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Alcohol Tremor

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21. Alcohol: Adult Unhealthy Drinking

. • For most patients, alcohol withdrawal may be managed within Primary Care in an outpatient setting, provided the patient has a reliable support network. • Pharmacologic treatment of alcohol withdrawal may be considered for patients with moderate or severe withdrawal symptoms, including increased systolic blood pressure, fever, tachycardia, agitation, insomnia, and tremors. 3 Background In the United States, the estimated prevalence of unhealthy drinking—which includes risky drinking and alcohol use (...) of alcohol withdrawal include anxiety, restlessness, tremor, insomnia, headache, palpitations, gastrointestinal disturbances, sweating, increased systolic blood pressure, rapid breathing, tachycardia, mild fever, problems with memory, and confusion. Withdrawal seizures, when they occur, begin within 48 hours of cessation of alcohol use. Delirium tremens—the most severe form of withdrawal—has a later onset, at 3–5 days after cessation of drinking. If untreated, delirium is associated with high mortality

2016 Kaiser Permanente Clinical Guidelines

22. Clinical and Physiological Studies of Tremor Syndromes

to not drink caffeine or alcohol for 12 hours before phenotyping and selected thematic study visits because both agents can modify brain activity and may confound outcome measures. INCLUSION CRITERIA FOR HEALTHY VOLUNTEERS: Age 18 or older. Able to give informed consent. Agree to not consume caffeine or alcohol for 12 hours before selected thematic study visits because both agents may modify the activity of the brain during the study. EXCLUSION CRITERIA FOR TREMOR PATIENTS: Problematic alcohol use (...) , as defined by a score of 8 or higher on the WHO Alcohol Use Disorders Identification Test (AUDIT). History of a brain tumor, a stroke, traumatic brain injury, epilepsy or a history of seizures. History of psychotic disorder, Bipolar Disorder or a current depressive episode. History or clinical evidence of another neurologic disorder than a tremor syndrome as defined above, which may interfere with the ability to comply with protocol requirements or interpret the obtained results. EXCLUSION CRITERIA

2017 Clinical Trials

23. Sodium Oxybate in Spasmodic Dysphonia and Voice Tremor

or present history of the following conditions will be excluded from the study; Except for SD and dystonic VT, any neurological disorders, such as stroke, movement disorders, brain tumors, traumatic brain injury with loss of consciousness, ataxias, myopathies, myasthenia gravis, demyelinating diseases, alcoholism, drug dependence. Patients with tremor affecting other body parts will be excluded from the study. All patients who have dystonic movements in the body regions other than the larynx (...) Sodium Oxybate in Spasmodic Dysphonia and Voice Tremor Sodium Oxybate in Spasmodic Dysphonia and Voice Tremor - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Sodium Oxybate in Spasmodic Dysphonia and Voice

2017 Clinical Trials

24. A Phase 2 RCT Study of CX-8998 for Essential Tremor

cause or explain subject's tremor, including, but not limited to: a. Parkinson's disease b. dystonia c. cerebellar disease, other than essential tremor d. Traumatic Brain Injury e. alcohol abuse or withdrawal f. mercury poisoning g. hyperthyroidism h. pheochromocytoma i. head trauma or cerebrovascular disease within 3 months prior to the onset of essential tremor j. multiple sclerosis k. polyneuropathy l. family history of Fragile X syndrome Prior MR-guided Focused Ultrasound or surgical (...) Inability to refrain from use of medication/substance(s) that might produce tremor or interfere with the evaluation of tremor on study visit days, such as but not limited to stimulant decongestants, beta-agonist bronchodilators, caffeine, alcohol and tobacco, based on Investigator assessment at baseline. Positive urine drug screen. Regular use of more than two units of alcohol per day. Sporadic use of a benzodiazepine, sleep medication or anxiolytic to improve sleep performance. Stable use

2017 Clinical Trials

25. A Pilot Study of the Cala ONE Device for Essential Tremor

or above in any one of the hand items) Currently or previously prescribed either propranolol or primidone for the treatment of essential tremor Stable dose of tremor medications for 30 days prior to study entry Stable dose of antidepressant medications for 90 days prior to study entry Willing to comply with study protocol requirements including: remaining on a stable dosage of tremor and antidepressant medications, if applicable, during the duration of the study; no significant alcohol or caffeine (...) A Pilot Study of the Cala ONE Device for Essential Tremor A Pilot Study of the Cala ONE Device for Essential Tremor - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Pilot Study of the Cala ONE Device

