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161. An Efficacy and Safety Study of AG-221 (CC-90007) Versus Conventional Care Regimens in Older Subjects With Late Stage Acute Myeloid Leukemia Harboring an Isocitrate Dehydrogenase 2 Mutation

An Efficacy and Safety Study of AG-221 (CC-90007) Versus Conventional Care Regimens in Older Subjects With Late Stage Acute Myeloid Leukemia Harboring an Isocitrate Dehydrogenase 2 Mutation An Efficacy and Safety Study of AG-221 (CC-90007) Versus Conventional Care Regimens in Older Subjects With Late Stage Acute Myeloid Leukemia Harboring an Isocitrate Dehydrogenase 2 Mutation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting (...) registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. An Efficacy and Safety Study of AG-221 (CC-90007) Versus Conventional Care Regimens in Older Subjects With Late Stage Acute Myeloid Leukemia Harboring an Isocitrate Dehydrogenase 2 Mutation (IDHENTIFY) The safety and scientific validity of this study is the responsibility

2015 Clinical Trials

162. Measurement of macular pigment optical density among healthy Chinese people and patients with early-stage age-related macular degeneration (Full text)

Measurement of macular pigment optical density among healthy Chinese people and patients with early-stage age-related macular degeneration To measure the macular pigment optical density (MPOD) in healthy Chinese people and patients with early age-related macular degeneration (AMD).Cross-sectional population based study. Demographic and lifestyle characteristics were ascertained by questionnaire. A food frequency questionnaire was completed for all participants. Participants underwent general

2015 International journal of ophthalmology PubMed abstract

163. Clinical Practice Guideline on management of patients with diabetes and chronic kidney disease stage 3b or higher (eGFR <45 mL/min)

Clinical Practice Guideline on management of patients with diabetes and chronic kidney disease stage 3b or higher (eGFR <45 mL/min) We use cookies to enhance your experience on our website. By continuing to use our website, you are agreeing to our use of cookies. You can change your cookie settings at any time. Clinical Practice Guideline on management of patients with diabetes and chronic kidney disease stage 3b or higher (eGFR <45 mL/min) | Nephrology Dialysis Transplantation | Oxford (...) Academic Search Account Menu Menu Navbar Search Filter Mobile Microsite Search Term Close search filter search input Article Navigation Close mobile search navigation Article navigation May 2015 Article Contents Article Navigation Clinical Practice Guideline on management of patients with diabetes and chronic kidney disease stage 3b or higher (eGFR <45 mL/min) Guideline development group Search for other works by this author on: Henk Bilo Search for other works by this author on: Luis Coentrão Search

2015 European Renal Best Practice

164. Using a bath or pool during first stage labour: A decision aid for women having a vaginal birth

Questionnaire. Journal of Nursing Research, 14(3): p. 190-197. [5] Brown, S.T., D. Campbell, and A. Kurtz, Characteristics of labor pain at two stages of cervical dilation. Pain, 1989. 39(3): p. 289-295. [6] Gaston-Johansson, f., G. Fridh, and K. Turner-Norvell, Progression of labor pain in primiparas and multiparas. Nursing Research, 1988. 37(2): p. 86-90. [7] Lowe, N.K., The nature of labor pain. American Journal of Obstetrics and Gynecology, 2002. 186(5, Supplement 1): p. S16-S24. [8] National (...) Using a bath or pool during first stage labour: A decision aid for women having a vaginal birth Using a bath or pool during first stage labour: A decision aid for women having a vaginal birthThis decision aid has been written to support women who are wanting to have a vaginal birth to know what to expect and to have a say in making decisions about using a bath or pool during labour. This decision aid provides information about two options: 1. Not using a bath or pool during labour 2 Using

2015 EUnetHTA

165. Sialanar (glycopyrronium) - for treating severe drooling of saliva in children and adolescents (aged 3 years and above) with conditions affecting the nervous system, such as cerebral palsy, epilepsy and neurodegenerative diseases

