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Adrenal Mass

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161. Cardiovascular Status in Adrenal Insufficiency

Cardiovascular Status in Adrenal Insufficiency Cardiovascular Status in Adrenal Insufficiency - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Cardiovascular Status in Adrenal Insufficiency (CVCORT-AI (...) to Brief Summary: Within this trial, the cardiovascular status and metabolic profile of patients with chronic primary adrenal insufficiency is evaluated. Condition or disease Intervention/treatment Adrenal Insufficiency Diagnostic Test: Cardiovascular evaluation Detailed Description: An unfavorable metabolic profile in patients with adrenal insufficiency (AI) under hormone replacement therapy with hydrocortisone (HC) has been revealed in one recent analysis. Furthermore an increased cardiovascular (CV

2018 Clinical Trials

162. The Effects of a Korean Ginseng, GINST15, on Hypo-Pituitary-Adrenal and Oxidative Activity Induced by Intense Work Stress. (Abstract)

The Effects of a Korean Ginseng, GINST15, on Hypo-Pituitary-Adrenal and Oxidative Activity Induced by Intense Work Stress. The effect of GINST15, an enzyme fermented ginseng supplement, on hormonal and inflammatory responses to physical stress in humans is unknown. The purpose of this investigation was to examine the constitutive and stress-induced effects of GINST15 supplement on hypo-pituitary-adrenal (HPA) and antioxidant activity in addition to muscle damage. Ten women (age: 38.7 ± 7.8 (...) years; height: 163.81 ± 4.4 cm; body mass 76.0 ± 11.6 kg) and nine men (age: 41.2. ± 9.7 years; height: 177.4 ± 5.3 cm; body mass: 88.5 ± 5.0 kg) participated in a double-blinded, placebo-controlled, counterbalanced within-group study. Participants completed three 14-day treatment cycles with different doses (high: 960 mg; low: 160 mg; placebo: 0 mg) separated by a 1-week washout period. At the end of treatment, physical stress was imposed with intense resistance exercise work stress. Participants

2018 Journal of medicinal food Controlled trial quality: uncertain

163. Malignant peripheral nerve sheath tumor originating from the adrenal gland in a dog Full Text available with Trip Pro

Malignant peripheral nerve sheath tumor originating from the adrenal gland in a dog A large abdominal mass was found in a dog. Histopathologically, the surface of the mass was covered with compressed adrenal gland tissue. The neoplastic cells showed typical features of malignant peripheral nerve sheath tumor (MPNST), including Antoni type A and type B pattern, and nuclear palisading. Immunohistochemically, these cells were positive for S100 protein, nerve growth factor receptor, nestin (...) and claudin-1. The dog was euthanized because of the developing multiple metastatic lesions. The metastatic cells showed quite similar histopathological and immunohistochemical features as those in the original tumor. Although MPNST can develop at many body sites, this is the first report of MPNST originating from the adrenal gland in a dog.

2018 The Journal of Veterinary Medical Science

164. Adrenal metastasis in sequentially developed combined hepatocellular carcinoma-cholangiocarcinoma: A case report Full Text available with Trip Pro

hepatocellular carcinoma. A 65-year-old female with a history of jaundice and abdominal discomfort was diagnosed with S4 ICC measuring 5 cm in diameter, and characterized histologically as papillary adenocarcinoma with intraductal growth, but without any evidence of malignant hepatocyte. S4 segmentectomy with hepaticojejunostomy revealed no additional masses. A follow-up CT scan 3 months after surgery showed a right adrenal mass with markedly increased serum AFP (4950 ng/mL), which was treated with right (...) adrenalectomy. Histopathology revealed a metastatic hepatocellular carcinoma testing positive for AFP, glypican-3, and hepatocytes, but negative for CD-10, inhibin-α, EMA, S-100, and cytokeratin-7. Serum AFP level immediately plummeted to 4.1 ng/mL upon adrenal mass removal. A recurrent S7 liver mass was suspected 1 year later with serum AFP value of 7.6 ng/mL, and characteristic CT imaging of HCC. TACE was performed with good response. Adrenal metastasis may manifest as the primary focus of hepatocellular

