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181. Economic evaluation of genomic test-directed chemotherapy for early-stage lymph node-positive breast cancer (Full text)

(Epidemiology); Cost-Benefit Analysis; Drug Costs; Female; Genetic Testing /economics; Genome, Human; Great Britain; Humans; Lymph Nodes /pathology; Lymphatic Metastasis; Markov Chains; Mastectomy, Segmental; Middle Aged; National Health Programs /ethics; Neoplasm Staging; Quality-Adjusted Life Years; Receptors, Estrogen /analysis; Research Design; Risk Assessment /methods AccessionNumber 22012001735 Date bibliographic record published 09/03/2012 Date abstract record published 23/05/2012 NHS Economic (...) Economic evaluation of genomic test-directed chemotherapy for early-stage lymph node-positive breast cancer Economic evaluation of genomic test-directed chemotherapy for early-stage lymph node-positive breast cancer Economic evaluation of genomic test-directed chemotherapy for early-stage lymph node-positive breast cancer Hall PS, McCabe C, Stein RC, Cameron D Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract

2012 NHS Economic Evaluation Database. PubMed abstract

182. Short-term outcomes of one-stage bilateral total hip arthroplasty in young patients (< 30 years old) (Full text)

Dysplasia of the Hip (DDH). The patients underwent one-stage bilateral total hip arthroplasties through the direct lateral approach. Standardized questionnaires were used to obtain mean Postel-Merle d'Aubigné (PMA) score, Oxford Hip Score (OHS), Visual Analogue Scale (VAS) Score, and Modified Harris Hip Score (MHHS), both preoperatively and post-operatively to evaluate functional outcomes. All patients were in the American Society of Anesthesiology (ASA) category 1 or 2. All complications were followed (...) Short-term outcomes of one-stage bilateral total hip arthroplasty in young patients (< 30 years old) Total hip arthroplasty is one of the best treatments for restoring function and activity in young patients with advanced joint diseases. One-Stage Bilateral Total Hip Arthroplasty (BTHA) offers many advantages, which are important to younger patients and diminished costs and time in comparison with sequential THA. There is currently much concern about the safety of this procedure. The current

2018 Orthopedic reviews PubMed abstract

183. Study of community-living Alzheimer’s patients’ adherence to the Mediterranean diet and risks of malnutrition at different disease stages (Full text)

Study of community-living Alzheimer’s patients’ adherence to the Mediterranean diet and risks of malnutrition at different disease stages Alzheimer's disease (AD) is a neurodegenerative disease that is characterized by deficits in episodic memory. It is the most common form of dementia and affects 50-70% of patients with cognitive impairments over the age of 65. Elderly people are particularly susceptible to malnutrition and that risk is even higher in patients with AD. This study assessed (...) the nutritional status of patients with AD at different stages of AD and explored how that status correlated with cognitive, functional and behavioural variables and caregiver overburden. The characteristics of the diet and the degree of adherence to the Mediterranean diet were also analysed.This was a cross-sectional study that was representative of the general population and it was carried out in the Unit of Cognitive Disorders, Lleida, Spain. The participants were 111 subjects with AD who were aged 65

2018 PeerJ PubMed abstract

184. Effect of induction chemotherapy on the quality-of-life in patients with advanced stage tongue cancer by a prospective study (Full text)

Effect of induction chemotherapy on the quality-of-life in patients with advanced stage tongue cancer by a prospective study Abstracts Objective To assess how induction chemotherapy affects the quality-of-life (QoL) in patients with advanced tongue cancer. Methods This prospective study included patients who were diagnosed with advanced tongue cancer. Each patient was asked to complete the University of Washington QoL (UW-QoL), version 4, questionnaire preoperatively and at 12 months after (...) surgery. Patients were divided into two groups based on whether or not they received induction chemotherapy. Results Of the 192 patients included in the analysis, 145 patients had received induction chemotherapy. There were no significant differences regarding age, sex, tumour stage, node stage, flap reconstruction, tumour resection range and radiotherapy between the two groups. The mean total hospital cost was significantly higher in patients who underwent induction chemotherapy compared with those

