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Adrenal Mass

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3801. Dual hormonal regulation of endocrine tissue mass and vasculature by adrenocorticotropin in the adrenal cortex. Full Text available with Trip Pro

Dual hormonal regulation of endocrine tissue mass and vasculature by adrenocorticotropin in the adrenal cortex. The mass of healthy adult tissues is stable and their vasculature is quiescent, but this equilibrium is disrupted under certain physiological or pathological situations. There is an emerging concept indicating that these trophic changes may be initiated by modifications of the vasculature. In the current study, we documented over a period of 14 d the serial alterations occurring (...) in both endocrine and endothelial compartments during adrenal atrophy induced by ACTH suppression in mice. After dexamethasone perfusion, a rapid fall of plasmatic ACTH and corticosterone concentrations was observed within the first 24 h. During the first 4 d of treatment, adrenal weight and adrenal cortex cellularity decreased rapidly. This was correlated with an inhibition of cell proliferation and a massive induction of endocrine cell apoptosis. Between d 4 and d 14, a slower but sustained decay

2004 Endocrinology

3802. Truncal distribution of fat mass, metabolic profile and hypothalamic-pituitary adrenal axis activity in prepubertal obese children. (Abstract)

Truncal distribution of fat mass, metabolic profile and hypothalamic-pituitary adrenal axis activity in prepubertal obese children. To investigate whether truncal distribution of fat mass (TDFM) is associated with variations of the hypothalamic-pituitary-adrenocortical (HPA) axis activity in prepubertal obese children.TDFM, assessed with dual energy X-ray absorptiometry and a comprehensive set of measures of HPA axis activity and reactivity have been studied in 45 prepubertal obese children (...) aged 6 to 11 years (girls) and 6 to 13 years (boys).After adjustment for whole body fat mass (%) (WBFM), TDFM correlated positively with insulin (r = 0.50, 95% CI [0.23; 0.70]) and homeostasis model assessment of insulin resistance (r = 0.52, 95% CI [0.25; 0.71]). When adjusted for WBFM, TDFM correlated positively with morning plasma cortisol (r = 0.38, 95% CI [0.15; 0.64]) in the total population. TDFM correlated negatively with the rise of salivary cortisol after a standard meal (r = -0.43, 95

2007 Journal of Pediatrics

3803. Management of the clinically inapparent adrenal mass ("incidentaloma"). (Abstract)

Management of the clinically inapparent adrenal mass ("incidentaloma"). The National Institutes of Health Consensus Development Program convened surgeons, endocrinologists, pathologists, biostatisticians, radiologists, oncologists, and other health care professionals, as well as members of the general public, to address the causes, prevalence, and natural history of clinically inapparent adrenal masses, or "incidentalomas"; the appropriate evaluation and treatment of such masses; and directions (...) for future research. Improvements in abdominal imaging techniques have increased detection of adrenal incidentalomas, and because the prevalence of these masses increases with age, appropriate management of adrenal tumors will be a growing challenge in our aging society. To address six predetermined questions, the 12-member nonfederal, nonadvocate state-of-the-science panel heard presentations from 21 experts in adrenal incidentalomas and consulted a systematic review of medical literature on the topic

2003 Annals of Internal Medicine

3804. Osteosarcoma invading adrenal gland: rare cause of adrenal mass. (Abstract)

Osteosarcoma invading adrenal gland: rare cause of adrenal mass. Adrenal gland metastasis from osteogenic sarcoma is extremely rare and is an atypical location for metastasis. Vascular hepatic exclusion techniques and the use of venovenous bypass with cardiac surgical techniques may be required to resect large adrenal masses that have invaded the inferior vena cava to achieve curative resection. The use of newer chemotherapeutic agents and aggressive surgical resection have prolonged

2005 Urology

3805. Comparison of hypothalamus-pituitary-adrenal axis suppression from superpotent topical steroids by standard endocrine function testing and gas chromatographic mass spectrometry. (Abstract)

Comparison of hypothalamus-pituitary-adrenal axis suppression from superpotent topical steroids by standard endocrine function testing and gas chromatographic mass spectrometry. We evaluated 38 males who had psoriasis vulgaris for evidence of hypothalamus-pituitary-adrenal axis suppression (HPAS) during treatment with superpotent topical glucocorticosteroids. All men were treated with 49 g per week of either Betamethasone Diproprionate in an optimized vehicle or Clobetasol Proprionate ointment (...) . Three methods used to assess HPAS were compared. Classic 8 a.m. plasma cortisol measurements, urinary-free cortisol, and 17-hydroxycorticosteroid determinations and gas chromatograph-mass spectrometry (GCMS) quantitation of urinary cortisol metabolites were compared. Values for all methods were obtained just prior to therapy and at days 4, 7, 14, and 21 during therapy and at day 28 after treatment was stopped for 7 d. Plasma cortisol measurements correlated well with other measures of HPAS. GCMS

