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Alcohol Tremor

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41. Risk Factors for Cognitive Impairment in Fragile X-Associated Tremor/Ataxia Syndrome Full Text available with Trip Pro

Risk Factors for Cognitive Impairment in Fragile X-Associated Tremor/Ataxia Syndrome Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disease with motor, psychiatric, and cognitive manifestations that occurs in carriers of the fragile X mental retardation 1 ( FMR1) gene premutations. This was a retrospective chart review of 196 individuals (127 men and 69 women) with FXTAS. Forty-six (23%) participants were cognitively impaired, of whom 19 (10%) had dementia (...) . Risk factors for dementia were examined (CGG repeat size; alcohol, benzodiazepine, and opioid use; diabetes; hyperlipidemia; hypertension; hypothyroidism; obesity; sleep apnea; surgeries with general anesthesia; depression; family history of dementia). Thirteen individuals with FXTAS and dementia were then compared to 13 cognitively intact individuals matched on age, gender, and FXTAS stage. CGG repeat size was significantly higher (mean = 98.5, standard deviation [SD] = 22.2) in the dementia group

2016 Journal of Geriatric Psychiatry and Neurology

42. Tremor and hand-arm vibration syndrome (HAVS) in road maintenance workers Full Text available with Trip Pro

Tremor and hand-arm vibration syndrome (HAVS) in road maintenance workers The aim of this study was to evaluate postural and rest tremor among workers using vibrating hand tools, taking into account the possible effects of toxicants such as alcohol and tobacco. A further aim was to study workers diagnosed with hand-arm vibration syndrome (HAVS) at the time of examination.This study comprises 103 road maintenance workers, 55 exposed to vibrating hand tools (age 41.0 years; range 21-62) and 48 (...) referents (age 38.5 years; range 19-64). They were examined with the CATSYS Tremor Pen®. Exposure to vibrating tools and serum biomarkers of alcohol and tobacco consumption were measured.Cumulative exposure to vibrating tools was associated with increased postural (p < 0.01) and rest tremor (p < 0.05) and with a higher Center Frequency of postural tremor (p < 0.01) among smokers and users of smokeless tobacco. Rest tremor Center Frequency was higher than postural tremor frequency (p < 0.001).The main

2016 International archives of occupational and environmental health

43. Public Knowledge and Attitude toward Essential Tremor: A Questionnaire Survey Full Text available with Trip Pro

/3 were either unsure or thought ET was the same disease as PD, 1/4 thought that ET was the same condition as frailty- or aging-associated tremor, 2/3 attributed it to odd causes (e.g., trauma or alcohol abuse), only 1/3 knew of the existence of therapeutic brain surgery, fewer than 1/2 knew that children could have ET, and 3/4 did not know of a celebrity or historical figure with ET. Hence, lack of knowledge and misconceptions were common.Public knowledge of the existence and features of ET (...) Public Knowledge and Attitude toward Essential Tremor: A Questionnaire Survey Public awareness of and attitude toward disease is an important issue for patients. Public awareness of essential tremor (ET) has never been studied.We administered a 10-min, 31-item questionnaire to 250 consecutive enrollees. These included three samples carefully chosen to have a potential range of awareness of ET: 100 individuals ascertained from a vascular disease clinic, 100 individuals from a general neurology

2016 Frontiers in neurology

44. A Study of Tolerability and Efficacy of Cannabidiol on Tremor in Parkinson's Disease

A Study of Tolerability and Efficacy of Cannabidiol on Tremor in Parkinson's Disease A Study of Tolerability and Efficacy of Cannabidiol on Tremor in Parkinson's Disease - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. A Study of Tolerability and Efficacy of Cannabidiol on Tremor in Parkinson's Disease The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02818777 Recruitment Status : Completed First Posted : June 30, 2016 Results First Posted : February 19, 2019 Last Update Posted : February 19, 2019 Sponsor