2018 Annals of Hepato-Biliary-Pancreatic Surgery

165. Lumark - lutetium, isotope of mass 177

Lumark - lutetium, isotope of mass 177 30 Churchill Place ? Canary Wharf ? London E14 5EU ? United Kingdom An agency of the European Union Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5520 Send a question via our website www.ema.europa.eu/contact 23 April 2015 EMA/427491/2015 Committee for Medicinal Products for Human Use (CHMP) Assessment report Lumark International non-proprietary name: lutetium, isotope of mass 177 Procedure No. EMEA/H/C/002749/0000 Note Assessment report (...) as adopted by the CHMP with all information of a commercially confidential nature deleted. Assessment report EMA/427491/2015 Page 2/53 Administrative information Name of the medicinal product: Lumark Applicant: I.D.B. Radiopharmacy B.V. Weverstraat 17 5111 PV Baarle-Nassau NETHERLANDS Active substance: Lutetium ( 177 Lu) International Nonproprietary Name/Common Name: lutetium, isotope of mass 177 Pharmaco-therapeutic group (ATC Code): Not yet assigned Therapeutic indication(s): Lumark

2015 European Medicines Agency - EPARs

166. Guidelines for the Minimally Invasive Treatment of Adrenal Pathology

of the current guideline begins after the decision to perform an adrenalectomy has been made. Outcomes of minimally invasive adrenalectomy Since the first description of a laparoscopic adrenalectomy by Michel Gagner in 1992, laparoscopic adrenalectomy has quickly become the standard of care for removing the majority of adrenal masses [1-2]. Multiple prospective and retrospective studies have demonstrated minimal morbidity, short convalescence, and excellent cosmesis with laparoscopic adrenalectomy [1, 3-30 (...) approach is warranted (+, strong). Laparoscopic adrenalectomy in large adrenal masses The use of laparoscopy for excision of large adrenal tumors is debated, and the literature on the subject is scant and retrospective in nature. As discussed in the section on laparoscopic adrenalectomy for suspected or adrenal cortical carcinoma, an open approach is recommend in patients with known or probable primary adrenal cortical carcinoma. Conversion from a laparoscopic to open approach is also recommended

2013 Society of American Gastrointestinal and Endoscopic Surgeons

167. Adrenal Myelolipoma: An Unusual Cause of Bilateral Highly 18F-FDG-Avid Adrenal Masses. Full Text available with Trip Pro

Adrenal Myelolipoma: An Unusual Cause of Bilateral Highly 18F-FDG-Avid Adrenal Masses. 22622025 2012 10 24 2016 11 25 1945-7197 97 8 2012 Aug The Journal of clinical endocrinology and metabolism J. Clin. Endocrinol. Metab. Adrenal myelolipoma: an unusual cause of bilateral highly 18F-FDG-avid adrenal masses. 2577-8 10.1210/jc.2012-1713 Castinetti F F Departments of Endocrinology, La Timone Hospital, Aix Marseille University, 13005 Marseille, France. Verschueren A A Cassagneau P P Brue T T Sebag (...) F F Daniel L L Taieb D D eng Case Reports Journal Article 2012 05 23 United States J Clin Endocrinol Metab 0375362 0021-972X 0 Radiopharmaceuticals 0Z5B2CJX4D Fluorodeoxyglucose F18 AIM IM Adrenal Gland Neoplasms diagnostic imaging Aged Fluorodeoxyglucose F18 Humans Male Myelolipoma diagnostic imaging Positron-Emission Tomography Radiopharmaceuticals Tomography, X-Ray Computed 2012 5 25 6 0 2012 5 25 6 0 2012 10 25 6 0 ppublish 22622025 jc.2012-1713 10.1210/jc.2012-1713

2012 Journal of Clinical Endocrinology and Metabolism

168. Pulsatile Abdominal Mass, Suspected Abdominal Aortic Aneurysm

Pulsatile Abdominal Mass, Suspected Abdominal Aortic Aneurysm Revised 2016 ACR Appropriateness Criteria ® 1 Pulsatile Abdominal Mass, Suspected AAA American College of Radiology ACR Appropriateness Criteria ® Pulsatile Abdominal Mass, Suspected Abdominal Aortic Aneurysm Variant 1: Pulsatile abdominal mass, suspected abdominal aortic aneurysm. Radiologic Procedure Rating Comments RRL* US aorta abdomen 9 O CTA abdomen with IV contrast 8 ??? MRA abdomen without and with IV contrast 8 O CT abdomen (...) without IV contrast 7 ??? CT abdomen with IV contrast 7 ??? CT abdomen without and with IV contrast 7 ???? MRA abdomen without IV contrast 7 O Aortography abdomen 4 ??? FDG-PET/CT abdomen 2 ???? Rating Scale: 1,2,3 Usually not appropriate; 4,5,6 May be appropriate; 7,8,9 Usually appropriate *Relative Radiation Level ACR Appropriateness Criteria ® 2 Pulsatile Abdominal Mass, Suspected AAA PULSATILE ABDOMINAL MASS, SUSPECTED ABDOMINAL AORTIC ANEURYSM Expert Panel on Vascular Imaging: Stephen P. Reis, MD