1988 The Journal of investigative dermatology Controlled trial quality: uncertain

3806. The incidentally discovered adrenal mass. Full Text available with Trip Pro

The incidentally discovered adrenal mass. With the wider application of increasingly sensitive computed tomographic scans, more adrenal masses will be discovered incidentally. Because benign lesions of the adrenal are much commoner than malignant ones, an approach is needed to determine which incidentally discovered masses should be removed. The history and physical examination may guide the evaluation. Imaging studies and needle biopsies have limited value. If the history and physical findings (...) do not suggest a diagnosis, an approach using the size of the mass, results of any cyst puncture, and a biochemical assessment may determine which patients should have surgery. This approach is based on the relative prevalence of benign and malignant clinically silent adrenal tumors.

1984 Annals of Surgery

3807. Identification of steroids in rat adrenal glands by liquid chromatography-thermospray mass spectrometry. Full Text available with Trip Pro

Identification of steroids in rat adrenal glands by liquid chromatography-thermospray mass spectrometry. Liquid chromatography-thermospray mass spectrometry was applied to identify corticosterone, 11-deoxy-18-hydroxycorticosterone, 18-hydroxycorticosterone and aldosterone as the major corticosteroids in the intracellular and extracellular pools of rat adrenals.

1987 Biochemical Journal

3808. Adrenal mass with virilisation: importance of endocrine investigation. Full Text available with Trip Pro

Adrenal mass with virilisation: importance of endocrine investigation. 8870581 1996 11 26 2018 11 30 0959-8138 313 7061 1996 Oct 05 BMJ (Clinical research ed.) BMJ Adrenal mass with virilisation: importance of endocrine investigation. 872-3 Nasir J J Michael White Diabetes and Endocrinology Centre, Royal Hull Hospitals. Walton C C eng Case Reports Journal Article Research Support, Non-U.S. Gov't England BMJ 8900488 0959-8138 0 Androgens 0 Steroids AIM IM BMJ. 1997 Jan 18;314(7075):229-30 (...) 9022472 Adolescent Adrenal Cortex Neoplasms complications diagnosis Adrenalectomy Adrenocortical Adenoma complications diagnosis Androgens metabolism Diagnosis, Differential Endocrine System Diseases complications diagnosis Female Humans Steroids therapeutic use Virilism etiology 1996 10 5 1996 10 5 0 1 1996 10 5 0 0 ppublish 8870581 PMC2359047 Clin Radiol. 1986 Mar;37(2):155-60 3698500 Pediatrics. 1981 Aug;68(2):242-6 6267548 Urology. 1985 Jan;25(1):1-7 3966274 Urology. 1985 Nov;26(5):435-40 4060383

1996 BMJ : British Medical Journal

3809. Functional molecular mass of rat hepatic lipase in liver, adrenal gland and ovary is different. Full Text available with Trip Pro

Functional molecular mass of rat hepatic lipase in liver, adrenal gland and ovary is different. Lipoprotein lipase (LPL) is functionally active only as a dimer. It is also generally assumed that the highly homologous hepatic lipase functions as a dimer, but no clear evidence has been presented. A hepatic lipase-like activity, also indicated as L-type lipase, is present in adrenal and ovary tissues. This enzyme is thought to originate from the liver and to be identical to hepatic lipase. We (...) determined the functional molecular mass of hepatic lipase in rat liver, adrenal gland and ovary by radiation inactivation, a method for determining the functional size of a protein without the need of prior purification. Samples were exposed to ionizing radiation at -135 degrees C. Hepatic lipase activity in liver homogenate showed a single exponential decay. The functional molecular mass was calculated to be 63 +/- 10 kDa. Hepatic lipase activity in adrenal homogenate was found to have a functional

1996 Biochemical Journal

3810. A retroperitoneal bronchogenic cyst: a rare cause of a mass in the adrenal region Full Text available with Trip Pro

