathology of ET. Ethanol may act via an influence of the inferior olive or directly on alcohol-sensitive gamma-aminobutyric acid receptors within the cerebellum.

2005 Neurology

1080. Effect of Alcohol on Tremors

Effect of Alcohol on Tremors Effect of Alcohol on Tremors - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effect of Alcohol on Tremors The safety and scientific validity of this study is the responsibility (...) . Consumption of alcohol has been known to reduce tremors in some patients. Researchers believe that the alcohol may work directly on the cells of the olivary nucleus. As a result, researchers would like to determine the effects of alcohol on three different kinds of tremors (physiological, symptomatic palatal, and essential palatal). Condition or disease Intervention/treatment Phase Tremor Drug: Alcohol Phase 2 Detailed Description: The pathophysiology and anatomical basis of most tremors remains poorly

1999 Clinical Trials

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