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Alcohol Tremor

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61. Essential Tremor (Diagnosis)

of maintenance medical therapy for essential tremor. These medications provide good benefit, reducing tremor amplitude in approximately 50-70% of patients. [ , , ] Some patients require only intermittent tremor reduction (eg, to attend a meeting or engage in a social activity). For these patients, a cocktail or beer prior to the activity may be sufficient, or they may take propranolol (10-40 mg) approximately one half hour prior to the event. Alcohol consumption is not an appropriate maintenance therapy (...) . Mov Disord . 2007 Aug 15. 22(11):1573-80. . Benito-Leon J, Louis ED, Bermejo-Pareja F. Elderly-onset essential tremor is associated with dementia. Neurology . 2006 May 23. 66(10):1500-5. . Klebe S, Stolze H, Grensing K, Volkmann J, Wenzelburger R, Deuschl G. Influence of alcohol on gait in patients with essential tremor. Neurology . 2005 Jul 12. 65(1):96-101. . Daniels C, Peller M, Wolff S, et al. Voxel-based morphometry shows no decreases in cerebellar gray matter volume in essential tremor

2014 eMedicine.com

62. Essential Tremor (Treatment)

tremor reduction, such as when attending a meeting or engaging in a social activity. For these patients, a cocktail or beer prior to the activity may be sufficient. An alternative is propranolol (10-40 mg) approximately one half hour prior to the event. Alcohol consumption is not an appropriate maintenance therapy for patients who seek tremor reduction throughout the day. [ ] Surgery For patients with disabling, medically refractory upper extremity tremor, surgery is considered. Stereotactic (...) , antagonism of alpha-amino-3-hydroxy-5-methylisoxazole-4 propionic acid/kainite receptors, and blockage of voltage-dependent calcium and sodium channels. Multiple studies indicate that tremor is reduced by an average of approximately 20% in comparison with placebo. However, clinical trials indicate a fairly substantial dropout rate of 40% because of adverse effects such as cognitive difficulty and somnolence. AAN Practice Parameter is as follows [ ] : Level B (probably effective) Alcohol The mechanism

2014 eMedicine.com

63. Essential Tremor (Follow-up)

tremor reduction, such as when attending a meeting or engaging in a social activity. For these patients, a cocktail or beer prior to the activity may be sufficient. An alternative is propranolol (10-40 mg) approximately one half hour prior to the event. Alcohol consumption is not an appropriate maintenance therapy for patients who seek tremor reduction throughout the day. [ ] Surgery For patients with disabling, medically refractory upper extremity tremor, surgery is considered. Stereotactic (...) , antagonism of alpha-amino-3-hydroxy-5-methylisoxazole-4 propionic acid/kainite receptors, and blockage of voltage-dependent calcium and sodium channels. Multiple studies indicate that tremor is reduced by an average of approximately 20% in comparison with placebo. However, clinical trials indicate a fairly substantial dropout rate of 40% because of adverse effects such as cognitive difficulty and somnolence. AAN Practice Parameter is as follows [ ] : Level B (probably effective) Alcohol The mechanism

2014 eMedicine.com

64. Functional Imaging of Tremor Circuits and Mechanisms of Treatment Response

members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 21 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: Yes Criteria Inclusion Criteria: Diagnosed with ET by a Movement Disorder Neurologist. Tremors that improve with alcohol. Ability to abstain (...) from drinking alcohol or caffeine for at least 2 days before both the screening and fMRI visits Over the age of 21. Exclusion Criteria: Significant non-ET related abnormal findings during neurological exam. Presence of a tremor at rest. Pregnant or nursing. Unable to safely undergo MRI based on completion of a safety questionnaire. History of dementia, brain tumor, stroke, head trauma or a vascular malformation based on history or MRI findings. Severe active medical condition

2013 Clinical Trials

65. Effects of Octanoic Acid for Treatment of Essential Voice Tremor

and Other Communication Disorders (NIDCD) Information provided by (Responsible Party): Soren Lowell, Syracuse University Study Details Study Description Go to Brief Summary: Essential voice tremor is a neurological condition that produces a regular, shaking quality in the voice. One form of drug treatment that produces some improvement in tremor of the hands is octanoic acid, which is a food additive that is similar to alcohol. Research suggests that octanoic acid may reduce tremor in the hands/arms (...) produces regular shaking and hoarseness in the voice, making it difficult speech difficult to understand Several previous studies have found that octanoic acid and octanol, which are related to alcohol, can improve tremor in some people without producing many side effects and without producing intoxication Researchers are interested in determining whether octanoic acid can improve tremor that affects the voice Objectives: To determine the effects of octanoic voice using voice recordings and listener