2016 Clinical Trials

45. A step toward essential tremor gene discovery: identification of extreme phenotype and screening of HTRA2 and ANO3. Full Text available with Trip Pro

patients suspected with ET were prospectively included in a prospective, monocentric study. Family history, age at onset (AAO), features of tremor, benefit of alcohol and drugs, electrophysiological recording findings were collected. Sanger sequencing was performed for HTRA2 and ANO3 mutations screening.Sixty eight patients were investigated. Fourteen diagnosed with psychogenic (5) or dystonic tremor (9) were excluded. Regarding the 54 ET patients, mean AAO was 48 years (6-77), and mean disease (...) A step toward essential tremor gene discovery: identification of extreme phenotype and screening of HTRA2 and ANO3. Essential tremor (ET) is characterized by a frequent family history. No monogenic form of ET has been identified. We aimed at exploring ET patients to identify distinct subgroups and facilitate the identification of ET genes. We tested for the presence of HTRA2 p.G399S, and ANO3 p. W490C, p. R484 W and p. S685G mutations.Between June 2011 and November 2013, all consecutive

2016 BMC Neurology

46. Can Biological markers predict Alcohol Withdrawal

presenting to the ED] are [CDT, Gamma GT and MCV reliable biological markers] at [predicting patients likely to suffer alcohol withdrawal syndrome?] Clinical Scenario A 47 year old female patient is brought to your ED. She admits to regular alcohol consumption, is tachycardic with extremities tremor and ataxia. She asks you for something to help her with her symptoms. She has not drunk any alcohol for two days. You wonder if any biological marker would allow you to predict if she is really at risk (...) Can Biological markers predict Alcohol Withdrawal BestBets: Can Biological markers predict Alcohol Withdrawal Can Biological markers predict Alcohol Withdrawal Report By: Neal Larkman - Medical Student Search checked by Dr John-Paul Williamson - Registrar Emergency Medicine Institution: Manchester Royal Infirmary Date Submitted: 28th June 2007 Date Completed: 24th July 2013 Last Modified: 24th July 2013 Status: Green (complete) Three Part Question In [Adult patients with chronic alcohol abuse

2013 BestBETS

47. The Essential Tremor (ET) and Parkinson Disease (PD) Tremor Acute Stimulation Study

The Essential Tremor (ET) and Parkinson Disease (PD) Tremor Acute Stimulation Study The Essential Tremor (ET) and Parkinson Disease (PD) Tremor Acute Stimulation Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. The Essential Tremor (ET) and Parkinson Disease (PD) Tremor Acute Stimulation Study The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01940406 Recruitment Status : Withdrawn (Internal desicions) First Posted : September 12, 2013 Last Update Posted : February 23, 2018 Sponsor: Rainbow

2013 Clinical Trials

48. Functional Outcomes of Awake vs. Asleep Deep Brain Stimulation (DBS) for Essential Tremor

Volunteers: Yes Criteria Inclusion Criteria: Essential Tremor diagnosed by criteria listed in the Consensus statement of the Movement Disorders Society on Tremor Age 18 - 85 years of age Motor skills allowing for capability to complete evaluations Medically cleared for undergoing anesthesia and DBS surgery Exclusion Criteria: Dementia per DSM-V criteria Medical or other condition precluding MRI History of supraspinal CNS disease other than Essential Tremor Alcohol use of more than 4 drinks per day (...) Functional Outcomes of Awake vs. Asleep Deep Brain Stimulation (DBS) for Essential Tremor Functional Outcomes of Awake vs. Asleep Deep Brain Stimulation (DBS) for Essential Tremor - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2015 Clinical Trials

49. Deep braIn Stimulation for Tremor TractographIC Versus Traditional

Deep braIn Stimulation for Tremor TractographIC Versus Traditional Deep braIn Stimulation for Tremor TractographIC Versus Traditional - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Deep braIn Stimulation (...) for Tremor TractographIC Versus Traditional (DISTINCT) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT02491554 Recruitment Status : Recruiting First Posted : July 8, 2015 Last Update Posted : November 13, 2017 See Sponsor

2015 Clinical Trials

50. An Efficacy/Safety Study of Perampanel for Reducing Essential Tremor

An Efficacy/Safety Study of Perampanel for Reducing Essential Tremor An Efficacy/Safety Study of Perampanel for Reducing Essential Tremor - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. An Efficacy/Safety (...) Study of Perampanel for Reducing Essential Tremor The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02668146 Recruitment Status : Unknown Verified September 2016 by Adrian Handforth, MD, VA Greater Los Angeles Healthcare System. Recruitment status was: Active, not recruiting First Posted : January 29