2016 American College of Radiology

169. Differential Diagnosis of Adrenal Mass Using Imaging Modality: Special Emphasis on F-18 Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography/Computed Tomography Full Text available with Trip Pro

Differential Diagnosis of Adrenal Mass Using Imaging Modality: Special Emphasis on F-18 Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography/Computed Tomography Adrenal incidentalomas are adrenal masses serendipitously detected during an imaging study performed for reasons unrelated to suspicion of adrenal disease. The incidence of adrenal incidentalomas has increased because of the widespread use of various imaging modalities. In oncology patients with adrenal incidentalomas (...) , the characterization of the adrenal masses is challenging because nearly 50% of incidental adrenal masses are metastatic lesions that need special medical attention. Although unenhanced computed tomography (CT) densitometry, chemical shift magnetic resonance imaging (MRI), delayed contrast-enhanced CT and CT histogram analysis have been used as sensitive and specific modalities for differentiating benign from malignant adrenal masses, F-18 fluoro-2-deoxy-D-glucose positron emission tomography (F-18 FDG PET)/CT

2014 Endocrinology and Metabolism

170. Fluorodeoxyglucose-Positron-Emission Tomography/Computed Tomography Imaging for Adrenal Masses in Patients with Lung Cancer: Review and Diagnostic Algorithm Full Text available with Trip Pro

Fluorodeoxyglucose-Positron-Emission Tomography/Computed Tomography Imaging for Adrenal Masses in Patients with Lung Cancer: Review and Diagnostic Algorithm Positron-emission tomography/computed tomography (PET/CT) with fluorine-18 fluorodeoxyglucose (FDG) is used as first-line staging for patients with newly diagnosed non-small cell lung cancer (NSCLC). Our purpose was to review the accuracy of FDG-PET/CT to predict adrenal gland metastasis, explain the causes for false-positive PET (...) , and provide a diagnostic algorithm.Two patients with incidentally discovered lung masses were found to have hypermetabolic adrenal activity by FDG-PET/CT with maximal standard uptake value (SUV) of 4.5 and 6.5. A MEDLINE search was performed on the topic of FDG-PET/CT, adrenal gland metastasis, and NSCLC. Literature was reviewed with regard to diagnosis, accuracy, outcomes, and alternative imaging or diagnostic strategies.Both patients underwent transabdominal laparoscopic adrenalectomy and were found

2014 Journal of Endourology

171. Adrenal androgen excess and body mass index in polycystic ovary syndrome. Full Text available with Trip Pro

Adrenal androgen excess and body mass index in polycystic ovary syndrome. Adrenal hyperandrogenism affects approximately 25% of polycystic ovary syndrome (PCOS) patients but its relation to obesity is not totally understood.This study aimed to assess dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) levels in relation to body mass index (BMI) in PCOS.This was a prospective observational study at an institutional practice at an obstetrics/gynecology hospital.The study

2014 Journal of Clinical Endocrinology and Metabolism

172. Case for the Wider Adoption of Mass Spectrometry-Based Adrenal Steroid Testing, and Beyond. Full Text available with Trip Pro

Case for the Wider Adoption of Mass Spectrometry-Based Adrenal Steroid Testing, and Beyond. 25322267 2015 10 07 2018 12 02 1945-7197 99 12 2014 Dec The Journal of clinical endocrinology and metabolism J. Clin. Endocrinol. Metab. Case for the wider adoption of mass spectrometry-based adrenal steroid testing, and beyond. 4434-7 10.1210/jc.2014-2258 Monaghan Phillip J PJ Department of Clinical Biochemistry (B.G.K.), University Hospital of South Manchester, Manchester M23 9LT, United Kingdom (...) States J Clin Endocrinol Metab 0375362 0021-972X 0 Adrenal Cortex Hormones 0 Gonadal Steroid Hormones AIM IM Adrenal Cortex Hormones analysis Adrenal Gland Diseases diagnosis Female Gonadal Steroid Hormones blood Humans Immunoassay Male Mass Spectrometry standards statistics & numerical data Reproducibility of Results 2014 10 17 6 0 2014 10 17 6 0 2015 10 8 6 0 ppublish 25322267 10.1210/jc.2014-2258

