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281. A liminal stage after predictive testing for Huntington disease. (Abstract)

carriers were examined using the Unified Huntington's Disease Rating Scale (UHDRS) motor score. Onset estimation made with the disease burden score was compared with UHDRS findings. We collected qualitative data with questionnaires and semistructured interviews.38 women and 37 men, aged 43.7 years±10.5 (20-68), were interviewed after a mean delay between test and study interview of 10.5 years±4.7 (from 4 to 21 years). Estimation of age at onset was 4.5±8.5 years earlier than data-derived age at onset (...) A liminal stage after predictive testing for Huntington disease. Following predictive testing for Huntington disease (HD), knowledge of one's carrier status may have consequences on disease onset. Our study aimed to address two questions. First, does knowledge of being a carrier of the pathological HD mutation trigger onset of the disease? Second, does this knowledge influence self-awareness and allow carriers to identify signs and symptoms of disease onset?Between 2012 and 2015, 75 HD mutation

2017 Journal of Medical Genetics

282. The utility of abbreviated patient-reported outcomes for predicting survival in early stage colorectal cancer. Full Text available with Trip Pro

in patients with early stage colorectal cancer.Patients who had newly diagnosed stage II or III colorectal cancer from 2009 to 2010 and had a consultation at the British Columbia Cancer Agency completed the brief Psychosocial Screen for Cancer (PSSCAN) questionnaire, which collects data on patients' perceived social supports, quality of life (QOL), anxiety and depression, and general health. PROs from the PSSCAN were linked with the Gastrointestinal Cancers Outcomes Database, which contains information (...) on patient and tumor characteristics, treatment details, and cancer outcomes. Cox regression models were constructed for overall survival (OS), and Fine and Gray regression models were developed for disease-specific survival (DSS).In total, 692 patients were included. The median patient age was 67 years (range, 26-95 years), and the majority had colon cancer (61%), were diagnosed with stage III disease (54%), and received chemotherapy (58%). In general, patients felt well supported and reported good

2017 Cancer

283. Does spinal deformity correction of non-dystrophic scoliosis in neurofibromatosis type-1 with one-stage posterior pedicle screw technique produce outcomes similar to adolescent idiopathic scoliosis? (Abstract)

and postoperative whole-spine radiographs were used to determine coronal and sagittal Cobb angles. Also, the distance between the C7 plumb line and the center sacral vertical line and the sagittal vertebral axis was measured to assess spinal balance. The Scoliosis Research Society (SRS)-22 questionnaire was used to evaluate functional outcomes.We matched 15 patients with non-dystrophic scoliosis in NF-1 with patients with AIS (ratio, 1:1) for age, sex, and degree of major deformity. The overall mean age (...) Does spinal deformity correction of non-dystrophic scoliosis in neurofibromatosis type-1 with one-stage posterior pedicle screw technique produce outcomes similar to adolescent idiopathic scoliosis? The efficacy of one-stage posterior pedicle screw instrument used in the treatment of non-dystrophic scoliosis in neurofibromatosis type I (NF-1) is unknown. Also, there is no study that has directly compared the results of spinal deformity correction between non-dystrophic scoliosis in NF-1

2017 The Spine Journal

284. Religious coping methods predict depression and quality of life among end-stage renal disease patients undergoing hemodialysis: a cross-sectional study. Full Text available with Trip Pro

161 ESRD patients over 18 years of age who had been undergoing HD for more than 3 months. R/S coping methods were assessed using the Religious Coping Questionnaire (RCOPE). The RCOPE generates scores (from 1 to 5) for positive and negative R/S coping methods. The higher the score, the more frequent the use of that coping method. Depression was evaluated using the 20-item version of the Center for Epidemiologic Studies Depression Scale (CES-D). Scores on the CES-D range from 0 to 60. A cutoff of 18 (...) Religious coping methods predict depression and quality of life among end-stage renal disease patients undergoing hemodialysis: a cross-sectional study. Poor quality of life (QOL) and a high prevalence of depression have been identified among end-stage renal disease (ESRD) patients undergoing hemodialysis (HD). We aimed to evaluate the associations between religious/spiritual (R/S) coping methods and both QOL and depression among ESRD patients undergoing hemodialysis (HD).The sample included