2015 Clinical Trials

51. Cala ONE Device for Essential Tremor

medical device, such as a pacemaker, defibrillator, or deep brain stimulator Previous thalamotomy procedure, including Stereotactic Thalamotomy, Gamma Knife Radiosurgical Thalamotomy, and focused ultrasound, for the treatment of tremor Suspected or diagnosed epilepsy or other seizure disorder Pregnant Swollen, infected, inflamed areas, or skin eruptions, open wounds, or cancerous lesions of skin at stimulation site Peripheral neuropathy affecting the tested upper extremity Alcoholism (score of 4 (...) to study enrollment Botulinum Toxin injection for hand tremor within 6 months prior to study enrollment Current participation in any other interventional research study Previous participation in any other Cala Health interventional research study Alcohol or caffeine consumption within 12 hours of study enrollment Subjects already taking medications for their essential tremor will remain on their medications during the study with no changes in medication type or dosage levels. Contacts and Locations Go

2015 Clinical Trials

52. Cognitive demands during quiet standing elicit truncal tremor in two frequency bands: differential relations to tissue integrity of corticospinal tracts and cortical targets Full Text available with Trip Pro

. As cerebellar system disruption is a common concomitant of alcoholism, we examined 46 alcoholics and 43 controls with a force platform to derive physiological indices of quiet standing during cognitive (solving simple, mental arithmetic problems) and visual (eyes closed) challenges. Also tested were relations between tremor velocity and regional gray matter and white matter tissue quality measured with the diffusion tensor imaging (DTI) metric of mean diffusivity (MD), indexing disorganized microstructure (...) . Spectral analysis of sway revealed greater tremor in alcoholic men than alcoholic women or controls. Cognitive dual-tasking elicited excessive tremor in two frequency bands, each related to DTI signs of degradation in separate brain systems: tremor velocity at a low frequency (2-5 Hz/0-2 Hz) correlated with higher MD in the cerebellar hemispheres and superior cingulate bundles, whereas tremor velocity at a higher frequency (5-7 Hz) correlated with higher MD in the motor cortex and internal capsule

2015 Frontiers in human neuroscience

53. Lead Exposure and Tremor among Older Men: The VA Normative Aging Study Full Text available with Trip Pro

lead and bone lead-a biomarker of cumulative lead exposure.We measured tibia (n = 670) and patella (n = 672) bone lead and blood lead (n = 807) among older men (age range, 50-98 years) in the VA Normative Aging Study cohort. A tremor score was created based on an approach using hand-drawing samples. ALAD genotype was dichotomized as ALAD-2 carriers or not. We used linear regression adjusted for age, education, smoking, and alcohol intake to estimate the associations between lead biomarkers (...) Lead Exposure and Tremor among Older Men: The VA Normative Aging Study Tremor is one of the most common neurological signs, yet its etiology is poorly understood. Case-control studies suggest an association between blood lead and essential tremor, and that this association is modified by polymorphisms in the δ-aminolevulinic acid dehydrogenase (ALAD) gene.We aimed to examine the relationship between lead and tremor, including modification by ALAD, in a prospective cohort study, using both blood

2015 Environmental health perspectives

54. Ketogenic Diet (KD) in Alcoholism

Institutes of Health Clinical Center (CC) ( National Institute on Alcohol Abuse and Alcoholism (NIAAA) ) Study Details Study Description Go to Brief Summary: Background: A ketogenic diet (KD) is high in fat and low in carbohydrates. Research has shown that a KD can lessen tremor in animals withdrawing from alcohol. KD can also help people who have difficulties with thinking, sleep, and mood. Researchers want to see if KD can lessen symptoms of alcohol withdrawal in people with alcohol use disorder (...) Ketogenic Diet (KD) in Alcoholism Ketogenic Diet (KD) in Alcoholism - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Ketogenic Diet (KD) in Alcoholism The safety and scientific validity of this study

2017 Clinical Trials

55. Octanoic Acid Suppresses Harmaline-Induced Tremor in Mouse Model of Essential Tremor Full Text available with Trip Pro

Octanoic Acid Suppresses Harmaline-Induced Tremor in Mouse Model of Essential Tremor Recent work exploring the use of high-molecular weight alcohols to treat essential tremor (ET) has identified octanoic acid as a potential novel tremor-suppressing agent. We used an established harmaline-based mouse model of ET to compare tremor suppression by 1-octanol and octanoic acid. The dose-related effect on digitized motion power within the tremor bandwidth as a fraction of overall motion power (...) was analyzed. Both 1-octanol and octanoic acid provided significant reductions in harmaline tremor. An 8-carbon alkyl alcohol and carboxylic acid each suppress tremor in a pre-clinical mouse model of ET. Further studies are warranted to determine the safety and efficacy of such agents in humans with ET.