Sialanar (glycopyrronium) - for treating severe drooling of saliva in children and adolescents (aged 3 years and above) with conditions affecting the nervous system, such as cerebral palsy, epilepsy and neurodegenerative diseases 30 Churchill Place ? Canary Wharf ? London E14 5EU ? United Kingdom An agency of the European Union Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5520 Send a question via our website www.ema.europa.eu/contact 21 July 2016 EMA/555265/2016 Committee (...) ) No 1901/2006. The eligibility to the centralised procedure was agreed upon by the EMA/CHMP on 24 October 2013. The applicant applied for the following indication: Treatment of sialorrhoea (chronic pathological drooling) in children aged 2 to M3 > M2/M4 > M5. GP is 2-4 times more selective for the M3 and M1 subtypes than M2, making it one of the most potent M3 blockers available (Bird et al. 2011). The applied dose is based on the weight of the child, starting with approximately 0.02 mg/kg per dose

2016 European Medicines Agency - EPARs

166. An update to the Greig Health Record: Preventive health care visits for children and adolescents aged 6 to 17 years ? Technical report

-impaired driving. The CRAFFT screening questionnaire is highly sensitive for alcohol and drug problems in adolescents and young adults under 21 years of age and is included in the Greig Health Record. - Note that prescription medications such as opioids and stimulants may also be abused. Caffeine Physicians may not be accustomed to asking children and youth about caffeine use and the use of energy drinks. The consumption of caffeinated energy drinks is problematic in youth who commonly combine them (...) An update to the Greig Health Record: Preventive health care visits for children and adolescents aged 6 to 17 years ? Technical report An update to the Greig Health Record: Preventive health care visits for children and adolescents aged 6 to 17 years – Technical report | Canadian Paediatric Society CPS In this section Protecting and promoting the health and well-being of children and youth CPS Policy & Advocacy Clinical Practice Education & Events News & Publications Programs Membership About

2016 Canadian Paediatric Society

167. One-Stage Posterior Multiple-Level Asymmetrical Ponte Osteotomies Versus Single-Level Posterior Vertebral Column Resection for Severe and Rigid Adult Idiopathic Scoliosis: A Minimum 2-Year Follow-up Comparative Study. (Abstract)

patients were included in MAPO group and 12 patients in VCR group with an average age of 26.65 ± 8.40 and 27.92 ± 7.50 years, respectively. The average follow-up was 30.24 ± 10.55 months. The surgical details and complications were recorded. The radiological parameters and clinical outcome including Oswestry Disability Index and Scoliosis Research Society-22 questionnaire scores were collected and analyzed.The main curve in MAPO and VCR group were corrected from an average of 98.52° ± 16.50° to 44.11 (...) One-Stage Posterior Multiple-Level Asymmetrical Ponte Osteotomies Versus Single-Level Posterior Vertebral Column Resection for Severe and Rigid Adult Idiopathic Scoliosis: A Minimum 2-Year Follow-up Comparative Study. Retrospective comparative study.To compare the efficacy and safety of one-stage posterior multiple-level asymmetrical Ponte osteotomies (MAPOs) and single-level posterior vertebral column resection (VCR) for severe and rigid adult idiopathic scoliosis (ADIS).The surgical treatment

2019 Spine

168. Relationship between serum homocysteine and different menopausal stage. (Abstract)

Relationship between serum homocysteine and different menopausal stage. Objective: This study aimed to investigate the serum level of homocysteine in menopausal women and to explore the association between menopausal status, blood lipids, and homocysteine concentrations. Methods: The study recruited females aged 40-60 years who were not receiving menopausal hormone therapy. The demographic characteristics and menopausal status of the women were collected in the form of questionnaires. The study (...) analyzed the association between hyperhomocysteinemia and variables using binary logistic stepwise regression. Results: Among 366 enrolled subjects, menopausal status was divided into four stages: premenopause stage (n = 135), menopausal transition stage (n = 91), early postmenopause stage (n = 87), and late postmenopause stage (n = 53). The proportion of hyperhomocysteinemia in the premenopausal stage, menopausal transition stage, and postmenopausal stage was 43%, 26.4%, and 45%, respectively (χ2