2017 BMC Nephrology

285. Increased body mass index is a risk factor for end-stage renal disease in the Chinese Singapore population. Full Text available with Trip Pro

Increased body mass index is a risk factor for end-stage renal disease in the Chinese Singapore population. The relationship between body mass index (BMI) and end-stage renal disease (ESRD) is confounded by co-morbidities associated with both conditions. Furthermore, the association at low range BMI is controversial. We studied this association in the Singapore Chinese Health Study, a population-based prospective cohort that recruited Singaporean Chinese men and women 45-74 years of age from (...) 1993 to 1998. Self-reported weight, height, lifestyle factors, usual diet, and medical history were collected via an interviewer-administered questionnaire. Incident ESRD cases were identified via record linkage with the nationwide ESRD registry. The computed Cox proportional hazard regression was adjusted for potential risk factors. After an average follow-up of 15.5 years, 827 incident ESRD cases were identified. Compared with a normal BMI of 18.5 to under 23 kg/m2, the hazard ratios and (95

2017 Kidney International

286. Preliminary Results of a Phase 1 Dose-Escalation Trial for Early-Stage Breast Cancer Using 5-Fraction Stereotactic Body Radiation Therapy for Partial-Breast Irradiation. Full Text available with Trip Pro

without exceeding the maximum tolerated dose.Eligible patients included those with ductal carcinoma in situ or invasive nonlobular epithelial histologies and stage 0, I, or II, with tumor size <3 cm. Patients and physicians completed baseline and subsequent cosmesis outcome questionnaires. Starting dose was 30 Gy in 5 fractions and was escalated by 2.5 Gy total for each cohort to 40 Gy.In all, 75 patients were enrolled, with a median age of 62 years. Median follow-up for 5 cohorts was 49.9, 42.5, 25.7 (...) Preliminary Results of a Phase 1 Dose-Escalation Trial for Early-Stage Breast Cancer Using 5-Fraction Stereotactic Body Radiation Therapy for Partial-Breast Irradiation. To evaluate the tolerability of a dose-escalated 5-fraction stereotactic body radiation therapy for partial-breast irradiation (S-PBI) in treating early-stage breast cancer after partial mastectomy; the primary objective was to escalate dose utilizing a robotic stereotactic radiation system treating the lumpectomy cavity

2017 Biology and Physics

287. Use of a computerised decision aid (DA) to inform the decision process on adjuvant chemotherapy in patients with stage II colorectal cancer: development and preliminary evaluation. Full Text available with Trip Pro

recruitment of 13 patients with stage II colorectal cancer, 12 of whom completed the study. Inclusion criteria were: age >18 years; complete resection for stage II adenocarcinoma of the colon or rectum; patients within 14-56 days after surgery; no contraindication to adjuvant chemotherapy; able to give written informed consent. Exclusion criterion: previous chemotherapy.Patient perceived usefulness (assessed by the PrepDM questionnaire) and acceptability of the DA.PrepDM scores, measuring the perceived (...) Use of a computerised decision aid (DA) to inform the decision process on adjuvant chemotherapy in patients with stage II colorectal cancer: development and preliminary evaluation. To develop a computerised decision aid (DA) to inform the decision process on adjuvant chemotherapy in patients with stage II colorectal cancer, and examine perceived usefulness, acceptability and areas for improvement of the DA.Mixed methods.Single outpatient oncology department in central London.Consecutive

2017 BMJ open

288. Use of complementary and alternative medicine by patients with end-stage renal disease on haemodialysis in Trinidad: A descriptive study. Full Text available with Trip Pro