2017 Clinical Trials

26. Risk Factors for Cognitive Impairment in Fragile X-Associated Tremor/Ataxia Syndrome (PubMed)

Risk Factors for Cognitive Impairment in Fragile X-Associated Tremor/Ataxia Syndrome Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disease with motor, psychiatric, and cognitive manifestations that occurs in carriers of the fragile X mental retardation 1 ( FMR1) gene premutations. This was a retrospective chart review of 196 individuals (127 men and 69 women) with FXTAS. Forty-six (23%) participants were cognitively impaired, of whom 19 (10%) had dementia (...) . Risk factors for dementia were examined (CGG repeat size; alcohol, benzodiazepine, and opioid use; diabetes; hyperlipidemia; hypertension; hypothyroidism; obesity; sleep apnea; surgeries with general anesthesia; depression; family history of dementia). Thirteen individuals with FXTAS and dementia were then compared to 13 cognitively intact individuals matched on age, gender, and FXTAS stage. CGG repeat size was significantly higher (mean = 98.5, standard deviation [SD] = 22.2) in the dementia group

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2016 Journal of Geriatric Psychiatry and Neurology

27. Tremor and hand-arm vibration syndrome (HAVS) in road maintenance workers (PubMed)

Tremor and hand-arm vibration syndrome (HAVS) in road maintenance workers The aim of this study was to evaluate postural and rest tremor among workers using vibrating hand tools, taking into account the possible effects of toxicants such as alcohol and tobacco. A further aim was to study workers diagnosed with hand-arm vibration syndrome (HAVS) at the time of examination.This study comprises 103 road maintenance workers, 55 exposed to vibrating hand tools (age 41.0 years; range 21-62) and 48 (...) referents (age 38.5 years; range 19-64). They were examined with the CATSYS Tremor Pen®. Exposure to vibrating tools and serum biomarkers of alcohol and tobacco consumption were measured.Cumulative exposure to vibrating tools was associated with increased postural (p < 0.01) and rest tremor (p < 0.05) and with a higher Center Frequency of postural tremor (p < 0.01) among smokers and users of smokeless tobacco. Rest tremor Center Frequency was higher than postural tremor frequency (p < 0.001).The main

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2016 International archives of occupational and environmental health

28. A Study of Tolerability and Efficacy of Cannabidiol on Tremor in Parkinson's Disease

A Study of Tolerability and Efficacy of Cannabidiol on Tremor in Parkinson's Disease A Study of Tolerability and Efficacy of Cannabidiol on Tremor in Parkinson's Disease - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. A Study of Tolerability and Efficacy of Cannabidiol on Tremor in Parkinson's Disease The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02818777 Recruitment Status : Completed First Posted : June 30, 2016 Results First Posted : February 19, 2019 Last Update Posted : February 19, 2019 Sponsor

2016 Clinical Trials

29. A step toward essential tremor gene discovery: identification of extreme phenotype and screening of HTRA2 and ANO3. (PubMed)

patients suspected with ET were prospectively included in a prospective, monocentric study. Family history, age at onset (AAO), features of tremor, benefit of alcohol and drugs, electrophysiological recording findings were collected. Sanger sequencing was performed for HTRA2 and ANO3 mutations screening.Sixty eight patients were investigated. Fourteen diagnosed with psychogenic (5) or dystonic tremor (9) were excluded. Regarding the 54 ET patients, mean AAO was 48 years (6-77), and mean disease (...) A step toward essential tremor gene discovery: identification of extreme phenotype and screening of HTRA2 and ANO3. Essential tremor (ET) is characterized by a frequent family history. No monogenic form of ET has been identified. We aimed at exploring ET patients to identify distinct subgroups and facilitate the identification of ET genes. We tested for the presence of HTRA2 p.G399S, and ANO3 p. W490C, p. R484 W and p. S685G mutations.Between June 2011 and November 2013, all consecutive

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2016 BMC Neurology

30. Tremor

and older people, but anyone can have them. The cause of tremors is a problem in the parts of the brain that control muscles in the body or in specific parts of the body, such as the hands. They commonly occur in otherwise healthy people. They may also be caused by problems such as Multiple sclerosis Stroke Traumatic brain injury Alcohol abuse and withdrawal Certain medicines Some forms are inherited and run in families. Others have no known cause. There is no cure for most tremors. Treatment to relieve (...) Tremor Tremor Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Tremor Tremor Aka: Tremor From Related Chapters II. Definition Body part

2018 FP Notebook

31. Early- and late-onset essential tremor patients represent clinically distinct subgroups. (PubMed)

and mathematical analysis of the age-at-onset distribution. Tremor severity in both groups was comparable. Tremor progression measured as Archimedes spiral score and the Fahn-Tolosa-Marin subscales divided by the disease duration in 10-year bins was significantly faster in late-onset patients when compared with early-onset patients. Early-onset patients more frequently reported a positive family history and alcohol sensitivity of the tremor.The age-at-onset distribution suggests a distinction between early (...) - and late-onset tremor. Early-onset and late-onset essential tremor differ in the progression rates and the frequencies of a positive family history and history of a positive effect of alcohol on tremor. © 2016 International Parkinson and Movement Disorder Society.© 2016 International Parkinson and Movement Disorder Society.