2013 Clinical Trials

66. ExAblate (Magnetic Resonance-guided Focused Ultrasound Surgery) for Treatment of Tremor

ExAblate (Magnetic Resonance-guided Focused Ultrasound Surgery) for Treatment of Tremor ExAblate (Magnetic Resonance-guided Focused Ultrasound Surgery) for Treatment of Tremor - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. ExAblate (Magnetic Resonance-guided Focused Ultrasound Surgery) for Treatment of Tremor The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01932463 Recruitment Status : Completed First Posted : August 30, 2013 Last Update Posted : August 30, 2013 Sponsor: InSightec Information

2013 Clinical Trials

67. Voice Tremor in Spasmodic Dysphonia: Central Mechanisms and Treatment Response

neurological problems, such as stroke, movement disorders other than SD and VT, brain tumors, traumatic brain injury with loss of consciousness, ataxias, myopathies, myasthenia gravis, demyelinating diseases, alcoholism, drug dependence will be excluded. As voice tremor is one of the forms of essential tremor, patients with moderate to severe essential tremor affecting other body parts will be excluded from the study. All patients who have dystonic movements in other than larynx body regions will also (...) Voice Tremor in Spasmodic Dysphonia: Central Mechanisms and Treatment Response Voice Tremor in Spasmodic Dysphonia: Central Mechanisms and Treatment Response - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2013 Clinical Trials

68. Familial Orthostatic Tremor: An Additional Report in Siblings. (PubMed)

D ED Waters Cheryl C Pullman Seth L SL eng Case Reports Journal Article Research Support, Non-U.S. Gov't 2012 07 03 United States Neurology 0401060 0028-3878 0 GABA Modulators 5PE9FDE8GB Clonazepam AIM IM Age of Onset Aged Alcohol Drinking Clonazepam therapeutic use Electromyography Essential Tremor drug therapy genetics physiopathology GABA Modulators therapeutic use Humans Male Muscle, Skeletal innervation physiopathology Neurologic Examination Posture physiology Siblings 2012 7 6 6 0 2012 7 6 (...) Familial Orthostatic Tremor: An Additional Report in Siblings. 22764256 2012 10 03 2018 11 13 1526-632X 79 3 2012 Jul 17 Neurology Neurology Familial orthostatic tremor: an additional report in siblings. 288-9 10.1212/WNL.0b013e31825fdfb3 Virmani Tuhin T Department of Neurology, G.H. Sergievsky Center and Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, College of Physicians and Surgeons, Mailman School of Public Health, Columbia University, New York, NY, USA. Louis Elan

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2012 Neurology

69. Tremor

and older people, but anyone can have them. The cause of tremors is a problem in the parts of the brain that control muscles in the body or in specific parts of the body, such as the hands. They commonly occur in otherwise healthy people. They may also be caused by problems such as Multiple sclerosis Stroke Traumatic brain injury Alcohol abuse and withdrawal Certain medicines Some forms are inherited and run in families. Others have no known cause. There is no cure for most tremors. Treatment to relieve (...) Tremor Tremor Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Tremor Tremor Aka: Tremor From Related Chapters II. Definition Body part

2015 FP Notebook

70. Alcohol - problem drinking

drinking gulidelines will not usually seek medical help, even though they may be aware that their drinking is putting them at risk. Incidental findings that raise suspicion of problem drinking may include: Abnormal blood tests such as a raised gamma-glutamyl transferase (GGT) and mean corpuscular volume (MCV). Signs of an alcohol problem, such as dilated facial capillaries, bloodshot eyes, or hand tremor. Symptoms suggestive of a possible alcohol problem — professionals should be aware (...) to cut down? No Yes, but not in the last year Yes, during the last year Data from: [ ] Symptoms of alcohol withdrawal Symptoms of alcohol withdrawal The symptoms of alcohol withdrawal can vary in severity and include: Mild — hypertension and tachycardia, anorexia, anxiety, emotional lability, insomnia, irritability, diaphoresis, headache, and fine tremor. Moderate — worsening mild symptoms plus agitation and coarse tremor. Severe/delirium tremens — worsening moderate symptoms plus confusion/delirium

2013 NICE Clinical Knowledge Summaries

71. Sodium Oxybate in the Treatment of Alcohol Withdrawal Syndrome: A Randomized Double-Blind Comparative Study versus Oxazepam. The GATE 1 Trial. (PubMed)