Use of complementary and alternative medicine by patients with end-stage renal disease on haemodialysis in Trinidad: A descriptive study. Despite the paucity of scientific evidence, complementary and alternative medicine (CAM) is widely used for the prevention and treatment of illness, holistic care, and counteracting the adverse effects of conventional medicine (CM). This study investigates the use of CAM by patients with end-stage renal disease (ESRD) on haemodialysis.This quantitative study (...) was conducted from November 1, 2014 to December 31, 2014 in the haemodialysis unit at San Fernando General Hospital (San Fernando, Trinidad). Face-to-face questionnaire-based interviews were held with101of 125 eligible patients (response rate, 80.5%) at the chairside during haemodialysis. The completed questionnaires were entered into a secure computer database. Data analysis included descriptive analysis, χ2 tests, and binary logistic regression analysis.A minority of the patients were CAM users (n = 19

2017 BMC Complementary and Alternative Medicine

289. Oxidative Balance Score and the Risk of End-Stage Renal Disease and Cardiovascular Disease. (Abstract)

history questionnaire and lifestyle assessment. We divided OBS into quartiles (Q1-Q4), with Q1 (predominance of pro-oxidants) as the reference. We analyzed OBS quartiles as an ordinal variable. Crude and adjusted hazards ratios (HRs) and 95% CIs were estimated using Cox proportional hazards models for time to ESRD and CVD.Compared to Q1, Q4 (high antioxidant) was associated with ESRD in the crude model (HR 1.35, 95% CI 1.08-1.69) and adjusting for age, sex, and race (HR 1.36, 95% CI 1.09-1.71 (...) Oxidative Balance Score and the Risk of End-Stage Renal Disease and Cardiovascular Disease. Oxidative balance score (OBS) is a composite measure of oxidative stress-related exposures. The aim of this study was to investigate the association between OBS, end-stage renal disease (ESRD), and cardiovascular disease (CVD).Using data from the Chronic Renal Insufficiency Cohort, we calculated the main exposure OBS by summing up 12 apriori-defined pro- and antioxidant factors obtained from the diet

2017 American journal of nephrology

290. Chilean Adaptation and Validation of the Early Adolescent Temperament Questionnaire-Revised Version Full Text available with Trip Pro

Chilean Adaptation and Validation of the Early Adolescent Temperament Questionnaire-Revised Version The aim of this study was to develop an adapted version of the Early Adolescent Temperament Questionnaire-Revised (EATQ-R) that would be valid and reliable for assessing temperament and its components in Chileans between 12 and 18 years of age. Originally, Ellis and Rothbart (2001) developed this questionnaire (EATQ-R) to be used in North American adolescents. For the study in Chile (...) , a translation protocol was developed, to maintain the original instrument's cultural and linguistic equivalence in the adapted version. Psychometric properties of the EATQ-R, such as factor structure, internal consistency, and convergent validity, were also assessed. The adaption and validation was carried out in two stages, with two different studies. The first study, which included 612 adolescent students from educational establishments in the cities of Santiago and Concepcion, Chile, developed

2017 Frontiers in psychology

291. Psychometric properties of the Urdu version of the World Health Organization's quality of life questionnaire (WHOQOL-BREF) Full Text available with Trip Pro

Psychometric properties of the Urdu version of the World Health Organization's quality of life questionnaire (WHOQOL-BREF) Background: The present study was conducted to translate and validate the World Health Organization's Quality-of-Life Scale - BREF into local language of Pakistan. Methods: A forward- backward translation procedure was followed to develop the Pakistani version of the questionnaire. Through a multi- stage clustered sampling technique, a sample of individuals aged 18 years (...) and above completed the questionnaire in Abbottabad district, Pakistan. Psychometric properties of the instrument including reliability (internal consistency and test-retest analysis), validity (known group comparison and items' correlation) and their domains were assessed. Satisfactory results were also shown in the correlation matrix in all domains. Results: A total of 2060 participants were recruited in this study. Participants' mean age was 35.51 (SD= 14.31) years in healthy individuals and 39.29

2017 Medical journal of the Islamic Republic of Iran

292. The Japanese version of the questionnaire about the process of recovery: development and validity and reliability testing. Full Text available with Trip Pro