2018 The Journal of international medical research PubMed abstract

185. Influence of cigarette smoking on hormone and lipid metabolism in women in late reproductive stage (Full text)

Influence of cigarette smoking on hormone and lipid metabolism in women in late reproductive stage The aim of the study was to analyze lipid and hormone metabolism, body mass index (BMI), and age parameters in late reproductive stage women in relation to cigarette smoking.The study enrolled 345 healthy late reproductive stage women living in Poland; 13.33% were smokers. The first part of the study assessed lipid metabolism (total cholesterol, high-density lipoprotein [HDL], low-density (...) lipoprotein [LDL], and triglycerides) and hormone metabolism (estradiol [E2], follicle-stimulating hormone [FSH], and anti-Müllerian hormone [AMH] levels) in women in the early phase of the follicular menstrual cycle. The second part of study was carried out using the diagnostic survey method, with a standardized questionnaire (Primary Care Evaluation of Mental Disorders [PRIME-MD]) and the authors' own research tools.The women were aged 42.3±4.5 years (mean ± SD). The BMI (24.8±4.04 kg/m2) did not differ

2018 Clinical interventions in aging PubMed abstract

186. Physical Activity Stage of Change and Its Related Factors in Secondary School Students of Sarableh City: A Perspective from Iran (Full text)

criteria were selected using the simple random sampling technique. After giving their informed consent, the students filled the stage of change questionnaire and the structures of the transtheoretical model in a self-reporting manner. Using SPSS.21, the data were analysed through One-way ANOVA and Pearson correlation test with a 0.05 level of significance.The mean age of the students was 16.16±0.89 years. According to the stage of change, 26.8 per cent (n = 70) were in preaction stages (...) Physical Activity Stage of Change and Its Related Factors in Secondary School Students of Sarableh City: A Perspective from Iran Physical activity is highly beneficial to health. These benefits are so important and indispensable for adolescents.The aim of this study was to investigate the Physical activity stage of change and its related factors in the male secondary School students of Sarableh city.In a cross-sectional study, 261 male secondary School students possessing the eligibility

2018 Open access Macedonian journal of medical sciences PubMed abstract

187. Reduced-dose Radiotherapy for Low-risk Stage III Patients With Nasopharyngeal Carcinoma

. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years to 70 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Pathological diagnosis of NPC(WHO II or III). Stage III(8thAJCC/UICC staging system) and pretreatment EBVDNA<4000opies/ml. Aged 18—70 years。 ECOG = 0-1。 HGB≥90 g/L,WBC≥4×109 /L,PLT≥100×109 /L. ALT,AST<2.5 fold of ULN;TBIL<2.0×ULN。 CCR≥60ml/min or Cr<1.5×ULN。 Signed informed consent (...) Reduced-dose Radiotherapy for Low-risk Stage III Patients With Nasopharyngeal Carcinoma Reduced-dose Radiotherapy for Low-risk Stage III Patients With Nasopharyngeal Carcinoma - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies

2018 Clinical Trials

188. Occupational Therapist-Led Work Intervention in Facilitating Work Maintenance or Re-entry to the Workforce in Patients With Stage I to III Breast Cancer Undergoing Chemotherapy

a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Stage I-III breast cancer patients who will be undergoing curative intent chemotherapy Working in a paid capacity (part or full-time) at time (...) Occupational Therapist-Led Work Intervention in Facilitating Work Maintenance or Re-entry to the Workforce in Patients With Stage I to III Breast Cancer Undergoing Chemotherapy Occupational Therapist-Led Work Intervention in Facilitating Work Maintenance or Re-entry to the Workforce in Patients With Stage I to III Breast Cancer Undergoing Chemotherapy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results

2018 Clinical Trials

189. Gut Microbiota Across Early Stages of Synucleinopathy: From High-risk Relatives, REM Sleep Behavior Disorder to Early Parkinson's Disease

will be immediately sent to pathology department and will be stored in a -80 oC freeze for processing of microbiota analyses. First degree relatives of patients with iRBD First degree relatives of patients with iRBD; Age-and sex-matched with PD subjects Chinese aged 50 or above; Absence of dream enactment behaviors; A total score on REM Sleep Behavior Questionnaire (RBDQ-HK) less than 19, which is the suggestive cut-off of a diagnosis of RBD; Not cohabiting with proband Diagnostic Test: Colonoscopy All subjects (...) with PD subjects; Chinese aged 50 or above; Absence of dream enactment behaviors; A total score on REM Sleep Behavior Questionnaire (RBDQ-HK) less than 19, which is the suggestive cut-off of a diagnosis of RBD; Cohabiting with proband. First degree relatives of healthy controls First degree relatives of healthy controls; Age-and sex-matched with PD subjects; Chinese aged 50 or above ; Absence of dream enactment behaviors; A total score on REM Sleep Behavior Questionnaire (RBDQ-HK) less than 19, which