Sodium Oxybate in the Treatment of Alcohol Withdrawal Syndrome: A Randomized Double-Blind Comparative Study versus Oxazepam. The GATE 1 Trial. Benzodiazepines (BDZs) are the gold standard in the treatment of alcohol withdrawal syndrome (AWS). Sodium oxybate (SMO) has been tested as a treatment for AWS with encouraging results. The aim of this phase IV, multicenter, randomized, double-blind, double-dummy study was to evaluate the efficacy of SMO in comparison with oxazepam in the treatment (...) of uncomplicated AWS.Alcohol-dependent outpatients (n = 126) affected by uncomplicated AWS according to the Clinical Institute Withdrawal Assessment for Alcohol-revised (CIWA-Ar) scale were enrolled in the study and randomized in two groups: 61 patients received SMO and 65 patients received oxazepam for 10 days. The primary endpoint was the reduction of symptoms of AWS measured by the change in the total CIWA-Ar score from baseline (day 1) to the end of the study (day 10). This study is registered

2014 CNS drugs

72. Fragile X-associated tremor/ataxia phenotype in a male carrier of unmethylated full mutation in the FMR1 gene. (PubMed)

Fragile X-associated tremor/ataxia phenotype in a male carrier of unmethylated full mutation in the FMR1 gene. The Fragile X syndrome is caused by a CGG repeat expansion >200 in the promoter of the Fragile X mental retardation 1 (FMR1) gene termed full mutation (FM). These alleles are silenced through methylation of the FMR1 promoter, leading to deficit of the FMR1 protein (FMRP), and neurodevelopmental changes. However, occasional FM individuals have a complete lack of methylation, and those (...) typically have only minor deficit of FMRP levels compared with normal controls and their intelligence may be in the normal range. FM alleles are generated through expansion of the CGG repeat from the premutation (PM) range of 55-200 repeats, linked to the late onset Fragile X-associated tremor/ataxia syndrome (FXTAS). This disorder has been attributed to a 'toxicity' of the FMR1 mRNA, which is significantly elevated in male carriers of PM alleles and of unmethylated FM alleles. This is the first report

2011 Clinical Genetics

73. Octanoic Acid for Essential Tremor

: Background: - Essential tremor (ET) is a condition of out-of-control shaking. Several drugs are used to treat ET. However, they are often only partly helpful and can have side effects. Many people with ET get some relief from drinking alcohol. Octanol, a food additive similar to alcohol, can improve tremor in animals and is less likely to make people feel drunk. One form of octanol, called 1-octanol, has been shown to improve tremor in some people and had few side effects. 1-octanol is converted (...) to octanoic acid, and research suggests that octanoic acid itself might suppress ET with no significant side effects such as drunkenness. Researchers want to see what dose of octanoic acid is most useful in reducing ET. Objectives: - To test different doses of octanoic acid to treat essential tremor. Eligibility: Individuals at least 21 years of age who have ET that responds to treatment with alcohol. Participants must be able to stop taking certain ET medications during the study. Design: This study

2011 Clinical Trials

74. Switching Study of Kidney Transplant Patients With Tremor to LCP-Tacro (STRATO)

Switching Study of Kidney Transplant Patients With Tremor to LCP-Tacro (STRATO) Switching Study of Kidney Transplant Patients With Tremor to LCP-Tacro (STRATO) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Switching Study of Kidney Transplant Patients With Tremor to LCP-Tacro (STRATO) (STRATO) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01438710 Recruitment Status : Completed First Posted : September 22, 2011 Results First Posted : May 8, 2015 Last Update Posted : October 1, 2015 Sponsor: Veloxis

2011 Clinical Trials

75. Comparative evaluation of treatments of alcohol withdrawal syndromes. (PubMed)

Paraldehyde AIM IM Alcoholism therapy Chloral Hydrate therapeutic use Chlordiazepoxide adverse effects therapeutic use Drug Synergism Ethanol therapeutic use Fever etiology Humans Male Middle Aged Paraldehyde therapeutic use Pneumonia etiology Promazine adverse effects therapeutic use Psychoses, Alcoholic drug therapy Seizures etiology Tremor drug therapy 1967 7 10 1967 7 10 0 1 1967 7 10 0 0 ppublish 6072348 (...) Comparative evaluation of treatments of alcohol withdrawal syndromes. 6072348 1967 12 15 2016 10 17 0098-7484 201 2 1967 Jul 10 JAMA JAMA Comparative evaluation of treatments of alcohol withdrawal syndromes. 99-102 Golbert T M TM Sanz C J CJ Rose H D HD Leitschuh T H TH eng Clinical Trial Comparative Study Journal Article Randomized Controlled Trial United States JAMA 7501160 0098-7484 3K9958V90M Ethanol 418M5916WG Chloral Hydrate 6RZ6XEZ3CR Chlordiazepoxide O9M39HTM5W Promazine S6M3YBG8QA