The Japanese version of the questionnaire about the process of recovery: development and validity and reliability testing. Personal recovery is increasingly recognised as an important outcome measure in mental health services. This study aimed to develop a Japanese version of the Questionnaire about the Process of Recovery (QPR-J) and test its validity and reliability.The study comprised two stages that employed the cross-sectional and prospective cohort designs, respectively. We translated (...) the questionnaire using a standard translation/back-translation method. Convergent validity was examined by calculating Pearson's correlation coefficients with scores on the Recovery Assessment Scale (RAS) and the Short-Form-8 Health Survey (SF-8). An exploratory factor analysis (EFA) was conducted to examine factorial validity. We used intraclass correlation and Cronbach's alpha to examine the test-retest and internal consistency reliability of the QPR-J's 22-item full scale, 17-item intrapersonal and 5-item

2017 BMC Psychiatry

293. Development of a parent‐reported questionnaire evaluating upper limb activity limitation in children with cerebral palsy Full Text available with Trip Pro

Development of a parent‐reported questionnaire evaluating upper limb activity limitation in children with cerebral palsy Upper limb activity measures for children with cerebral palsy have a number of limitations, for example, lack of validity and poor responsiveness. To overcome these limitations, we developed the Children's Arm Rehabilitation Measure (ChARM), a parent-reported questionnaire validated for children with cerebral palsy aged 5-16 years. This paper describes both the development (...) activity performance, and these natural orders of achievement formed each item's response options. Items underwent face validity testing with health care professionals, parents of children with cerebral palsy, academics, and lay persons. A Rasch analysis was performed on ChARM questionnaires completed by the parents of 170 children with cerebral palsy from 12 hospital paediatric services. The ChARM was amended, and the procedure repeated on 148 ChARMs (from children's mean age: 10 years and 1 month

2017 Physiotherapy Research International

294. Validation of the Croatian version of CIVIQ quality of life questionnaire in patients with chronic venous disorders Full Text available with Trip Pro

, and reliability of the Croatian CIVIQ 20-item questionnaire completed by 428 adult patients (78% women) with chronic venous disorders classified according to the Clinical-Etiologic-Anatomic-Pathophysiologic (CEAP) C classification as stages C1-C6.Median patient age was 52 years (5th-95th percentile, 30-77). The distribution according to the clinical stages of chronic venous disorders was as follows: C1 (n=78, 18%), C2 (n=192, 45%), C3 (n=53, 12%), C4 (n=44, 10%), C5 (n=13, 3%), and C6 (n=48, 11%). The CIVIQ (...) Validation of the Croatian version of CIVIQ quality of life questionnaire in patients with chronic venous disorders To test the psychometric properties of the Croatian version of the Chronic Venous Insufficiency Quality of Life (CIVIQ) Questionnaire and to assess the quality of life in patients with chronic venous disorders of all stages.This cross-sectional study performed between 2014 and 2015 in a private family practice assessed the factorial validity, cross-sectional validity

2017 Croatian medical journal

295. Development of a self-scored persistent airflow obstruction screening questionnaire in a general Japanese population: the Hisayama study Full Text available with Trip Pro

draft questionnaire items about COPD. Eligible subjects aged 40 and older living in Japan were solicited to participate in a health checkup from 2014 to 2015. In study I, 2,338 subjects who fully completed the initial draft questionnaire and who had valid spirometry measurements were statistically analyzed to determine the final questionnaire items as a COPD screening questionnaire (COPD-Q). Persistent AO was defined as a post-bronchodilator FEV1/FVC <0.70. In study II, the working group analyzed (...) -0.788). A cutoff of 4 points resulted in a sensitivity of 71.0% and a specificity of 70.1%. The positive predictive value was 10.8%, and the negative predictive value was 97.9%. The crude odds ratio of the COPD-Q for AO was 5.8.The five-item COPD-Q is a useful questionnaire for diagnosing persistent AO in a general Japanese population and is expected to be an effective first-stage screening tool for detecting COPD.

