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Alcohol Tremor

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21. Sodium Oxybate in Spasmodic Dysphonia and Voice Tremor

or present history of the following conditions will be excluded from the study; Except for SD and dystonic VT, any neurological disorders, such as stroke, movement disorders, brain tumors, traumatic brain injury with loss of consciousness, ataxias, myopathies, myasthenia gravis, demyelinating diseases, alcoholism, drug dependence. Patients with tremor affecting other body parts will be excluded from the study. All patients who have dystonic movements in the body regions other than the larynx (...) Sodium Oxybate in Spasmodic Dysphonia and Voice Tremor Sodium Oxybate in Spasmodic Dysphonia and Voice Tremor - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Sodium Oxybate in Spasmodic Dysphonia and Voice

2017 Clinical Trials

22. Clinical and Physiological Studies of Tremor Syndromes

to not drink caffeine or alcohol for 12 hours before phenotyping and selected thematic study visits because both agents can modify brain activity and may confound outcome measures. INCLUSION CRITERIA FOR HEALTHY VOLUNTEERS: Age 18 or older. Able to give informed consent. Agree to not consume caffeine or alcohol for 12 hours before selected thematic study visits because both agents may modify the activity of the brain during the study. EXCLUSION CRITERIA FOR TREMOR PATIENTS: Problematic alcohol use (...) , as defined by a score of 8 or higher on the WHO Alcohol Use Disorders Identification Test (AUDIT). History of a brain tumor, a stroke, traumatic brain injury, epilepsy or a history of seizures. History of psychotic disorder, Bipolar Disorder or a current depressive episode. History or clinical evidence of another neurologic disorder than a tremor syndrome as defined above, which may interfere with the ability to comply with protocol requirements or interpret the obtained results. EXCLUSION CRITERIA

2017 Clinical Trials

23. A Phase 2 RCT Study of CX-8998 for Essential Tremor

cause or explain subject's tremor, including, but not limited to: a. Parkinson's disease b. dystonia c. cerebellar disease, other than essential tremor d. Traumatic Brain Injury e. alcohol abuse or withdrawal f. mercury poisoning g. hyperthyroidism h. pheochromocytoma i. head trauma or cerebrovascular disease within 3 months prior to the onset of essential tremor j. multiple sclerosis k. polyneuropathy l. family history of Fragile X syndrome Prior MR-guided Focused Ultrasound or surgical (...) Inability to refrain from use of medication/substance(s) that might produce tremor or interfere with the evaluation of tremor on study visit days, such as but not limited to stimulant decongestants, beta-agonist bronchodilators, caffeine, alcohol and tobacco, based on Investigator assessment at baseline. Positive urine drug screen. Regular use of more than two units of alcohol per day. Sporadic use of a benzodiazepine, sleep medication or anxiolytic to improve sleep performance. Stable use

2017 Clinical Trials

24. A Pilot Study of the Cala ONE Device for Essential Tremor

or above in any one of the hand items) Currently or previously prescribed either propranolol or primidone for the treatment of essential tremor Stable dose of tremor medications for 30 days prior to study entry Stable dose of antidepressant medications for 90 days prior to study entry Willing to comply with study protocol requirements including: remaining on a stable dosage of tremor and antidepressant medications, if applicable, during the duration of the study; no significant alcohol or caffeine (...) A Pilot Study of the Cala ONE Device for Essential Tremor A Pilot Study of the Cala ONE Device for Essential Tremor - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Pilot Study of the Cala ONE Device

2017 Clinical Trials

25. Mapping Functional Networks of Brain Activity Using EEG in Patients With Essential Tremor or Parkinson Disease Before and After MR-guided Focused Ultrasound Thalamotomy for Tremor

Mapping Functional Networks of Brain Activity Using EEG in Patients With Essential Tremor or Parkinson Disease Before and After MR-guided Focused Ultrasound Thalamotomy for Tremor Mapping Functional Networks of Brain Activity Using EEG in Patients With Essential Tremor or Parkinson Disease Before and After MR-guided Focused Ultrasound Thalamotomy for Tremor - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results (...) information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Mapping Functional Networks of Brain Activity Using EEG in Patients With Essential Tremor or Parkinson Disease Before and After MR-guided Focused Ultrasound Thalamotomy for Tremor The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing

2016 Clinical Trials

26. Alcohol: Adult Unhealthy Drinking

. • For most patients, alcohol withdrawal may be managed within Primary Care in an outpatient setting, provided the patient has a reliable support network. • Pharmacologic treatment of alcohol withdrawal may be considered for patients with moderate or severe withdrawal symptoms, including increased systolic blood pressure, fever, tachycardia, agitation, insomnia, and tremors. 3 Background In the United States, the estimated prevalence of unhealthy drinking—which includes risky drinking and alcohol use (...) of alcohol withdrawal include anxiety, restlessness, tremor, insomnia, headache, palpitations, gastrointestinal disturbances, sweating, increased systolic blood pressure, rapid breathing, tachycardia, mild fever, problems with memory, and confusion. Withdrawal seizures, when they occur, begin within 48 hours of cessation of alcohol use. Delirium tremens—the most severe form of withdrawal—has a later onset, at 3–5 days after cessation of drinking. If untreated, delirium is associated with high mortality

2016 Kaiser Permanente Clinical Guidelines

27. Alcohol toolkit

Alcohol toolkit A toolkit for improving care June 2015 Alcohol The Royal College of Emergency Medicine: Alcohol Toolkit © The Royal College of Emergency Medicine (2015) 2 Foreword from the President of the Royal College of Emergency Medicine It is a great privilege to introduce this toolkit – the first we have issued as a Royal College - and the subject could not be more worthy. The EM profession has major concerns with current licensing laws, the increased number of retail outlets selling (...) alcohol, the unwelcome association of alcohol sponsorship with major sporting events and the failure, to date, to introduce a minimum unit price for alcohol. Although we have published numerous articles highlighting these concerns, they have mostly appeared in the ‘dull but worthy’ section of national newspapers and hence transited to recycling bins without troubling the intended audience. It is heartening to know that the same fate will not befall this toolkit! Not only is this toolkit comprehensive

2015 Royal College of Emergency Medicine

29. Tremor

and older people, but anyone can have them. The cause of tremors is a problem in the parts of the brain that control muscles in the body or in specific parts of the body, such as the hands. They commonly occur in otherwise healthy people. They may also be caused by problems such as Multiple sclerosis Stroke Traumatic brain injury Alcohol abuse and withdrawal Certain medicines Some forms are inherited and run in families. Others have no known cause. There is no cure for most tremors. Treatment to relieve (...) Tremor Tremor Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Tremor Tremor Aka: Tremor From Related Chapters II. Definition Body part

2018 FP Notebook

30. Alcohol - problem drinking

drinking gulidelines will not usually seek medical help, even though they may be aware that their drinking is putting them at risk. Incidental findings that raise suspicion of problem drinking may include: Abnormal blood tests such as a raised gamma-glutamyl transferase (GGT) and mean corpuscular volume (MCV). Signs of an alcohol problem, such as dilated facial capillaries, bloodshot eyes, or hand tremor. Symptoms suggestive of a possible alcohol problem — professionals should be aware (...) to cut down? No Yes, but not in the last year Yes, during the last year Data from: [ ] Symptoms of alcohol withdrawal Symptoms of alcohol withdrawal The symptoms of alcohol withdrawal can vary in severity and include: Mild — hypertension and tachycardia, anorexia, anxiety, emotional lability, insomnia, irritability, diaphoresis, headache, and fine tremor. Moderate — worsening mild symptoms plus agitation and coarse tremor. Severe/delirium tremens — worsening moderate symptoms plus confusion/delirium

2018 NICE Clinical Knowledge Summaries

31. Alcohol challenge and sensitivity to change of the essential tremor rating assessment scale. Full Text available with Trip Pro

Alcohol challenge and sensitivity to change of the essential tremor rating assessment scale. The ability of the Essential Tremor (ET) Rating Assessment Scale (TETRAS) to detect changes in tremor severity is unknown.Fifteen adult ET patients received a single oral ethanol dose calculated to reach 0.05 g/dL breath alcohol content (brAC). Effects were investigated independently with accelerometry and TETRAS.Accelerometry data were log-transformed and a cumulative score logACC(R+L) was calculated

2013 Movement Disorders

32. Octanoic acid in alcohol-responsive essential tremor: A randomized controlled study. Full Text available with Trip Pro