2012 Neurotherapeutics

56. Harmaline Tremor: Underlying Mechanisms in a Potential Animal Model of Essential Tremor Full Text available with Trip Pro

are not required. Enhanced synaptic norepinephrine or blockade of ionic glutamate receptors suppresses tremor, whereas enhanced synaptic serotonin exacerbates tremor. Benzodiazepines and muscimol suppress tremor. Alcohol suppresses harmaline tremor but exacerbates harmaline-associated neural damage. Recent investigations on the mechanism of harmaline tremor have focused on the T-type calcium channel.Like essential tremor, harmaline tremor involves the cerebellum, and classic medications for essential tremor (...) Harmaline Tremor: Underlying Mechanisms in a Potential Animal Model of Essential Tremor Harmaline and harmine are tremorigenic β-carbolines that, on administration to experimental animals, induce an acute postural and kinetic tremor of axial and truncal musculature. This drug-induced action tremor has been proposed as a model of essential tremor. Here we review what is known about harmaline tremor.Using the terms harmaline and harmine on PubMed, we searched for papers describing the effects

2012 Tremor and Other Hyperkinetic Movements

57. Alcohol Withdrawal

) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Alcohol Withdrawal Delirium (C0001957) Definition (MSH) An acute organic mental disorder induced by cessation or reduction in chronic alcohol consumption. Clinical characteristics include CONFUSION; DELUSIONS; vivid HALLUCINATIONS; TREMOR; agitation; insomnia; and signs of autonomic hyperactivity (e.g., elevated blood pressure and heart rate, dilated pupils, and diaphoresis). This condition may (...) occasionally be fatal. It was formerly called delirium tremens. (From Adams et al., Principles of Neurology, 6th ed, p1175) Definition (PSY) Acute alcoholic, psychotic condition characterized by intense tremors, anxiety, hallucinations, and delusions. Concepts Disease or Syndrome ( T047 ) MSH ICD9 291.0 ICD10 SnomedCT 192211007 , 154853008 , 8635005 DSM4 291.0 English Delirium Tremens , Delirium, Alcohol Withdrawal , Men & behav dis due alcohl: withdrawl state with delirium , Mental and behavioral

2018 FP Notebook

58. Deep Brain Stimulation (DBS) for the Suppression of Tremor

Deep Brain Stimulation (DBS) for the Suppression of Tremor Deep Brain Stimulation (DBS) for the Suppression of Tremor - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Deep Brain Stimulation (DBS (...) ) for the Suppression of Tremor The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02087046 Recruitment Status : Unknown Verified February 2015 by Abbott Medical Devices. Recruitment status was: Active, not recruiting First Posted : March 14, 2014 Last Update Posted : March 2, 2015 Sponsor: Abbott Medical Devices

2014 Clinical Trials

59. Experimental Therapeutics in Essential Tremor Using Cerebellar Transcranial Direct Current Stimulation

Experimental Therapeutics in Essential Tremor Using Cerebellar Transcranial Direct Current Stimulation Experimental Therapeutics in Essential Tremor Using Cerebellar Transcranial Direct Current Stimulation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Experimental Therapeutics in Essential Tremor Using Cerebellar Transcranial Direct Current Stimulation (ELECTRE2) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02052271 Recruitment Status : Unknown Verified April 2016 by Institut National de la Santé Et

2014 Clinical Trials

60. Botulinum Toxin A to Treat Arm Tremor

should be reached 4 weeks before screening and intended for the time during the study drug evaluation. Trauma to the central nervous system or the nerves of the target limb within the three months preceding the onset of tremor. Evidence of psychogenic origins of tremor. Life habits (e.g. smoking, alcohol or substance abuse) prejudicial to study participation. Prior surgery to treat tremor Recent (16 weeks) treatment with any Botulinum toxin product for any reason. Relevant recent or planned surgery (...) Botulinum Toxin A to Treat Arm Tremor Botulinum Toxin A to Treat Arm Tremor - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Botulinum Toxin A to Treat Arm Tremor The safety and scientific validity

2014 Clinical Trials

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