2014 Journal of Clinical Endocrinology and Metabolism

173. Two Clinical Lectures on Addison's Disease, with Notes of Three Cases, in One of which Suprarenal Extract Produced Marked Improvement, and in which the Suprarenal Bodies were Found after Death to be Absent and Replaced by Masses of Fat: Delivered at the E Full Text available with Trip Pro

Two Clinical Lectures on Addison's Disease, with Notes of Three Cases, in One of which Suprarenal Extract Produced Marked Improvement, and in which the Suprarenal Bodies were Found after Death to be Absent and Replaced by Masses of Fat: Delivered at the E 20756696 2011 03 29 2011 03 29 0007-1447 1 1879 1897 Jan 02 British medical journal Br Med J Two Clinical Lectures on Addison's Disease, with Notes of Three Cases, in One of which Suprarenal Extract Produced Marked Improvement, and in which (...) the Suprarenal Bodies were Found after Death to be Absent and Replaced by Masses of Fat: Delivered at the Edinburgh Royal Infirmary. 1-4 Bramwell B B eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1897 1 2 0 0 1897 1 2 0 1 ppublish 20756696 PMC2432708

1897 British medical journal

174. Two Clinical Lectures on Addison's Disease, with Notes of Three Cases, in One of which Suprarenal Extract Produced Marked Improvement, and in which the Suprarenal Bodies were Found after Death to be Absent and Replaced by Masses of Fat: Delivered at the E Full Text available with Trip Pro

Two Clinical Lectures on Addison's Disease, with Notes of Three Cases, in One of which Suprarenal Extract Produced Marked Improvement, and in which the Suprarenal Bodies were Found after Death to be Absent and Replaced by Masses of Fat: Delivered at the E 20756729 2011 03 29 2011 03 29 0007-1447 1 1880 1897 Jan 09 British medical journal Br Med J Two Clinical Lectures on Addison's Disease, with Notes of Three Cases, in One of which Suprarenal Extract Produced Marked Improvement, and in which (...) the Suprarenal Bodies were Found after Death to be Absent and Replaced by Masses of Fat: Delivered at the Edinburgh Royal Infirmary. 67-72 Bramwell B B eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1897 1 9 0 0 1897 1 9 0 1 ppublish 20756729 PMC2432645

1897 British medical journal

175. Plasma metabolomic profile varies with glucocorticoid dose in patients with congenital adrenal hyperplasia Full Text available with Trip Pro

Plasma metabolomic profile varies with glucocorticoid dose in patients with congenital adrenal hyperplasia Glucocorticoid replacement therapy is the mainstay of treatment for congenital adrenal hyperplasia (CAH) but has a narrow therapeutic index and dose optimisation is challenging. Metabolomic profiling was carried out on plasma samples from 117 adults with 21-hydroxylase deficiency receiving their usual glucocorticoid replacement therapy who were part of the CaHASE study. Samples were (...) profiled by using hydrophilic interaction chromatography with high resolution mass spectrometry. The patients were also profiled using nine routine clinical measures. The data were modelled by using both multivariate and univariate statistics by using the clinical metadata to inform the choice of patient groupings. Comparison of 382 metabolites amongst groups receiving different glucocorticoid doses revealed a clear distinction between patients receiving ≤5 mg (n = 64) and >5 mg (n = 53) daily

2017 Scientific reports

176. Giant Cavernous Hemangioma of the Adrenal Gland in an Elderly Patient Full Text available with Trip Pro

Giant Cavernous Hemangioma of the Adrenal Gland in an Elderly Patient Cavernous hemangioma is a rare, non-functional, benign adrenal tumor. Adrenal cavernous hemangioma is often diagnosed after surgery with a histologic examination. A 70-year-old man complaining of appetite loss was admitted to our hospital. An incidental large left adrenal mass was found by computed tomography (CT). There were no clinical signs of adrenogenital syndrome, Cushing's syndrome or primary aldosteronism. Total (...) resection was carried out. The pathological diagnosis was cavernous hemangioma. The differentiation of adrenal tumor is necessary in cases of large tumors, and resection is desirable given the risks of hemorrhaging and rupture.