Octanoic acid in alcohol-responsive essential tremor: A randomized controlled study. To assess safety and efficacy of an oral, single, low dose of octanoic acid (OA) in subjects with alcohol-responsive essential tremor (ET).We conducted a double-blind, placebo-controlled, crossover, phase I/II clinical trial evaluating the effect of 4 mg/kg OA in 19 subjects with ET. The primary outcome was accelerometric postural tremor power of the dominant hand 80 minutes after administration. Secondary (...) outcomes included digital spiral analysis, pharmacokinetic sampling, as well as safety measures.OA was safe and well tolerated. Nonserious adverse events were mild (Common Terminology Criteria for Adverse Events grade 1) and equally present after OA and placebo. At the primary outcome, OA effects were not different from placebo. Secondary outcome analyses of digital spiral analysis, comparison across the entire time course in weighted and nonweighted accelerometry, as well as nondominant hand tremor

2013 Neurology Controlled trial quality: predicted high

33. Alcohol Tremor

Alcohol Tremor Alcohol Tremor Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Alcohol Tremor Alcohol Tremor Aka: Alcohol Tremor (...) , Alcohol Withdrawal Tremor From Related Chapters II. Epidemiology Rarely a of Contrast with 50% in III. Signs and symptoms Frequency: 6 to 10.5 Hz (Usually > 8 Hz) Contrast with (Usually < 8 Hz) Only hands affected Contrast with Less severe than IV. Management 160 mg per day Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Alcohol Tremor." Click on the image (or right click) to open the source website in a new browser window. Related

2015 FP Notebook

34. The effects of TPA023, a GABAAα2,3 subtype-selective partial agonist, on essential tremor in comparison to alcohol. (Abstract)

The effects of TPA023, a GABAAα2,3 subtype-selective partial agonist, on essential tremor in comparison to alcohol. Essential tremor (ET) is a relatively frequent neurological disorder that responds in some patients to gamma-aminobutyric acid A (GABA(A)) agonists such as the benzodiazepines. Partial subtype-selective GABA(A) agonists may have an improved side effect profile compared to non-selective GABA(A) agonists. However, it is unknown which GABA(A) subtypes are involved in the therapeutic (...) effects of benzodiazepines in ET. The effects of 2 mg TPA023, a GABA(A) α2,3 subtype-selective partial agonist, on ET were compared to the effects of a stable alcohol level (0.6 g/L) and placebo in nine patients with ET. Tremor evaluation included laboratory accelerometry and a performance-based scale. Additional measurements were performed to evaluate other effects on the central nervous system (CNS). Alcohol significantly diminished tremor symptoms in the postural and kinetic condition, as assessed

2012 Journal of psychopharmacology (Oxford, England) Controlled trial quality: uncertain

35. The effects of a novel histamine-3 receptor inverse agonist on essential tremor in comparison to stable levels of alcohol. (Abstract)

The effects of a novel histamine-3 receptor inverse agonist on essential tremor in comparison to stable levels of alcohol. Essential tremor (ET) is a common movement disorder. Animal studies show that histaminergic modulation may affect the pathological processes involved in the generation of ET. Histamine-3 receptor inverse agonists (H3RIA) have demonstrated attenuating effects on ET in the harmaline rat model. In this double-blind, three-way cross-over, single-dose, double-dummy study (...) the effects of 25 mg of a novel H3RIA (MK-0249) and a stable alcohol level (0.6 g L(-1)) were compared with placebo, in 18 patients with ET. Tremor was evaluated using laboratory tremorography, portable tremorography and a clinical rating scale. The Leeds Sleep Evaluation Questionnaire (LSEQ) and a choice reaction time (CRT) test were performed to evaluate potential effects on sleep and attention, respectively. A steady state of alcohol significantly diminished tremor as assessed by laboratory