2019 Climacteric

169. Accuracy and Psychometric Properties of the Brazilian Version of the Montreal Cognitive Assessment as a Brief Screening Tool for Mild Cognitive Impairment and Alzheimer's Disease in the Initial Stages in the Elderly. (Abstract)

and cognitively healthy elderly.The results of the study show that the Brazilian version of MoCA is a reliable cognitive tracking tool and is accurate for the detection of MCI and early stage AD, with good applicability on the elderly with education equal to or more than 4 years and adequate to discriminate between cognitively healthy elderly, and those with MCI and mild, proving to be superior to MMSE in tracking MCI and similar to this test when tracking mild AD.© 2019 S. Karger AG, Basel. (...) Accuracy and Psychometric Properties of the Brazilian Version of the Montreal Cognitive Assessment as a Brief Screening Tool for Mild Cognitive Impairment and Alzheimer's Disease in the Initial Stages in the Elderly. To evaluate the applicability and the psychometric properties of Montreal Cognitive Assessment Brazilian Version (MoCA-BR) in the elderly, as well as comparing its accuracy as a tracking test for mild cognitive impairment (MCI) and mild Alzheimer's disease (AD) with the accuracy

2019 Dementia and Geriatric Cognitive Disorders

170. Return to Sport After Bilateral Single Stage Total Hip Arthroplasty Using the Direct Anterior Approach: A Case Control Study. (Abstract)

was conducted between 2013 and 2017. All patients who underwent bilateral single stage THA were included. The control group had unilateral THA performed and was matched based on age, body mass index, gender, and surgery date (2 controls for each bilateral case). All surgeries were performed by a single senior surgeon using the direct anterior approach. The University of California Los Angeles activity score was collected at the last follow-up. A questionnaire regarding RTS, motivation, and satisfaction (...) Return to Sport After Bilateral Single Stage Total Hip Arthroplasty Using the Direct Anterior Approach: A Case Control Study. Total hip arthroplasty (THA) is currently performed on active patients with increasing functional demands. Single stage bilateral THA is indicated in younger patients in good general health. Our objective is to evaluate the return to sport (RTS) in patients who underwent bilateral single stage THA compared to unilateral THA.This retrospective case control study

2019 Journal of Arthroplasty

171. Axillary dissection in sentinel lymph node positive breast cancer: Is the staging information worthwhile for patients? (Abstract)

trade-off questions to determine the maximum chance of developing arm side-effects from axillary dissection to justify the benefit of additional axillary staging information. Social, demographic, and clinical details were collected.Ninety-nine of the 126 eligible patients returned the questionnaire and 76 completed the trade-off assessment. The median age of participants was 62 years. The median numbers of sentinel and axillary nodes removed were 2 and 12, respectively. Forty-seven percent (...) Axillary dissection in sentinel lymph node positive breast cancer: Is the staging information worthwhile for patients? The Z0011 randomized trial demonstrated no significant difference in axillary recurrence rate or survival with or without axillary dissection in patients with a positive sentinel node biopsy. However, there is continuing controversy regarding the generalizability of its results, and axillary dissection provides additional pathologic staging information that may guide adjuvant

2019 Asia-Pacific journal of clinical oncology Controlled trial quality: uncertain

172. Two-stage posterior spinal fusion for early-onset scoliosis: Two case reports. (Full text)

degrees at age 11 years.Whole-spine radiographs were performed to diagnose scoliosis.Both patients received 2-stage posterior spinal fusion.Postoperative Cobb angle of the major curve improved to 46 and 48 degrees, respectively. Thoracic height respectively improved from 160 and 148 mm before surgery to 206 and 211 mm at final follow-up. Surgical outcome as evaluated by Scoliosis Research Society-22 patient questionnaires revealed acceptable results without any severe complications.Based (...) and radiological features of 2 patients with EOS who received 2-stage posterior spinal fusion. This surgical method for EOS represents the first of its kind.Case 1 was a 10-year-old girl who was diagnosed as having scoliosis with Prader Willi syndrome at the age of 2 years. Her preoperative major curve Cobb angle was 100 degrees at age 10 years. Case 2 was an 11-year-old boy who was found to have scoliosis with 22q11.2 deletion syndrome at the age of 4 years. His preoperative major curve Cobb angle was 77