2018 Clinical Trials

190. Evaluation of the Effect of Cooled Haemodialysis on Cognitive Function in Patients Suffering With End-stage KD

to the end of the study. The intervention group is split into 3 brackets, stratified by age group (patients under 55 years of age, 55-75 and above 75). A third group will also be recruited, but not randomised, consisting of the primary carers (family, friends, etc) of the patients in the other two group to measure the burden they feel in caring for a patient with renal problems. Masking: Single (Outcomes Assessor) Masking Description: One nurse, that gives the patients their cognitive questionnaire (...) Evaluation of the Effect of Cooled Haemodialysis on Cognitive Function in Patients Suffering With End-stage KD Evaluation of the Effect of Cooled Haemodialysis on Cognitive Function in Patients Suffering With End-stage KD - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2018 Clinical Trials

191. Carbon Dioxide Fractional Laser in Treating Participants With Stage 0-III Hormone Receptor-Positive Breast Cancer With Vulvovaginal Atrophy

. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Histological confirmation of adenocarcinoma of the breast stage 0-III Evidence of hormone sensitivity with estrogen receptor (ER) and/or progesterone receptor (PR) positive >= 1% of primary tumor tissue Currently or will be starting on aromatase inhibitor (letrozole, anastrozole (...) Carbon Dioxide Fractional Laser in Treating Participants With Stage 0-III Hormone Receptor-Positive Breast Cancer With Vulvovaginal Atrophy Carbon Dioxide Fractional Laser in Treating Participants With Stage 0-III Hormone Receptor-Positive Breast Cancer With Vulvovaginal Atrophy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study

2018 Clinical Trials

192. Comparing a Single-Dose vs. Twice Yearly Zoledronate in Patients With Early Stage Breast Cancer (REaCT-ZOL)

, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Commencing zoledronate within 3 months of starting neoadjuvant or adjuvant endocrine therapy or within 3 months of completion of neoadjuvant or adjuvant chemotherapy for early stage breast (...) Comparing a Single-Dose vs. Twice Yearly Zoledronate in Patients With Early Stage Breast Cancer (REaCT-ZOL) Comparing a Single-Dose vs. Twice Yearly Zoledronate in Patients With Early Stage Breast Cancer (REaCT-ZOL) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies

2018 Clinical Trials

193. Study of Pembrolizumab (MK-3475) Versus Placebo in Combination With Neoadjuvant Chemotherapy & Adjuvant Endocrine Therapy in the Treatment of Early-Stage Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2-) Breast Canc

Study of Pembrolizumab (MK-3475) Versus Placebo in Combination With Neoadjuvant Chemotherapy & Adjuvant Endocrine Therapy in the Treatment of Early-Stage Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2-) Breast Canc Study of Pembrolizumab (MK-3475) Versus Placebo in Combination With Neoadjuvant Chemotherapy & Adjuvant Endocrine Therapy in the Treatment of Early-Stage Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2 (...) in the Treatment of Early-Stage Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2-) Breast Cancer (MK-3475-756/KEYNOTE-756) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03725059 Recruitment

2018 Clinical Trials

194. Growth and Safety of a Two-stage Feeding System in Preterm Infants

Growth and Safety of a Two-stage Feeding System in Preterm Infants Growth and Safety of a Two-stage Feeding System in Preterm Infants - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Growth and Safety (...) of a Two-stage Feeding System in Preterm Infants The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03728764 Recruitment Status : Recruiting First Posted : November 2, 2018 Last Update Posted : November 2, 2018 See Sponsor

2018 Clinical Trials

195. Automatized "Semi-Whole-Body"-MRI Protocol for Cancer Staging

)/CT to compare patient comfort between PET/CT and wb-MRI using a dedicated questionnaire to compare duration of image acquisition with regards to cost-effectiveness Condition or disease Intervention/treatment Phase Oncology Diagnostic Test: Semi whole-body MRI Not Applicable Detailed Description: Whole-body imaging becomes increasingly important in oncologic patients not only for primary cancer staging, but also for assessment of response to therapy. So far, PET/CT is a key method to assess cancer (...) Automatized "Semi-Whole-Body"-MRI Protocol for Cancer Staging Automatized "Semi-Whole-Body"-MRI Protocol for Cancer Staging - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Automatized "Semi-Whole-Body"-MRI

