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Adrenal Mass

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3661. The diagnosis of congenital adrenal hyperplasia in the newborn by gas chromatography/mass spectrometry analysis of random urine specimens. (PubMed)

The diagnosis of congenital adrenal hyperplasia in the newborn by gas chromatography/mass spectrometry analysis of random urine specimens. Definitive neonatal diagnosis of congenital adrenal hyperplasia (CAH) is frequently complicated by normal 17-hydroxyprogesterone levels in 21-hydroxylase-deficient patients, residual maternal steroids, and other interfering substances in neonatal blood. In an effort to improve the diagnosis, we developed a gas chromatography/mass spectrometry method (...) -hydroxysteroid dehydrogenase deficiencies were used. The throughput for one bench-top gas chromatography/mass spectrometry instrument is 20 samples per day. Thus, this method affords an accurate, rapid, noninvasive means for the differential diagnosis of CAH in the newborn period without the need for invasive testing and ACTH stimulation.

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2002 The Journal of clinical endocrinology and metabolism

3662. Comparison of hypothalamus-pituitary-adrenal axis suppression from superpotent topical steroids by standard endocrine function testing and gas chromatographic mass spectrometry. (PubMed)

Comparison of hypothalamus-pituitary-adrenal axis suppression from superpotent topical steroids by standard endocrine function testing and gas chromatographic mass spectrometry. We evaluated 38 males who had psoriasis vulgaris for evidence of hypothalamus-pituitary-adrenal axis suppression (HPAS) during treatment with superpotent topical glucocorticosteroids. All men were treated with 49 g per week of either Betamethasone Diproprionate in an optimized vehicle or Clobetasol Proprionate ointment (...) . Three methods used to assess HPAS were compared. Classic 8 a.m. plasma cortisol measurements, urinary-free cortisol, and 17-hydroxycorticosteroid determinations and gas chromatograph-mass spectrometry (GCMS) quantitation of urinary cortisol metabolites were compared. Values for all methods were obtained just prior to therapy and at days 4, 7, 14, and 21 during therapy and at day 28 after treatment was stopped for 7 d. Plasma cortisol measurements correlated well with other measures of HPAS. GCMS

1988 The Journal of investigative dermatology

3663. Decision to resect an adrenal mass depends on size of mass and age of patient. (PubMed)

Decision to resect an adrenal mass depends on size of mass and age of patient. 9022472 1997 03 04 2008 11 20 0959-8138 314 7075 1997 Jan 18 BMJ (Clinical research ed.) BMJ Decision to resect an adrenal mass depends on size of mass and age of patient. 229-30 Sharma A K AK Wheeler M H MH eng Comment Letter England BMJ 8900488 0959-8138 AIM IM BMJ. 1996 Oct 5;313(7061):872-3 8870581 Adrenal Gland Diseases surgery Adrenalectomy Decision Making Humans 1997 1 18 1997 1 18 0 1 1997 1 18 0 0 ppublish

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1997 BMJ : British Medical Journal

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