2019 Medicine PubMed abstract

173. Staging of nutrition disorders in non-small-cell lung cancer patients: utility of skeletal muscle mass assessment. (Full text)

parameters.This was a cross-sectional and non-interventional multicentre study. SMM was assessed by analysing L3 computed tomography-scan images. Patients completed the anorexia/CAX subscale of the Functional Assessment of Anorexia/Cachexia Therapy, EORTC QLQ-C30 quality of life (QoL) and International Physical Activity Questionnaire (IPAQ).Patients were recruited in 56 sites. The analysis population comprised 531 patients, and SMM was assessed in 312 patients. Male patients were 66.5%, with a mean (SD) age (...) Activity Questionnaire (P < 0.001). Sarcopenia was present in 66.7% of CAX and 68.5% of pre-CAX patients. Overall, 43.8% of pre-CAX patients had only sarcopenia with limited weight loss (≤2%) and no anorexia.This is the first study to show the distribution of CAX in a population of NSCLC patients and an association between molecular abnormality in NSCLC and CAX. The original Fearon classification for CAX stages was supported by the associated functional QoL scores and physical activity levels

2019 Journal of cachexia, sarcopenia and muscle PubMed abstract

174. The outcomes of Kulkarni's one-stage oral mucosa graft urethroplasty in patients with panurethral stricture: a single centre experience. (Abstract)

data were recorded prospectively and patient age, etiology of the stricture, comorbidities, previous treatments, postoperative maximal flow rate, pre and post-operative erectile function, perioperative and postoperative complications and quality of life questionnaire for this study.The mean patient age was 58.8 and mean stricture length was 13.6 (10-16) cm. Patients had previously 1-17 procedures. Patients had a mean peak flow rate of 25.4 ml/sec at the first postoperative visit. During the follow (...) The outcomes of Kulkarni's one-stage oral mucosa graft urethroplasty in patients with panurethral stricture: a single centre experience. To present the results of our one-stage oral mucosa graft urethroplasty series for panurethral strictures.We included the first 35 patients who had one stage oral mucosa graft urethroplasty with one side dissection of the urethra which was described by Kulkarni, between January 2015 and June 2018 and had at least 6 months follow-up. From the first case, all

2019 World journal of urology

175. Analysis of the association between paternity and reoperation for urethral obstruction in adult hypospadias patients who underwent two-stage repair in childhood. (Full text)

patients who underwent the same kind of two-stage repair in our institute by a single surgeon, were initially treated at < 18 years old, and who were ≥ 18 years old during the survey were included in the study. Present physical, social, and life status were evaluated by a mailed self-entry questionnaire, and clinical background and surgical outcome data were evaluated by medical records. National survey data of the general population were used as external control. The paternity rate of the patient (...) Analysis of the association between paternity and reoperation for urethral obstruction in adult hypospadias patients who underwent two-stage repair in childhood. The association between surgical outcome of hypospadias repair and long-term male reproductive function has not been documented. The purpose of this study was to clarify association between paternity in adult hypospadias patients and reoperation for urethral obstruction after two-stage repair during childhood.Ninety hypospadias

2019 BMC Urology PubMed abstract

176. ART adherence and viral suppression are high among most non-pregnant individuals with early-stage, asymptomatic HIV infection: an observational study from Uganda and South Africa. (Full text)

prospectively observed three groups initiating ART in routine care in Uganda and South Africa: men and non-pregnant women with early-stage HIV infection (CD4 > 350 cells/μL), pregnant women with early-stage HIV infection and men and non-pregnant women with late-stage HIV infection (CD4 < 200 cells/μL). Socio-behavioural questionnaires were administered and viral loads were performed at 0, 6 and 12 months. Adherence was monitored electronically.Adherence data were available for 869 participants: 322 (37 (...) in Uganda, adherence was higher with increasing age and lower with structural barriers; whereas in South Africa, adherence was higher with regular income, higher perceived stigma and use of other medications, but lower with maladaptive coping and cigarette smoking.ART adherence among non-pregnant individuals with early-stage infection is as high or higher than with late-stage initiation, supporting universal access to ART. Challenges remain for some pregnant women and individuals with late-stage

2019 Journal of the International AIDS Society PubMed abstract

177. Food Supplementation for Improving the Physical and Psychosocial Health of Socio?economically Disadvantaged Children Aged Three Months to Five Years: A Systematic Review (Full text)