1967 JAMA

76. Alcoholic Ketoacidosis (Follow-up)

be considered only in the face of severe, life-threatening acidosis (ie, pH < 7.1) that is unresponsive to fluid therapy. Previous Next: Management of Alcohol Withdrawal Syndrome Evaluate the patient for signs of alcohol withdrawal syndrome, which may include the following: Tremors Agitation Diaphoresis Tachycardia Hypertension Tremors Agitation Seizures Delirium Exclude other causes of autonomic hyperactivity and altered mental status. If the diagnosis of alcohol withdrawal syndrome is established (...) Alcoholic Ketoacidosis (Follow-up) Alcoholic Ketoacidosis Treatment & Management: Approach Considerations, Treatment of Severe Acidosis, Management of Alcohol Withdrawal Syndrome Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache

2014 eMedicine.com

77. Alcohol-Related Psychosis (Diagnosis)

Alcohol-Related Psychosis (Diagnosis) Alcohol-Related Psychosis: Background, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjg5ODQ4LW92ZXJ2aWV3 processing > Alcohol-Related Psychosis (...) Updated: Dec 01, 2017 Author: Zhongshu Yang, MD, PhD; Chief Editor: Ana Hategan, MD, FRCPC Share Email Print Feedback Close Sections Sections Alcohol-Related Psychosis Overview Background Alcohol-related psychosis is a secondary psychosis that manifests as prominent hallucinations and delusions occurring in a variety of alcohol-related conditions. For patients with alcohol use disorder, previously known as alcohol abuse and alcohol dependence, psychosis can occur during phases of acute intoxication

2014 eMedicine.com

78. Alcoholism (Diagnosis)

. The following are signs and symptoms of alcohol withdrawal: Nausea and vomiting Diaphoresis Agitation and anxiety Headache Tremor Seizures Visual and auditory hallucinations: Many patients who are not disoriented—and who therefore do not have delirium tremens—have hallucinations The following are signs of delirium tremens (ie, alcohol withdrawal delirium): Tachycardia and hypertension Temperature elevation Delirium The following are signs of chronic alcoholism: Gynecomastia Spider angiomata Dupuytren (...) is withdrawn, the central nervous system experiences increased excitability. Persons who abuse alcohol over the long term are more prone to alcohol withdrawal syndrome than persons who have been drinking for only short periods. Brain excitability caused by long-term alcohol ingestion can lead to cell death and cerebellar degeneration, Wernicke-Korsakoff syndrome, tremors, alcoholic hallucinosis, delirium tremens, and withdrawal seizures. Opiate receptors are increased in the brains of recently abstinent

2014 eMedicine.com

79. Alcoholic Ketoacidosis (Treatment)

be considered only in the face of severe, life-threatening acidosis (ie, pH < 7.1) that is unresponsive to fluid therapy. Previous Next: Management of Alcohol Withdrawal Syndrome Evaluate the patient for signs of alcohol withdrawal syndrome, which may include the following: Tremors Agitation Diaphoresis Tachycardia Hypertension Tremors Agitation Seizures Delirium Exclude other causes of autonomic hyperactivity and altered mental status. If the diagnosis of alcohol withdrawal syndrome is established (...) Alcoholic Ketoacidosis (Treatment) Alcoholic Ketoacidosis Treatment & Management: Approach Considerations, Treatment of Severe Acidosis, Management of Alcohol Withdrawal Syndrome Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache

2014 eMedicine.com

80. Alcoholism (Overview)

. The following are signs and symptoms of alcohol withdrawal: Nausea and vomiting Diaphoresis Agitation and anxiety Headache Tremor Seizures Visual and auditory hallucinations: Many patients who are not disoriented—and who therefore do not have delirium tremens—have hallucinations The following are signs of delirium tremens (ie, alcohol withdrawal delirium): Tachycardia and hypertension Temperature elevation Delirium The following are signs of chronic alcoholism: Gynecomastia Spider angiomata Dupuytren (...) is withdrawn, the central nervous system experiences increased excitability. Persons who abuse alcohol over the long term are more prone to alcohol withdrawal syndrome than persons who have been drinking for only short periods. Brain excitability caused by long-term alcohol ingestion can lead to cell death and cerebellar degeneration, Wernicke-Korsakoff syndrome, tremors, alcoholic hallucinosis, delirium tremens, and withdrawal seizures. Opiate receptors are increased in the brains of recently abstinent

2014 eMedicine.com

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