2017 Internal Medicine

177. Clinical, Biochemical, and Radiological Characteristics of a Single-Center Retrospective Cohort of 705 Large Adrenal Tumors Full Text available with Trip Pro

with adrenal tumors, 705 (17%) had adrenal masses measuring 4 cm or more in diameter; of these, 373 (53%) were women, with a median age of 59 years (range, 18-91 years) and median tumor size of 5.2 cm (range, 4.0-24.4 cm). Underlying diagnoses were adrenocortical adenomas (n=216 [31%]), pheochromocytomas (n=158 [22%]), other benign adrenal tumors (n=116 [16%]), adrenocortical carcinomas (n=88 [13%]), and other malignant tumors (n=127 [18%]). Compared with benign tumors, malignant tumors were less (...) Clinical, Biochemical, and Radiological Characteristics of a Single-Center Retrospective Cohort of 705 Large Adrenal Tumors To characterize large adrenal tumors (≥4 cm in diameter) and to identify features associated with malignancy.We investigated the clinical, biochemical, and imaging characteristics in a large retrospective single-center cohort of patients with adrenal tumors of 4 cm or more in diameter during the period of January 1, 2000, through December 31, 2014.Of 4085 patients

2017 Mayo Clinic Proceedings. Innovations, Quality & Outcomes

178. Case report: schwannoma arising from the unilateral adrenal area with bilateral hyperaldosteronism. Full Text available with Trip Pro

Case report: schwannoma arising from the unilateral adrenal area with bilateral hyperaldosteronism. We report a rare case of a juxta-adrenal schwannoma that could not be discriminated from an adrenal tumor before surgical resection and was complicated by bilateral hyperaldosteronism. To the best of our knowledge, this is first case in which both a juxta-adrenal schwannoma and hyperaldosteronism co-existed.A 69-year-old male treated for hypertension was found to have a left supra-renal mass (5.8 (...)  × 5.2 cm) by abdominal computed tomography. His laboratory data showed that his plasma aldosterone concentration (PAC) was within the normal range, but his plasma renin activity (PRA) was reduced, resulting in an increased aldosterone/renin ratio (ARR). Load tests of captopril or furosemide in the standing position demonstrated autonomous aldosterone secretion and renin suppression. Adrenal venous sampling (AVS) with ACTH stimulation indicated bilateral hypersecretion of aldosterone. A left supra

2017 BMC Endocrine Disorders

179. Resetting the Abnormal Circadian Cortisol Rhythm in Adrenal Incidentaloma Patients With Mild Autonomous Cortisol Secretion. Full Text available with Trip Pro

Resetting the Abnormal Circadian Cortisol Rhythm in Adrenal Incidentaloma Patients With Mild Autonomous Cortisol Secretion. Adrenal incidentalomas (AIs) are found commonly on axial imaging. Around 30% exhibit autonomous cortisol secretion (ACS) associated with increased cardiovascular events and death.We hypothesized that AI/ACS patients have an abnormal cortisol rhythm that could be reversed by use of carefully timed short-acting cortisol synthesis blockade, with improvement in cardiovascular (...) disease markers.In a phase 1/2a, prospective study (Eudract no. 2012-002586-35), we recruited six patients with AI/ACS and two control groups of six sex-, age-, and body mass index-matched individuals: (1) patients with AI and no ACS (AI/NoACS) and (2) healthy volunteers with no AI [healthy controls (HC)]. Twenty-four-hour circadian cortisol analysis was performed to determine any differences between groups and timing of intervention for cortisol lowering using the 11β-hydroxylase inhibitor metyrapone

2017 Journal of Clinical Endocrinology and Metabolism

180. The utility of 18F-FDG PET/CT for the diagnosis of adrenal metastasis in lung cancer: a PRISMA-compliant meta-analysis. (Abstract)

in evaluating adrenal mass in lung cancer patients was performed. Pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio of F-FDG PET/CT on a per lesion-based analysis were calculated. The area under the curve was calculated to measure the accuracy of F-FDG PET/CT.A total of nine studies, involving 707 lung cancer patients with 810 adrenal masses, were included in the present meta-analysis. Of 810 adrenal masses from lung cancer, 411 (50.7%) and 399 (...) excellent performance.F-FDG PET/CT plays a vital role in the differentiation of adrenal metastasis from a benign adrenal mass in lung cancer patients, with excellent diagnostic performance.

2017 Nuclear medicine communications

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