Food Supplementation for Improving the Physical and Psychosocial Health of Socio?economically Disadvantaged Children Aged Three Months to Five Years: A Systematic Review Food Supplementation for Improving the Physical and Psychosocial Health of Socio‐economically Disadvantaged Children Aged Three Months to Five Years: A Systematic Review - Kristjansson - 2015 - Campbell Systematic Reviews - Wiley Online Library By continuing to browse this site, you agree to its use of cookies as described (...) in our . Search within Search term Search term SYSTEMATIC REVIEW Open Access Food Supplementation for Improving the Physical and Psychosocial Health of Socio‐economically Disadvantaged Children Aged Three Months to Five Years: A Systematic Review School of Psychology, Faculty of Social Sciences, University of Ottawa, Ottawa, Canada Epidemiology Research Unit, University of West Indies, Mona, Kingston 7, Jamaica Nutrition Research Team, Menzies School of Health Research, Charles Darwin University

2015 Campbell Collaboration PubMed abstract

178. The Patient Health Questionnaire-9 as a Screening Tool for Depression in Individuals with Type 2 Diabetes Mellitus: The Maastricht Study (Abstract)

The Patient Health Questionnaire-9 as a Screening Tool for Depression in Individuals with Type 2 Diabetes Mellitus: The Maastricht Study To assess the psychometric properties and identify the best cutoff value of the Patient Health Questionnaire-9 (PHQ-9) for depression screening in individuals with type 2 diabetes mellitus (T2DM).Observational population-based cohort study.The Maastricht Study.Individuals with and without T2DM (mean age 58.6 ± 8.1, 44.6% male) according to an oral glucose (...) analysis suggested a similar two-factor structure in both groups (affective and somatic symptoms).Patient Health Questionnaire-9 performs well as a screening tool for depressive symptoms in individuals with and without T2DM based on the cutoff value of 5, indicating that the PHQ-9 can be used in two-stage screening in primary care to select individuals with T2DM for further psychological evaluation.© 2016, Copyright the Authors Journal compilation © 2016, The American Geriatrics Society.

2016 EvidenceUpdates

179. Impact of early protein and energy intakes on neurodevelopment at 2 years of corrected age in very low birth weight infants: A single-center observational study. (Full text)

the first two weeks after birth on neurodevelopmental outcomes.This retrospective cohort study of very low birth weight infants born between January 2012 and December 2015 was conducted at one tertiary neonatal intensive care unit. The primary outcome was a neurodevelopmental impairment (NDI) at 2 years corrected age defined by a cerebral palsy or a 24 month Ages and Stages Questionnaires score on any of the five domains lower than 2 standard deviation below the mean score. Multivariable logistic (...) Impact of early protein and energy intakes on neurodevelopment at 2 years of corrected age in very low birth weight infants: A single-center observational study. Aggressive nutritional strategy, particularly enhancing early provision of energy and protein, has appeared to reduce postnatal growth failure and improve later developmental outcomes. But the amount of macronutrients required remains unclear. The aim of this study was to investigate the impact of protein and energy intakes during

2019 PLoS ONE PubMed abstract

180. Prevalence and correlates of anemia among children aged 6-23 months in Wolaita Zone, Southern Ethiopia. (Full text)

Prevalence and correlates of anemia among children aged 6-23 months in Wolaita Zone, Southern Ethiopia. Anemia, the world's most common micro-nutrient deficiency disorder, can affect a person at any time and at all stages of life. Though all members of the community may face the problem, children aged 6-23 months are particularly at higher risk. If left untreated, it adversely affects the health, cognitive development, school achievement, and work performance. However, little was investigated (...) among young children in Sub-Saharan countries including Ethiopia. This research aimed to investigate its magnitude and correlates to address the gap and guide design of evidence based intervention.A community-based cross-sectional study was conducted from May -June 2016 in rural districts of Wolaita Zone. Multi-stage sampling technique was applied and 990 mother-child pairs were selected. Socio-demography, health and nutritional characteristics were collected by administering interview questionnaire

2019 PLoS ONE PubMed abstract

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