2017 International journal of chronic obstructive pulmonary disease

296. Assessment of quality of life in patients undergoing hemodialysis using WHOQOL-BREF questionnaire: a multicenter study Full Text available with Trip Pro

Assessment of quality of life in patients undergoing hemodialysis using WHOQOL-BREF questionnaire: a multicenter study Assessment of quality of life (QOL) of patients with end-stage renal disease has become increasingly important, both in order to evaluate the influence of the disease on patients and the type of renal replacement therapy they require. Therefore, in this study, we aimed to assess QOL in patients undergoing hemodialysis and evaluated the effects of various sociodemographic (...) factors affecting QOL of such patients in Nepal.A cross-sectional study was conducted among 150 patients with chronic kidney disease undergoing hemodialysis at two major centers in Nepal. Demographic data including age, sex, ethnicity, educational status, marital status, employment, income, duration of illness, and duration on hemodialysis were collected. QOL was assessed using the World Health Organization Quality of life (WHOQOL-BREF) questionnaire. Four domains (physical, psychological, social

2017 International journal of nephrology and renovascular disease

297. Reliability and validity of the SF-36 Health Survey Questionnaire in patients with brain tumors: a cross-sectional study Full Text available with Trip Pro

Depression Inventory-II or BDI-II); and functional status (Barthel index or BI). Final histological diagnosis was obtained from pathology reports.Two-hundred and twenty-seven (completion rate of 82%) patients (69% women; mean age 55.8 ± 14.4 years) completed the SF-36 questionnaire. The most common brain tumor diagnosis was meningioma (40%), followed high-grade glioma (19%). Missing data rates were ≤4%. Internal consistency was adequate for all (Cronbach α ≥ .728) but Social Functioning (Cronbach α (...) Reliability and validity of the SF-36 Health Survey Questionnaire in patients with brain tumors: a cross-sectional study Deterioration of health related quality of life (HRQoL) is common in brain tumor patients. This study evaluated validity and reliability of the Medical Outcomes Study 36-Item Short Form (SF-36) in patients with brain tumors.Two hundred and seventy-seven patients admitted for brain tumor surgery were evaluated for HRQoL (SF-36 questionnaire); depressive symptoms (Beck

2017 Health and quality of life outcomes

298. Implementation of a Computer-based Questionnaire for Preoperative Evaluation in Anesthesia Ambulance

and implementation of a practical computer-based individualized and risk-adapted questionnaire for the daily routine Condition or disease Patient Satisfaction In-hospital Process Optimization Detailed Description: The study was a step-by-step process. In the first investigation in 2013 the investigators included 50 patients and 81 patients in 2016. Questionnaires were identical in both testing stages for comparability. Practicability of a computer-based questionnaire on patient medical history, diagnosis as well (...) Study Start Date : October 4, 2016 Actual Primary Completion Date : October 14, 2016 Actual Study Completion Date : October 14, 2016 Groups and Cohorts Go to Outcome Measures Go to Primary Outcome Measures : Utilization of computer-based questionnaire measured by duration time [ Time Frame: Time in the outpatient clinic of anesthesia, an average of 1 hour ] Number of assistance during filling-out in depending of age [ Time Frame: Time in the outpatient clinic of anesthesia, an average of 1 hour

2017 Clinical Trials

299. Comparison of the STarT back screening tool and the örebro musculoskeletal pain screening questionnaire used as outcome measure

Comparison of the STarT back screening tool and the örebro musculoskeletal pain screening questionnaire used as outcome measure Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any (...) are not reported or unclear, we will attempt to contact authors by e-mail (max. 2 attempts). In case an outcome is measured at multiple time points, data from the time point where efficacy is highest will be included. ">Methods for data extraction Example: Experimental groups, control group(s) and number of animals per group. ">Data to be extracted: study design Example: Species, sex, weight, age, co‐morbidity, anaesthetic agent used, method of induction of cardiac ischemia, duration of ischemia and duration

2019 PROSPERO

300. The measurement properties of sleep questionnaires for adults with pain conditions: a systematic review

The measurement properties of sleep questionnaires for adults with pain conditions: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files (...) or unclear, we will attempt to contact authors by e-mail (max. 2 attempts). In case an outcome is measured at multiple time points, data from the time point where efficacy is highest will be included. ">Methods for data extraction Example: Experimental groups, control group(s) and number of animals per group. ">Data to be extracted: study design Example: Species, sex, weight, age, co‐morbidity, anaesthetic agent used, method of induction of cardiac ischemia, duration of ischemia and duration

2019 PROSPERO

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