2016 Movement Disorders

32. Public Knowledge and Attitude toward Essential Tremor: A Questionnaire Survey (PubMed)

/3 were either unsure or thought ET was the same disease as PD, 1/4 thought that ET was the same condition as frailty- or aging-associated tremor, 2/3 attributed it to odd causes (e.g., trauma or alcohol abuse), only 1/3 knew of the existence of therapeutic brain surgery, fewer than 1/2 knew that children could have ET, and 3/4 did not know of a celebrity or historical figure with ET. Hence, lack of knowledge and misconceptions were common.Public knowledge of the existence and features of ET (...) Public Knowledge and Attitude toward Essential Tremor: A Questionnaire Survey Public awareness of and attitude toward disease is an important issue for patients. Public awareness of essential tremor (ET) has never been studied.We administered a 10-min, 31-item questionnaire to 250 consecutive enrollees. These included three samples carefully chosen to have a potential range of awareness of ET: 100 individuals ascertained from a vascular disease clinic, 100 individuals from a general neurology

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2016 Frontiers in neurology

33. Alcohol challenge and sensitivity to change of the essential tremor rating assessment scale. (PubMed)

Alcohol challenge and sensitivity to change of the essential tremor rating assessment scale. The ability of the Essential Tremor (ET) Rating Assessment Scale (TETRAS) to detect changes in tremor severity is unknown.Fifteen adult ET patients received a single oral ethanol dose calculated to reach 0.05 g/dL breath alcohol content (brAC). Effects were investigated independently with accelerometry and TETRAS.Accelerometry data were log-transformed and a cumulative score logACC(R+L) was calculated

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2013 Movement Disorders

34. Octanoic acid in alcohol-responsive essential tremor: A randomized controlled study. (PubMed)

Octanoic acid in alcohol-responsive essential tremor: A randomized controlled study. To assess safety and efficacy of an oral, single, low dose of octanoic acid (OA) in subjects with alcohol-responsive essential tremor (ET).We conducted a double-blind, placebo-controlled, crossover, phase I/II clinical trial evaluating the effect of 4 mg/kg OA in 19 subjects with ET. The primary outcome was accelerometric postural tremor power of the dominant hand 80 minutes after administration. Secondary (...) outcomes included digital spiral analysis, pharmacokinetic sampling, as well as safety measures.OA was safe and well tolerated. Nonserious adverse events were mild (Common Terminology Criteria for Adverse Events grade 1) and equally present after OA and placebo. At the primary outcome, OA effects were not different from placebo. Secondary outcome analyses of digital spiral analysis, comparison across the entire time course in weighted and nonweighted accelerometry, as well as nondominant hand tremor

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2013 Neurology

35. The effects of a novel histamine-3 receptor inverse agonist on essential tremor in comparison to stable levels of alcohol. (PubMed)

The effects of a novel histamine-3 receptor inverse agonist on essential tremor in comparison to stable levels of alcohol. Essential tremor (ET) is a common movement disorder. Animal studies show that histaminergic modulation may affect the pathological processes involved in the generation of ET. Histamine-3 receptor inverse agonists (H3RIA) have demonstrated attenuating effects on ET in the harmaline rat model. In this double-blind, three-way cross-over, single-dose, double-dummy study (...) the effects of 25 mg of a novel H3RIA (MK-0249) and a stable alcohol level (0.6 g L(-1)) were compared with placebo, in 18 patients with ET. Tremor was evaluated using laboratory tremorography, portable tremorography and a clinical rating scale. The Leeds Sleep Evaluation Questionnaire (LSEQ) and a choice reaction time (CRT) test were performed to evaluate potential effects on sleep and attention, respectively. A steady state of alcohol significantly diminished tremor as assessed by laboratory

2012 Journal of psychopharmacology (Oxford, England)

36. The effects of TPA023, a GABAAα2,3 subtype-selective partial agonist, on essential tremor in comparison to alcohol. (PubMed)