A retroperitoneal bronchogenic cyst: a rare cause of a mass in the adrenal region This report documents a bronchogenic cyst presenting as an adrenal tumour in a 51 year old man with persistent epigastric pain. The cyst is regarded as a developmental abnormality of the primitive foregut, which typically occurs in the chest. Subdiaphragmatic, and retroperitoneal locations in particular, are unusual. The differential diagnosis of a bronchogenic cyst in the retroperitoneum includes cystic teratoma

2001 Journal of Clinical Pathology

3811. The diagnosis of congenital adrenal hyperplasia in the newborn by gas chromatography/mass spectrometry analysis of random urine specimens. Full Text available with Trip Pro

The diagnosis of congenital adrenal hyperplasia in the newborn by gas chromatography/mass spectrometry analysis of random urine specimens. Definitive neonatal diagnosis of congenital adrenal hyperplasia (CAH) is frequently complicated by normal 17-hydroxyprogesterone levels in 21-hydroxylase-deficient patients, residual maternal steroids, and other interfering substances in neonatal blood. In an effort to improve the diagnosis, we developed a gas chromatography/mass spectrometry method (...) -hydroxysteroid dehydrogenase deficiencies were used. The throughput for one bench-top gas chromatography/mass spectrometry instrument is 20 samples per day. Thus, this method affords an accurate, rapid, noninvasive means for the differential diagnosis of CAH in the newborn period without the need for invasive testing and ACTH stimulation.

2002 The Journal of clinical endocrinology and metabolism

3812. CT-scan, MRI and image-guided FNA cytology of incidental adrenal masses. (Abstract)

CT-scan, MRI and image-guided FNA cytology of incidental adrenal masses. The aim of this study was to compare the usefulness of computed tomography (CT)-scan, magnetic resonance imaging (MRI), and fine-needle aspiration (FNA) cytology in patients with incidentally discovered adrenal masses.Thirty-four consecutive patients (six men and 28 women, median age of 47 years, range 26-80) with non-functioning adrenal masses of 2 cm or more (median 3.5 cm, range 2-9) were studied. All patients underwent (...) CT-scan, MRI, and image-guided FNA cytology using spinal-type narrow-gauge needles prior to further procedures. Nineteen patients underwent adrenalectomy.Final pathology showed 13 benign adrenal lesions, four adrenocortical carcinomas, and two unsuspected adrenal metastases. Fifteen patients who did not have surgery were considered definitively as having benign adrenal lesions since the mass was unchanged on CT-scans performed during follow-up. The sensitivity, specificity, and positive

2003 European Journal of Surgical Oncology

3813. Decision to resect an adrenal mass depends on size of mass and age of patient. Full Text available with Trip Pro

Decision to resect an adrenal mass depends on size of mass and age of patient. 9022472 1997 03 04 2008 11 20 0959-8138 314 7075 1997 Jan 18 BMJ (Clinical research ed.) BMJ Decision to resect an adrenal mass depends on size of mass and age of patient. 229-30 Sharma A K AK Wheeler M H MH eng Comment Letter England BMJ 8900488 0959-8138 AIM IM BMJ. 1996 Oct 5;313(7061):872-3 8870581 Adrenal Gland Diseases surgery Adrenalectomy Decision Making Humans 1997 1 18 1997 1 18 0 1 1997 1 18 0 0 ppublish

1997 BMJ : British Medical Journal

3814. Normal bone mineral density and lean body mass, but increased fat mass, in young adult patients with congenital adrenal hyperplasia. Full Text available with Trip Pro

Normal bone mineral density and lean body mass, but increased fat mass, in young adult patients with congenital adrenal hyperplasia. Patients with congenital adrenal hyperplasia attributable to 21-hydroxylase deficiency are treated with glucocorticoids. Glucocorticoid administration, even in substitution doses, may cause decreased bone mineral density (BMD) and obesity. The purpose of this study was to determine BMD, lean mass, and fat mass in young adult male (M, n = 15) and female (F, n = 15 (...) ) patients with 21-hydroxylase deficiency, who had been treated with currently recommended low doses of glucocorticoids. Measurements were performed with dual-x-ray absorptiometry. In addition, calcaneal ultrasound measurements were performed (broadband ultrasound attenuation and speed of sound). Results were compared with those in age- and sex-matched controls; to adjust for height, lean and fat mass were divided by (height)(2). M and F patients [M, 21.7 +/- 2.4; F, 20.6 +/- 2.9 yr old (mean +/- SD

2003 Journal of Clinical Endocrinology and Metabolism

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