2012 Journal of psychopharmacology (Oxford, England) Controlled trial quality: uncertain

36. Are Benzodiazepines Effective for Alcohol Withdrawal?

selected results are shown in the Table.) Commentary In the United States, about half of the population reports drinking alcoholic beverages and about 5% drink heav- ily, with alcohol withdrawal symp- toms reported in less than 5% of the general population. 2,3 Acute alcohol withdrawal can produce signi?cant morbidity and occasional mortality. Alcoholwithdrawalsyndromecanbe- gin as early as 6 hours, usually peaks in 1 to 2 days, and can last up to 5 days. Symptoms can include nausea, tremors (...) Are Benzodiazepines Effective for Alcohol Withdrawal? SystematicReviewSnapshot TAKE-HOME MESSAGE When compared with placebo, benzodiazepines offer signi?cant bene?t in preventing alcohol withdrawal seizures. METHODS DATA SOURCES The authors searched Cochrane Drugs and Alcohol Group’ Regis- ter of Trials, PubMed, EMBASE, CINAHL, the American Economic Association’s electronic bibliogra- phy, the reference lists of relevant articles, and relevant conference proceedings and contacted inves

2012 Annals of Emergency Medicine Systematic Review Snapshots

37. Correlation Between mMINDS and CIWA-Ar Scoring Tools in Patients With Alcohol Withdrawal Syndrome. Full Text available with Trip Pro

Correlation Between mMINDS and CIWA-Ar Scoring Tools in Patients With Alcohol Withdrawal Syndrome. Many alcohol withdrawal scoring tools are used in hospitalized patients to assess the severity of alcohol withdrawal and guide treatment. The revised Clinical Institute Withdrawal Assessment (CIWA-Ar) and the modified Minnesota Detoxification Scale (mMINDS) are commonly used but have never been correlated.To determine the strength of correlation between the CIWA-Ar and mMINDS scoring tools (...) in patients with alcohol withdrawal syndrome.A single-center, prospective correlation study conducted at a large academic medical center. Patients treated for alcohol withdrawal syndrome according to the Yale Alcohol Withdrawal Protocol were identified daily, and both the CIWA-Ar and mMINDS were administered at each time point required by the protocol. Clinical data were obtained from the electronic medical records.A total of 185 CIWA-Ar and mMINDS scores were collected in 30 patients. The Pearson

2018 American Journal of Critical Care

38. Predictors of alcohol responsiveness in dystonia. Full Text available with Trip Pro

to alcohol (p < 0.001). Alcohol responsiveness differed across dystonia subgroups (multifocal/generalized > segmental [p = 0.014]; cervical and laryngeal > cranial and limb [p < 0.001]) and was related to a positive family history of movement disorders (p = 0.001), and presence of tremor (p < 0.001).The association of alcohol responsiveness with a positive family history for movement disorders, generalized dystonia, and an earlier age at onset suggests that patients with dystonia who have an underlying (...) genetic contribution may be more likely to respond beneficially to alcohol. The fact that dystonic tremor may respond to alcohol is in keeping with the observation that the intake of GABAergic drugs may have a beneficial effect in a proportion of patients.© 2018 American Academy of Neurology.

2018 Neurology

39. Finger tremor in alcoholic patients. Full Text available with Trip Pro

Finger tremor in alcoholic patients. 5866607 1966 06 23 2018 11 13 0022-3050 28 6 1965 Dec Journal of neurology, neurosurgery, and psychiatry J. Neurol. Neurosurg. Psychiatry Finger tremor in alcoholic patients. 529-32 Carrie J R JR eng Journal Article England J Neurol Neurosurg Psychiatry 2985191R 0022-3050 IM Adult Alcoholism complications Female Fingers Humans Male Middle Aged Psychoses, Alcoholic Tremor 1965 12 1 1965 12 1 0 1 1965 12 1 0 0 ppublish 5866607 PMC495956 J Physiol. 1954 Feb

1965 Journal of neurology, neurosurgery, and psychiatry

40. Early- and late-onset essential tremor patients represent clinically distinct subgroups. (Abstract)

and mathematical analysis of the age-at-onset distribution. Tremor severity in both groups was comparable. Tremor progression measured as Archimedes spiral score and the Fahn-Tolosa-Marin subscales divided by the disease duration in 10-year bins was significantly faster in late-onset patients when compared with early-onset patients. Early-onset patients more frequently reported a positive family history and alcohol sensitivity of the tremor.The age-at-onset distribution suggests a distinction between early (...) - and late-onset tremor. Early-onset and late-onset essential tremor differ in the progression rates and the frequencies of a positive family history and history of a positive effect of alcohol on tremor. © 2016 International Parkinson and Movement Disorder Society.© 2016 International Parkinson and Movement Disorder Society.

2016 Movement Disorders

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