The effects of TPA023, a GABAAα2,3 subtype-selective partial agonist, on essential tremor in comparison to alcohol. Essential tremor (ET) is a relatively frequent neurological disorder that responds in some patients to gamma-aminobutyric acid A (GABA(A)) agonists such as the benzodiazepines. Partial subtype-selective GABA(A) agonists may have an improved side effect profile compared to non-selective GABA(A) agonists. However, it is unknown which GABA(A) subtypes are involved in the therapeutic (...) effects of benzodiazepines in ET. The effects of 2 mg TPA023, a GABA(A) α2,3 subtype-selective partial agonist, on ET were compared to the effects of a stable alcohol level (0.6 g/L) and placebo in nine patients with ET. Tremor evaluation included laboratory accelerometry and a performance-based scale. Additional measurements were performed to evaluate other effects on the central nervous system (CNS). Alcohol significantly diminished tremor symptoms in the postural and kinetic condition, as assessed

2012 Journal of psychopharmacology (Oxford, England)

37. Alcohol Tremor

Alcohol Tremor Alcohol Tremor Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Alcohol Tremor Alcohol Tremor Aka: Alcohol Tremor (...) , Alcohol Withdrawal Tremor From Related Chapters II. Epidemiology Rarely a of Contrast with 50% in III. Signs and symptoms Frequency: 6 to 10.5 Hz (Usually > 8 Hz) Contrast with (Usually < 8 Hz) Only hands affected Contrast with Less severe than IV. Management 160 mg per day Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Alcohol Tremor." Click on the image (or right click) to open the source website in a new browser window. Related

2015 FP Notebook

38. Predictors of alcohol responsiveness in dystonia. (PubMed)

to alcohol (p < 0.001). Alcohol responsiveness differed across dystonia subgroups (multifocal/generalized > segmental [p = 0.014]; cervical and laryngeal > cranial and limb [p < 0.001]) and was related to a positive family history of movement disorders (p = 0.001), and presence of tremor (p < 0.001).The association of alcohol responsiveness with a positive family history for movement disorders, generalized dystonia, and an earlier age at onset suggests that patients with dystonia who have an underlying (...) genetic contribution may be more likely to respond beneficially to alcohol. The fact that dystonic tremor may respond to alcohol is in keeping with the observation that the intake of GABAergic drugs may have a beneficial effect in a proportion of patients.© 2018 American Academy of Neurology.

2018 Neurology

39. Correlation Between mMINDS and CIWA-Ar Scoring Tools in Patients With Alcohol Withdrawal Syndrome. (PubMed)

Correlation Between mMINDS and CIWA-Ar Scoring Tools in Patients With Alcohol Withdrawal Syndrome. Many alcohol withdrawal scoring tools are used in hospitalized patients to assess the severity of alcohol withdrawal and guide treatment. The revised Clinical Institute Withdrawal Assessment (CIWA-Ar) and the modified Minnesota Detoxification Scale (mMINDS) are commonly used but have never been correlated.To determine the strength of correlation between the CIWA-Ar and mMINDS scoring tools (...) in patients with alcohol withdrawal syndrome.A single-center, prospective correlation study conducted at a large academic medical center. Patients treated for alcohol withdrawal syndrome according to the Yale Alcohol Withdrawal Protocol were identified daily, and both the CIWA-Ar and mMINDS were administered at each time point required by the protocol. Clinical data were obtained from the electronic medical records.A total of 185 CIWA-Ar and mMINDS scores were collected in 30 patients. The Pearson

2018 American Journal of Critical Care

40. Are Benzodiazepines Effective for Alcohol Withdrawal?

selected results are shown in the Table.) Commentary In the United States, about half of the population reports drinking alcoholic beverages and about 5% drink heav- ily, with alcohol withdrawal symp- toms reported in less than 5% of the general population. 2,3 Acute alcohol withdrawal can produce signi?cant morbidity and occasional mortality. Alcoholwithdrawalsyndromecanbe- gin as early as 6 hours, usually peaks in 1 to 2 days, and can last up to 5 days. Symptoms can include nausea, tremors (...) Are Benzodiazepines Effective for Alcohol Withdrawal? SystematicReviewSnapshot TAKE-HOME MESSAGE When compared with placebo, benzodiazepines offer signi?cant bene?t in preventing alcohol withdrawal seizures. METHODS DATA SOURCES The authors searched Cochrane Drugs and Alcohol Group’ Regis- ter of Trials, PubMed, EMBASE, CINAHL, the American Economic Association’s electronic bibliogra- phy, the reference lists of relevant articles, and relevant conference proceedings and contacted inves

2012 Annals of Emergency Medicine Systematic Review Snapshots

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