2018 Clinical Trials

196. Direct Full-stage Implantation of Sacral Neuromodulation

months postoperative) Willing and able to complete study questionnaires, use Medtronic device programmer, return for scheduled follow-up appointments Surgical candidate able to hold antiplatelet or anticoagulation prior to surgery Health insurance provider that will cover full-stage implantation Exclusion Criteria: Age <18 Pregnant or planning to become pregnant Male gender Unable or unwilling to stop anticholingeric and/or beta-3 agonist agents during the study period Treatment with botulinum toxin (...) questionnaires preoperatively and postoperatively. Therapeutic and adverse outcomes will be evaluated. The use of medical resources and time off of work will be analyzed as well. This will be a descriptive study with no additional arms or randomization. Condition or disease Intervention/treatment Urinary Bladder, Overactive Urge Incontinence Device: full stage implantation of sacral neuromodulation Study Design Go to Layout table for study information Study Type : Observational Estimated Enrollment : 30

2018 Clinical Trials

197. Shenlingcao Oral Liquid for Patients With Stage II or IIIA NSCLC

Shenlingcao Oral Liquid for Patients With Stage II or IIIA NSCLC Shenlingcao Oral Liquid for Patients With Stage II or IIIA NSCLC - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Shenlingcao Oral Liquid (...) for Patients With Stage II or IIIA NSCLC The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03712969 Recruitment Status : Recruiting First Posted : October 19, 2018 Last Update Posted : November 8, 2018 See Sponsor: West China

2018 Clinical Trials

198. Effect of Low Intensity Vibration (LIV) on Aromatase Inhibitor- Induced Musculoskeletal Dysfunction in Early Stage Breast Cancer Survivors

Inclusion Criteria: Age ≥ 18 years Post- menopausal and planned to initiate an AI Post- menopausal defined as ≥ 60 years of age, prior bilateral oophorectomy, or age ≥ 50 and absence of any menstrual periods in the last 12 months. Chemical ovarian suppression is not allowed. Prior use of a SERM and now switching to an AI is allowed. Diagnosis of DCIS or stage I, II, or III breast cancer Completion of all primary therapy for breast cancer, including surgery, radiation, and chemotherapy. Patients must (...) Effect of Low Intensity Vibration (LIV) on Aromatase Inhibitor- Induced Musculoskeletal Dysfunction in Early Stage Breast Cancer Survivors Effect of Low Intensity Vibration (LIV) on Aromatase Inhibitor- Induced Musculoskeletal Dysfunction in Early Stage Breast Cancer Survivors - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study

2018 Clinical Trials

199. Effectiveness of a Brief Cognitive and Behavioral Skills Program on Stage Transitions for Chronic Ketamine Abusers

regulations and laws, and the risks and modes of transmission of infectious diseases, including HIV and hepatitis C. Outcome Measures Go to Primary Outcome Measures : Motivation to change [ Time Frame: 15 minutes ] Stage of Change Scale: Have you thought of abstaining from Ketamine? In 30 days? In six months? Secondary Outcome Measures : Knowledge about ketamine [ Time Frame: 3 minutes ] 5 items questionnaire about consequences of using ketamine: micturition, perception distortion, depression, behavioral (...) Effectiveness of a Brief Cognitive and Behavioral Skills Program on Stage Transitions for Chronic Ketamine Abusers Effectiveness of a Brief Cognitive and Behavioral Skills Program on Stage Transitions for Chronic Ketamine Abusers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2018 Clinical Trials

200. Brentuximab Vedotin and Nivolumab in Treating Participants With Early Stage Classic Hodgkin Lymphoma

Brentuximab Vedotin and Nivolumab in Treating Participants With Early Stage Classic Hodgkin Lymphoma Brentuximab Vedotin and Nivolumab in Treating Participants With Early Stage Classic Hodgkin Lymphoma - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Brentuximab Vedotin and Nivolumab in Treating Participants With Early Stage Classic Hodgkin Lymphoma The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03712202 Recruitment

2018 Clinical Trials

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